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Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care (2022)
Journal Article
Watson, L., Belcher, J., Nicholls, E., Chandratre, P., Blagojevic-Bucknall, M., Hider, S., …Roddy, E. (2022). Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care. Rheumatology, 62(8), 2748-2756. https://doi.org/10.1093/rheumatology/keac706

Objective To describe factors associated with change in health-related quality of life (HRQOL) in people living with gout in primary care. Methods In a UK prospective cohort study, adults with a diagnosis of gout registered with 20 general practices... Read More about Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care.

Treat-to-target urate-lowering therapy and hospitalisations for gout: results from a nationwide cohort study in England. (2022)
Journal Article
Roddy, E., Russell, M. D., Rutherford, A. I., Ellis, B., Norton, S., Douiri, A., …Galloway, J. B. (2023). Treat-to-target urate-lowering therapy and hospitalisations for gout: results from a nationwide cohort study in England. Rheumatology, 62(7), 2426-2434. https://doi.org/10.1093/rheumatology/keac638

Objective To investigate associations between treat-to-target urate-lowering therapy (ULT) and hospitalizations for gout. Methods Using linked Clinical Practice Research Datalink and NHS Digital Hospital Episode Statistics data, we described the inci... Read More about Treat-to-target urate-lowering therapy and hospitalisations for gout: results from a nationwide cohort study in England..

A Genome-Wide Association Analysis of 2,622,830 Individuals Reveals New Pathogenic Pathways in Gout (2022)
Presentation / Conference
Merriman, T., Matsuo, H., Takei, R., Leask, M., Topless, R., Shirai, Y., …Major, T. (2022, November). A Genome-Wide Association Analysis of 2,622,830 Individuals Reveals New Pathogenic Pathways in Gout. Presented at ACR Convergence 2022

Background/Purpose: Genome-wide association studies (GWAS) in gout have been relatively small (≤13,179 people with gout) and have provided little insight into the progression from hyperuricemia to gout. We present a gout GWAS that includes 120,282 pe... Read More about A Genome-Wide Association Analysis of 2,622,830 Individuals Reveals New Pathogenic Pathways in Gout.

British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids (2022)
Journal Article
Russell, M. D., Dey, M., Flint, J., Davie, P., Allen, A., Crossley, A., …Williams, E. (2022). British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids. Rheumatology, 62(4), e48-e88. https://doi.org/10.1093/rheumatology/keac551

Association of Gout Polygenic Risk Score with Age at Disease Onset and Tophaceous Disease in European and Polynesian Men with Gout. (2022)
Journal Article
Roddy, E. (2022). Association of Gout Polygenic Risk Score with Age at Disease Onset and Tophaceous Disease in European and Polynesian Men with Gout. Arthritis and Rheumatology, 75(5), 816-825. https://doi.org/10.1002/art.42393

OBJECTIVE: To determine whether a gout polygenic risk score (PRS) associates with age at gout onset and tophaceous disease in European (EUR), East Polynesian (EP), and West Polynesian (WP) men/women with gout. METHODS: A 19-variant gout PRS was p... Read More about Association of Gout Polygenic Risk Score with Age at Disease Onset and Tophaceous Disease in European and Polynesian Men with Gout..

A Genome-Wide Association Analysis of 2,622,830 Individuals Reveals New Pathogenic Pathways in Gout (2022)
Journal Article
Roddy. (2022). A Genome-Wide Association Analysis of 2,622,830 Individuals Reveals New Pathogenic Pathways in Gout. Arthritis and Rheumatology, 3338 - 3341

Background/Purpose: Genome-wide association studies (GWAS) in gout have been relatively small (=13,179 people with gout) and have provided little insight into the progression from hyperuricemia to gout. We present a gout GWAS that includes 120,282 pe... Read More about A Genome-Wide Association Analysis of 2,622,830 Individuals Reveals New Pathogenic Pathways in Gout.

