All Outputs (101)

Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply (2014)
Journal Article
Sugimura, S., Ritter, L. J., Sutton-McDowall, M. L., Mottershead, D. G., Thompson, J. G., & Gilchrist, R. B. (2014). Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply. Molecular Human Reproduction, 20(6), 499-513. https://doi.org/10.1093/molehr/gau013

This study assessed the participation of amphiregulin (AREG) and bone morphogenetic protein 15 (BMP15) during maturation of bovine cumulus-oocyte complexes (COCs) on cumulus cell function and their impact on subsequent embryo development. AREG treatm... Read More about Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply.

Outcomes in patients with acute and stable coronary syndromes: insights from the prospective NOBORI-2 study (2014)
Journal Article
Mamas. (2014). Outcomes in patients with acute and stable coronary syndromes: insights from the prospective NOBORI-2 study. PloS one, e88577 -?. https://doi.org/10.1371/journal.pone.0088577

BACKGROUND: Contemporary data remains limited regarding mortality and major adverse cardiac events (MACE) outcomes in patients undergoing PCI for different manifestations of coronary artery disease. OBJECTIVES: We evaluated mortality and MACE outcome... Read More about Outcomes in patients with acute and stable coronary syndromes: insights from the prospective NOBORI-2 study.

Major bleeding after percutaneous coronary intervention and risk of subsequent mortality: a systematic review and meta-analysis. (2014)
Journal Article
Mamas, M., & Nolan, J. (2014). Major bleeding after percutaneous coronary intervention and risk of subsequent mortality: a systematic review and meta-analysis. Open Heart, e000021 -?. https://doi.org/10.1136/openhrt-2013-000021

OBJECTIVES: To examine the relationship between periprocedural bleeding complications and major adverse cardiovascular events (MACEs) and mortality outcomes following percutaneous coronary intervention (PCI) and study differences in the prognostic im... Read More about Major bleeding after percutaneous coronary intervention and risk of subsequent mortality: a systematic review and meta-analysis..

Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat (2014)
Journal Article
Bake, T., Morgan, D., & Mercer, J. (2014). Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat. Physiology and Behavior, 128, 70-79. https://doi.org/10.1016/j.physbeh.2014.01.018

Providing rats and mice with access to palatable high fat diets for a short period each day induces the consumption of substantial binge-like meals. Temporal food intake structure (assessed using the TSE PhenoMaster/LabMaster system) and metabolic ou... Read More about Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat.

FAST INdiCATE Trial protocol. Clinical efficacy of functional strength training for upper limb motor recovery early after stroke: neural correlates and prognostic indicators. (2014)
Journal Article
Hunter, S. (2014). FAST INdiCATE Trial protocol. Clinical efficacy of functional strength training for upper limb motor recovery early after stroke: neural correlates and prognostic indicators. International Journal of Stroke, 240 -245. https://doi.org/10.1111/ijs.12179

RATIONALE: Functional strength training in addition to conventional physical therapy could enhance upper limb recovery early after stroke more than movement performance therapy plus conventional physical therapy. AIMS: To determine (a) the relative c... Read More about FAST INdiCATE Trial protocol. Clinical efficacy of functional strength training for upper limb motor recovery early after stroke: neural correlates and prognostic indicators..

Changes of synovial fluid protein concentrations in supra-patellar bursitis patients after the injection of different molecular weights of hyaluronic acid (2014)
Journal Article
Chen, C. P., Hsu, C. C., Pei, Y., Chen, R. L., Zhou, S., Shen, H., …Tsai, W. C. (2014). Changes of synovial fluid protein concentrations in supra-patellar bursitis patients after the injection of different molecular weights of hyaluronic acid. Experimental Gerontology, 52, 30-35. https://doi.org/10.1016/j.exger.2014.01.016

Knee pain is commonly seen in orthopedic and rehabilitation outpatient clinical settings, and in the aging population. Bursitis of the knee joint, especially when the volume of the synovial fluid is large enough, can compress and distend the nearby s... Read More about Changes of synovial fluid protein concentrations in supra-patellar bursitis patients after the injection of different molecular weights of hyaluronic acid.

An in vitro spinal cord injury model to screen neuroregenerative materials (2014)
Journal Article
Weightman, A. P., Pickard, M. R., Yang, Y., & Chari, D. M. (2014). An in vitro spinal cord injury model to screen neuroregenerative materials. Biomaterials, 35(12), 3756-3765. https://doi.org/10.1016/j.biomaterials.2014.01.022

Implantable ‘structural bridges’ based on nanofabricated polymer scaffolds have great promise to aid spinal cord regeneration. Their development (optimal formulations, surface functionalizations, safety, topographical influences and degradation profi... Read More about An in vitro spinal cord injury model to screen neuroregenerative materials.

microRNAs as Anti-Cancer Therapy (2014)
Journal Article
Garofalo, M., Di Leva, G., & Croce, C. (2014). microRNAs as Anti-Cancer Therapy. Current Pharmaceutical Design, 20(33), 5328-5335. https://doi.org/10.2174/1381612820666140128211346

MicroRNAs (miRNAs) are endogenously expressed and evolutionarily conserved small non-coding RNAs, which regulate gene expression. Several studies have shown that they are involved in fundamental biological processes, such as proliferation and apoptos... Read More about microRNAs as Anti-Cancer Therapy.

