NO TREATMENT EFFECTS OF ORAL GLUCOSAMINE FOR SUBGROUPS OF KNEE AND HIP OSTEOARTHRITIS PATIENTS; AN INDIVIDUAL PATIENT DATA META-ANALYSIS FROM THE OA TRIAL BANK

Runhaar, J.; Rozendaal, R.; van Middelkoop, M.; Bijlsma, J.; Doherty, M.; Dziedzic, K.; Lohmander, L.; McAlindon, T.; Zhang, W.; Bierma-Zeinstra, S.

doi:10.1136/annrheumdis-2017-eular.5986

Relationship of anxiety with joint pain and its management: A population survey (2018)
Journal Article
Barnett, L. A., Pritchard, M. G., Edwards, J. J., Afolabi, E. K., Jordan, K. P., Healey, E. L., …Dziedzic, K. S. (2018). Relationship of anxiety with joint pain and its management: A population survey. Musculoskeletal Care, 16(3), 353-362. https://doi.org/10.1002/msc.1243

Objectives
The aims of the present study was to examine the associations between the severity of pain and anxiety in a community population reporting joint pain, and to investigate the management of joint pain in the presence of comorbid anxiety.... Read More about Relationship of anxiety with joint pain and its management: A population survey.

Challenges and controversies of complex interventions in osteoarthritis management: recognizing inappropriate and discordant care (2018)
Journal Article
Dziedzic, K. S., & Allen, K. D. (2018). Challenges and controversies of complex interventions in osteoarthritis management: recognizing inappropriate and discordant care. Rheumatology, 57(S4), 88 - 98. https://doi.org/10.1093/rheumatology/key062

A number of controversies and challenges exist for the management of OA in health care. This paper describes the challenges and gaps in OA care, particularly in relation to population health management, complex interventions and outcomes. It sets thi... Read More about Challenges and controversies of complex interventions in osteoarthritis management: recognizing inappropriate and discordant care.

Implementing international osteoarthritis guidelines in an integrated care model – results from a cluster randomized controlled trial (2018)
Journal Article
Østerås, N., Moseng, T., van Bodegom-Vos, L., Dziedzic, K., Mdala, I., Natvig, B., …Hagen, K. (2018). Implementing international osteoarthritis guidelines in an integrated care model – results from a cluster randomized controlled trial. Osteoarthritis and Cartilage, 26(S1), https://doi.org/10.1016/j.joca.2018.02.085

Purpose: Previous research indicates that people with osteoarthritis (OA) are not receiving the recommended and optimal treatment. Based on international treatment recommendations for hip and knee OA and previous research, the SAMBA model for integra... Read More about Implementing international osteoarthritis guidelines in an integrated care model – results from a cluster randomized controlled trial.

Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis: A Randomized Trial (2018)
Journal Article
Dziedzic. (2018). Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis: A Randomized Trial. Annals of Internal Medicine, https://doi.org/10.7326/M17-1430

Background: Synovitis is believed to play a role in producing symptoms in persons with hand osteoarthritis, but data on slow-acting anti-inflammatory treatments are sparse. Objective: To determine the effectiveness of hydroxychloroquine versus placeb... Read More about Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis: A Randomized Trial.

Cost-effectiveness of a model consultation to support self-management in patients with osteoarthritis (2018)
Journal Article
Oppong, R., Jowett, S., Lewis, M., Clarkson, K., Paskins, Z., Croft, P., …Dziedzic, K. (2018). Cost-effectiveness of a model consultation to support self-management in patients with osteoarthritis. Rheumatology, 57(6), 1056-1063. https://doi.org/10.1093/rheumatology/key037

Objectives: The aim of this study was to estimate the cost-effectiveness of a model OA consultation for OA to support self-management compared with usual care. Methods: An incremental cost-utility analysis using patient responses to the three-level E... Read More about Cost-effectiveness of a model consultation to support self-management in patients with osteoarthritis.

Evidence flowers: An innovative, visual method of presenting “best evidence” summaries to health professional and lay audiences (2018)
Journal Article
Babatunde, O., Tan, V., Jordan, J., Dziedzic, K., Chew-Graham, C., Jinks, C., …Van Der Windt, D. (2018). Evidence flowers: An innovative, visual method of presenting “best evidence” summaries to health professional and lay audiences. Research Synthesis Methods, 9(2), 273-284. https://doi.org/10.1002/jrsm.1295

Background & Aims
Barriers to dissemination and engagement with evidence pose a threat to implementing evidence-based medicine. Understanding, retention, and recall can be enhanced by visual presentation of information. The aim of this exploratory r... Read More about Evidence flowers: An innovative, visual method of presenting “best evidence” summaries to health professional and lay audiences.