Large variation in participant eligibility criteria used in plantar heel pain research studies - a systematic review. (2022)
Journal Article
Riel, H., Plinsinga, M. L., Delahunt, E., Jensen, M. B., Landorf, K. B., van Middelkoop, M., …Olesen, J. L. (2022). Large variation in participant eligibility criteria used in plantar heel pain research studies - a systematic review. Journal of Foot and Ankle Research, 15(1), Article 69. https://doi.org/10.1186/s13047-022-00573-0

INTRODUCTION: Variable eligibility criteria across studies on plantar heel pain may result in compromising the generalisability of meta-analyses when heterogeneity is not accounted for. We aimed to explore: (i) heterogeneity of participant eligibilit... Read More about Large variation in participant eligibility criteria used in plantar heel pain research studies - a systematic review..

Incidence and Progression of Hallux Valgus: A Prospective Cohort Study (2022)
Journal Article
Menz, H. B., Marshall, M., Thomas, M. J., Rathod‐Mistry, T., Peat, G. M., & Roddy, E. (2023). Incidence and Progression of Hallux Valgus: A Prospective Cohort Study. Arthritis Care and Research, 75(1), 166-173. https://doi.org/10.1002/acr.24754

OBJECTIVE: Hallux valgus is a common and disabling condition. The objective of this study was to identify factors associated with hallux valgus incidence and progression. METHODS: Participants were from a population-based prospective cohort study, th... Read More about Incidence and Progression of Hallux Valgus: A Prospective Cohort Study.

Evaluating the long-term effect of allopurinol use in gout using marginal structural models: A primary care electronic health records study (2022)
Presentation / Conference
Rathod-Mistry, T., Roddy, E., Jordan, K., Mallen, C., & Blagojevic-Bucknall, M. (2022, August). Evaluating the long-term effect of allopurinol use in gout using marginal structural models: A primary care electronic health records study

Background: Allopurinol is intended to be taken for life in the treatment of gout. In UK primary care, treatment is suboptimal with up to 30% of indicated patients being treated within five years of diagnosis and once prescribed allopurinol, treatmen... Read More about Evaluating the long-term effect of allopurinol use in gout using marginal structural models: A primary care electronic health records study.

Effects of Shoe-Stiffening Inserts on Lower Limb Kinematics in Individuals with First Metatarsophalangeal Joint Osteoarthritis. (2022)
Journal Article
Roddy, E., McClelland, J. A., Allan, J. J., Auhl, M., Buldt, A. K., Landorf, K. B., …Munteanu, S. E. (2022). Effects of Shoe-Stiffening Inserts on Lower Limb Kinematics in Individuals with First Metatarsophalangeal Joint Osteoarthritis. Arthritis Care and Research, 74(11), 1849-1856. https://doi.org/10.1002/acr.24647

OBJECTIVE: To examine the effects of shoe-stiffening inserts on lower limb kinematics in individuals with first metatarsophalangeal (MTP) joint osteoarthritis (OA). METHODS: Forty-eight individuals with radiographically confirmed first MTP joint... Read More about Effects of Shoe-Stiffening Inserts on Lower Limb Kinematics in Individuals with First Metatarsophalangeal Joint Osteoarthritis..

Footwear, foot orthoses and strengthening exercises for the non-surgical management of hallux valgus: protocol for a randomised pilot and feasibility trial (2022)
Journal Article
Roddy, Menz, H. B., Lim, P. Q., Hurn, S. E., Mickle, K. J., Buldt, A. K., …Munteanu, S. E. (2022). Footwear, foot orthoses and strengthening exercises for the non-surgical management of hallux valgus: protocol for a randomised pilot and feasibility trial. Journal of Foot and Ankle Research, 15(1), Article ARTN 45. https://doi.org/10.1186/s13047-022-00553-4

Background: Hallux valgus is a common and disabling condition. This randomised pilot and feasibility trial aims to determine the feasibility of conducting a fully-powered parallel group randomised trial to evaluate the effectiveness of a multifaceted... Read More about Footwear, foot orthoses and strengthening exercises for the non-surgical management of hallux valgus: protocol for a randomised pilot and feasibility trial.

NEUROPATHIC PAIN IN FIRST METATARSOPHALANGEAL JOINT OSTEOARTHRITIS: FREQUENCY AND ASSOCIATED FACTORS (2022)
Presentation / Conference
Roddy. (2022, May). NEUROPATHIC PAIN IN FIRST METATARSOPHALANGEAL JOINT OSTEOARTHRITIS: FREQUENCY AND ASSOCIATED FACTORS. Presented at Australian Rheumatology Association 62nd Annual Scientific Meeting, Sydney, Adelaide, Brisbane, Hobart, Melbourne, Australia and Auckland, New Zealand

Aim: To determine whether neuropathic pain is a feature of first metatarsophalangeal (MTP) joint osteoarthritis (OA). Method: Ninety-eight participants (54 women and 44 men, mean age 57.4?years, standard deviation 10.3) with symptomatic radiographic... Read More about NEUROPATHIC PAIN IN FIRST METATARSOPHALANGEAL JOINT OSTEOARTHRITIS: FREQUENCY AND ASSOCIATED FACTORS.

P182 Health literacy and gout characteristics in a primary care cohort (2022)
Journal Article
Watson, L., Protheroe, J., Mallen, C., Muller, S., & Roddy, E. (2022). P182 Health literacy and gout characteristics in a primary care cohort. Rheumatology, 61(S1), https://doi.org/10.1093/rheumatology/keac133.181

Abstract Background/Aims Gout is the most common inflammatory arthritis, affecting 2.5% of the UK population. It is often suboptimally managed, despite the availability of effective urate-lowering therapy. Health literacy has been conceptualised to... Read More about P182 Health literacy and gout characteristics in a primary care cohort.

P145 Safety of colchicine or NSAID prophylaxis when initiating allopurinol for gout: propensity score-matched cohort studies (2022)
Journal Article
Roddy, E., Bajpai, R., Forrester, H., Partington, R., Mallen, C. D., Clarson, L., …Muller, S. (2022). P145 Safety of colchicine or NSAID prophylaxis when initiating allopurinol for gout: propensity score-matched cohort studies. Rheumatology, 61(S1), https://doi.org/10.1093/rheumatology/keac133.144

Abstract Background/Aims Initiating urate-lowering therapy for gout commonly triggers a gout flare and hence co-prescription of colchicine or non-steroidal anti-inflammatory drug (NSAID) prophylaxis is recommended. However, little is known about the... Read More about P145 Safety of colchicine or NSAID prophylaxis when initiating allopurinol for gout: propensity score-matched cohort studies.

P064 Impact of COVID-19 on physical and mental health of people with inflammatory conditions: the ICEPAC survey (2022)
Journal Article
Roddy, Hider, Muller, & Paskins. (2022). P064 Impact of COVID-19 on physical and mental health of people with inflammatory conditions: the ICEPAC survey. Rheumatology, https://doi.org/10.1093/rheumatology/keac133.063

Abstract Background/Aims Concerns about the risk of COVID-19 infection led to guidelines advocating shielding for many people with inflammatory conditions. We aimed to assess the impact of the pandemic on the self-reported physical and mental health... Read More about P064 Impact of COVID-19 on physical and mental health of people with inflammatory conditions: the ICEPAC survey.

The effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome: 24-month follow-up of a randomized trial (2022)
Journal Article
Burton, C., Rathod-Mistry, T., Blackburn, S., Blagojevic-Bucknall, M., Bucknall, M., Chesterton, L., …Roddy, E. (2023). The effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome: 24-month follow-up of a randomized trial. Rheumatology, 62(2), 546–554. https://doi.org/10.1093/rheumatology/keac219

Objectives This follow-up study of the INSTinCTS (INjection vs SplinTing in Carpal Tunnel Syndrome) trial compared the effects of corticosteroid injection (CSI) and night splinting (NS) for the initial management of mild-to-moderate carpal tunnel sy... Read More about The effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome: 24-month follow-up of a randomized trial.

Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial (2022)
Journal Article
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Hennings, S., …Mallen, C. D. (2022). Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial. BMJ, 377, Article ARTN e068446. https://doi.org/10.1136/bmj-2021-068446

Objectives: to compare the clinical effectiveness of best current treatment (BCT) plus single ultrasound-guided intra-articular hip injection (USGI) of 40mg triamcinolone acetonide and 4ml 1% lidocaine hydrochloride [BCT+US-Triamcinolone-Lidocaine] w... Read More about Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial.