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All Outputs (303)

Recommended and observed statin use among US adults with and without cancer. (2024)
Journal Article
Kobo, O., Michos, E. D., Roguin, A., Bagur, R., Gulati, M., & Mamas, M. A. (in press). Recommended and observed statin use among US adults with and without cancer. European Journal of Preventive Cardiology, Article zwae057. https://doi.org/10.1093/eurjpc/zwae057

Patients with cancer are at increased cardiovascular risk. We aimed to compare the recommended and observed statin use among individuals with and without cancer. Using three 2-year cycles from the National Health and Nutrition Examination Survey [NHA... Read More about Recommended and observed statin use among US adults with and without cancer..

Understanding how therapeutic exercise prescription changes outcomes important to patients with persistent non-specific low back pain: a realist review protocol (2024)
Journal Article
Wood, L., Booth, V., Dean, S., Foster, N. E., Hayden, J. A., & Booth, A. (in press). Understanding how therapeutic exercise prescription changes outcomes important to patients with persistent non-specific low back pain: a realist review protocol. Systematic Reviews, 13(1), 63. https://doi.org/10.1186/s13643-024-02466-8

Introduction: Persistent low back pain (LBP) is the leading cause of disability worldwide, and therapeutic exercise is recommended as a first-line treatment in international guidelines. The effects of exercise on clinical outcomes of pain and physica... Read More about Understanding how therapeutic exercise prescription changes outcomes important to patients with persistent non-specific low back pain: a realist review protocol.

Evaluating the impact of the supporting the advancement of research skills (STARS) programme on research knowledge, engagement and capacity-building in a health and social care organisation in England (2024)
Journal Article
Tajuria, G., Dobel-Ober, D., Bradley, E., Charnley, C., Lambley-Burke, R., Mallen, C., …Kingstone, T. (in press). Evaluating the impact of the supporting the advancement of research skills (STARS) programme on research knowledge, engagement and capacity-building in a health and social care organisation in England. BMC Medical Education, 24(1), Article 126. https://doi.org/10.1186/s12909-024-05059-0

Objectives To evaluate the impact a novel education programme - to improve research engagement, awareness, understanding and confidence - had on a diverse health and social care workforce. Barriers and facilitators to engagement were explored togeth... Read More about Evaluating the impact of the supporting the advancement of research skills (STARS) programme on research knowledge, engagement and capacity-building in a health and social care organisation in England.

Betwixt and between student and professional identities: UK medical students during COVID times (2024)
Journal Article
Polidano, K., Wenning, B., Mallen, C. D., & Dikomitis, L. (2024). Betwixt and between student and professional identities: UK medical students during COVID times. SN Social Sciences, 4(2), Article 53. https://doi.org/10.1007/s43545-024-00844-6

The COVID-19 pandemic lockdown in Spring 2020 brought about unprecedented disruption to medical education in the United Kingdom (UK). Medical students were encouraged to take up paid roles in the National Health Service to help with workforce shortag... Read More about Betwixt and between student and professional identities: UK medical students during COVID times.

An online clinical decision tool to screen for vertebral fragility fractures (Vfrac) in older women presenting with back pain in general practice: protocol for a feasibility study in preparation for a future cluster randomised controlled trial (2024)
Journal Article
Khalid, T. Y., Peters, T. J., Pocock, L. V., Drew, S., Hardcastle, S. A., Paskins, Z., …Clark, E. M. (in press). An online clinical decision tool to screen for vertebral fragility fractures (Vfrac) in older women presenting with back pain in general practice: protocol for a feasibility study in preparation for a future cluster randomised controlled trial. Archives of Osteoporosis, 19(1), 12. https://doi.org/10.1007/s11657-023-01364-1

Summary: This feasibility study for a future definitive randomized trial assesses the use and acceptability of a new clinical decision tool to identify risk of a vertebral fracture and those who should be referred for spinal radiography in women aged... Read More about An online clinical decision tool to screen for vertebral fragility fractures (Vfrac) in older women presenting with back pain in general practice: protocol for a feasibility study in preparation for a future cluster randomised controlled trial.

The information required by people with inflammatory arthritis to take methotrexate: a mixed-methods systematic review (2024)
Journal Article
Logan, S. J., Hider, S., Green, J., & Ryan, S. J. (in press). The information required by people with inflammatory arthritis to take methotrexate: a mixed-methods systematic review. Rheumatology, https://doi.org/10.1093/rheumatology/keae055

Objectives This mixed-methods systematic review aimed to identify and synthesize knowledge of the characteristics, content, and preferred format of information to support people with inflammatory arthritis (IA) to take methotrexate. Methods A literat... Read More about The information required by people with inflammatory arthritis to take methotrexate: a mixed-methods systematic review.

An online clinical decision tool to screen for vertebral fragility fractures (Vfrac) in older women presenting with back pain in general practice: protocol for a feasibility study in preparation for a future cluster randomized controlled trial (2024)
Journal Article
Khalid, T. Y., Peters, T. J., Pocock, L., Drew, S., Hardcastle, S., Paskins, Z., …Clark, E. (2024). An online clinical decision tool to screen for vertebral fragility fractures (Vfrac) in older women presenting with back pain in general practice: protocol for a feasibility study in preparation for a future cluster randomized controlled trial. Archives of Osteoporosis, 19, Article 12. https://doi.org/10.1007/s11657-023-01364-1

Summary This feasibility study for a future definitive randomized trial assesses the use and acceptability of a new clinical decision tool to identify risk of a vertebral fracture and those who should be referred for spinal radiography in women aged... Read More about An online clinical decision tool to screen for vertebral fragility fractures (Vfrac) in older women presenting with back pain in general practice: protocol for a feasibility study in preparation for a future cluster randomized controlled trial.

Identifying prior signals of bipolar disorder using primary care electronic health records: a nested case-control study. (2024)
Journal Article
Morgan, C., Ashcroft, D. M., Chew-Graham, C. A., Sperrin, M., Webb, R. T., Francis, A., …Yung, A. R. (in press). Identifying prior signals of bipolar disorder using primary care electronic health records: a nested case-control study. British Journal of General Practice (BJGP), 74, e165-e173. https://doi.org/10.3399/BJGP.2022.0286

Bipolar disorders are serious mental illnesses, yet evidence suggests that the diagnosis and treatment of bipolar disorder can be delayed by around 6 years. To identify signals of undiagnosed bipolar disorder using routinely collected electronic heal... Read More about Identifying prior signals of bipolar disorder using primary care electronic health records: a nested case-control study..

Social determinants of spatial inequalities in COVID-19 outcomes across England: A multiscale geographically weighted regression analysis. (2024)
Journal Article
Khedmati Morasae, E., Derbyshire, D. W., Amini, P., & Ebrahimi, T. (2024). Social determinants of spatial inequalities in COVID-19 outcomes across England: A multiscale geographically weighted regression analysis. SSM - Population Health, 25, Article 101621. https://doi.org/10.1016/j.ssmph.2024.101621

A variety of factors are associated with greater COVID-19 morbidity or mortality, due to how these factors influence exposure to (in the case of morbidity) or severity of (in the case of mortality) COVID-19 infections. We use multiscale geographicall... Read More about Social determinants of spatial inequalities in COVID-19 outcomes across England: A multiscale geographically weighted regression analysis..

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches (2024)
Journal Article
Kehoe, O., Welsh, J. A., Goberdhan, D. C., O'Driscoll, L., Buzas, E. I., Blenkiron, C., …Witwer, K. W. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13(2), Article e12404. https://doi.org/10.1002/jev2.12404

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated b... Read More about Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.

Global primary care research challenges (2024)
Journal Article
Akhtar, S., Poppleton, A., & Caleyachetty, R. (in press). Global primary care research challenges. InnovAiT: Education and inspiration for general practice, https://doi.org/10.1177/17557380231225590

Healthcare needs are changing globally as people live longer, but not necessarily in better health. Increased population migration is leading to culturally diverse patient populations with more diverse health needs and expectations. The provision of... Read More about Global primary care research challenges.

Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study (2024)
Journal Article
Weight, N., Moledina, S., Kontopantelis, E., Van Spall, H., Dafaalla, M., Chieffo, A., …Mamas, M. A. (in press). Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study. European Heart Journal - Quality of Care and Clinical Outcomes, Article qcae011. https://doi.org/10.1093/ehjqcco/qcae011

Background Contemporary studies demonstrate that non-ST-segment elevation myocardial infarction (NSTEMI) processes of care vary according to sex. Little is known regarding variation in practice between geographical areas and centres. Methods We... Read More about Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study.

Quality improvement project assessing the feasibility of using canister weight to estimate remaining doses in a salbutamol pressurised metered-dose inhaler. (2024)
Journal Article
Beckett, R. S., Jagadish, A., Carroll, W., & Gilchrist, F. J. (in press). Quality improvement project assessing the feasibility of using canister weight to estimate remaining doses in a salbutamol pressurised metered-dose inhaler. Archives of Disease in Childhood, archdischild-2023-326678. https://doi.org/10.1136/archdischild-2023-326678

Counting the Lifetime Cost of Obesity: Analysis based on National England Data (2024)
Journal Article
Fryer, A. A., Heald, A., Stedman, M., Stedman, M., Davies, M. B., Rutter, M. K., …Whyte, M. (2024). Counting the Lifetime Cost of Obesity: Analysis based on National England Data. Diabetes, Obesity and Metabolism, 26(4), 1464-1478. https://doi.org/10.1111/dom.15447

Aim Obesity has a significant impact on all-cause mortality rate and overall health care resource use (HCRU). These outcomes are also strongly linked to age, sex and local deprivation of the population. We aimed to establish the lifetime costs of ob... Read More about Counting the Lifetime Cost of Obesity: Analysis based on National England Data.

Primary care provision for young people with ADHD: A multi-perspective qualitative study (2024)
Journal Article
Gudka, R., Becker, K., Ward, J., Smith, J., Mughal, F., Melendez-Torres, G. J., …Price, A. (in press). Primary care provision for young people with ADHD: A multi-perspective qualitative study. British Journal of General Practice (BJGP), 74(743), e408-e416. https://doi.org/10.3399/bjgp.2023.0626

Background: Attention deficit hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder. United Kingdom (UK) guidance states primary care has a vital role in effective ADHD management including referral, medication prescribing a... Read More about Primary care provision for young people with ADHD: A multi-perspective qualitative study.

C-peptide in diabetes: A player in a dual hormone disorder? (2024)
Journal Article
Dakroub, A., Dbouk, A., Asfour, A., Nasser, S. A., El‐Yazbi, A. F., Sahebkar, A., …Eid, A. A. (in press). C-peptide in diabetes: A player in a dual hormone disorder?. Journal of Cellular Physiology, 10.1002/jcp.31212. https://doi.org/10.1002/jcp.31212

C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) and early T2DM. C-peptide pro... Read More about C-peptide in diabetes: A player in a dual hormone disorder?.

Behavioural activation to mitigate the psychological impacts of COVID-19 restrictions on older people in England and Wales (BASIL+): a pragmatic randomised controlled trial. (2024)
Journal Article
Gilbody, S., Littlewood, E., McMillan, D., Atha, L., Bailey, D., Baird, K., …Ekers, D. (2024). Behavioural activation to mitigate the psychological impacts of COVID-19 restrictions on older people in England and Wales (BASIL+): a pragmatic randomised controlled trial. The Lancet Healthy Longevity, 5(2), e97-e107. https://doi.org/10.1016/S2666-7568%2823%2900238-6

Older adults were more likely to be socially isolated during the COVID-19 pandemic, with increased risk of depression and loneliness. We aimed to investigate whether a behavioural activation intervention delivered via telephone could mitigate depress... Read More about Behavioural activation to mitigate the psychological impacts of COVID-19 restrictions on older people in England and Wales (BASIL+): a pragmatic randomised controlled trial..

Does workforce explain the relationship between funding and patient experience? A mediation analysis of primary care data in England (2024)
Journal Article
Salant, N., Massou, E., Awan, H., & Ford, J. A. (2024). Does workforce explain the relationship between funding and patient experience? A mediation analysis of primary care data in England. BMJ Open, 14(2), Article e072498. https://doi.org/10.1136/bmjopen-2023-072498

Objectives: To determine whether general practitioner (GP) workforce contributes to the link between practice funding and patient experience. Specifically, to determine whether increased practice funding is associated with better patient experience,... Read More about Does workforce explain the relationship between funding and patient experience? A mediation analysis of primary care data in England.

Barriers, enablers and motivators of the “I’m an active Hero” physical activity intervention for preschool children: a qualitative study (2024)
Journal Article
Al-walah, M. A., Donnelly, M., & Heron, N. (in press). Barriers, enablers and motivators of the “I’m an active Hero” physical activity intervention for preschool children: a qualitative study. Frontiers in Pediatrics, 12, https://doi.org/10.3389/fped.2024.1333173

Background: Insufficient physical activity (PA) in early childhood is linked to adverse health outcomes and a heightened risk of obesity. Successful PA programmes often require input from key stakeholders, such as parents and educators. However, rese... Read More about Barriers, enablers and motivators of the “I’m an active Hero” physical activity intervention for preschool children: a qualitative study.