Recent advances in the enzymatic synthesis of sugar-nucleotides using nucleotidylyltransferases and glycosyltransferases

Ahmadipour, Sanaz; Beswick, Laura; Miller, Gavin

Abstract

Sugar-nucleotides are imperative to carbohydrate metabolism and glycoconjugate biosynthesis. Enzymatic methods to access these key materials offer a powerful alternative to traditional chemical synthesis routes. Herein we review recent advances in the enzymatic pyrophosphorylation of glycosyl 1-phosphates for the provision of both native and modified sugar-nucleotides.

Citation

Ahmadipour, S., Beswick, L., & Miller, G. (2018). Recent advances in the enzymatic synthesis of sugar-nucleotides using nucleotidylyltransferases and glycosyltransferases. Carbohydrate Research, 469, 38 - 47. https://doi.org/10.1016/j.carres.2018.09.002

• Journal Article Type: Article
• Acceptance Date: Sep 10, 2018
• Online Publication Date: Sep 14, 2018
• Publication Date: 2018-11
• Publicly Available Date: May 26, 2023
• Journal: Carbohydrate Research
• Print ISSN: 0008-6215
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 469
• Pages: 38 - 47
• DOI: https://doi.org/10.1016/j.carres.2018.09.002
• Keywords: Sugar-nucleotide, Glycosyl-1-phosphate, Pyrophosphorylase, Enzymatic synthesis, Nucleotidylyltransferase
• Publisher URL: https://doi.org/10.1016/j.carres.2018.09.002