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Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase (2024)
Journal Article
Tishova, Y., Kalinchenko, S., Mskhalaya, G., Hackett, G., Livingston, M., König, C., …Ramachandran, S. (2024). Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase. Diabetes, Obesity and Metabolism, 26(6), 2147-2157. https://doi.org/10.1111/dom.15520

Aims To describe changes in homeostasis model assessment of insulin resistance index (HOMA-IR) following testosterone therapy in men with hypogonadism and metabolic syndrome (MetS). Materials and Methods A randomized, placebo-controlled, double-... Read More about Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase.

Testosterone Replacement Therapy: Effects on Blood Pressure in Hypogonadal Men (2024)
Journal Article
Hackett, G., Mann, A., Haider, A., Haider, K. S., Desnerck, P., König, C. S., …Ramachandran, S. (in press). Testosterone Replacement Therapy: Effects on Blood Pressure in Hypogonadal Men. The World Journal of Men's Health, 42, https://doi.org/10.5534/wjmh.230239

While testosterone therapy can improve the various pathologies associated with adult-onset testosterone deficiency (TD), Summary of Product Characteristics (SPC) of five testosterone preparations caution that treatment may be associated with hyperten... Read More about Testosterone Replacement Therapy: Effects on Blood Pressure in Hypogonadal Men.

Testosterone replacement therapy: association with mortality in high‐risk patient subgroups (2023)
Journal Article
Mann, A., Strange, R. C., König, C. S., Hackett, G., Haider, A., Haider, K. S., …Ramachandran, S. (in press). Testosterone replacement therapy: association with mortality in high‐risk patient subgroups. Andrology, https://doi.org/10.1111/andr.13582

Objectives We describe studies determining the association between testosterone therapy (TTh) and mortality. Materials & methods We used a registry database of 737 men with adult-onset testosterone deficiency defined as presenting with low serum... Read More about Testosterone replacement therapy: association with mortality in high‐risk patient subgroups.

P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound (2017)
Journal Article
Koenig, C., Atherton, M., Cavazzuti, M., Ramachandran, S., Gomm, C., Strange, R., …Schenkel, T. (2017). P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound. Artery Research, 20(C), 76-76. https://doi.org/10.1016/j.artres.2017.10.099

Introduction: Ischemic heart disease (IHD) has been associated with lower peak systolic velocity (PSV) on penile Doppler measurements [1]. This study establishes whether carotid ultrasound (US) PSV was associated with computational fluid dynamics (CF... Read More about P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound.

Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli – A preliminary study (2007)
Journal Article
Kapoor, B., Dunlop, C., Wynn-Jones, C., Fryer, A. A., Strange, R. C., & Maffulli, N. (2007). Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli – A preliminary study. Journal of Negative Results in BioMedicine, 6, Article 7. https://doi.org/10.1186/1477-5751-6-7

We investigated the association of developmental dysplasia of the hip (DDH) and primary protrusion acetabuli (PPA) with Vitamin D receptor polymorphisms Taq I and Fok I and oestrogen receptor polymorphisms Pvu II and Xba I. 45 patients with DDH and 2... Read More about Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli – A preliminary study.

Asthma severity and atopy: how clear is the relationship? (2006)
Journal Article
Carroll, W. D., Lenney, W., Child, F., Strange, R. C., Jones, P. W., Whyte, M. K., …Fryer, A. A. (2006). Asthma severity and atopy: how clear is the relationship?. Archives of Disease in Childhood, 91(5), 405 - 409. https://doi.org/10.1136/adc.2005.088278

BACKGROUND: The relationship between asthma severity and atopy is complex. Many studies have failed to show significant relationships between clinical severity or lung function and markers of atopic sensitisation. AIM: To determine whether increasing... Read More about Asthma severity and atopy: how clear is the relationship?.

Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. (2005)
Journal Article
Carroll, W., Lenney, W., Jones, P., Strange, R., Child, F., Whyte, M., …Fryer, A. (2005). Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. Clinical and Experimental Allergy, 35(9), 1155 - 1161. https://doi.org/10.1111/j.1365-2222.2005.02313.x

RATIONALE: Previous data have suggested that glutathione-S-transferase (GST) genotypes are important in determining the rate of lung function growth in childhood. This effect was most marked in Caucasian children with asthma. OBJECTIVES: We investiga... Read More about Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families..

Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. (2005)
Journal Article
Carroll, W., Lenney, W., Child, F., Strange, R., Jones, P., & Fryer, A. (2005). Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. Pediatric Allergy and Immunology, 16(1), 32 - 39. https://doi.org/10.1111/j.1399-3038.2005.00249.x

Maternal factors are known to influence the heritability and expression of asthma and atopy. We report the association of maternal, paternal and proband GSTP1 genotype with lung function in 145 Caucasian children with asthma. GSTP1 Val105/Val105 and... Read More about Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma..

Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes (2001)
Journal Article
Luscombe, C. J., French, M. E., Liu, S., Saxby, M. F., Jones, P. W., Fryer, A. A., & Strange, R. C. (2001). Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes. British journal of cancer, 85, 1504 - 1509. https://doi.org/10.1054/bjoc.2001.2097

Exposure to ultraviolet radiation may reduce prostate cancer risk, suggesting that polymorphism in genes that mediate host pigmentation will be associated with susceptibility to this cancer. We studied 210 prostate cancer cases and 155 controls to de... Read More about Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes.

