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SAT-371 Correlation of Midnight and Post Dexamethasone Salivary Cortisone and Cortisol with Post Dexamethasone Serum Cortisol Concentrations In Patients with Unilateral and Bilateral Adrenal Incidentalomas (2019)
Journal Article
Naseem, A., Mason, O., Ensah, G., Keevil, B., Hanna, F., Fryer, A., & Issa, B. (2019). SAT-371 Correlation of Midnight and Post Dexamethasone Salivary Cortisone and Cortisol with Post Dexamethasone Serum Cortisol Concentrations In Patients with Unilateral and Bilateral Adrenal Incidentalomas. Journal of the Endocrine Society, 3(Supplement_1), https://doi.org/10.1210/js.2019-sat-371

Correlation between midnight and post dexamethasone salivary cortisone and cortisol and post dexamethasone serum cortisol concentrations in patients with unilateral and bilateral adrenal incidentalomas Background: The commonest functional abnormality... Read More about SAT-371 Correlation of Midnight and Post Dexamethasone Salivary Cortisone and Cortisol with Post Dexamethasone Serum Cortisol Concentrations In Patients with Unilateral and Bilateral Adrenal Incidentalomas.

SAT-372 Correlation of Serum Dexamethasone and Cortisol Concentrations Post Dexamethasone 1 Mg in the Overnight Dexamethasone Suppression Test in Patients with Unilateral and Bilateral Adrenal Incidentalomas (2019)
Journal Article
Naseem, A., Mason, O., Ensah, G., Keevil, B., Hanna, F. W. F., Fryer, A., & Issa, B. (2019). SAT-372 Correlation of Serum Dexamethasone and Cortisol Concentrations Post Dexamethasone 1 Mg in the Overnight Dexamethasone Suppression Test in Patients with Unilateral and Bilateral Adrenal Incidentalomas. Journal of the Endocrine Society, 3(Supplement_1), Article SAT-372. https://doi.org/10.1210/js.2019-sat-372

Background: The most common functional abnormality in adrenal incidentalomas (AI) is autonomous cortisol secretion. Most guidelines recommend a 1 mg overnight dexamethasone suppression test (ONDST) as a screening test for this abnormality. There is s... Read More about SAT-372 Correlation of Serum Dexamethasone and Cortisol Concentrations Post Dexamethasone 1 Mg in the Overnight Dexamethasone Suppression Test in Patients with Unilateral and Bilateral Adrenal Incidentalomas.

More frequent lithium testing in UK Primary Care associates with a lower hospital admission rate for bipolar disorder-What this can tell us about GP practice engagement with this group. (2019)
Journal Article
Holland, D., Duff, C. J., Farman, S., Fryer, A. A., Yung, A., Bailey, S., & Heald, A. H. (2019). More frequent lithium testing in UK Primary Care associates with a lower hospital admission rate for bipolar disorder-What this can tell us about GP practice engagement with this group. International Journal of Clinical Practice, 73(4), e13277. https://doi.org/10.1111/ijcp.13277

The frequency of testing for glycated haemoglobin, HbA1c, is linked to the probability of achieving target levels in patients with suboptimally controlled diabetes mellitus. (2018)
Journal Article
Duff, C. J., Solis-Trapala, I., Driskell, O. J., Holland, D., Wright, H., Waldron, J. L., …Fryer, A. A. (2018). The frequency of testing for glycated haemoglobin, HbA1c, is linked to the probability of achieving target levels in patients with suboptimally controlled diabetes mellitus. Clinical Chemistry and Laboratory Medicine, https://doi.org/10.1515/cclm-2018-0503

Introduction:
We previously showed, in patients with diabetes, that >50% of monitoring tests for glycated hemoglobin (HbA1c) are outside recommended intervals and that this is linked to diabetes control. Here, we examined the impact of tests/year on... Read More about The frequency of testing for glycated haemoglobin, HbA1c, is linked to the probability of achieving target levels in patients with suboptimally controlled diabetes mellitus..

Real-world practice level data analysis confirms link between variability within Blood Glucose Monitoring Strip (BGMS) and glycosylated haemoglobin (HbA1c) in Type 1 Diabetes. (2018)
Journal Article
Heald, A. H., Livingston, M., Fryer, A., Cortes, G., Anderson, S. G., Gadsby, R., …Stedman, M. (2018). Real-world practice level data analysis confirms link between variability within Blood Glucose Monitoring Strip (BGMS) and glycosylated haemoglobin (HbA1c) in Type 1 Diabetes. International Journal of Clinical Practice, 72, Article e13252. https://doi.org/10.1111/ijcp.13252

AIMS/HYPOTHESIS: Our aim was to quantify the impact of Blood Glucose Monitoring Strips variability (BGMSV) at GP practice level on the variability of reported glycated haemoglobin (HbA1cV) levels. METHODS: Overall GP Practice BGMSV and HbA1cV were ca... Read More about Real-world practice level data analysis confirms link between variability within Blood Glucose Monitoring Strip (BGMS) and glycosylated haemoglobin (HbA1c) in Type 1 Diabetes..

The association of sex hormone-binding globulin with mortality is mediated by age and testosterone in men with type 2 diabetes. (2018)
Journal Article
Ramachandran, S., Strange, R., Fryer, A., Saad, F., & Hackett, G. (2018). The association of sex hormone-binding globulin with mortality is mediated by age and testosterone in men with type 2 diabetes. Andrology, 6(6), 846-853. https://doi.org/10.1111/andr.12520

BACKGROUND:
Serum sex hormone-binding globulin levels have been associated with mortality in adult men with type 2 diabetes (T2DM).

