All Outputs (8)

Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model (2024)
Journal Article
Perry, J., Mennan, C., Cool, P., McCarthy, H. S., Newell, K., Hopkins, T., …Roberts, S. (2024). Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model. Cartilage, https://doi.org/10.1177/19476035241287832

Objective To determine if mesenchymal stromal cells (MSCs) derived from human umbilical cords (hUC) could reduce degeneration developing when injected into the knee of a large animal model of osteoarthritis (OA). Design Ten million culture-expanded U... Read More about Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.

Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model (2024)
Journal Article
Perry, J., Mennan, C., Cool, P., McCarthy, H., Newell, K., Hopkins, T., …Roberts, S. (2024). Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model. Cartilage, https://doi.org/10.1177/19476035241287832

Objective
To determine if mesenchymal stromal cells (MSCs) derived from human umbilical cords (hUC) could reduce degeneration developing when injected into the knee of a large animal model of osteoarthritis (OA).
Design
Ten million culture-expande... Read More about Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.

A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation (2024)
Journal Article
Orfanos, G., McCarthy, H. S., Williams, M., Dugard, N., Gallacher, P. D., Glover, A. W., …Kuiper, J. H. (2024). A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation. Cartilage, https://doi.org/10.1177/19476035241279943

Objective
Traditional autologous chondrocyte implantation (ACI) involves arthroscopically harvesting a cartilage biopsy (stage 1), followed by arthrotomy 3-4 weeks later to apply a periosteal patch and implant culture-expanded chondrocytes underneat... Read More about A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation.

Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome (2024)
Journal Article
Tierney, L., Kuiper, J. H., Roberts, S., Snow, M., Williams, M., Harrington, M. B., …Wright, K. T. (in press). Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1002/ksa.12433

Purpose
To investigate patient demographic, injury and surgery/treatment-associated factors that can influence the patient-reported outcome (Lysholm score), following autologous chondrocyte implantation (ACI) in a large, ‘real-world’, nonuniform, pr... Read More about Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome.

275 PATIENTS LIVING IN AREAS OF HIGHER SOCIOECONOMIC AREA DEPRIVATION HAVE SIGNIFICANTLY POORER PATIENT-REPORTED OUTCOMES FOLLOWING AUTOLOGOUS CHONDROCYTE IMPLANTATION IN THE UNITED KINGDOM (2024)
Presentation / Conference
Ismael, S., McCarthy, H. S., Williams, M., Barnett, A., Gallacher, P., Jermin, P., …Kuiper, J. H. (2024, April). 275 PATIENTS LIVING IN AREAS OF HIGHER SOCIOECONOMIC AREA DEPRIVATION HAVE SIGNIFICANTLY POORER PATIENT-REPORTED OUTCOMES FOLLOWING AUTOLOGOUS CHONDROCYTE IMPLANTATION IN THE UNITED KINGDOM. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

284 Lower Cell Number Implanted is Consistently Associated with Improved Functional Outcome Post-Autologous Chondrocyte Implantation in Longitudinal Multilevel Modelling Analyses. (2024)
Presentation / Conference
Kuiper, J. H., Dewan, V., Tierney, L., Roberts, S., Harrison, P., Gallacher, P., …Wright, K. T. (2024, April). 284 Lower Cell Number Implanted is Consistently Associated with Improved Functional Outcome Post-Autologous Chondrocyte Implantation in Longitudinal Multilevel Modelling Analyses. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

444 Differential Transcriptome Signatures of Success are Identified within Different Cell Populations used for Treating Cartilage Defects in the Knee (2024)
Presentation / Conference
Tierney, L., Jones, A., McCarthy, H. S., Roberts, S., Tonge, D., & Wright, K. T. (2024, April). 444 Differential Transcriptome Signatures of Success are Identified within Different Cell Populations used for Treating Cartilage Defects in the Knee. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

The clinical potential of meniscal progenitor cells (2024)
Journal Article
Yan, W., Wang, J., Fan, P., Roberts, S., Wright, K., & Zhang, Z. (2024). The clinical potential of meniscal progenitor cells. Journal of Cartilage & Joint Preservation (JCJP), 100166. https://doi.org/10.1016/j.jcjp.2024.100166

Introduction
The meniscus is an important cushioning structure of the knee joint, the maintenance of its normal structure and function plays a crucial role in protecting the joint from early degeneration. Stem/pro... Read More about The clinical potential of meniscal progenitor cells.