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All Outputs (48)

Investigation into the Role of Long-Non-Coding RNA MIAT in Leukemia (2023)
Journal Article
Ostini, A., & Mourtada-Maarabouni, M. (2023). Investigation into the Role of Long-Non-Coding RNA MIAT in Leukemia. Non-Coding RNA, 9(4), Article 47. https://doi.org/10.3390/ncrna9040047

Myocardial Infarction Associated Transcript (MIAT) is a nuclear long non-coding RNA (LncRNA) with four different splicing variants. MIAT dysregulation is associated with carcinogenesis, mainly acting as an oncogene regulating cellular growth, invasio... Read More about Investigation into the Role of Long-Non-Coding RNA MIAT in Leukemia.

New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate (2023)
Journal Article
Kavousi, N., Tonge, D. P., & Mourtada-Maarabouni, M. (2023). New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate. International Journal of Biological Macromolecules, 233, Article 123467. https://doi.org/10.1016/j.ijbiomac.2023.123467

The serine/threonine protein phosphatase 4 holoenzyme consists of a PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits. Previous studies have shown that PP4c acts as a tumour suppressor. Emerging evidence suggests t... Read More about New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate.

The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions (2020)
Journal Article
Frank, F., Kavousi, N., Bountali, A., B. Dammer, E., Mourtada-Maarabouni, M., & A. Ortlund, E. (2020). The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions. Cell Reports, https://doi.org/10.1016/j.celrep.2020.107933

There is increasing evidence that the architecture of long non-coding RNAs (lncRNAs) just like that of proteins-is hierarchically organized into independently folding sub-modules with distinct functions. Studies characterizing the cellular activities... Read More about The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions.

SAT-LB138 The LncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules With Independent Functions (2020)
Journal Article
Frank, F., Kavousi, N., Bountali, A., Dammer, E., Mourtada-Maarabouni, M., & Ortlund, E. (2020). SAT-LB138 The LncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules With Independent Functions. Journal of the Endocrine Society, https://doi.org/10.1210/jendso/bvaa046.2327

The growth arrest-specific 5 (gas5) gene encodes a long non-coding RNA (lncRNA) that is required for normal growth arrest, slows down the cell cycle, controls apoptosis, and is required for the inhibition of cell growth by mTOR inhibitors such as rap... Read More about SAT-LB138 The LncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules With Independent Functions.

RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate (2019)
Journal Article
Bountal, A., Tonge, D. P., & Mourtada-Maarabouni, M. (2019). RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate. International Journal of Biological Macromolecules, 878-891. https://doi.org/10.1016/j.ijbiomac.2019.03.005

Myocardial Infarction Associated Transcript (MIAT) is a subnuclear lncRNA that interferes with alternative splicing and is associated with increased risk of various heart conditions and nervous system tumours. The current study aims to elucidate the... Read More about RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate.

Long noncoding RNA MIAT regulates apoptosis and the apoptotic response to chemotherapeutic agents in breast cancer cell lines (2018)
Journal Article
Almnaseer, Z. A., & Mourtada-Maarabouni, M. (2018). Long noncoding RNA MIAT regulates apoptosis and the apoptotic response to chemotherapeutic agents in breast cancer cell lines. Bioscience Reports, 38(4), https://doi.org/10.1042/BSR20180704

The long noncoding RNA myocardial infarction associated transcript (MIAT) is involved in a number of diseases, including myocardial infarction and diabetic retinopathy. Emerging evidence suggests that MIAT expression levels are increased in different... Read More about Long noncoding RNA MIAT regulates apoptosis and the apoptotic response to chemotherapeutic agents in breast cancer cell lines.

The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells (2016)
Journal Article
Mohammed, H. N., Pickard, M. R., & Mourtada-Maarabouni, M. (2016). The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells. Cellular Signalling, 1389 - 1400. https://doi.org/10.1016/j.cellsig.2016.06.011

Background: The control of breast cell survival is of critical importance for preventing breast cancer initiation and progression. The activity of many proteins which regulate cell survival is controlled by reversible phosphorylation, so that the re... Read More about The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells.

Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate (2014)
Journal Article
Hudson, W. H., Pickard, M. R., de Vera, I. M. S., Kuiper, E. G., Mourtada-Maarabouni, M., Conn, G. L., …Ortlund, E. A. (2014). Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate. Nature Communications, 5(1), Article 5395. https://doi.org/10.1038/ncomms6395

The majority of the eukaryotic genome is transcribed, generating a significant number of long intergenic noncoding RNAs (lincRNAs). Although lincRNAs represent the most poorly understood product of transcription, recent work has shown lincRNAs fulfil... Read More about Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.

Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5 (2013)
Journal Article
Mourtada-Maarabouni, M., & Williams, G. T. (2013). Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5. BioMed Research International, 2013, Article 358015. https://doi.org/10.1155/2013/358015

Nonsense-mediated decay is a key RNA surveillance mechanism responsible for the rapid degradation of mRNAs containing premature termination codons and hence prevents the synthesis of truncated proteins. More recently, it has been shown that nonsense-... Read More about Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5.

Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines (2013)
Journal Article
Pickard, M., Mourtada-Maarabouni, M., & Williams, G. (2013). Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines. BBA - Biochimica et Biophysica Acta, 1832(10), 1613 - 1623. https://doi.org/10.1016/j.bbadis.2013.05.005

While the role of small non-coding RNAs, such as miRNAs, in apoptosis control is well established, long non-coding RNAs (lncRNAs) have received less attention. Growth Arrest-Specific 5 (GAS5) encodes multiple snoRNAs within its introns, while exonic... Read More about Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines.

Apoptosis Suppression by Candidate Oncogene PLAC8 is Reversed in Other Cell Types (2013)
Journal Article
Mourtada-Maarabouni, M., Watson, D., Munir, M., Farzaneh, F., & T. Williams, G. (2013). Apoptosis Suppression by Candidate Oncogene PLAC8 is Reversed in Other Cell Types. Current Cancer Drug Targets, 13(1), 80-91. https://doi.org/10.2174/156800913804486584

Targets for cancer therapy are conventionally selected by identification of molecules acting downstream of established tumour suppressors and oncoproteins, such as p53, c-Myc and Ras. However, the forward genetics approach provides an alternative, co... Read More about Apoptosis Suppression by Candidate Oncogene PLAC8 is Reversed in Other Cell Types.

Candidate tumour suppressor Fau regulates apoptosis in human cells: An essential role for Bcl-G (2011)
Journal Article
Pickard, M. R., Mourtada-Maarabouni, M., & Williams, G. T. (2011). Candidate tumour suppressor Fau regulates apoptosis in human cells: An essential role for Bcl-G. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1812(9), 1146-1153. https://doi.org/10.1016/j.bbadis.2011.04.009

FAU, which encodes a ubiquitin-like protein (termed FUBI) with ribosomal protein S30 as a carboxy-terminal extension, has recently been identified as a pro-apoptotic regulatory gene. This activity may be mediated by Bcl-G (a pro-apoptotic member of t... Read More about Candidate tumour suppressor Fau regulates apoptosis in human cells: An essential role for Bcl-G.

A critical role for non-coding RNA GAS5 in growth arrest and rapamycin inhibition in human T-lymphocytes (2011)
Journal Article
Williams, G. T., Mourtada-Maarabouni, M., & Farzaneh, F. (2011). A critical role for non-coding RNA GAS5 in growth arrest and rapamycin inhibition in human T-lymphocytes. Biochemical Society Transactions, 39(2), 482–486. https://doi.org/10.1042/BST0390482

Non-coding RNA GAS5 (growth arrest-specific transcript 5) is a 5′-TOP (5′-terminal oligopyrimidine tract) RNA, whose translation, and consequently also stability, is controlled by the mTOR (mammalian target of rapamycin) pathway. GAS5 was identified... Read More about A critical role for non-coding RNA GAS5 in growth arrest and rapamycin inhibition in human T-lymphocytes.

GNB2L1 (guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1) (2011)
Journal Article
Mourtada-Maarabouni, M. GNB2L1 (guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1). Atlas of Genetics and Cytogenetics in Oncology and Haematology, https://doi.org/10.4267/2042/38501

GNB2L1 encodes a cytosolic protein with a molecular mass of approximatively 35 kDa (317 amino acids). The protein has seven internal Trp-Asp 40 (WD40 domain) repeats. The WD40 repeats of RACK1/GNB2L1 are predicted to form a seven-bladed propeller str... Read More about GNB2L1 (guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1).

Inhibition of Human T-Cell Proliferation by mTOR antagonists requires Non-Coding RNA growth-arrest-specific transcript 5 (GAS5) (2010)
Journal Article
Mourtada-Maarabouni, M., Hasan, A. M., Farzaneh, F., & Williams, G. T. (2010). Inhibition of Human T-Cell Proliferation by mTOR antagonists requires Non-Coding RNA growth-arrest-specific transcript 5 (GAS5). Molecular Pharmacology, 78(1), 19 - 28. https://doi.org/10.1124/mol.110.064055

BACKGROUND: Eosinophils are characteristic participants in allergic inflammation. The intracellular signalling mechanisms involved in the migration of eosinophils to sites of allergic inflammation are poorly understood. Chemotactic responses of eosin... Read More about Inhibition of Human T-Cell Proliferation by mTOR antagonists requires Non-Coding RNA growth-arrest-specific transcript 5 (GAS5).

Inhibition of human T-cell proliferation by mammalian target of rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5) (2010)
Journal Article
Mourtada-Maarabouni, M., Hasan, A. M., Farzaneh, F., & Williams, G. T. (2010). Inhibition of human T-cell proliferation by mammalian target of rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5). Molecular Pharmacology, 78(1), 19-28. https://doi.org/10.1124/mol.110.064055

The central importance of the serine/threonine protein kinase mTOR (mammalian Target of Rapamycin) in the control of cell growth and proliferation is well established. However, our knowledge both of the upstream pathways controlling mTOR activity and... Read More about Inhibition of human T-cell proliferation by mammalian target of rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5).