All Outputs (28)

Chain length impact on the retro Diels-Alder mediated release of gemcitabine from hybrid nanoparticles towards pancreatic cancer therapy. (2023)
Journal Article
Oluwasanmi, A., Lindsay, S., Curtis, A., Perrie, Y., & Hoskins, C. (2023). Chain length impact on the retro Diels-Alder mediated release of gemcitabine from hybrid nanoparticles towards pancreatic cancer therapy. International Journal of Pharmaceutics, 644, Article 123304. https://doi.org/10.1016/j.ijpharm.2023.123304

Previously reported gold coated iron oxide nanoparticles (Au-IONP's) have demonstrated their effectiveness as drug delivery vehicles for gemcitabine conjugated to a thermally labile Diels-Alder linker containing a chain of 4 carbon atoms (TTLD4) for... Read More about Chain length impact on the retro Diels-Alder mediated release of gemcitabine from hybrid nanoparticles towards pancreatic cancer therapy..

New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan (2023)
Journal Article
Khomenko, T. M., Zakharenko, A. L., Kornienko, T. E., Chepanova, A. A., Dyrkheeva, N. S., Artemova, A. O., …Lavrik, O. I. (in press). New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan. International Journal of Molecular Sciences, 24(11), Article 9155. https://doi.org/10.3390/ijms24119155

Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is an important enzyme in the DNA repair system. The ability of the enzyme to repair DNA damage induced by a topoisomerase 1 poison such as the anticancer drug topotecan makes TDP1 a promising target for complex... Read More about New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan.

Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles (2021)
Journal Article
Curtis. (2021). Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles. Nanomaterials, 2976 - 2976. https://doi.org/10.3390/nano11112976

Hybrid iron oxide-gold nanoparticles are of increasing interest for applications in nanomedicine, photonics, energy storage, etc. However, they are often difficult to synthesise without experience or 'know-how'. Additionally, standard protocols do no... Read More about Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles.

Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation (2021)
Journal Article
Curtis, A., Alsuraifi, A., Mathew, E., Lamprou, D. A., & Hoskins, C. (2021). Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation. International Journal of Pharmaceutics, 601, Article ARTN 120570. https://doi.org/10.1016/j.ijpharm.2021.120570

Thermally active polymers, can respond structurally to temperature changes, making them interesting as potential drug delivery vehicles. Polymers of N-(3-aminopropyl) methacrylamide hydrochloride (APMA) are cationic with primary amine groups in their... Read More about Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation.

Silver Nanoparticle-Mediated Therapies in the Treatment of Pancreatic Cancer (2019)
Journal Article
Foulkes, R., Ali Asgari, M., Curtis, A., & Hoskins, C. (2019). Silver Nanoparticle-Mediated Therapies in the Treatment of Pancreatic Cancer. ACS Applied Nano Material, 1758-1772. https://doi.org/10.1021/acsanm.9b00439

Pancreatic cancer is an extremely aggressive disease for which patient prognosis is poor and survival is extremely unlikely. It is an extremely under-represented cancer in the research field, due to the dense tumors formed and complexities surroundin... Read More about Silver Nanoparticle-Mediated Therapies in the Treatment of Pancreatic Cancer.

The use of nanotechnology in cardiovascular disease (2018)
Journal Article
Chandarana, M., Curtis, A., & Hoskins, C. (2018). The use of nanotechnology in cardiovascular disease. Applied Nanoscience, 1607-1619. https://doi.org/10.1007/s13204-018-0856-z

Cardiovascular diseases claim a number of lives globally; many of which are preventable. With the increase in diets that consist of high saturated fat, salt, and sugar, people often living sedentary lifestyles, and a rise in cases of obesity, the inc... Read More about The use of nanotechnology in cardiovascular disease.

