The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: Research update

Maarabouni, Mirna M; Williams, Gwyn T

Abstract

The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumour regulation. This review highlights recent evidence that further implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and focuses on the observations that confirm the tumour-suppressor activity of this gene.

Citation

Maarabouni, M. M., & Williams, G. T. (2006). The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: Research update. Scientific World Journal, 1705 - 1712. https://doi.org/10.1100/tsw.2006.268

• Journal Article Type: Article
• Acceptance Date: Dec 28, 2006
• Publication Date: Dec 28, 2006
• Publicly Available Date: May 26, 2023
• Journal: Scientific World Journal
• Print ISSN: 2356-6140
• Publisher: Hindawi
• Pages: 1705 - 1712
• ISBN: 1537744X
• DOI: https://doi.org/10.1100/tsw.2006.268
• Keywords: Apoptosis (D017209), Cell Cycle Proteins (D018797), Cell Proliferation (D049109), DNA-Binding Proteins (D004268), Gene Expression Regulation, Neoplastic (D015972), Genes, Tumor Suppressor (D016147), Humans (D006801), Lung Neoplasms (D008175), RNA-Binding
• Publisher URL: https://www.hindawi.com/journals/tswj/2006/819835/