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All Outputs (467)

Acceptability of predictive testing for ischemic heart disease in those with a family history and the impact of results on behavioural intention and behaviour change: a systematic review. (2022)
Journal Article
Wells, I., Simons, G., Davenport, C., Mallen, C., Raza, K., & Falahee, M. (2022). Acceptability of predictive testing for ischemic heart disease in those with a family history and the impact of results on behavioural intention and behaviour change: a systematic review. BMC Public Health, 22, Article 1751. https://doi.org/10.1186/s12889-022-14116-6

BACKGROUND: Tests to predict the development of chronic diseases in those with a family history of the disease are becoming increasingly available and can identify those who may benefit most from preventive interventions. It is important to understan... Read More about Acceptability of predictive testing for ischemic heart disease in those with a family history and the impact of results on behavioural intention and behaviour change: a systematic review..

Development and validation of a prediction model for self-reported mobility decline in community-dwelling older adults. (2022)
Journal Article
Sanchez-Santos, M., Williamson, E., Nicolson, P., Bruce, J., Collins, G., Mallen, C., …OPAL study team, .. (2022). Development and validation of a prediction model for self-reported mobility decline in community-dwelling older adults. Journal of Clinical Epidemiology, 70-79. https://doi.org/10.1016/j.jclinepi.2022.09.002

OBJECTIVE: To develop and validate two models to predict 2-year risk of self-reported mobility decline among community-dwelling older adults.

STUDY DESIGN AND SETTING: We used data from a prospective cohort study of people aged 65 years and over... Read More about Development and validation of a prediction model for self-reported mobility decline in community-dwelling older adults..

Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic. (2022)
Journal Article
Fuller, A., Hancox, J., Vedhara, K., Card, T., Mallen, C., Van-Tam, J., & Abhishek, A. (2022). Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic. PloS one, 17(9), Article e0267769. https://doi.org/10.1371/journal.pone.0267769

OBJECTIVES: To explore barriers and facilitators to COVID-19, influenza, and pneumococcal vaccine uptake in immunosuppressed adults with immune-mediated inflammatory diseases (IMIDs).

METHODS: Recruiting through national patient charities and a l... Read More about Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic..

Is vaccination against COVID-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis (2022)
Journal Article
Nakafero, G., Grainge, M. J., Abhishek, A., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Williams, H. C. (2023). Is vaccination against COVID-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis. Rheumatology, 62(4), 1445-1450. https://doi.org/10.1093/rheumatology/keac484

AbstractObjectivesTo investigate the association between vaccination against coronavirus disease 2019 (COVID-19) and autoimmune rheumatic disease (AIRD) flare.Material and methodsPatients with AIRDs vaccinated against COVID-19 who consulted for disea... Read More about Is vaccination against COVID-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis.

Patients’ and healthcare professionals’ perspectives on a community-based intervention for schizophrenia in Pakistan: A focus group study (2022)
Journal Article
Ishaq Khattak, M., Dikomitis, L., Firaz Khan, M., Ul Haq, M., Saeed, U., Riaz Awan, N., …Farooq, S. (2022). Patients’ and healthcare professionals’ perspectives on a community-based intervention for schizophrenia in Pakistan: A focus group study. PloS one, https://doi.org/10.1371/journal.pone.0273286

OBJECTIVE: To explore the perceptions and experiences of schizophrenia from patients, their care givers, health care providers, spiritual and traditional healers to develop a community-based intervention for improving treatment adherence for people w... Read More about Patients’ and healthcare professionals’ perspectives on a community-based intervention for schizophrenia in Pakistan: A focus group study.

The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study (2022)
Journal Article
Simons, G., Ismail, N., Sandhu, K., Mallen, C. D., Stack, R. J., Pontefract, S., …Falahee, M. (in press). The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study. BMC Rheumatology, 6, Article 50. https://doi.org/10.1186/s41927-022-00280-0

<h4>Background: </h4> Rheumatoid arthritis (RA) is a chronic inflammatory arthritis which can cause joint damage and reduced quality of life. Early treatment of RA within 3 months of symptom onset is associated with improved clinical outcomes. Howeve... Read More about The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study.

The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study. (2022)
Journal Article
Ismail, N., Sandhu, K., Mallen, C., Stack, R., Pontefract, S., Simons, G., …Falahee, M. (2022). The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study. BMC Rheumatology, 50 - ?. https://doi.org/10.1186/s41927-022-00280-0

BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory arthritis which can cause joint damage and reduced quality of life. Early treatment of RA within 3 months of symptom onset is associated with improved clinical outcomes. However, this wi... Read More about The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study..

The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study (2022)
Journal Article
Muller, S., Hider, S. L., Hider, S., Ranasinghe, . P., Helliwell, T., Lawton, S. A., …Mallen, C. (2022). The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study. Rheumatology Advances in Practice, 6(3), https://doi.org/10.1093/rap/rkac070

Objectives To determine the impact of polymyalgia rheumatica (PMR) on intimate and sexual relationships over time. Methods The PMR Cohort study (UKCRN ID16477) is a longitudinal study of patients with incident PMR in English primary care. Participant... Read More about The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study.

Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: cost-effectiveness of a screening strategy evaluated in a randomized controlled trial in England (2022)
Journal Article
Hill, N. R., Groves, L., Dickerson, C., Boyce, R., Lawton, S., Hurst, M., …Cohen, A. T. (2022). Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: cost-effectiveness of a screening strategy evaluated in a randomized controlled trial in England. https://doi.org/10.1080/13696998.2022.2102355

OBJECTIVE: The PULsE-AI trial sought to determine the effectiveness of a screening strategy that included a machine learning risk prediction algorithm in conjunction with diagnostic testing for identification of undiagnosed atrial fibrillation (AF) i... Read More about Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: cost-effectiveness of a screening strategy evaluated in a randomized controlled trial in England.

Risk-based stratified primary care for common musculoskeletal pain presentations (STarT MSK): a cluster-randomised, controlled trial (2022)
Journal Article
Hill, J. C., Garvin, S., Bromley, K., Saunders, B., Kigozi, J., Cooper, V., …Foster, N. E. (2022). Risk-based stratified primary care for common musculoskeletal pain presentations (STarT MSK): a cluster-randomised, controlled trial. The Lancet Rheumatology, 4(9), e591 - e602. https://doi.org/10.1016/S2665-9913%2822%2900159-X

Background Risk-based stratified care shows clinical effectiveness and cost-effectiveness versus usual primary care for non-specific low back pain but is untested for other common musculoskeletal disorders. We aimed to test the clinical effectiveness... Read More about Risk-based stratified primary care for common musculoskeletal pain presentations (STarT MSK): a cluster-randomised, controlled trial.

Influence of the Danish Co-morbidity Index Score on the Treatment and Outcomes of 2.5 Million Patients Admitted With Acute Myocardial Infarction in the United States. (2022)
Journal Article
Mamas, M., & Mallen, C. (2022). Influence of the Danish Co-morbidity Index Score on the Treatment and Outcomes of 2.5 Million Patients Admitted With Acute Myocardial Infarction in the United States. American Journal of Cardiology, https://doi.org/10.1016/j.amjcard.2022.06.008

This study aimed to determine the association between the Danish Co-morbidity Index for Acute Myocardial Infarction (DANCAMI) and restricted DANCAMI (rDANCAMI) scores and clinical outcomes in patients hospitalized with AMI. Using the National Inpatie... Read More about Influence of the Danish Co-morbidity Index Score on the Treatment and Outcomes of 2.5 Million Patients Admitted With Acute Myocardial Infarction in the United States..

Metformin use and the risk of total knee replacement among diabetic patients: a propensity-score-matched retrospective cohort study. (2022)
Journal Article
Lai, F., Yip, B., Hunter, D., Rabago, D., Mallen, C., Yeoh, E., …Sit, R. (2022). Metformin use and the risk of total knee replacement among diabetic patients: a propensity-score-matched retrospective cohort study. Scientific reports, 11571 - ?. https://doi.org/10.1038/s41598-022-15871-7

Metformin has been shown to modulate meta-inflammation, an important pathogenesis in knee osteoarthritis (OA). The study aimed to test the association between regular metformin use with total knee replacement (TKR) in patients with diabetes. This is... Read More about Metformin use and the risk of total knee replacement among diabetic patients: a propensity-score-matched retrospective cohort study..

Missed Opportunities in the Diagnosis of Heart Failure: Evaluation of Pathways to Determine Sources of Delay to Specialist Evaluation. (2022)
Journal Article
Kwok, C., Burke, H., McDermott, S., Welsh, V., Barker, D., Patwala, A., …Mallen, C. (2022). Missed Opportunities in the Diagnosis of Heart Failure: Evaluation of Pathways to Determine Sources of Delay to Specialist Evaluation. Current Heart Failure Reports, https://doi.org/10.1007/s11897-022-00551-4

Missed opportunities are incidents where different actions by those involved could have resulted in more desirable events. Heart failure is a complex clinical syndrome presenting as symptoms and signs common to other diagnoses, in patients frequently... Read More about Missed Opportunities in the Diagnosis of Heart Failure: Evaluation of Pathways to Determine Sources of Delay to Specialist Evaluation..

Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum (2022)
Journal Article
Nakafero, G., Grainge, M., Card, T., Mallen, C., Riley, R., van der Windt, D., …Abhishek, A. (2022). Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum. Rheumatology Advances in Practice, 6(2), Article rkac046. https://doi.org/10.1093/rap/rkac046

Objective: The aim was to examine the incidence and pattern of MMF discontinuation associated with abnormal monitoring blood-test results. Methods Data from people prescribed MMF for common inflammatory conditions in the Clinical Practice Research Da... Read More about Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum.

OP0228 USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND RISK OF COMORBIDITIES IN PEOPLE WITH AND WITHOUT OSTEOARTHRITIS - A UK PRIMARY CARE DATABASE COHORT STUDY (2022)
Journal Article
Mallen, C. (2022). OP0228 USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND RISK OF COMORBIDITIES IN PEOPLE WITH AND WITHOUT OSTEOARTHRITIS - A UK PRIMARY CARE DATABASE COHORT STUDY. Annals of the Rheumatic Diseases, 150 - 151. https://doi.org/10.1136/annrheumdis-2022-eular.110

<jats:sec><jats:title>Background</jats:title><jats:p>People with osteoarthritis (OA) are at higher risk of developing a wide array of comorbidities. Whether the use of non-steroidal anti-inflammatory drugs (NSAIDs) contributes to the increased risk o... Read More about OP0228 USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND RISK OF COMORBIDITIES IN PEOPLE WITH AND WITHOUT OSTEOARTHRITIS - A UK PRIMARY CARE DATABASE COHORT STUDY.

POS1124 EVALUATION OF COMORBIDITY PATTERNS AND IDENTIFICATION OF SUB-GROUPS IN PATIENTS DIAGNOSED WITH HIP OSTEOARTHRITIS IN 94,720 PATIENTS FROM SPAIN (2022)
Journal Article
Pineda-Moncusí, M., Strauss, V., Robinson, D., Swain, S., Runhaar, J., Kamps, A., …Khalid, S. (2022). POS1124 EVALUATION OF COMORBIDITY PATTERNS AND IDENTIFICATION OF SUB-GROUPS IN PATIENTS DIAGNOSED WITH HIP OSTEOARTHRITIS IN 94,720 PATIENTS FROM SPAIN. Annals of the Rheumatic Diseases, 890.2 - 891. https://doi.org/10.1136/annrheumdis-2022-eular.3121

Background Osteoarthritis (OA) patients are more likely to have other comorbidities (Swain, Sarmanova et al. 2020). Improving the understanding of comorbidity profiles of OA patients may lead to improvement in their clinical care.

Objectives To id... Read More about POS1124 EVALUATION OF COMORBIDITY PATTERNS AND IDENTIFICATION OF SUB-GROUPS IN PATIENTS DIAGNOSED WITH HIP OSTEOARTHRITIS IN 94,720 PATIENTS FROM SPAIN.

Development and psychometric evaluation of the PMR-Impact Scale: a new patient reported outcome measure for polymyalgia rheumatica. (2022)
Journal Article
Twohig, H., Mitchell, C., Mallen, C., & Muller, S. (2022). Development and psychometric evaluation of the PMR-Impact Scale: a new patient reported outcome measure for polymyalgia rheumatica. Rheumatology, https://doi.org/10.1093/rheumatology/keac317/6593480

OBJECTIVES: Polymyalgia rheumatica (PMR) causes pain, stiffness and disability in older adults. Measuring the impact of the condition from the patient's perspective is vital to high-quality research and patient-centred care, yet there are no validate... Read More about Development and psychometric evaluation of the PMR-Impact Scale: a new patient reported outcome measure for polymyalgia rheumatica..

Long-term use of glucocorticoids for polymyalgia rheumatica: follow-up of the PMR Cohort Study (2022)
Journal Article
Muller, S., Hider, S. L., Sokhal, B. S., Lawton, S. A., Helliwell, T., & Mallen, C. D. (2022). Long-term use of glucocorticoids for polymyalgia rheumatica: follow-up of the PMR Cohort Study. Rheumatology Advances in Practice, 6(2), Article rkac034. https://doi.org/10.1093/rap/rkac034

Objectives PMR is a common inflammatory condition in older adults, characterized by bilateral hip and shoulder pain and stiffness. Reducing oral glucocorticoids, classically used for <= 2 years, are the mainstay of treatment. This study considers the...

Negotiating agency and belonging during the first lockdown of the COVID-19 pandemic: an interview study among older adults in England, UK. (2022)
Journal Article
Wenning, B., Polidano, K., Mallen, C., & Dikomitis, L. (2022). Negotiating agency and belonging during the first lockdown of the COVID-19 pandemic: an interview study among older adults in England, UK. BMJ Open, e060405 - ?. https://doi.org/10.1136/bmjopen-2021-060405

OBJECTIVES: The aim of this study was to explore the agency of older adults and their strategies to restructure ways of being and belonging in a rapidly and radically changed social environment during the UK's first COVID-19 lockdown in Spring 2020.... Read More about Negotiating agency and belonging during the first lockdown of the COVID-19 pandemic: an interview study among older adults in England, UK..