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Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. (2021)
Journal Article
Holden, M., Callaghan, M., Felson, D., Birrell, F., Nicholls, E., Jowett, S., …Peat, G. (2021). Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. BMJ Open, 11(3), Article e048196. https://doi.org/10.1136/bmjopen-2020-048196

BACKGROUND: Brace effectiveness for knee osteoarthritis (OA) remains unclear and international guidelines offer conflicting recommendations. Our trial will determine the clinical and cost-effectiveness of adding knee bracing (matched to patients' cli... Read More about Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial..

Moderators of the effects of therapeutic exercise for people with knee and hip osteoarthritis: A systematic review of sub-group analyses from randomised controlled trials (2020)
Journal Article
Quicke, J., Runhaar, J., Van Der Windt, D., Healey, E., Foster, N., & Holden, M. (2020). Moderators of the effects of therapeutic exercise for people with knee and hip osteoarthritis: A systematic review of sub-group analyses from randomised controlled trials. Osteoarthritis and Cartilage Open, 2(4), Article 100113. https://doi.org/10.1016/j.ocarto.2020.100113

Objective
1) To identify potential moderators of the effect of therapeutic exercise explored in randomised controlled trials (RCTs) of knee and hip osteoarthritis (OA); 2) summarise the extent, strength and quality of evidence reported for moderator... Read More about Moderators of the effects of therapeutic exercise for people with knee and hip osteoarthritis: A systematic review of sub-group analyses from randomised controlled trials.

Guidance for Implementing Best Practice Therapeutic Exercise for Patients With Knee and Hip Osteoarthritis: What Does the Current Evidence Base Tell Us? (2020)
Journal Article
Holden, M. A., Button, K., Collins, N. J., Henrotin, Y., Hinman, R. S., Larsen, J. B., …Bennell, K. (2021). Guidance for Implementing Best Practice Therapeutic Exercise for Patients With Knee and Hip Osteoarthritis: What Does the Current Evidence Base Tell Us?. Arthritis Care and Research, 73(12), 1746-1753. https://doi.org/10.1002/acr.24434

Therapeutic exercise is a recommended first‐line treatment for patients with knee and hip osteoarthritis (OA); however, there is little specific advice or practical resources to guide clinicians in its implementation. As the first in a series of proj... Read More about Guidance for Implementing Best Practice Therapeutic Exercise for Patients With Knee and Hip Osteoarthritis: What Does the Current Evidence Base Tell Us?.

Moderators of the effects of exercise for hip and knee osteoarthritis: a systematic review of subgroup analyses from randomised controlled trials (2020)
Journal Article
Van Der Windt, Healey, & Holden. (2020). Moderators of the effects of exercise for hip and knee osteoarthritis: a systematic review of subgroup analyses from randomised controlled trials. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2020.02.263

Meta-analyses of randomised controlled trials (RCTs) of exercise interventions in people with knee and hip osteoarthritis (OA) provide strong evidence of, on average, a small-to-medium effect on pain and function outcomes compared to comparison inter... Read More about Moderators of the effects of exercise for hip and knee osteoarthritis: a systematic review of subgroup analyses from randomised controlled trials.

Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments (2020)
Journal Article
Paskins, Holden, Mallen, Jinks, Hawarden, & Roddy. (2020). Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments. Rheumatology, https://doi.org/10.1093/rheumatology/keaa111.125

Background
The HIT trial compared ultrasound-guided intra-articular hip injection (USGI) of triamcinolone acetonide and 1% lidocaine hydrochloride combined with best current treatment (BCT) with (i) BCT alone and (ii) an USGI of 1% lidocaine only co... Read More about Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments.

O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT) (2020)
Presentation / Conference
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Cherrington, A., …Roddy, E. (2020, April). O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT). Presented at British Society for Rheumatology Annual Conference 2020, Glasgow, Scotland, UK

Background
Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited. The HIT trial compared the clinical and cost-effectiveness of an ultrasound-guided intra-articular hip injection (USGI) of 4... Read More about O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT).