OBJECTIVES:
To confirm the association of serum sex hormone-binding globulin with mortality and then determine wh... Read More about The association of sex hormone-binding globulin with mortality is mediated by age and testosterone in men with type 2 diabetes..

Long-term conditions and the National Diabetes Audit (2018)
Journal Article
Heald, A., Stedman, M., Farman, S., Fryer, A., Bailey, S., & Gadsby, R. (2018). Long-term conditions and the National Diabetes Audit. British Journal of General Practice (BJGP), 68(672), 320.2-320. https://doi.org/10.3399/bjgp18x697637

The management of long-term conditions1 in primary care has hit the headlines thanks to a report from the Academy of Medical Sciences,2 which highlighted the clustering of different physical and mental health conditions in a single patient, and estim... Read More about Long-term conditions and the National Diabetes Audit.

Photodynamic therapy corrects abnormal cancer-associated gene expression observed in actinic keratosis lesions and induces a remodeling effect in photodamaged skin (2018)
Journal Article
Joly, F., Deret, S., Gamboa, B., Menigot, C., Fogel, P., Mounier, C., …Voegel, J. J. (2018). Photodynamic therapy corrects abnormal cancer-associated gene expression observed in actinic keratosis lesions and induces a remodeling effect in photodamaged skin. Journal of Dermatological Science, 91(2), 206-218. https://doi.org/10.1016/j.jdermsci.2018.05.002

Background
Actinic keratoses (AK) are proliferations of neoplastic keratinocytes in the epidermis resulting from cumulative exposure to ultraviolet radiation (UVR), which are liable to transform into squamous cell carcinoma (SCC). Organ Transplant R... Read More about Photodynamic therapy corrects abnormal cancer-associated gene expression observed in actinic keratosis lesions and induces a remodeling effect in photodamaged skin.

Reduction of unnecessary N-terminal pro-brain natriuretic peptide (NT-proBNP) tests: A further lesson in demand management (2018)
Journal Article
Livingston, M., Kalansooriya, A., Hartland, A., Fryer, A. A., Gupta, J., & Heald, A. H. (2018). Reduction of unnecessary N-terminal pro-brain natriuretic peptide (NT-proBNP) tests: A further lesson in demand management. International Journal of Clinical Practice, 72(4), Article ARTN e13071. https://doi.org/10.1111/ijcp.13071

The number of laboratory tests performed in the UK is steadily increasing (average 8-10% year-on-year increase).1 Funding for these tests is not increasing at the same rate. Hence, considerable interest has focused on managing the demand for patholog... Read More about Reduction of unnecessary N-terminal pro-brain natriuretic peptide (NT-proBNP) tests: A further lesson in demand management.

Sodium‐glucose co‐transporter‐2 inhibitors, the latest residents on the block: Impact on glycaemic control at a general practice level in England (2018)
Journal Article
Heald, A. H., Fryer, A. A., Anderson, S. G., Livingston, M., Lunt, M., Davies, M., …Stedman, M. (2018). Sodium‐glucose co‐transporter‐2 inhibitors, the latest residents on the block: Impact on glycaemic control at a general practice level in England. Diabetes, Obesity and Metabolism, 20(7), 1659-1669. https://doi.org/10.1111/dom.13281

Aims
To determine, using published general practice-level data, how differences in Type 2 diabetes mellitus (T2DM) prescribing patterns relate to glycaemic target achievement levels.

Methods
Multiple linear regression modelling was used to link... Read More about Sodium‐glucose co‐transporter‐2 inhibitors, the latest residents on the block: Impact on glycaemic control at a general practice level in England.

Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies (2018)
Journal Article
Wu, P., Farrell, W., Haworth, K., Emes, R., Kitchen, M., Glossop, J., …Fryer, A. (2018). Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies. Epigenetics, 122-128. https://doi.org/10.1080/15592294.2016.1166321

Several recent reports have described associations between gestational diabetes (GDM) and changes to the epigenomic landscape where the DNA samples were derived from either cord or placental sources. We employed genome-wide 450K array analysis to det... Read More about Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies.

Identification of rare diseases by screening a population selected on the basis of routine pathology results—the PATHFINDER project: lysosomal acid lipase/cholesteryl ester storage disease substudy (2018)
Journal Article
Reynolds, T. M., Mewies, C., Hamilton, J., Wierzbicki, A. S., & Fryer, T. (2018). Identification of rare diseases by screening a population selected on the basis of routine pathology results—the PATHFINDER project: lysosomal acid lipase/cholesteryl ester storage disease substudy. Journal of Clinical Pathology, 71(7), 608-613. https://doi.org/10.1136/jclinpath-2017-204727

Aims Lysosomal acid lipase deficiency (LALD) is an autosomal recessive disorder of cholesterol ester storage associated with hepatic disease, cirrhosis and accelerated atherosclerosis. Its prevalence in the general population, patients with dyslipida... Read More about Identification of rare diseases by screening a population selected on the basis of routine pathology results—the PATHFINDER project: lysosomal acid lipase/cholesteryl ester storage disease substudy.

Management of incidental adrenal tumours. (2018)
Journal Article
Hanna, F., Issa, B., Sim, J., Keevil, B., & Fryer, A. (2018). Management of incidental adrenal tumours. BMJ, j5674 - ?. https://doi.org/10.1136/bmj.j5674

An incidental adrenal tumour, described in this article as an “adrenal incidentaloma,” is an adrenal mass discovered during imaging that was not performed for suspected adrenal disease. These are being detected more frequently in an ageing population... Read More about Management of incidental adrenal tumours..