Interventions for preventing relapse or recurrence of major depressive disorder in adults in a primary care setting: a network meta-analysis

Moriarty, Andrew S; Robertson, Lindsay; Mughal, Faraz; Cook, Natalie; Gilbody, Simon; McMillan, Dean; Chew-Graham, Carolyn A; Ali, Shehzad; Hetrick, Sarah E; Churchill, Rachel; Meader, Nicholas

Abstract

Objectives
This is a protocol for a Cochrane Review (intervention). The objectives are as follows:

The aim is to assess, using network meta‐analysis (NMA), the effectiveness and safety of interventions for preventing relapse‐recurrence of depression in adults in a primary care setting. NMA is a technique for comparing three or more interventions simultaneously in a single analysis by combining both direct and indirect evidence across a network of studies.

The objectives are to:

estimate the relative effectiveness of pharmacological, psychological and other interventions to prevent relapse‐recurrence, compared with each other and controls (e.g. pill placebo, treatment as usual) on relapse‐recurrence outcomes and adverse events;

assess the effect of interventions on quality of life outcomes and social and occupational functioning;

estimate the relative ranking of included interventions on relapse‐recurrence, quality of life, and adverse events;

summarise availability and principal findings of eligible economic evaluations.

Citation

Moriarty, A. S., Robertson, L., Mughal, F., Cook, N., Gilbody, S., McMillan, D., …Meader, N. (in press). Interventions for preventing relapse or recurrence of major depressive disorder in adults in a primary care setting: a network meta-analysis. Cochrane Database of Systematic Reviews, 2021(11), https://doi.org/10.1002/14651858.cd014832

• Journal Article Type: Article
• Acceptance Date: Nov 15, 2021
• Online Publication Date: Nov 15, 2021
• Deposit Date: Jan 19, 2024
• Journal: Cochrane Database of Systematic Reviews
• Publisher: Cochrane Collaboration
• Peer Reviewed: Peer Reviewed
• Volume: 2021
• Issue: 11
• DOI: https://doi.org/10.1002/14651858.cd014832
• Keywords: Pharmacology (medical)
• Publisher URL: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD014832/full