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Future directions in flow biocatalysis: The impact of new technology on sustainability (2024)
Journal Article
Ruscoe, R. E., & Cosgrove, S. C. (2024). Future directions in flow biocatalysis: The impact of new technology on sustainability. Current Opinion in Green and Sustainable Chemistry, 49, Article 100954. https://doi.org/10.1016/j.cogsc.2024.100954

Flow chemistry is now a key technology for synthetic chemistry, with the different operating windows available allowing new chemistry to be optimised and discovered. The related area of flow biocatalysis is also becoming increasingly recognised as an... Read More about Future directions in flow biocatalysis: The impact of new technology on sustainability.

Accessing active fragments for drug discovery utilising nitroreductase biocatalysis. (2024)
Journal Article
Holder, L., Yuce, E., Oriomah, G., Jenkins, A.-P., Reynisson, J., Winter, A., & Cosgrove, S. (in press). Accessing active fragments for drug discovery utilising nitroreductase biocatalysis. ChemBioChem, Article e202400428. https://doi.org/10.1002/cbic.202400428

Biocatalysis has played a limited role in the early stages of drug discovery. This is often attributed to the limited substrate scope of enzymes not affording access to vast areas of novel chemical space. Here, we have shown a promiscuous nitroreduct... Read More about Accessing active fragments for drug discovery utilising nitroreductase biocatalysis..

Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides (2023)
Journal Article
Wahart, A. J. C., Dolan, J. P., Anderson, S. D., Cheallaigh, A. N., Staniland, J., Lima, M. A., …Cosgrove, S. C. (2023). Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides. ChemBioChem, Article e202300752. https://doi.org/10.1002/cbic.202300752

Wahart et al. demonstrate the use of an immobilised oxidase enzyme coupled to an extractive amino resin for the bioremediation of a common industrial surfactant. This allows the facile purification of alkyl monoglucosides without the need for high en... Read More about Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides.

Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides. (2023)
Journal Article
Wahart, A. J. C., Dolan, J. P., Anderson, S. D., Cheallaigh, A. N., Staniland, J., Lima, M. A., …Cosgrove, S. C. (in press). Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides. ChemBioChem, Article e202300625. https://doi.org/10.1002/cbic.202300625

As the world moves towards net-zero carbon emissions, the development of sustainable chemical manufacturing processes is essential. Within manufacturing, purification by distillation is often used, however this process is energy intensive and methods... Read More about Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides..

RetroBioCat Database: A Platform for Collaborative Curation and Automated Meta-Analysis of Biocatalysis Data (2023)
Journal Article
Finnigan, W., Lubberink, M., Hepworth, L. J., Citoler, J., Mattey, A. P., Ford, G. J., …Turner, N. J. (2023). RetroBioCat Database: A Platform for Collaborative Curation and Automated Meta-Analysis of Biocatalysis Data. ACS catalysis, 13(17), 11771-11780. https://doi.org/10.1021/acscatal.3c01418

Despite the increasing use of biocatalysis for organic synthesis, there are currently no databases that adequately capture synthetic biotransformations. The lack of a biocatalysis database prevents accelerating biocatalyst characterization efforts fr... Read More about RetroBioCat Database: A Platform for Collaborative Curation and Automated Meta-Analysis of Biocatalysis Data.

Realizing the Continuous Chemoenzymatic Synthesis of Anilines Using an Immobilized Nitroreductase (2023)
Journal Article
Cosgrove, S. C., Miller, G. J., Bornadel, A., & Dominguez, B. (2023). Realizing the Continuous Chemoenzymatic Synthesis of Anilines Using an Immobilized Nitroreductase. ACS sustainable chemistry & engineering, 11(23), 8556-8561. https://doi.org/10.1021/acssuschemeng.3c01204

The use of biocatalysis for classically synthetic transformations has seen an increase in recent years, driven by the sustainability credentials bio-based approaches can offer the chemical industry. Despite this, the biocatalytic reduction of aromati... Read More about Realizing the Continuous Chemoenzymatic Synthesis of Anilines Using an Immobilized Nitroreductase.

One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines (2023)
Journal Article
Sangster, J. J., Ruscoe, R. E., Cosgrove, S. C., Mangas-Sánchez, J., & Turner, N. J. (2023). One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines. Journal of the American Chemical Society, 145(8), 4431-4437. https://doi.org/10.1021/jacs.2c09176

Herein, we report a one-pot, chemoenzymatic process for the synthesis of enantioenriched C(1)-allylated tetrahydroisoquinolines. This transformation couples a monoamine oxidase (MAO-N)-catalyzed oxidation with a metal catalyzed allylboration, followe... Read More about One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines.

Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis (2022)
Journal Article
Cosgrove, Miller, & Dolan. (2022). Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis. JACS Au, 47-61. https://doi.org/10.1021/jacsau.2c00529

While the field of biocatalysis has bloomed over the past 20–30 years, advances in the understanding and improvement of carbohydrate-active enzymes, in particular, the sugar nucleotides involved in glycan building block biosynthesis, have progressed... Read More about Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis.

Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues. (2022)
Journal Article
Cosgrove, S. C., & Miller, G. J. (2022). Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues. Expert Opinion on Drug Discovery, 17(4), 355-364. https://doi.org/10.1080/17460441.2022.2039620

INTRODUCTION: Nucleoside analogues represent a cornerstone of achievement in drug discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery over the last 60 years. Traditionally accessed using chemical synthesis... Read More about Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues..

Oxidase enzymes as sustainable oxidation catalysts (2022)
Journal Article
Wahart, A. J. C., Staniland, J., Miller, G. J., & Cosgrove, S. C. (2022). Oxidase enzymes as sustainable oxidation catalysts. Royal Society Open Science, 9(1), https://doi.org/10.1098/rsos.211572

Oxidation is one of the most important processes used by the chemical industry. However, many of the methods that are used pose significant sustainability and environmental issues. Biocatalytic oxidation offers an alternative to these methods, with a... Read More about Oxidase enzymes as sustainable oxidation catalysts.

Reaching new biocatalytic reactivity using continuous flow reactors (2021)
Journal Article
Cosgrove, S. C., & Mattey, A. P. (2022). Reaching new biocatalytic reactivity using continuous flow reactors. Chemistry - A European Journal, 28(13), https://doi.org/10.1002/chem.202103607

The use of flow reactors in biocatalysis has increased significantly in recent years. Chemists have begun to design flow systems that even allow new biocatalytic reactions to take place. This concept article will focus on the design of flow systems t... Read More about Reaching new biocatalytic reactivity using continuous flow reactors.

Development of continuous flow systems to access secondary amines through previously incompatible biocatalytic cascades. (2021)
Journal Article
Mattey, A. P., Ford, G. J., Citoler, J., Baldwin, C., Marshall, J. R., Palmer, R. B., …Flitsch, S. L. (2021). Development of continuous flow systems to access secondary amines through previously incompatible biocatalytic cascades. Angewandte Chemie International Edition, 60(34), 18660-18665. https://doi.org/10.1002/anie.202103805

A key aim of biocatalysis is to mimic the ability of eukaryotic cells to carry out multistep cascades in a controlled and selective way. As biocatalytic cascades get more complex, reactions become unattainable under typical batch conditions. Here a n... Read More about Development of continuous flow systems to access secondary amines through previously incompatible biocatalytic cascades..

Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades** (2021)
Journal Article
Cosgrove, S. C., Mattey, A. P., Ford, G. J., Citoler, J., Baldwin, C., Marshall, J. R., …Flitsch, S. L. (2021). Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades**. Angewandte Chemie, 133(34), 18808-18813. https://doi.org/10.1002/ange.202103805

A key aim of biocatalysis is to mimic the ability of eukaryotic cells to carry out multistep cascades in a controlled and selective way. As biocatalytic cascades get more complex, reactions become unattainable under typical batch conditions. Here a n... Read More about Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades**.

Production of High Value Amine Intermediates via Biocatalytic Cascades in Continuous Flow (2021)
Journal Article
Baldwin, C., Thompson, M., Turner, N., Pamer, R., Ford, G., Citoler, J., …Cosgrove, S. (2021). Production of High Value Amine Intermediates via Biocatalytic Cascades in Continuous Flow. ChemRxiv, https://doi.org/10.26434/chemrxiv.14039141.v1

<jats:p>A key aim of biocatalysis is to mimic the ability of eukaryotic cells to carry out compartmentalized multistep cascades in a controlled and selective way. As biocatalytic cascades get longer and more complex, reactions become unattainable und... Read More about Production of High Value Amine Intermediates via Biocatalytic Cascades in Continuous Flow.

Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases (2020)
Journal Article
Mangas-Sanchez, J., Sharma, M., Cosgrove, S. C., Ramsden, J. I., Marshall, J. R., Thorpe, T. W., …Turner, N. J. (in press). Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases. Chemical Science, 11(19), 5052-5057. https://doi.org/10.1039/d0sc02253e

Chiral primary amines are important intermediates in the synthesis of pharmaceutical compounds. Fungal reductive aminases (RedAms) are NADPH-dependent dehydrogenases that catalyse reductive amination of a range of ketones with short-chain primary ami... Read More about Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases.

Is it time for biocatalysis in fragment-based drug discovery? (2020)
Journal Article
Cosgrove. (2020). Is it time for biocatalysis in fragment-based drug discovery?. Chemical Science, 11104 - 11112. https://doi.org/10.1039/D0SC04103C

The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature... Read More about Is it time for biocatalysis in fragment-based drug discovery?.

One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald-Hartwig N-Arylation. (2020)
Journal Article
Cosgrove. (2020). One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald-Hartwig N-Arylation. Angewandte Chemie, 18156 - 18160. https://doi.org/10.1002/anie.202006246

The combination of biocatalysis and chemo-catalysis increasingly offers chemists access to more diverse chemical architectures. Here, we describe the combination of a toolbox of chiral-amine-producing biocatalysts with a Buchwald-Hartwig cross-coupli... Read More about One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald-Hartwig N-Arylation..

Natural heterogeneous catalysis with immobilised oxidase biocatalysts (2020)
Journal Article
Mattey, A. P., Sangster, J. J., Ramsden, J. I., Baldwin, C., Birmingham, W. R., Heath, R. S., …Flitsch, S. L. (in press). Natural heterogeneous catalysis with immobilised oxidase biocatalysts. RSC advances, 10(33), 19501-19505. https://doi.org/10.1039/d0ra03618h

The generation of immobilised oxidase biocatalysts allowing multifunctional oxidation of valuable chemicals using molecular oxygen is described. Engineered galactose oxidase (GOase) variants M1 and M3–5, an engineered choline oxidase (AcCO6) and mono... Read More about Natural heterogeneous catalysis with immobilised oxidase biocatalysts.