Enhancing delivery of osteoarthritis care in the general practice consultation: evaluation of a behaviour change intervention (2018)
Journal Article
Porcheret, M., Main, C., Croft, P., & Dziedzic, K. (2018). Enhancing delivery of osteoarthritis care in the general practice consultation: evaluation of a behaviour change intervention. BMC Family Practice, 19, Article 26. https://doi.org/10.1186/s12875-018-0715-8

BACKGROUND: Professionally-focussed behaviour change intervention (BCI) workshops were utilised in the Management of OsteoArthritis in Consultations (MOSAICS) trial investigating the feasibility of implementing the National Institute for Health and C... Read More about Enhancing delivery of osteoarthritis care in the general practice consultation: evaluation of a behaviour change intervention.

Clinical course and prognostic factors across different musculoskeletal pain sites: A secondary analysis of individual patient data from randomised clinical trials. (2018)
Journal Article
Green, D., Lewis, M., Mansell, G., Artus, M., Dziedzic, K., Hay, E., …Van Der Windt, D. (2018). Clinical course and prognostic factors across different musculoskeletal pain sites: A secondary analysis of individual patient data from randomised clinical trials. European Journal of Pain, 22(6), 1057-1070. https://doi.org/10.1002/ejp.1190

BACKGROUND: Previous research has identified similar prognostic factors in patients with musculoskeletal (MSK) conditions regardless of pain presentation, generating opportunities for management based on prognosis rather than specific pain presentati... Read More about Clinical course and prognostic factors across different musculoskeletal pain sites: A secondary analysis of individual patient data from randomised clinical trials..

Patterns of routine primary care for osteoarthritis in the UK: a cross-sectional electronic health records study (2017)
Journal Article
Jackson, H., Barnett, L. A., Jordan, K. P., Dziedzic, K. S., Cottrell, E., Finney, A. G., …Edwards, J. J. (2017). Patterns of routine primary care for osteoarthritis in the UK: a cross-sectional electronic health records study. BMJ Open, https://doi.org/10.1136/bmjopen-2017-019694

Abstract
Objective To determine common patterns of recorded primary care for osteoarthritis (OA), and patient and provider characteristics associated with the quality of recorded care.

Design An observational study nested within a cluster-randomi... Read More about Patterns of routine primary care for osteoarthritis in the UK: a cross-sectional electronic health records study.

Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol. (2017)
Journal Article
Van Der Windt, Holden, & Dziedzic. (2017). Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol. BMJ Open, e018971 - ?. https://doi.org/10.1136/bmjopen-2017-018971

INTRODUCTION: Knee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physic... Read More about Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol..

Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour (2017)
Journal Article
Finney, A., Dziedzic, K., Lewis, A., & Healey, E. (2017). Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour. BMC Musculoskeletal Disorders, 18, Article 535. https://doi.org/10.1186/s12891-017-1896-3

Background
Research into musculoskeletal conditions often focusses on pain at single sites, such as the knee, yet several studies have previously reported the high prevalence of multiple sites of musculoskeletal pain. The most common form of musculo... Read More about Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour.

Integrating musculoskeletal research into clinical care by using a network of ‘evidence into practice groups’ (2017)
Journal Article
Stevenson, K., Hadley-Barrows, T., Rimmer, Y., Larkin, T., Salt, E., Quicke, J., …Dziedzic, K. (2017). Integrating musculoskeletal research into clinical care by using a network of ‘evidence into practice groups’. Physiotherapy, 103(S1), e89. https://doi.org/10.1016/j.physio.2017.11.058

Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): A cluster randomised controlled trial (2017)
Journal Article
Dziedzic, K., Hay, E., Porcheret, M., Afolabi, E., Lewis, A., Morden, A., …Healey, E. (2018). Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): A cluster randomised controlled trial. Osteoarthritis and Cartilage, 26(1), 43-53. https://doi.org/10.1016/j.joca.2017.09.010

Objective
To determine the effectiveness of a model osteoarthritis consultation, compared with usual care, on physical function and uptake of National Institute for Health and Care Excellence (NICE) osteoarthritis recommendations, in adults =45 year... Read More about Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): A cluster randomised controlled trial.

Hydroxychloroquine in hand OA; results of the UK HERO trial (vol 25, pg S3, 2017) (2017)
Journal Article
Kingsbury, S. R., Tharmanathan, P., Keding, A., Ronaldson, S., Grainger, A., Wakefield, R., …Conaghan, P. G. (2017). Hydroxychloroquine in hand OA; results of the UK HERO trial (vol 25, pg S3, 2017). Osteoarthritis and Cartilage, 25(12), 2147-2147. https://doi.org/10.1016/j.joca.2017.10.001

Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trial bank. (2017)
Journal Article
Runhaar, J., Rozendaal, R., van Middelkoop, M., Bijlsma, H., Doherty, M., Dziedzic, K., …Bierma Zeinstra, S. (2017). Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trial bank. Annals of the Rheumatic Diseases, 76(11), 1862 - 1869. https://doi.org/10.1136/annrheumdis-2017-211149

OBJECTIVE: To evaluate the effectiveness of oral glucosamine in subgroups of people with hip or knee osteoarthritis (OA) based on baseline pain severity, body mass index (BMI), sex, structural abnormalities and presence of inflammation using individu... Read More about Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trial bank..