A Novel PAA Derivative with Enhanced Drug Efficacy in Pancreatic Cancer Cell Lines (2018)
Journal Article
Alsuraifi, A., Kong Thoo Lin, P., Curtis, A., Lamprou, D., & Hoskins, C. (2018). A Novel PAA Derivative with Enhanced Drug Efficacy in Pancreatic Cancer Cell Lines. Pharmaceuticals, https://doi.org/10.3390/ph11040091

Nanoparticles have been shown to be effective drug carriers in cancer therapy. Pancreatic cancer forms dense tumours which are often resistant to drug molecules. In order to overcome such multidrug resistance, new drug entities, novel delivery system... Read More about A Novel PAA Derivative with Enhanced Drug Efficacy in Pancreatic Cancer Cell Lines.

Stimuli Responsive Polymeric Systems for Cancer Therapy. (2018)
Journal Article
Curtis, A., Lamprou, D., Hoskins, C., & Alsuraifi, A. (2018). Stimuli Responsive Polymeric Systems for Cancer Therapy. Pharmaceutics, https://doi.org/10.3390/pharmaceutics10030136

Nanoscale polymers systems have dominated the revolution of drug delivery advancement. Their potential in the fight against cancer is unrivalled with other technologies. Their functionality increase, targeting ability and stimuli responsive nature ha... Read More about Stimuli Responsive Polymeric Systems for Cancer Therapy..

Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy (2018)
Journal Article
Al-Shakarchi, W., Alsuraifi, A., Curtis, A., & Hoskins, C. (2018). Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy. Pharmaceutics, https://doi.org/10.3390/pharmaceutics10020063

Liver cancer treatments are often hindered by poor drug physicochemical properties, hence there is a need for improvement in order to increase patient survival and outlook. Combination therapies have been studied in order to evaluate whether increase... Read More about Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy.

Combined effect of anticancer agents and cytochrome C decorated hybrid nanoparticles for liver cancer therapy (2018)
Journal Article
Al-Shakarci, W., Alsuraifi, A., Abed, M., Abdullah, M., Hoskins, C., Richardson, A., & Curtis, A. (2018). Combined effect of anticancer agents and cytochrome C decorated hybrid nanoparticles for liver cancer therapy. Pharmaceutics, 48. https://doi.org/10.3390/pharmaceutics10020048

Hepatocellular carcinoma is an aggressive form of liver cancer that displays minimal symptoms until its late stages. Unfortunately, patient prognosis still remains poor with only 10% of patients surviving more than five years after diagnosis. Current... Read More about Combined effect of anticancer agents and cytochrome C decorated hybrid nanoparticles for liver cancer therapy.

Application of Nanoparticle Technologies in the Combat against Anti-Microbial Resistance (2018)
Journal Article
Curtis, A., Kumar, M., & Hoskins, C. (2018). Application of Nanoparticle Technologies in the Combat against Anti-Microbial Resistance. Pharmaceutics, https://doi.org/10.3390/pharmaceutics10010011

Anti-microbial resistance is a growing problem that has impacted the world and brought about the beginning of the end for the old generation of antibiotics. Increasingly, more antibiotics are being prescribed unnecessarily and this reckless practice... Read More about Application of Nanoparticle Technologies in the Combat against Anti-Microbial Resistance.

Nanotechnologies in Pancreatic Cancer Therapy. (2017)
Journal Article
Manzur, A., Hoskins, C., Oluwasanmi, A., Moss, D., & Curtis, A. (2017). Nanotechnologies in Pancreatic Cancer Therapy. Pharmaceutics, https://doi.org/10.3390/pharmaceutics9040039

Pancreatic cancer has been classified as a cancer of unmet need. After diagnosis the patient prognosis is dismal with few surviving over 5 years. Treatment regimes are highly patient variable and often the patients are too sick to undergo surgical re... Read More about Nanotechnologies in Pancreatic Cancer Therapy..

Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy (2017)
Journal Article
Oluwasanmi, A., Al-Shakarchi, W., Manzur, A., Aldebasi, M. H., Elsini, R. S., Albusair, M. K., …Hoskins, C. (2017). Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy. Journal of Controlled Release, 355-364. https://doi.org/10.1016/j.jconrel.2017.09.027

Hybrid nanoparticles (HNPs) have shown huge potential as drug delivery vehicles for pancreatic cancer. Currently, the first line treatment, gemcitabine, is only effective in 23.8% of patients. To improve this, a thermally activated system was develop... Read More about Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy.

Thermally Triggered Theranostics for Pancreatic Cancer Therapy (2017)
Journal Article
Malekigorji, M., Alfahad, M., Kong Thoo Lin, P., Jones, S., Curtis, A., & Hoskins, C. (2017). Thermally Triggered Theranostics for Pancreatic Cancer Therapy. Nanoscale, https://doi.org/10.1039/C7NR02751F

Hybrid iron oxide-gold nanoparticles (HNPs) are capable of drug binding onto their surface with a triggered release at elevated temperatures. The iron oxide core allows for diagnostic imaging whilst heating of the gold shell upon laser irradiation re... Read More about Thermally Triggered Theranostics for Pancreatic Cancer Therapy.

The co-administration of anticancer and pro-apoptotic agents as novel approach in liver cancer therapy (2017)
Presentation / Conference
Varbiro, G., Curtis, A., Hoskins, C., & Al Shakarchi, W. (2017, April). The co-administration of anticancer and pro-apoptotic agents as novel approach in liver cancer therapy. Presented at European Nanomedicine Meeting, London

Further correction: Synthesis and characterization of TPGS-gemcitabine prodrug micelles for pancreatic cancer therapy (2017)
Journal Article
Khare, V., Sakarchi, W., Gupta, P., Curtis, A., & Hoskins, C. (2017). Further correction: Synthesis and characterization of TPGS-gemcitabine prodrug micelles for pancreatic cancer therapy. RSC advances, 17367 - 17367. https://doi.org/10.1039/C7RA90041D

Further correction for ’Synthesis and characterization of TPGS-gemcitabine prodrug micelles for pancreatic cancer therapy’ by Vaibhav Khare et al., RSC Adv., 2016, 6, 60126-60137.

Synthesis and characterization of TPGS-gemcitabine prodrug micelles for pancreatic cancer therapy (2017)
Journal Article
Khare, V., Al Sakarchi, W., Gupta, P., Curtis, A., & Hoskins, C. (2017). Synthesis and characterization of TPGS-gemcitabine prodrug micelles for pancreatic cancer therapy. RSC advances, 12598 - 12598. https://doi.org/10.1039/C7RA90021J

Correction for ‘Synthesis and characterization of TPGS–gemcitabine prodrug micelles for pancreatic cancer therapy’ by Vaibhav Khare et al., RSC Adv., 2016, 6, 60126–60137.

Potential of hybrid iron oxide–gold nanoparticles as thermal triggers for pancreatic cancer therapy (2016)
Journal Article
Oluwasanmi, A., Malekigorji, M., Jones, S., Curtis, A., & Hoskins, C. (2016). Potential of hybrid iron oxide–gold nanoparticles as thermal triggers for pancreatic cancer therapy. RSC advances, https://doi.org/10.1039/c6ra20552f

Theranostics are emerging platforms for rapid cancer diagnosis and therapy. Hybrid iron oxide–gold nanoparticles (HNPs) have shown potential as theranostics due to their ability for imaging using MRI, heating using laser irradiation and carrier abili... Read More about Potential of hybrid iron oxide–gold nanoparticles as thermal triggers for pancreatic cancer therapy.

Synthesis of novel hybrid nanoparticle-prodrug constructs for pancreatic cancer therapy (2016)
Presentation / Conference
Hoskins, C., Curtis, A., & Alfahad, M. (2016, September). Synthesis of novel hybrid nanoparticle-prodrug constructs for pancreatic cancer therapy. Presented at APS PharmSci 2016, Glasgow

Temperature Controlled Theranostics for Pancreatic Cancer (2016)
Presentation / Conference
Malekigorji, M., Kong Thoo Lin, P., Lees, M., Gueorguieva, M., Curtis, A., & Hoskins, C. (2016, September). Temperature Controlled Theranostics for Pancreatic Cancer. Presented at The 7th APS International PharmSci 2016, University of Strathclyde, Glasgow