Simultaneous identification of GSTP1 Ile105-->Val105 and Ala114-->Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma (2001)
Journal Article
Hemmingsen, A., Fryer, A. A., Hepple, M., Strange, R. C., & Spiteri, M. A. (2001). Simultaneous identification of GSTP1 Ile105-->Val105 and Ala114-->Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma. Respiratory Research, 255 -260. https://doi.org/10.1186/rr64

BACKGROUND The glutathione S-transferase (GST) enzyme GSTP1 utilizes byproducts of oxidative stress. We previously showed that alleles of GSTP1 that encode the Ile105-->Val105 substitution are associated with the asthma phenotypes of atopy and bronc... Read More about Simultaneous identification of GSTP1 Ile105-->Val105 and Ala114-->Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma.

The therapeutic response to D-penicillamine in rheumatoid arthritis: influence of glutathione S-transferase polymorphisms (1999)
Journal Article
Layton, M. A., Jones, P. W., Alldersea, J. E., Strange, R. C., Fryer, A. A., Dawes, P. T., & Mattey, D. L. (1999). The therapeutic response to D-penicillamine in rheumatoid arthritis: influence of glutathione S-transferase polymorphisms. Rheumatology, 38(1), 43 - 47. https://doi.org/10.1093/rheumatology/38.1.43

To investigate whether the therapeutic response of rheumatoid arthritis (RA) patients to D-penicillamine is associated with polymorphisms in genes of the glutathione S-transferase (GST) supergene family.

Influence of polymorphisms at glutathione-S-transferase gene loci on allelic losses in head and neck squamous cell carcinomas,Einfluss yon genpolymorphismen in den entgiftenden enzymen der glutathion-S-transferasen auf die chromosomale stabilitat yon plattenepithelkarzinomen im kopf-hals-bereich (1998)
Journal Article
Matthias, C., Bockmühl, U., Jahnke, V., Petersen, I., Dietel, M., Fryer, A., & Strange, R. (1998). Influence of polymorphisms at glutathione-S-transferase gene loci on allelic losses in head and neck squamous cell carcinomas,Einfluss yon genpolymorphismen in den entgiftenden enzymen der glutathion-S-transferasen auf die chromosomale stabilitat yon plattenepithelkarzinomen im kopf-hals-bereich. Laryngo-Rhino-Otologie, 77(4), 201-206. https://doi.org/10.1055/s-2007-996961

Background: While cigarette smoking and chronic alcohol consumption are the major risk factors for the development of head and neck cancer, it is assumed that genetic factors contribute to risk. Material and methods: We examined genotype frequencies... Read More about Influence of polymorphisms at glutathione-S-transferase gene loci on allelic losses in head and neck squamous cell carcinomas,Einfluss yon genpolymorphismen in den entgiftenden enzymen der glutathion-S-transferasen auf die chromosomale stabilitat yon plattenepithelkarzinomen im kopf-hals-bereich.

Risk factors for basal cell carcinoma in the UK: case-control study in 806 patients. (1997)
Journal Article
Lear, J. T., Tan, B. B., Smith, A. G., Bowers, W., Jones, P. W., Heagerty, A. H., …Fryer, A. A. (1997). Risk factors for basal cell carcinoma in the UK: case-control study in 806 patients. Journal of the Royal Society of Medicine, 90(7), https://doi.org/10.1177/014107689709000704

Basal cell carcinoma (BCC) is the commonest malignant neoplasm in white people. We present a large UK case-control study in which conditional logistic regression analysis of age-matched and gender-matched data sets was used to compare, first, cases w... Read More about Risk factors for basal cell carcinoma in the UK: case-control study in 806 patients..

Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction. (1997)
Journal Article
Lear, J. T., Smith, A. G., Bowers, B., Heagearty, A. H., Jones, P. W., Gilford, J., …Fryer, A. A. (1997). Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction. Journal of Investigative Dermatology, 108(4), 519-522. https://doi.org/10.1111/1523-1747.ep12289738

Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma (1997)
Journal Article
Jahnke, V., Strange, R., Matthias, C., & Fryer, A. (1997). Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma. European Archives of Oto-Rhino-Laryngology, 254, S147–S149. https://doi.org/10.1007/BF02439747

While cigarette smoking and alcohol consumption have been linked to laryngeal squamous cell carcinoma (SCC), the role of genetic factors in determining individual susceptibility is unknown. We describe the role of allelism at the glutathione S-transf... Read More about Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma.

Tumor necrosis factor microsatellite haplotypes are different in male and female patients with RA. (1997)
Journal Article
Hajeer, A., John, S., Ollier, W. E., Silman, A. J., Dawes, P., Hassell, A., …Worthington, J. (1997). Tumor necrosis factor microsatellite haplotypes are different in male and female patients with RA. Journal of Rheumatology, 24(1), 217-219

We investigated whether tumor necrosis factor (TNF) microsatellite polymorphisms are associated with sex and age at disease onset in rheumatoid arthritis (RA). A case-control study was used to compare the frequencies of TNF microsatellite alleles in... Read More about Tumor necrosis factor microsatellite haplotypes are different in male and female patients with RA..