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All Outputs (18)

Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth (2022)
Journal Article
Reader, K. L., John-McHaffie, S., Zellhuber-McMillan, S., Jowett, T., Mottershead, D. G., Cunliffe, H. E., & Gold, E. J. (2022). Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth. Cancers, 15(1), Article 147. https://doi.org/10.3390/cancers15010147

Current prognostic and diagnostic tests for prostate cancer are not able to accurately distinguish between aggressive and latent cancer. Members of the transforming growth factor-β (TGFB) family are known to be important in regulating prostate cell g... Read More about Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth.

Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation (2022)
Journal Article
Mottershead. (2022). Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation. https://doi.org/10.22074/CELLJ.2022.8155

Objective: In vitro maturation (IVM) and cryopreservation of oocytes are two important parts of assisted reproductive technology (ART), but their efficacy is low. This study aimed to improve the quality of in vitro vitrified-warmed maturated oocytes... Read More about Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation.

Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation (2022)
Journal Article
Bahrami, Z., Hatamian, N., Talkhabi, M., Zand, E., Mottershead, D., & Fathi, R. (2022). Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation. https://doi.org/10.22074/cellj.2022.8155

OBJECTIVE: In vitro maturation (IVM) and cryopreservation of oocytes are two important parts of assisted reproductive technology (ART), but their efficacy is low. This study aimed to improve the quality of in vitro vitrified-warmed maturated oocytes... Read More about Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation.

Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM (2022)
Journal Article
Mottershead, D. (2022). Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM. Journal of Assisted Reproduction and Genetics, 39, Article 127–140. https://doi.org/10.1007/s10815-021-02382-z

PURPOSE: In vitro maturation (IVM) is a technology that generates mature oocytes following culture of immature cumulus-oocyte complexes (COC) in vitro. IVM is characterized by minimal patient stimulation, making it attractive for certain patient grou... Read More about Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM.

Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro (2019)
Journal Article
Mottershead. (2019). Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro. Endocrinology, 160(4), 853-862. https://doi.org/10.1210/en.2018-01026

The oocyte-secreted factors bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) interact functionally and it is hypothesised that this interaction may be mediated by formation of a GDF9:BMP15 heterodimer, termed cumulin.... Read More about Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro.

Seminal fluid factors regulate activin A and follistatin synthesis in female cervical epithelial cells (2015)
Journal Article
Sharkey, D. J., Schjenken, J. E., Mottershead, D. G., & Robertson, S. A. (2015). Seminal fluid factors regulate activin A and follistatin synthesis in female cervical epithelial cells. Molecular and Cellular Endocrinology, 417(11), 178-190. https://doi.org/10.1016/j.mce.2015.09.022

Background:
Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency. Using a rat model that recapitulates features of human ESCC,... Read More about Seminal fluid factors regulate activin A and follistatin synthesis in female cervical epithelial cells.

Promotion of EGF receptor signaling improves the quality of low developmental competence oocytes (2015)
Journal Article
Sugimura, S., Ritter, L. J., Rose, R. D., Thompson, J. G., Smitz, J., Mottershead, D. G., & Gilchrist, R. B. (2015). Promotion of EGF receptor signaling improves the quality of low developmental competence oocytes. Developmental Biology, 403(2), 139-149. https://doi.org/10.1016/j.ydbio.2015.05.008

Oocytes acquire developmental competence with progressive folliculogenesis. Cumulus oocyte complexes (COCs) from small antral follicles have inherent low competence and are poorly responsive to amphiregulin (AREG) which normally mediates oocyte matur... Read More about Promotion of EGF receptor signaling improves the quality of low developmental competence oocytes.

Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone (2015)
Journal Article
Sutton-McDowall, M. L., Purdey, M., Brown, H. M., Abell, A. D., Mottershead, D. G., Cetica, P. D., …Thompson, J. G. (2015). Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone. Molecular Reproduction and Development, 82(4), 281-294. https://doi.org/10.1002/mrd.22470

The developmental competence of cumulus oocyte complexes (COCs) can be increased during in vitro oocyte maturation with the addition of exogenous oocyte-secreted factors, such as bone morphogenetic protein 15 (BMP15), in combination with hormones. FS... Read More about Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone.

Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15 (2014)
Journal Article
Reader, K. L., Mottershead, D. G., Martin, G. A., Gilchrist, R. B., Heath, D. A., McNatty, K. P., & Juengel, J. L. (2016). Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15. Reproduction, Fertility and Development, 28(4), 491. https://doi.org/10.1071/rd14099

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) act synergistically to regulate granulosa cell proliferation and steroid production in several species. Several non-Sma and mothers against decapentaplegic (SMAD) signal... Read More about Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15.

Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence (2014)
Journal Article
Mottershead. (2014). Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence. PloS one, https://doi.org/10.1371/journal.pone.0103563

Developmental competence of in vitro matured (IVM) oocytes needs to be improved and this can potentially be achieved by adding recombinant bone morphogenetic protein 15 (BMP15) or growth differentiation factor (GDF9) to IVM. The aim of this study was... Read More about Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence.

Mouse GDF9 decreases KITL gene expression in human granulosa cells (2014)
Journal Article
Tuck, A. R., Mottershead, D. G., Fernandes, H. A., Norman, R. J., Tilley, W. D., Robker, R. L., & Hickey, T. E. (2015). Mouse GDF9 decreases KITL gene expression in human granulosa cells. Endocrine, 48(2), 686-695. https://doi.org/10.1007/s12020-014-0335-6

Kit ligand (KITL) is an important granulosa cell-derived growth factor in ovarian folliculogenesis, but its expression and function in human granulosa cells are currently poorly understood. Based on studies performed in animal models, it was hypothes... Read More about Mouse GDF9 decreases KITL gene expression in human granulosa cells.

Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders (2014)
Journal Article
Simpson, C. M., Robertson, D. M., Al-Musawi, S. L., Heath, D. A., McNatty, K. P., Ritter, L. J., …Stanton, P. G. (2014). Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders. The Journal of Clinical Endocrinology & Metabolism, 99(4), E615-E624. https://doi.org/10.1210/jc.2013-3949

Context:
Growth differentiation factor 9 (GDF9) is a central regulator of folliculogenesis and ovulation rate. Fourteen mutations in human (h) GDF9 have been reported in women with premature ovarian failure or polycystic ovarian syndrome as well as... Read More about Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders.

Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply (2014)
Journal Article
Sugimura, S., Ritter, L. J., Sutton-McDowall, M. L., Mottershead, D. G., Thompson, J. G., & Gilchrist, R. B. (2014). Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply. Molecular Human Reproduction, 20(6), 499-513. https://doi.org/10.1093/molehr/gau013

This study assessed the participation of amphiregulin (AREG) and bone morphogenetic protein 15 (BMP15) during maturation of bovine cumulus-oocyte complexes (COCs) on cumulus cell function and their impact on subsequent embryo development. AREG treatm... Read More about Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply.

Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development (2014)
Journal Article
Sudiman, J., Ritter, L. J., Feil, D. K., Wang, X., Chan, K., Mottershead, D. G., …Gilchrist, R. B. (2014). Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development. Journal of Assisted Reproduction and Genetics, 31(3), 295-306. https://doi.org/10.1007/s10815-013-0152-5

Purpose
We hypothesised that varying native oocyte-secreted factor (OSF) exposure or using different recombinant OSF peptides would have differential effects on post-in vitro maturation (IVM) embryo and fetal development.

Methods
Mouse cumulus o... Read More about Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development.

Oocyte-Secreted Factors in Domestic Animals (2013)
Book Chapter
Thompson, J. G., Mottershead, D. G., & Gilchrist, R. B. Oocyte-Secreted Factors in Domestic Animals. . Wiley. https://doi.org/10.1002/9781118538074.ch4

Summary
This chapter contains sections titled:
Introduction
Historical Background
Localization and Specificity
Structure and Genetic Diversity of Gdf9 and Bmp15
Signalling Mechanisms of Gdf9 and Bmp15
Roles of Oocyte-Secreted Factors
Manipula... Read More about Oocyte-Secreted Factors in Domestic Animals.