Ashim Gupta
Allogenic platelet-rich plasma for treatment of knee and hip osteoarthritis
Gupta, Ashim; Potty, Anish G.; Maffulli, Nicola
Authors
Anish G. Potty
Nicola Maffulli
Abstract
Osteoarthritis (OA) induces tremendous amounts of stress and financial burden on patients and healthcare systems worldwide. Current treatments have limitations and do not address the etiopathogenetic cause of OA. Regenerative medicine may circumvent limitations posed by traditional modalities and relies on the utilization of biologics including platelet-rich plasma (PRP). Several peer-reviewed studies have documented the safety and efficacy of autologous PRP in mitigating symptoms in knee and hip OA patients. Nonetheless, only few studies investigated the safety and efficacy of allogenic PRP. This mini review summarizes the outcomes of preclinical and clinical studies using allogenic PRP for treatment of knee or hip OA. We identified 3 preclinical and 1 clinical study using allogenic PRP for treatment of knee OA, and only 1 clinical study using allogenic PRP for treatment of hip OA. Administration of allogenic PRP is safe and probably efficacious in patients with knee or hip OA. However, more pre-clinical studies and high-powered, multi-center, non-randomized and randomized controlled trials with extended follow-up are warranted to further establish the safety and efficacy of allogenic PRP to justify its clinical use.
Citation
Gupta, A., Potty, A. G., & Maffulli, N. (in press). Allogenic platelet-rich plasma for treatment of knee and hip osteoarthritis. Frontiers in Pain Research, 4, https://doi.org/10.3389/fpain.2023.1216190
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 1, 2023 |
Online Publication Date | Jun 15, 2023 |
Deposit Date | Jan 12, 2024 |
Journal | Frontiers in Pain Research |
Print ISSN | 2673-561X |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Volume | 4 |
DOI | https://doi.org/10.3389/fpain.2023.1216190 |
Keywords | General Medicine |
Publisher URL | https://www.frontiersin.org/articles/10.3389/fpain.2023.1216190/full |
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