Skip to main content

Research Repository

Advanced Search

Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission

Relph, Katharine A; Russell, Clark D; Fairfield, Cameron J; Turtle, Lance; de Silva, Thushan I; Siggins, Matthew K; Drake, Thomas M; Thwaites, Ryan S; Abrams, Simon; Moore, Shona C; Hardwick, Hayley E; Oosthuyzen, Wilna; Harrison, Ewen M; Docherty, Annemarie B; Openshaw, Peter J M; Baillie, J Kenneth; Semple, Malcolm G; Ho, Antonia; Consortium Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators, International Severe Acute Respiratory and Emerging Infections

Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission Thumbnail


Authors

Katharine A Relph

Clark D Russell

Cameron J Fairfield

Lance Turtle

Thushan I de Silva

Matthew K Siggins

Thomas M Drake

Ryan S Thwaites

Simon Abrams

Shona C Moore

Hayley E Hardwick

Wilna Oosthuyzen

Ewen M Harrison

Annemarie B Docherty

Peter J M Openshaw

J Kenneth Baillie

Malcolm G Semple

Antonia Ho

International Severe Acute Respiratory and Emerging Infections Consortium Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators



Contributors

J. Kenneth Baillie
Project Leader

Malcolm G. Semple
Project Manager

Peter J.M. Openshaw
Project Manager

Gail Carson
Project Manager

Beatrice Alex
Researcher

Benjamin Bach
Researcher

Wendy S. Barclay
Researcher

Debby Bogaert
Researcher

Meera Chand
Researcher

Graham S. Cooke
Researcher

Annemarie B. Docherty
Researcher

Jake Dunning
Researcher

Ana da Silva Filipe
Researcher

Tom Fletcher
Researcher

Christopher A. Green
Researcher

Ewen M. Harrison
Researcher

Julian A. Hiscox
Researcher

Antonia Ying Wai Ho
Researcher

Peter W. Horby
Researcher

Samreen Ijaz
Researcher

Saye Khoo
Researcher

Paul Klenerman
Researcher

Andrew Law
Researcher

Wei Shen Lim
Researcher

Alexander J. Mentzer
Researcher

Laura Merson
Researcher

Alison M. Meynert
Researcher

Mahdad Noursadeghi
Researcher

Shona C Moore
Researcher

Massimo Palmarini
Researcher

William A. Paxton
Researcher

Georgios Pollakis
Researcher

Nicholas Price
Researcher

Andrew Rambaut
Researcher

David L. Robertson
Researcher

Clark D. Russell
Researcher

Vanessa Sancho-Shimizu
Researcher

Janet T. Scott
Researcher

Thushan de Silva
Researcher

Louise Sigfrid
Researcher

Tom Solomon
Researcher

Shiranee Sriskandan
Researcher

David Stuart
Researcher

Charlotte Summers
Researcher

Richard S. Tedder
Researcher

Emma C. Thomson
Researcher

A.A. Roger Thompson
Researcher

Ryan S. Thwaites
Researcher

Lance C.W. Turtle
Researcher

Rishi K. Gupta
Researcher

Maria Zambon
Researcher

Hayley Hardwick
Project Manager

Chloe Donohue
Project Manager

Ruth Lyons
Project Manager

Fiona Griffiths
Project Manager

Wilna Oosthuyzen
Project Manager

Lisa Norman
Data Curator

Riinu Pius
Data Curator

Thomas M. Drake
Data Curator

Cameron J. Fairfield
Data Curator

Stephen R. Knight
Data Curator

Kenneth A. Mclean
Data Curator

Derek Murphy
Data Curator

Catherine A. Shaw
Data Curator

Jo Dalton
Data Manager

Michelle Girvan
Data Manager

Egle Saviciute
Data Manager

Stephanie Roberts
Data Manager

Janet Harrison
Data Manager

Laura Marsh
Data Manager

Marie Connor
Data Manager

Sophie Halpin
Data Manager

Clare Jackson
Data Manager

Carrol Gamble
Data Manager

Gary Leeming
Data Collector

Andrew Law
Data Collector

Murray Wham
Data Collector

Sara Clohisey
Data Collector

Ross Hendry
Data Collector

James Scott-Brown
Data Collector

William Greenhalf
Project Member

Victoria Shaw
Project Member

Sara McDonald.
Project Member

Seán Keating
Project Member

Katie A. Ahmed
Researcher

Jane A. Armstrong
Researcher

Milton Ashworth
Researcher

Innocent G. Asiimwe
Researcher

Siddharth Bakshi
Researcher

Samantha L. Barlow
Researcher

Laura Booth
Researcher

Benjamin Brennan
Researcher

Katie Bullock
Researcher

Benjamin W.A. Catterall
Researcher

Jordan J. Clark
Researcher

Emily A. Clarke
Researcher

Sarah Cole
Researcher

Louise Cooper
Researcher

Helen Cox
Researcher

Christopher Davis
Researcher

Oslem Dincarslan
Researcher

Chris Dunn
Researcher

Philip Dyer
Researcher

Angela Elliott
Researcher

Anthony Evans
Researcher

Lorna Finch
Researcher

Lewis W.S. Fisher
Researcher

Terry Foster
Researcher

Isabel Garcia-Dorival
Researcher

William Greenhalf
Researcher

Philip Gunning
Researcher

Catherine Hartley
Researcher

Rebecca L. Jensen
Researcher

Christopher B. Jones
Researcher

Trevor R. Jones
Researcher

Shadia Khandaker
Researcher

Katharine King
Researcher

Robyn T. Kiy
Researcher

Chrysa Koukorava
Researcher

Annette Lake
Researcher

Suzannah Lant
Researcher

Diane Latawiec
Researcher

Lara Lavelle-Langham
Researcher

Daniella Lefteri
Researcher

Lauren Lett
Researcher

Lucia A. Livoti
Researcher

Maria Mancini
Researcher

Sarah McDonald
Researcher

Laurence McEvoy
Researcher

John McLauchlan
Researcher

Soeren Metelmann
Researcher

Nahida S. Miah
Researcher

Joanna Middleton
Researcher

Joyce Mitchell
Researcher

Shona C. Moore
Researcher

Ellen G. Murphy
Researcher

Rebekah Penrice-Randal
Researcher

Jack Pilgrim
Researcher

Tessa Prince
Researcher

Will Reynolds
Researcher

P. Matthew Ridley
Researcher

Debby Sales
Researcher

Victoria E. Shaw
Researcher

Rebecca K. Shears
Researcher

Benjamin Small
Researcher

Krishanthi S. Subramaniam
Researcher

Agnieska Szemiel
Researcher

Aislynn Taggart
Researcher

Jolanta Tanianis-Hughes
Researcher

Jordan Thomas
Researcher

Erwan Trochu
Researcher

Libby van Tonder
Researcher

Eve Wilcock
Researcher

J. Eunice Zhang
Researcher

Lisa Flaherty
Researcher

Nicole Maziere
Researcher

Emily Cass
Researcher

Alejandra Doce Carracedo
Researcher

Nicola Carlucci
Researcher

Anthony Holmes
Researcher

Hannah Massey
Researcher

Lee Murphy
Researcher

Nicola Wrobel
Researcher

Sarah McCafferty
Researcher

Kirstie Morrice
Researcher

Alan MacLean. Local Principal Investigators: Kayode Adeniji
Researcher

Daniel Agranoff
Researcher

Ken Agwuh
Researcher

Dhiraj Ail
Researcher

Erin L. Aldera
Researcher

Ana Alegria
Researcher

Brian Angus
Researcher

Abdul Ashish
Researcher

Dougal Atkinson
Researcher

Shahedal Bari
Researcher

Gavin Barlow
Researcher

Stella Barnass
Researcher

Nicholas Barrett
Researcher

Christopher Bassford
Researcher

Sneha Basude
Researcher

David Baxter
Researcher

Michael Beadsworth
Researcher

Jolanta Bernatoniene
Researcher

John Berridge
Researcher

Nicola Best
Researcher

Pieter Bothma
Researcher

David Chadwick
Researcher

Robin Brittain-Long
Researcher

Naomi Bulteel
Researcher

Tom Burden
Researcher

Andrew Burtenshaw
Researcher

Vikki Caruth
Researcher

David Chadwick
Researcher

Duncan Chambler
Researcher

Nigel Chee
Researcher

Jenny Child
Researcher

Srikanth Chukkambotla
Researcher

Tom Clark
Researcher

Paul Collini
Researcher

Catherine Cosgrove
Researcher

Jason Cupitt
Researcher

Maria-Teresa Cutino-Moguel
Researcher

Paul Dark
Researcher

Chris Dawson
Researcher

Samir Dervisevic
Researcher

Phil Donnison
Researcher

Sam Douthwaite
Researcher

Ingrid DuRand
Researcher

Ahilanadan Dushianthan
Researcher

Tristan Dyer
Researcher

Cariad Evans
Researcher

Chi Eziefula
Researcher

Christopher Fegan
Researcher

Adam Finn
Researcher

Duncan Fullerton
Researcher

Sanjeev Garg
Researcher

Sanjeev Garg
Researcher

Atul Garg
Researcher

Effrossyni Gkrania-Klotsas
Researcher

Jo Godden
Researcher

Arthur Goldsmith
Researcher

Clive Graham
Researcher

Elaine Hardy
Researcher

Stuart Hartshorn
Researcher

Daniel Harvey
Researcher

Peter Havalda
Researcher

Daniel B. Hawcutt
Researcher

Maria Hobrok
Researcher

Luke Hodgson
Researcher

Anil Hormis
Researcher

Michael Jacobs
Researcher

Susan Jain
Researcher

Paul Jennings
Researcher

Agilan Kaliappan
Researcher

Vidya Kasipandian
Researcher

Stephen Kegg
Researcher

Michael Kelsey
Researcher

Jason Kendall
Researcher

Caroline Kerrison
Researcher

Ian Kerslake
Researcher

Oliver Koch
Researcher

Gouri Koduri
Researcher

George Koshy
Researcher

Shondipon Laha
Researcher

Steven Laird
Researcher

Susan Larkin
Researcher

Tamas Leiner
Researcher

Patrick Lillie
Researcher

James Limb
Researcher

Vanessa Linnett
Researcher

Jeff Little
Researcher

Mark Lyttle
Researcher

Michael MacMahon
Researcher

Emily MacNaughton
Researcher

Ravish Mankregod
Researcher

Huw Masson
Researcher

Elijah Matovu
Researcher

Katherine McCullough
Researcher

Ruth McEwen
Researcher

Manjula Meda
Researcher

Gary Mills
Researcher

Jane Minton
Researcher

Mariyam Mirfenderesky
Researcher

Kavya Mohandas
Researcher

Quen Mok
Researcher

James Moon
Researcher

Elinoor Moore
Researcher

Patrick Morgan
Researcher

Craig Morris
Researcher

Katherine Mortimore
Researcher

Samuel Moses
Researcher

Mbiye Mpenge
Researcher

Rohinton Mulla
Researcher

Michael Murphy
Researcher

Megan Nagel
Researcher

Thapas Nagarajan
Researcher

Mark Nelson
Researcher

Matthew K. O’Shea
Researcher

Igor Otahal
Researcher

Marlies Ostermann
Researcher

Mark Pais
Researcher

Selva Panchatsharam
Researcher

Hassan Paraiso
Researcher

Brij Patel
Researcher

Natalie Pattison
Researcher

Justin Pepperell
Researcher

Mark Peters
Researcher

Mandeep Phull
Researcher

Stefania Pintus
Researcher

Jagtur Singh Pooni
Researcher

Frank Post
Researcher

David Price
Researcher

Rachel Prout
Researcher

Nikolas Rae
Researcher

Henrik Reschreiter
Researcher

Tim Reynolds
Researcher

Neil Richardson
Researcher

Mark Roberts
Researcher

Devender Roberts
Researcher

Alistair Rose
Researcher

Guy Rousseau
Researcher

Brendan Ryan
Researcher

Taranprit Saluja
Researcher

Aarti Shah
Researcher

Prad Shanmuga
Researcher

Anil Sharma
Researcher

Anna Shawcross
Researcher

Jeremy Sizer
Researcher

Manu Shankar-Hari
Researcher

Richard Smith
Researcher

Catherine Snelson
Researcher

Nick Spittle
Researcher

Nikki Staines
Researcher

Tom Stambach
Researcher

Richard Stewart
Researcher

Pradeep Subudhi
Researcher

Tamas Szakmany
Researcher

Kate Tatham
Researcher

Jo Thomas
Researcher

Chris Thompson
Researcher

Robert Thompson
Researcher

Ascanio Tridente
Researcher

Darell Tupper-Carey
Researcher

Mary Twagira
Researcher

Andrew Ustianowski
Researcher

Nick Vallotton
Researcher

Lisa Vincent-Smith
Researcher

Shico Visuvanathan
Researcher

Alan Vuylsteke
Researcher

Sam Waddy
Researcher

Rachel Wake
Researcher

Andrew Walden
Researcher

Ingeborg Welters
Researcher

Tony Whitehouse
Researcher

Paul Whittaker
Researcher

Ashley Whittington
Researcher

Padmasayee Papineni
Researcher

Meme Wijesinghe
Researcher

Martin Williams
Researcher

Lawrence Wilson
Researcher

Sarah Cole
Researcher

Stephen Winchester
Researcher

Martin Wiselka
Researcher

Adam Wolverson
Researcher

Daniel G. Wootton
Researcher

Andrew Workman
Researcher

Bryan Yates
Researcher

Peter Young
Researcher

Abstract

<jats:title>Abstract</jats:title> <jats:p>Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51–.60]).</jats:p>

Citation

Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., …Consortium Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators, I. S. A. R. A. E. I. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5), https://doi.org/10.1093/ofid/ofac179

Journal Article Type Article
Acceptance Date Apr 1, 2022
Online Publication Date May 1, 2022
Publication Date May 2, 2022
Publicly Available Date May 30, 2023
Journal Open Forum Infectious Diseases
Print ISSN 2328-8957
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 9
Issue 5
DOI https://doi.org/10.1093/ofid/ofac179
Publisher URL https://academic.oup.com/ofid/article/9/5/ofac179/6576799