Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design?

Leslie, Kathryn G.; Berry, Sian S.; Miller, Gavin J.; Mahon, Clare S.

Abstract

Multivalent interactions between receptors and glycans play an important role in many different biological processes, including pathogen infection, self-recognition, and the immune response. The growth in the number of tools and techniques toward the assembly of multivalent glycoconjugates means it is possible to create synthetic systems that more and more closely resemble the diversity and complexity we observe in nature. In this Perspective we present the background to the recognition and binding enabled by multivalent interactions in nature, and discuss the strategies used to construct synthetic glycoconjugate equivalents. We highlight key discoveries and the current state of the art in their applications to glycan arrays, vaccines, and other therapeutic and diagnostic tools, with an outlook toward some areas we believe are of most interest for future work in this area.

Citation

Leslie, K. G., Berry, S. S., Miller, G. J., & Mahon, C. S. (2024). Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design?. Journal of the American Chemical Society, 146(40), 27215-27232. https://doi.org/10.1021/jacs.4c08818

• Journal Article Type: Article
• Acceptance Date: Sep 19, 2024
• Online Publication Date: Sep 28, 2024
• Publication Date: Oct 9, 2024
• Deposit Date: Oct 11, 2024
• Publicly Available Date: Oct 11, 2024
• Journal: Journal of the American Chemical Society
• Print ISSN: 0002-7863
• Electronic ISSN: 1520-5126
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 146
• Issue: 40
• Pages: 27215-27232
• DOI: https://doi.org/10.1021/jacs.4c08818
• Public URL: https://keele-repository.worktribe.com/output/950281
• Publisher URL: https://pubs.acs.org/doi/10.1021/jacs.4c08818