All Outputs (3)

POS0992 PARIS STUDY: POTENTIAL BIOMARKERS PREDICTING RESPONSE TO TNFI IN PSORIATIC ARTHRITIS (2025)
Journal Article
Makos, A., Grime, H., Amarasena, R., Kuiper, J., & Kehoe, O. (in press). POS0992 PARIS STUDY: POTENTIAL BIOMARKERS PREDICTING RESPONSE TO TNFI IN PSORIATIC ARTHRITIS. Annals of the Rheumatic Diseases, 83, 710-711. https://doi.org/10.1136/annrheumdis-2024-eular.2980

Background:
Psoriatic Arthritis (PsA) is a complex immune-mediated disease. TNF inhibitors (TNFi) are the first-line biologic drugs to treat PsA, targeting soluble TNF-α (sTNF) and membrane-bound TNF-α (mTNF). TNF... Read More about POS0992 PARIS STUDY: POTENTIAL BIOMARKERS PREDICTING RESPONSE TO TNFI IN PSORIATIC ARTHRITIS.

Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming (2023)
Journal Article
Hyland, M., Mennan, C., Davies, R., Wilson, E., Tonge, D. P., Clayton, A., & Kehoe, O. (2023). Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming. Stem Cell Reviews and Reports, 19, 2391–2406. https://doi.org/10.1007/s12015-023-10586-2

Autoimmune conditions, such as rheumatoid arthritis, are characterised by a loss of immune tolerance, whereby the immune cells attack self-antigens causing pain and inflammation. These conditions can be brought into remission using pharmaceutical tre... Read More about Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming.

Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis (2021)
Journal Article
Kay, A. G., Roach, P., Morgan, R., Lodge, R., Hyland, M., Piccinini, A. M., …Treadwell, K. (2021). Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis. International Journal of Molecular Sciences, 23(1), 126 - 126. https://doi.org/10.3390/ijms23010126

<jats:p>Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion of extracellular vesicles (EVs) in the cell secretome. We evaluated the therapeutic potential of MSCs-derived small EVs... Read More about Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis.