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Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells (2023)
Journal Article
Llewellyn, J., Mallikarjun, V., Gilbert, H., Richardson, S., Hubbard, S., Swift, J., …Osipova, M. (2023). Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells. Proceedings of the National Academy of Sciences of the United States of America, https://doi.org/10.1073/pnas.2210745120

<jats:p>Cells respond to stress by synthesizing chaperone proteins that seek to correct protein misfolding and maintain function. However, abrogation of protein homeostasis is a hallmark of aging, leading to loss of function and the formation of prot... Read More about Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells.

Floral enhancement of arable field margins increases moth abundance and diversity (2023)
Journal Article
Blumgart, D., Botham, M. S., Menéndez, R., & Bell, J. R. (2023). Floral enhancement of arable field margins increases moth abundance and diversity. Journal of Insect Conservation, 27, 455–465. https://doi.org/10.1007/s10841-023-00469-9

Moth populations have declined across large parts of north-western Europe since the mid-20th century due, in part, to agricultural intensification. Agri-environment schemes (AES) are widely implemented across Europe to protect biodiversity in agricul... Read More about Floral enhancement of arable field margins increases moth abundance and diversity.

The potential future role of antiviral fabrics within healthcare systems (2023)
Journal Article
Morris, H., Forrester-Soto, N., & Ogrodnik, P. (in press). The potential future role of antiviral fabrics within healthcare systems. Journal of the Textile Institute, 115(3), 453-459. https://doi.org/10.1080/00405000.2023.2193278

Health care-associated infection is acquired by patients while receiving care and represents the most frequent adverse event with a prevalence internationally ranging from 5.7% to 19.1%. Whilst the role of textiles as a fomite in infection has been q... Read More about The potential future role of antiviral fabrics within healthcare systems.

Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination. (2023)
Journal Article
Turnbull, J. (2023). Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination. Glia, 71(7), 1683-1698. https://doi.org/10.1002/glia.24363

There is an urgent need for therapies that target the multicellular pathology of central nervous system (CNS) disease. Modified, nonanticoagulant heparins mimic the heparan sulfate glycan family and are known regulators of multiple cellular processes... Read More about Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination..

Validation of Recombinant Heparan Sulphate Reagents for CNS Repair. (2023)
Journal Article
Turnbull, J. (2023). Validation of Recombinant Heparan Sulphate Reagents for CNS Repair. Biology, 12(3), Article 407. https://doi.org/10.3390/biology12030407

Therapies that target the multicellular pathology of central nervous system (CNS) disease/injury are urgently required. Modified non-anticoagulant heparins mimic the heparan sulphate (HS) glycan family and have been proposed as therapeutics for CNS r... Read More about Validation of Recombinant Heparan Sulphate Reagents for CNS Repair..

Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties. (2023)
Journal Article
Reynisson, J. (2023). Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms24043834

Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a promising target for antitumor therapy; the use of TDP1 inhibitors with a topoisomerase 1 poison such as topotecan is a potential combination therapy. In this work, a novel series of 3,5-disubstituted thiaz... Read More about Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties..

Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. (2023)
Journal Article
Devlin, A. J., Mycroft-West, C. J., Turnbull, J. E., Andrade De Lima, M., Guerrini, M., Yates, E. A., & Skidmore, M. A. (2023). Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. ACS Central Science, 9, 381-392. https://doi.org/10.1021/acscentsci.2c01176

Heparin is a polydisperse, heterogeneous polysaccharide of the glycosaminoglycan (GAG) class that has found widespread clinical use as a potent anticoagulant and is classified as an essential medicine by the World Health Organization. The importance... Read More about Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State..

Induction of aphid resistance in tobacco by the cucumber mosaic virus CMV?2b mutant is jasmonate-dependent. (2023)
Journal Article
Arinaitwe, W., Tungadi, T. D., Pate, A. E., Joyce, J., Baek, E., Murphy, A. M., & Carr, J. P. (2023). Induction of aphid resistance in tobacco by the cucumber mosaic virus CMV?2b mutant is jasmonate-dependent. Molecular Plant Pathology, 24(4), 391 - 395. https://doi.org/10.1111/mpp.13305

Cucumber mosaic virus (CMV) is vectored by aphids, including Myzus persicae. Tobacco (Nicotiana tabacum 'Xanthi') plants infected with a mutant of the Fny strain of CMV (Fny-CMV?2b, which cannot express the CMV 2b protein) exhibit strong resistance a... Read More about Induction of aphid resistance in tobacco by the cucumber mosaic virus CMV?2b mutant is jasmonate-dependent..

qSanger: Quantification of Genetic Variants in Bacterial Cultures by Sanger Sequencing (2023)
Journal Article
Prakash, S., Racovita, A., Petrucci, T., Galizi, R., & Jaramillo, A. (in press). qSanger: Quantification of Genetic Variants in Bacterial Cultures by Sanger Sequencing. BioDesign Research, 5, Article 0007. https://doi.org/10.34133/bdr.0007

Genetic variations such as mutations and recombinations arise spontaneously in all cultured organisms. Although it is possible to identify nonneutral mutations by selection or counterselection, the identification of neutral mutations in a heterogeneo... Read More about qSanger: Quantification of Genetic Variants in Bacterial Cultures by Sanger Sequencing.

High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. (2023)
Journal Article
Maciej-Hulme, M. L., Leprince, A. C., Lavin, A., Guimond, S. E., Turnbull, J. E., Pelletier, J., …Skidmore, M. A. (2023). High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. Analytical Methods, 15(11), 1461-1469. https://doi.org/10.1039/d2ay01803a

The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in... Read More about High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts..

New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate (2023)
Journal Article
Kavousi, N., Tonge, D. P., & Mourtada-Maarabouni, M. (2023). New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate. International Journal of Biological Macromolecules, 233, Article 123467. https://doi.org/10.1016/j.ijbiomac.2023.123467

The serine/threonine protein phosphatase 4 holoenzyme consists of a PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits. Previous studies have shown that PP4c acts as a tumour suppressor. Emerging evidence suggests t... Read More about New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate.

Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors (2023)
Journal Article
Clennell, B., Steward, T. G., Hanman, K., Needham, T., Benachour, J., Jepson, M., …Whitcomb, D. J. (2023). Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors. Brain Stimulation, 16(2), https://doi.org/10.1016/j.brs.2023.01.1674

Background
Focused ultrasound stimulation (FUS) has the potential to provide non-invasive neuromodulation of deep brain regions with unparalleled spatial precision. However, the cellular and molecular consequences of ultrasound stimulation on neuron... Read More about Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors.

A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1). (2023)
Journal Article
Mycroft-West, C., Devlin, A., Cooper, L., Guimond, S., Procter, P., Miller, G., …Skidmore, M. (2023). A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1). Carbohydrate Research, 525, Article 108747. https://doi.org/10.1016/j.carres.2023.108747

The clinically important anticoagulant heparin, a member of the glycosaminoglycan family of carbohydrates that is extracted predominantly from porcine and bovine tissue sources, has previously been shown to inhibit the ß-site amyloid precursor protei... Read More about A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1)..

The disproportionate case–fatality ratio of COVID-19 between countries with the highest vaccination rates and the rest of the world (2023)
Journal Article
Haider, N., Nayeem Hasan, M., Guitian, J., Khan, R. A., McCoy, D., Ntoumi, F., …Kock, R. A. (2023). The disproportionate case–fatality ratio of COVID-19 between countries with the highest vaccination rates and the rest of the world. IJID Regions, 6, 159-166. https://doi.org/10.1016/j.ijregi.2023.01.011

Objectives
The global reported cumulative case–fatality ratios (rCFRs) and excess mortality rates of the 20 countries with the highest coronavirus disease 2019 (COVID-19) vaccination rates, the rest of the world and Sub-Saharan Africa (SSA) were com... Read More about The disproportionate case–fatality ratio of COVID-19 between countries with the highest vaccination rates and the rest of the world.

Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose. (2023)
Journal Article
Porter, J., Lima, M. A., Pongener, I., & Miller, G. (2023). Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose. Carbohydrate Research, 524, Article 108759. https://doi.org/10.1016/j.carres.2023.108759

Sulfur containing glycosides offer an exciting prospect for inclusion within noncanonical glycan sequences, particularly as enabling probes for chemical glycobiology and for carbohydrate-based therapeutic development. In this context, we required acc... Read More about Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose..

Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements (2023)
Journal Article
Anderson, M. A. E., Gonzalez, E., Ang, J. X. D., Shackleford, L., Nevard, K., Verkuijl, S. A. N., …Alphey, L. (in press). Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements. Nature communications, 14(1), Article 338. https://doi.org/10.1038/s41467-023-36029-7

CRISPR/Cas9-based homing gene drives have emerged as a potential new approach to mosquito control. While attempts have been made to develop such systems in Aedes aegypti, none have been able to match the high drive efficiency observed in Anopheles sp... Read More about Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements.