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Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes. (2008)
Journal Article
(2008). Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes. Cell, 48 - 61. https://doi.org/10.1016/j.cell.2008.04.051

A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host red cells. These changes are caused by parasite proteins exported to... Read More about Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes..

Beneficial links for the control of aphids: the effects of compost applications on predators and prey (2008)
Journal Article
Bell, J. R., Traugott, M., Sunderland, K. D., Skirvin, D. J., Mead, A., Kravar-Garde, L., …Symondson, W. O. (2008). Beneficial links for the control of aphids: the effects of compost applications on predators and prey. Journal of Applied Ecology, 45(4), 1266-1273. https://doi.org/10.1111/j.1365-2664.2008.01479.x

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Polyphagous predators, such as spiders and beetles, perform a fundamental ecosystem service as regulators of agricultural pests, particularly aphids. They are most effective when they colonize the crop before the pest has reached its exponential g... Read More about Beneficial links for the control of aphids: the effects of compost applications on predators and prey.

Do functional traits improve prediction of predation rates for a disparate group of aphid predators? (2008)
Journal Article
Bell, J., Mead, A., Skirvin, D., Sunderland, K., Fenlon, J., & Symondson, W. (2008). Do functional traits improve prediction of predation rates for a disparate group of aphid predators?. Bulletin of Entomological Research, 98(6), 587 - 597. https://doi.org/10.1017/s0007485308005919

Aphid predators are a systematically disparate group of arthropods united on the basis that they consume aphids as part of their diet. In Europe, this group includes Araneae, Opiliones, Heteroptera, chrysopids, Forficulina, syrphid larvae, carabids,... Read More about Do functional traits improve prediction of predation rates for a disparate group of aphid predators?.

Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence (2008)
Journal Article
Horrocks. (2008). Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence. PloS one, e2386 - ?. https://doi.org/10.1371/journal.pone.0002386

Reversible modification of proteins through the attachment of ubiquitin or ubiquitin-like modifiers is an essential post-translational regulatory mechanism in eukaryotes. The conjugation of ubiquitin or ubiquitin-like proteins has been demonstrated t... Read More about Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence.

High genetic differentiation between the M and S molecular forms of Anopheles gambiae in Africa (2008)
Journal Article
(2008). High genetic differentiation between the M and S molecular forms of Anopheles gambiae in Africa. PloS one, e1968 - ?. https://doi.org/10.1371/journal.pone.0001968

Anopheles gambiae, a major vector of malaria, is widely distributed throughout sub-Saharan Africa. In an attempt to eliminate infective mosquitoes, researchers are trying to develop transgenic strains that are refractory to the Plasmodium parasite. B... Read More about High genetic differentiation between the M and S molecular forms of Anopheles gambiae in Africa.

Plasmodium falciparum icam-1-based cytoadherence-related signalling in endothelical cells (2008)
Journal Article
Jenkins, N., Wu, Y., Chakravorty, S., Kai, O., Marsh, K., & Craig, A. (2008). Plasmodium falciparum icam-1-based cytoadherence-related signalling in endothelical cells. Journal of Infection, 56(4), 299. https://doi.org/10.1016/j.jinf.2008.01.018

Background: Cytoadherence of Plasmodium falciparum infected erythrocytes to host endothelium has been associated with pathology in severe malaria, but despite extensive information on the primary processes involved in the adhesive interactions the me... Read More about Plasmodium falciparum icam-1-based cytoadherence-related signalling in endothelical cells.

Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5) (2008)
Journal Article
Mourtada-Maarabouni, M., Hedge, V. L., Kirkham, L., Farzaneh, F., & Williams, G. T. (2008). Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5). Journal of Cell Science, 121(7), 939-946. https://doi.org/10.1242/jcs.024646

The control of growth of lymphocyte populations is crucial to the physiological regulation of the immune system, and to the prevention of both leukaemic and autoimmune disease. This control is mediated through modulation of the cell cycle and regulat... Read More about Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5).

Host response to cytoadherence inPlasmodium falciparum (2008)
Journal Article
Chakravorty, S., Hughes, K., & Craig, A. (2008). Host response to cytoadherence inPlasmodium falciparum. Biochemical Society Transactions, 36(2), 221-228. https://doi.org/10.1042/bst0360221

Cytoadherence of PRBCs (Plasmodium falciparum-infected red blood cells) to host endothelium has been associated with pathology in severe malaria, but, despite extensive information on the primary processes involved in the adhesive interactions, the m... Read More about Host response to cytoadherence inPlasmodium falciparum.

Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells (2008)
Journal Article
Mourtada-Maarabouni, M., & Williams, G. T. (2008). Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1783(8), 1490-1502. https://doi.org/10.1016/j.bbamcr.2008.03.005

The proteins which regulate apoptosis are of great importance both in normal cell biological processes and in the development of pathology in the diverse diseases which involve apoptosis dysfunction. The activity of many of these proteins is controll... Read More about Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells.

Acoustic information as a distant cue for habitat recognition by nocturnally migrating passerines during landfall (2008)
Journal Article
Mukhin, A., Chernetsov, N., & Kishkinev, D. (2008). Acoustic information as a distant cue for habitat recognition by nocturnally migrating passerines during landfall. Behavioral Ecology, 19(4), 716-723. https://doi.org/10.1093/beheco/arn025

During migration, birds must fly over suboptimal habitats differing from those selected during breeding and wintering. Nocturnally migrating passerines need to assess the suitability of potential stopover habitats during landfall. Before actual landf... Read More about Acoustic information as a distant cue for habitat recognition by nocturnally migrating passerines during landfall.

A Long-Distance Avian Migrant Compensates for Longitudinal Displacement during Spring Migration (2008)
Journal Article
Chernetsov, N., Kishkinev, D., & Mouritsen, H. (2008). A Long-Distance Avian Migrant Compensates for Longitudinal Displacement during Spring Migration. Current Biology, 18(3), 188-190. https://doi.org/10.1016/j.cub.2008.01.018

In order to perform true bicoordinate navigation, migratory birds need to be able to determine geographic latitude and longitude. The determination of latitude is relatively easy from either stellar or magnetic cues 1, 2, 3, but the determination of... Read More about A Long-Distance Avian Migrant Compensates for Longitudinal Displacement during Spring Migration.

Weed and invertebrate community compositions in arable farmland (2008)
Journal Article
Smith, V., Bohan, D. A., Clark, S. J., Haughton, A. J., Bell, J. R., & Heard, M. S. (2008). Weed and invertebrate community compositions in arable farmland. Arthropod-Plant Interactions, 2, Article 21-30. https://doi.org/10.1007/s11829-007-9027-y

A large proportion of the land surface area of Great Britain (GB) is used for arable agriculture. Due to changes in farm management practices over the last 50 years, there have been marked declines in the abundance of arable wildlife groups of conser... Read More about Weed and invertebrate community compositions in arable farmland.

Migratory programme of juvenile pied flycatchers, Ficedula hypoleuca, from Siberia implies a detour around Central Asia (2007)
Journal Article
Chernetsov, N., Kishkinev, D., Gashkov, S., Kosarev, V., & Bolshakov, C. V. (2008). Migratory programme of juvenile pied flycatchers, Ficedula hypoleuca, from Siberia implies a detour around Central Asia. Animal Behaviour, 75(2), 539-545. https://doi.org/10.1016/j.anbehav.2007.05.019

Field studies suggest that in autumn, passerine Siberian-African migrants make a detour around Central Asia. We tested whether it results from an innate spatiotemporal programme. We hand-raised juvenile pied flycatchers from Europe and western Siberi... Read More about Migratory programme of juvenile pied flycatchers, Ficedula hypoleuca, from Siberia implies a detour around Central Asia.

Ballooning dispersal in arthropod taxa: conditions at take-off (2007)
Journal Article
Reynolds, A. M., Bohan, D. A., & Bell, J. R. (2007). Ballooning dispersal in arthropod taxa: conditions at take-off. Biology Letters, 3(3), https://doi.org/10.1098/rsbl.2007.0109

We have solved a long-standing and seemingly paradoxical set of questions that relate to the conditions which govern spider ballooning. We show that observations of spider ballooning excursions are best explained by meteorological conditions which ma... Read More about Ballooning dispersal in arthropod taxa: conditions at take-off.

Altered phenotype and gene transcription in endothelial cells, induced by Plasmodium falciparum-infected red blood cells: Pathogenic or protective? (2007)
Journal Article
Chakravorty, S. J., Carret, C., Nash, G. B., Ivens, A., Szestak, T., & Craig, A. G. (2007). Altered phenotype and gene transcription in endothelial cells, induced by Plasmodium falciparum-infected red blood cells: Pathogenic or protective?. International Journal for Parasitology, 37(8-9), 975-987. https://doi.org/10.1016/j.ijpara.2007.02.006

Severe malaria is associated with sequestration of Plasmodium falciparum-infected red blood cells (PRBC) in the microvasculature and elevation of intercellular adhesion molecule-1 (ICAM-1) and TNF. In vitro co-culture of human umbilical vein endothel... Read More about Altered phenotype and gene transcription in endothelial cells, induced by Plasmodium falciparum-infected red blood cells: Pathogenic or protective?.

An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31 (2006)
Journal Article
Chakravorty, S. J., McGettrick, H. M., Butler, L. M., Buckley, C. D., Rainger, G. . E., & Nash, G. B. (2006). An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31. Biorheology, 43(1), 71-82

To model the later stages of neutrophil migration into tissue, we developed an assay in which human umbilical vein endothelial cells (HUVEC) were cultured on porous filters, treated with the inflammatory cytokine tumour necrosis factor-α (TNF), and t... Read More about An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31.

Isolation of genes controlling apoptosis through their effects on cell survival (2006)
Journal Article
Williams, G. T., Hughes, J. P., Stoneman, V., Anderson, C. L., McCarthy, N. J., Mourtada-Maarabouni, M., …Farzaneh, F. (2006). Isolation of genes controlling apoptosis through their effects on cell survival. Gene Therapy and Molecular Biology, 10(28), 255-262

The identification of the most suitable molecular targets for gene and drug therapy is the crucial first step in the development of new disease treatments. The rational identification of such targets depends on a detailed understanding of the patholo... Read More about Isolation of genes controlling apoptosis through their effects on cell survival.

The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: Research update (2006)
Journal Article
Maarabouni, M. M., & Williams, G. T. (2006). The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: Research update. Scientific World Journal, 1705 - 1712. https://doi.org/10.1100/tsw.2006.268

The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis... Read More about The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: Research update.