The hip injection trial (HIT) nested qualitative study: experiences of living with hip Osteoarthritis and receiving trial treatments. (2020)
Journal Article
Holden, M., Hawarden, A., Paskins, Z., Roddy, E., Mallen, C., Jinks, C., & Trial Team, T. H. (2020). The hip injection trial (HIT) nested qualitative study: experiences of living with hip Osteoarthritis and receiving trial treatments. Osteoarthritis and Cartilage, 28, S499. https://doi.org/10.1016/j.joca.2020.02.782

Purpose: Evidence about the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited. The HIT trial compared ultrasound-guided intra-articular hip injection (USGI) of triamcinolone acetonide and 1% lidocaine hy... Read More about The hip injection trial (HIT) nested qualitative study: experiences of living with hip Osteoarthritis and receiving trial treatments..

CLINICAL AND COST-EFFECTIVENESS OF ULTRASOUND-GUIDED INTRA-ARTICULAR CORTICOSTEROID AND LOCAL ANAESTHETIC INJECTION FOR HIP OSTEOARTHRITIS: A RANDOMISED CONTROLLED TRIAL (HIT) (2020)
Journal Article
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Cherrington, A., …Roddy, E. (2020). CLINICAL AND COST-EFFECTIVENESS OF ULTRASOUND-GUIDED INTRA-ARTICULAR CORTICOSTEROID AND LOCAL ANAESTHETIC INJECTION FOR HIP OSTEOARTHRITIS: A RANDOMISED CONTROLLED TRIAL (HIT). Osteoarthritis and Cartilage, 28(S1), https://doi.org/10.1016/j.joca.2020.02.751

Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders. (2020)
Journal Article
Mallett, R., McLean, S., Holden, M. A., Potia, T., Gee, M., & Haywood, K. (2020). Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders. BMJ Open, 10(2), https://doi.org/10.1136/bmjopen-2019-031591

Objectives The objective was to the undertake nominal group technique (NGT) to evaluate current exercise adherence measures and isolated domains to develop stakeholder consensus on the domains to include in the measurement of therapeutic exercise adh... Read More about Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders..

Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders (2020)
Journal Article
Holden, M. (2020). Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders. BMJ Open, e031591 - ?. https://doi.org/10.1136/+bmjopen-2019-031591

OBJECTIVES: The objective was to the undertake nominal group technique (NGT) to evaluate current exercise adherence measures and isolated domains to develop stakeholder consensus on the domains to include in the measurement of therapeutic exercise ad... Read More about Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders.

Do comorbidities predict pain and function in knee osteoarthritis following an exercise intervention, and do they moderate the effect of exercise? Analyses of data from three randomized controlled trials. (2019)
Journal Article
Legha, A., Burke, D. L., Foster, N. E., Van Der Windt, D. A., Quicke, J. G., Healey, E. L., …Holden, M. A. (2020). Do comorbidities predict pain and function in knee osteoarthritis following an exercise intervention, and do they moderate the effect of exercise? Analyses of data from three randomized controlled trials. Musculoskeletal Care, 18(1), 3-11. https://doi.org/10.1002/msc.1425

BACKGROUND: Although exercise is a core treatment for people with knee osteoarthritis (OA), it is currently unknown whether those with additional comorbidities respond differently to exercise than those without. We explored whether comorbidities pred... Read More about Do comorbidities predict pain and function in knee osteoarthritis following an exercise intervention, and do they moderate the effect of exercise? Analyses of data from three randomized controlled trials..

Therapeutic alliance facilitates adherence to physiotherapy-led exercise and physical activity for older adults with knee pain: a longitudinal qualitative study (2019)
Journal Article
Moore, A. J., Holden, M. A., Foster, N. E., & Jinks, C. (2020). Therapeutic alliance facilitates adherence to physiotherapy-led exercise and physical activity for older adults with knee pain: a longitudinal qualitative study. Journal of Physiotherapy, 66(1), 45-53. https://doi.org/10.1016/j.jphys.2019.11.004

Objectives: To investigate patients’ experiences and impact of physiotherapist (physical therapist) led exercise interventions for knee pain attributable to osteoarthritis, and to explore barriers and facilitators to change in exercise and physical a... Read More about Therapeutic alliance facilitates adherence to physiotherapy-led exercise and physical activity for older adults with knee pain: a longitudinal qualitative study.

Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT) (2019)
Presentation / Conference
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Cherrington, A., …Roddy, E. (2019, November). Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT). Paper presented at 2019 ACR/ARP Annual Meeting, Atlanta, GA, USA

Background/Purpose: Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited and conflicting. The HIT trial compared the clinical effectiveness of an ultrasound-guided intra-articular hip inject... Read More about Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT).

Priorities for the effective implementation of osteoarthritis management programs: an OARSI international consensus exercise (2019)
Journal Article
Eyles, J. P., Hunter, D. J., Bennell, K. L., Dziedzic, K. S., Hinman, R. S., van der Esch, M., …Jinks, C. (2019). Priorities for the effective implementation of osteoarthritis management programs: an OARSI international consensus exercise. Osteoarthritis and Cartilage, 27(9), 1270-1279. https://doi.org/10.1016/j.joca.2019.05.015

Objective
The Joint Effort Initiative was endorsed by Osteoarthritis Research Society International (OARSI) in 2018 as a collaboration between international researchers and clinicians with an interest in the implementation of osteoarthritis manageme... Read More about Priorities for the effective implementation of osteoarthritis management programs: an OARSI international consensus exercise.

How do UK physiotherapists address weight loss among individuals with hip osteoarthritis? A mixed-methods study (2019)
Journal Article
Holden, M. A., Waterfield, J., Whittle, R., Bennell, K., Quicke, J. G., Chesterton, L., & Mallen, C. (2019). How do UK physiotherapists address weight loss among individuals with hip osteoarthritis? A mixed-methods study. Musculoskeletal Care, 17(1), 133-144. https://doi.org/10.1002/msc.1383

BACKGROUND
Weight loss is recommended as a core treatment for individuals with hip osteoarthritis who are overweight or obese. Physiotherapists play an important role in managing patients with hip osteoarthritis, but little is known about how they a... Read More about How do UK physiotherapists address weight loss among individuals with hip osteoarthritis? A mixed-methods study.

Identification and Evaluation of Self-Report Physical Activity Instruments in Adults With Osteoarthritis: A Systematic Review (2018)
Journal Article
Dziedzic, K., Holden, M., & Healey, E. L. (2019). Identification and Evaluation of Self-Report Physical Activity Instruments in Adults With Osteoarthritis: A Systematic Review. Arthritis Care and Research, 71(2), 237-251. https://doi.org/10.1002/acr.23787

OBJECTIVE
To identify and evaluate the measurement properties of self-report physical activity (PA) instruments suitable for those with osteoarthritis (OA).

METHODS
A comprehensive two-stage systematic review using multiple electronic databases... Read More about Identification and Evaluation of Self-Report Physical Activity Instruments in Adults With Osteoarthritis: A Systematic Review.

A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis. (2018)
Journal Article
Holden, M., Whittle, R., Waterfield, J., Chesterton, L., Cottrell, E., Quicke, J., & Mallen, C. (2019). A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis. Physiotherapy, 105(3), 328 - 337. https://doi.org/10.1016/j.physio.2018.08.003

OBJECTIVE: To explore how physiotherapists currently address analgesic use among patients with hip osteoarthritis, and their beliefs about the acceptability of prescribing for these patients. METHODS: A cross-sectional questionnaire was mailed to 312... Read More about A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis..

A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol (2018)
Journal Article
Paskins, Z., Hughes, G., Myers, H., Hughes, E., Hennings, S., Cherrington, A., …Roddy, E. (2018). A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol. BMC Musculoskeletal Disorders, 19, Article 218. https://doi.org/10.1186/s12891-018-2153-0

BACKGROUND: Evidence on the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis is limited and conflicting. The primary objective of the Hip Injection Trial (HIT) is to compare pain intensity over 6 months, in people with... Read More about A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol.