Moderators of the effects of exercise for hip and knee osteoarthritis: a systematic review of subgroup analyses from randomised controlled trials

Van Der Windt; Healey; Holden

Abstract

Meta-analyses of randomised controlled trials (RCTs) of exercise interventions in people with knee and hip osteoarthritis (OA) provide strong evidence of, on average, a small-to-medium effect on pain and function outcomes compared to comparison interventions/controls. However, not everyone responds to exercise and sub-groups may exist who respond differently. Baseline variables within trials that alter the effect of an intervention are known as moderators. Aims: 1) to identify potential moderators of the effect of exercise explored or tested in RCTs of exercise for knee and hip OA; 2) summarise the evidence reported for these moderators.

Citation

Van Der Windt, Healey, & Holden. (2020). Moderators of the effects of exercise for hip and knee osteoarthritis: a systematic review of subgroup analyses from randomised controlled trials. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2020.02.263

• Acceptance Date: Apr 1, 2020
• Publication Date: Apr 20, 2020
• Journal: Osteoarthritis and Cartilage
• Print ISSN: 1063-4584
• Publisher: Elsevier
• DOI: https://doi.org/10.1016/j.joca.2020.02.263
• Publisher URL: https://doi.org/10.1016/j.joca.2020.02.263