Adam T. Hancock
Association between polymyalgia rheumatica and vascular disease: A systematic review
Hancock, Adam T.; Mallen, Christian D.; Belcher, John; Hider, Samantha L.
Authors
Christian Mallen c.d.mallen@keele.ac.uk
John Belcher j.belcher@keele.ac.uk
Samantha Hider s.hider@keele.ac.uk
Abstract
Objective
To systematically identify and appraise the existing literature on the association between polymyalgia rheumatica (PMR) and vascular disease.
Methods
The Medline, Embase, CINAHL, and Cochrane databases were searched from inception to September 2010. Search criteria included observational studies containing patients with isolated PMR reporting on a vascular outcome. Data were extracted and articles were assessed for quality.
Results
The database search identified 545 articles. Eight articles reporting on 7 unique studies were included in the final review. Four studies reported on vascular mortality and 3 studies reported on other vascular outcomes. Four of the studies reported statistically significant positive associations between PMR and vascular disease and 3 studies reported no statistically significant results. The heterogeneity of the results was investigated; the strongest explanatory variable was that 2 of 3 studies that reported nonsignificant results were prospective, whereas all of those studies reporting significant results were retrospective.
Conclusion
There is some evidence to suggest that, like other inflammatory rheumatic disorders, PMR may be linked to an increased risk of vascular disease. Further studies are required to quantify the level of risk to determine whether patients with PMR should be actively screened for cardiovascular disease and its risk factors.
Citation
Hancock, A. T., Mallen, C. D., Belcher, J., & Hider, S. L. (2012). Association between polymyalgia rheumatica and vascular disease: A systematic review. Arthritis Care and Research, 64(9), 1301-1305. https://doi.org/10.1002/acr.21712
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Apr 12, 2012 |
| Online Publication Date | Apr 18, 2012 |
| Publication Date | 2012-09 |
| Deposit Date | Aug 25, 2023 |
| Journal | ARTHRITIS CARE & RESEARCH |
| Print ISSN | 2151-464X |
| Publisher | Wiley |
| Peer Reviewed | Peer Reviewed |
| Volume | 64 |
| Issue | 9 |
| Pages | 1301-1305 |
| DOI | https://doi.org/10.1002/acr.21712 |
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