Response to: 'Different glucosamine sulfate products generate different outcomes on osteoarthritis symptoms' by Reginster et al (2017)
Journal Article
Runhaar, J., Rozendaal, R. M., van Middelkoop, M., Bijlsma, H. J. W., Doherty, M., Dziedzic, K. S., …Zeinstra, S. B. (2018). Response to: 'Different glucosamine sulfate products generate different outcomes on osteoarthritis symptoms' by Reginster et al. Annals of the Rheumatic Diseases, 77(7), Article ARTN e40. https://doi.org/10.1136/annrheumdis-2017-212276

Integrating case finding and initial management for osteoarthritis, anxiety and depression into routine primary care nurse-led long-term condition reviews: results from the enhance pilot trial (2017)
Journal Article
Jinks, C., Nicholls, E., Liddle, J., Healey, E., Evans, A., Chew-Graham, C., …Team, E. (2017). Integrating case finding and initial management for osteoarthritis, anxiety and depression into routine primary care nurse-led long-term condition reviews: results from the enhance pilot trial. Annals of the Rheumatic Diseases, 76(S2), 1433-1433. https://doi.org/10.1136/annrheumdis-2017-eular.2473

Background Co-morbid osteoarthritis (OA), anxiety and depression are undermanaged in primary care yet have significant impact on pain, disability and outcomes of other long-term conditions (LTCs).

Objectives To test the feasibility and acceptabili... Read More about Integrating case finding and initial management for osteoarthritis, anxiety and depression into routine primary care nurse-led long-term condition reviews: results from the enhance pilot trial.

IMPROVING CARE FOR PATIENTS WITH OSTEOARTHRITIS IN FIVE EUROPEAN COUNTRIES: THE JIGSAW-E PATIENT PANEL (2017)
Journal Article
Blackburn, S., Meesters, J., De Wit, M., Campbell, L., Rhodes, C., Schiphof, D., …Dziedzic, K. (2017). IMPROVING CARE FOR PATIENTS WITH OSTEOARTHRITIS IN FIVE EUROPEAN COUNTRIES: THE JIGSAW-E PATIENT PANEL. Annals of the Rheumatic Diseases, 76(S2), 1343-1344. https://doi.org/10.1136/annrheumdis-2017-eular.2711

CELEBRATING TEN YEARS OF SUCCESSFUL PATIENT INVOLVEMENT IN RESEARCH OF INFLAMMATORY CONDITIONS (2017)
Presentation / Conference
Higginbottom, A., Blackburn, S., Campbell, L., Rhodes, C., Taylor, R., Machin, A., …Dziedzic, K. (2017, June). CELEBRATING TEN YEARS OF SUCCESSFUL PATIENT INVOLVEMENT IN RESEARCH OF INFLAMMATORY CONDITIONS. Poster presented at EULAR: Annual European Congress of Rheumatology 2017, Madrid, Spain

NO TREATMENT EFFECTS OF ORAL GLUCOSAMINE FOR SUBGROUPS OF KNEE AND HIP OSTEOARTHRITIS PATIENTS; AN INDIVIDUAL PATIENT DATA META-ANALYSIS FROM THE OA TRIAL BANK (2017)
Presentation / Conference
Runhaar, J., Rozendaal, R., van Middelkoop, M., Bijlsma, J., Doherty, M., Dziedzic, K., …Bierma-Zeinstra, S. (2017, June). NO TREATMENT EFFECTS OF ORAL GLUCOSAMINE FOR SUBGROUPS OF KNEE AND HIP OSTEOARTHRITIS PATIENTS; AN INDIVIDUAL PATIENT DATA META-ANALYSIS FROM THE OA TRIAL BANK. Poster presented at EULAR 2017: Annual European Congress of Rheumatology, Madrid, Spain

Background The effectiveness of oral glucosamine for symptoms of osteoarthritis (OA) is debated. Individual trials are not powered to show effects within subgroups of patients.

Objectives To evaluate the effectiveness of oral glucosamine in clinic... Read More about NO TREATMENT EFFECTS OF ORAL GLUCOSAMINE FOR SUBGROUPS OF KNEE AND HIP OSTEOARTHRITIS PATIENTS; AN INDIVIDUAL PATIENT DATA META-ANALYSIS FROM THE OA TRIAL BANK.

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