Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes

Wieczorek, Anna; Błauż, Andrzej; Żal, Aleksandra; Arabshahi, Homayon John; Reynisson, Jóhannes; Hartinger, Christian G.; Rychlik, Błażej; Plażuk, Damian

Abstract

A series of ferrocenyl analogues and derivatives of paclitaxel and docetaxel were synthesised and assayed for their antiproliferative/cytotoxic effects, impact on the cell cycle distribution and ability to induce tubulin polymerisation. The replacement of the 3′-N-benzoyl group of paclitaxel with a ferrocenoyl moiety, in particular, led to formation of an analogue that was at least one order of magnitude more potent in terms of antiproliferative activity than the parent compound (IC50 values of 0.11 versus 1.11 μm, respectively), but still preserved the classical taxane mode of action, that is, microtubule stabilisation leading to mitotic arrest. Molecular docking studies revealed an unexpected binding pocket in the tubulin structure for the ferrocenoyl group introduced in the paclitaxel backbone.

Citation

Wieczorek, A., Błauż, A., Żal, A., Arabshahi, H. J., Reynisson, J., Hartinger, C. G., …Plażuk, D. (2016). Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes. Chemistry - A European Journal, 22(32), 11413-11421. https://doi.org/10.1002/chem.201601809

• Journal Article Type: Article
• Online Publication Date: Jul 4, 2016
• Publication Date: Aug 1, 2016
• Deposit Date: Jun 9, 2023
• Journal: Chemistry - A European Journal
• Print ISSN: 0947-6539
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 22
• Issue: 32
• Pages: 11413-11421
• DOI: https://doi.org/10.1002/chem.201601809
• Keywords: General Chemistry; Catalysis; Organic Chemistry