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Subcellular localised small molecule fluorescent probes to image mobile Zn2+

Fang, Le; Watkinson, Michael

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Authors

Le Fang

Michael Watkinson



Abstract

Zn2+, as the second most abundant d-block metal in the human body, plays an important role in a wide range of biological processes, and the dysfunction of its homeostasis is related to many diseases, including Type 2 diabetes, Alzheimer's disease and prostate and breast cancers. Small molecule fluorescent probes, as effective tools for real-time imaging, have been widely used to study Zn2+ related processes. However, the failure to control their localisation in cells has limited their utility somewhat, as they are generally incapable of studying individual processes in a specific cellular location. This perspective presents an overview of the recent developments in specific organelle localised small molecule fluorescent Zn2+ probes and their application in biological milieu, which could help to extend our understanding of the mechanisms that cells use to respond to dysfunction of zinc homeostasis and its roles in disease initiation and development.

Citation

Fang, L., & Watkinson, M. (2020). Subcellular localised small molecule fluorescent probes to image mobile Zn2+. Chemical Science, 11(42), 11366 - 11379. https://doi.org/10.1039/D0SC04568C

Journal Article Type Article
Acceptance Date Oct 7, 2020
Publication Date Oct 9, 2020
Journal Chemical Science
Print ISSN 2041-6520
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 11
Issue 42
Pages 11366 - 11379
DOI https://doi.org/10.1039/D0SC04568C
Publisher URL https://doi.org/10.1039/D0SC04568C

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