Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society

Kwok, Chun Shing; Anderson, Simon G.; McAllister, Katherine S.L.; Sperrin, Matthew; O'Kane, Peter D.; Keavney, Bernard; Nolan, James; Myint, Phyo Kyaw; Zaman, Azfar; Buchan, Iain; Ludman, Peter F.; de Belder, Mark A.; Mamas, Mamas A.

Abstract

Background
Around one third of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. Whilst the prevalence of LV dysfunction is known to increase with age, the prevalence of LV dysfunction in different age groups in the PCI setting is not known and the effect of age on the prognostic value of LV function in the PCI setting has not been examined.

Methods
The relationship between LV function and 30-day mortality in patients undergoing PCI in different age groups (<60 years, 60 to <70 years, 70 to <80 years and ≥80 years) was studied in 246,840 patients in the UK between 2006 and 2011.

Results
Prevalent LV dysfunction in patients undergoing PCI increased with age; 25,106/83,161 (30.2%: <60 years), 24,114/76,895 (31.4%: 60 to <70 years), 23,580/64,711 36.4% (70 to <80 years) and 9,851/22,073 (44.6%) in patients aged 80 or over (P < 0.0001). Poor LV function was independently associated with increased risk of 30-day mortality outcomes in all age groups (OR 5.65:95% CI 4.21–7.58, age <60 years; OR 5.07: 95% CI 3.91–6.57, age 60 to <70 years; OR 4.50: 95% CI 3.64–5.57, 70 to <80 years and OR 4.83:95% CI 3.79–6.15, age ≥80 years).

Conclusions
Our analysis suggests that worsening LV function is an important independent predictor of worse 30-day mortality outcomes across all age groups and underscores the need for a measure of LV function in all patients for accurate risk stratification prior to PCI. © 2014 Wiley Periodicals, Inc.

Citation

Kwok, C. S., Anderson, S. G., McAllister, K. S., Sperrin, M., O'Kane, P. D., Keavney, B., …Mamas, M. A. (2015). Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society. Catheterization and Cardiovascular Interventions, 85(6), 944-951. https://doi.org/10.1002/ccd.25732

• Journal Article Type: Article
• Acceptance Date: Nov 2, 2014
• Online Publication Date: Nov 19, 2014
• Publication Date: 2015-05
• Deposit Date: Nov 30, 2023
• Journal: Catheterization and Cardiovascular Interventions
• Print ISSN: 1522-1946
• Electronic ISSN: 1522-726X
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 85
• Issue: 6
• Pages: 944-951
• DOI: https://doi.org/10.1002/ccd.25732
• Keywords: Cardiology and Cardiovascular Medicine; Radiology, Nuclear Medicine and imaging; General Medicine