Breast screening atypia and subsequent development of cancer: protocol for an observational analysis of the Sloane database in England (Sloane atypia cohort study)

Jenkinson, David; Freeman, Karoline; Clements, Karen; Hilton, Bridget; Dulson-Cox, Joanne; Kearins, Olive; Stallard, Nigel; Wallis, Matthew G; Sharma, Nisha; Kirwan, Cliona Clare; Pinder, Sarah; Provenzano, Elena; Shaaban, Abeer; Stobart, Hilary; McDonnell, Samantha; Thompson, Alistair M; Taylor-Phillips, Sian

doi:10.1136/bmjopen-2021-058050

All Outputs (8)

P194 Prescribing of bisphosphonates and their impact on the risk of fractures in patients with polymyalgia rheumatica (PMR) in England: a cohort study and target-trial in the Clinical Practice Research Datalink Aurum (2025)
Presentation / Conference Contribution
Twohig, H., Jenkinson, D., Bailey, J., Hider, S., Scott, I., & Muller, S. (2025, April). P194 Prescribing of bisphosphonates and their impact on the risk of fractures in patients with polymyalgia rheumatica (PMR) in England: a cohort study and target-trial in the Clinical Practice Research Datalink Aurum. Poster presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England, UK

Background/Aims PMR is a common indication for long-term glucocorticoid (GC) treatment with real-world data on GC treatment in PMR showing that one quarter of patients continue them for >4 years. People with PMR have a 63% increased risk of fractu... Read More about P194 Prescribing of bisphosphonates and their impact on the risk of fractures in patients with polymyalgia rheumatica (PMR) in England: a cohort study and target-trial in the Clinical Practice Research Datalink Aurum.

Management of musculoskeletal pain in children and young people with mental health or neurodivergent comorbidity (CLIMB Study) (2024)
Presentation / Conference Contribution
Jenkinson, D., Bailey, J., Mughal, F., Dunn, K., & Mason, K. (2024, July). Management of musculoskeletal pain in children and young people with mental health or neurodivergent comorbidity (CLIMB Study). Presented at SAPC ASM 2024, Bristol

SNOMED Clinical terminology and Clinical Practice Record Datalink (CPRD) AURUM dataset code lists from the CLIMB Study:

The aim of the CLIMB study is to investigate whether children and young people (aged 8-18 years) with musculoskeletal pain are... Read More about Management of musculoskeletal pain in children and young people with mental health or neurodivergent comorbidity (CLIMB Study).

Fatigue and vigilance in medical experts detecting breast cancer (2024)
Journal Article
Taylor-Phillips, S., Jenkinson, D., Stinton, C., Kunar, M. A., Watson, D. G., Freeman, K., Mansbridge, A., Wallis, M. G., Kearins, O., Hudson, S., & Clarke, A. (2024). Fatigue and vigilance in medical experts detecting breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 121(11), https://doi.org/10.1073/pnas.2309576121

An abundance of laboratory-based experiments has described a vigilance decrement of reducing accuracy to detect targets with time on task, but there are few real-world studies, none of which have previously controlled the environment to control for b... Read More about Fatigue and vigilance in medical experts detecting breast cancer.

Atypia detected during breast screening and subsequent development of cancer: observational analysis of the Sloane atypia prospective cohort in England (2024)
Journal Article
Freeman, K., Jenkinson, D., Clements, K., Wallis, M. G., Pinder, S. E., Provenzano, E., Stobart, H., Stallard, N., Kearins, O., Sharma, N., Shaaban, A., Kirwan, C. C., Hilton, B., Thompson, A. M., & Taylor-Phillips, S. (in press). Atypia detected during breast screening and subsequent development of cancer: observational analysis of the Sloane atypia prospective cohort in England. BMJ, Article 384. https://doi.org/10.1136/bmj-2023-077039

Objective To explore how the number and type of breast cancers developed after screen detected atypia compare with the anticipated 11.3 cancers detected per 1000 women screened within one three year screening round in the United Kingdom.

Design Ob... Read More about Atypia detected during breast screening and subsequent development of cancer: observational analysis of the Sloane atypia prospective cohort in England.

Evidence-informed recommendations on managing breast screening atypia: perspectives from an expert panel consensus meeting reviewing results from the Sloane atypia project (2023)
Journal Article
Freeman, K., Mansbridge, A., Stobart, H., Clements, K., Wallis, M. G., Pinder, S. E., Kearins, O., Shaaban, A. M., Kirwan, C. C., Wilkinson, L. S., Webb, S., O'Sullivan, E., Jenkins, J., Wright, S., Taylor, K., Bailey, C., Holcombe, C., Wyld, L., Edwards, K., Jenkinson, D., …Taylor-Phillips, S. (2023). Evidence-informed recommendations on managing breast screening atypia: perspectives from an expert panel consensus meeting reviewing results from the Sloane atypia project. British Journal of Radiology, https://doi.org/10.1093/bjr/tqad053

Development and Quality Appraisal of a new English Breast Screening linked dataset as part of the Age, test Threshold and frequency of Mammography screening (ATHENA-M) study (2023)
Journal Article
Brettschneider, J., Morrison, B., Jenkinson, D., Freeman, K., Walton, J., Sitch, A., Hudson, S., Kearins, O., Mansbridge, A., Pinder, S. E., Given-Wilson, R., Wilkinson, L., Wallis, M. G., Cheung, S., & Taylor-Phillips, S. (2023). Development and Quality Appraisal of a new English Breast Screening linked dataset as part of the Age, test Threshold and frequency of Mammography screening (ATHENA-M) study. British Journal of Radiology, https://doi.org/10.1093/bjr/tqad023

Optimizing the Pairs of Radiologists That Double Read Screening Mammograms (2023)
Journal Article
Gommers, J. J. J., Abbey, C. K., Strand, F., Taylor-Phillips, S., Jenkinson, D. J., Larsen, M., Hofvind, S., Sechopoulos, I., & Broeders, M. J. M. (2023). Optimizing the Pairs of Radiologists That Double Read Screening Mammograms. Radiology, 309(1), https://doi.org/10.1148/radiol.222691

Breast screening atypia and subsequent development of cancer: protocol for an observational analysis of the Sloane database in England (Sloane atypia cohort study) (2022)
Journal Article
Jenkinson, D., Freeman, K., Clements, K., Hilton, B., Dulson-Cox, J., Kearins, O., Stallard, N., Wallis, M. G., Sharma, N., Kirwan, C. C., Pinder, S., Provenzano, E., Shaaban, A., Stobart, H., McDonnell, S., Thompson, A. M., & Taylor-Phillips, S. (2022). Breast screening atypia and subsequent development of cancer: protocol for an observational analysis of the Sloane database in England (Sloane atypia cohort study). BMJ British medical journal, 12(1), https://doi.org/10.1136/bmjopen-2021-058050

Introduction The National Health Service (NHS) Breast Screening Programme aims to detect cancer earlier when treatment is more effective but can harm women by over diagnosing and overtreating cancers which would never have become symptomatic. As well... Read More about Breast screening atypia and subsequent development of cancer: protocol for an observational analysis of the Sloane database in England (Sloane atypia cohort study).