MicroRNAs in Cancer (2014)
Journal Article
Di Leva, G., Garofalo, M., & Croce, C. M. (2014). MicroRNAs in Cancer. Annual Review of Pathology: Mechanisms of Disease, 9(1), 287-314. https://doi.org/10.1146/annurev-pathol-012513-104715

MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation... Read More about MicroRNAs in Cancer.

Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain (2014)
Journal Article
Jozwiak, A., Liu, Y., Yang, Y., & Gates, M. (2014). Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain. BioMed Research International, 651236 -?. https://doi.org/10.1155/2014/651236

Implanting pieces of tissue or scaffolding material into the mammalian central nervous system (CNS) is wrought with difficulties surrounding the size of tools needed to conduct such implants and the ability to maintain the orientation and integrity o... Read More about Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain.

New strategies for the treatment of ovarian cancer (2014)
Journal Article
Robinson, E., Fisher, N., Stamelos, V., Redman, C., & Richardson, A. (2014). New strategies for the treatment of ovarian cancer. Biochemical Society Transactions, 42(1), 125-129. https://doi.org/10.1042/bst20130203

Ovarian cancer usually responds well to chemotherapy, but once the disease becomes resistant to chemotherapy, the treatment options available are inadequate. A number of strategies are currently undergoing clinical evaluation, among which angiogenesi... Read More about New strategies for the treatment of ovarian cancer.

Development and face validation of an instrument to assess and improve clinical consultation skills (2014)
Journal Article
Lefroy. (2014). Development and face validation of an instrument to assess and improve clinical consultation skills. Advances in health sciences education : theory and practice, 661-685. https://doi.org/10.1007/s10459-014-9493-9

While formative workplace based assessment can improve learners’ skills, it often does not because the procedures used do not facilitate feedback which is sufficiently specific to scaffold improvement. Provision of pre-formulated strategies to addres... Read More about Development and face validation of an instrument to assess and improve clinical consultation skills.

Crystallization kinetics and soft magnetic properties in metalloid-free (Fe, Co)90Zr10 amorphous and nanocrystalline alloys (2014)
Journal Article
Blázquez, J., Ipus, J., Conde, C., Cabrera, D., Franco, V., & Conde, A. (2014). Crystallization kinetics and soft magnetic properties in metalloid-free (Fe, Co)90Zr10 amorphous and nanocrystalline alloys. Journal of Alloys and Compounds, 615, S213-S216. https://doi.org/10.1016/j.jallcom.2014.01.095

Microstructure and magnetic properties of metalloid-free (Fe100−xCox)90Zr10 amorphous and nanocrystalline alloys were characterized. Devitrification of these amorphous alloys occurs in two overlapped transformations leading to the formation of α-Fe(C... Read More about Crystallization kinetics and soft magnetic properties in metalloid-free (Fe, Co)90Zr10 amorphous and nanocrystalline alloys.

Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. (2014)
Journal Article
Wright, K., & Roberts, S. (2014). Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. Spine Journal, 1722 - 1733. https://doi.org/10.1016/j.spinee.2014.01.021

BACKGROUND CONTEXT: Transplantation of bone marrow cells into spinal cord lesions promotes functional recovery in animal models, and recent clinical trials suggest possible recovery also in humans. The mechanisms responsible for these improvements ar... Read More about Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells..

Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy (2014)
Journal Article
Jenkins, S., Pickard, M., Khong, M., Smith, H., Mann, C., Emes, R., & Chari, D. (2014). Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy. ACS chemical neuroscience, 51 -63. https://doi.org/10.1021/cn400167n

Corticosteroid (CS) therapy is used widely in the treatment of a range of pathologies, but can delay production of myelin, the insulating sheath around central nervous system nerve fibers. The cellular targets of CS action are not fully understood, t... Read More about Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy.

Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53. (2014)
Journal Article
Akram, K. M., Lomas, N. J., Forsyth, N. R., & Spiteri, M. A. (2014). Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53. International Journal of Clinical and Experimental Pathology, 7(2), 552-564

Idiopathic pulmonary fibrosis (IPF) is a progressive, debilitating, and fatal lung disease of unknown aetiology with no current cure. The pathogenesis of IPF remains unclear but repeated alveolar epithelial cell (AEC) injuries and subsequent apoptosi... Read More about Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53..

Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development (2014)
Journal Article
Sudiman, J., Ritter, L. J., Feil, D. K., Wang, X., Chan, K., Mottershead, D. G., …Gilchrist, R. B. (2014). Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development. Journal of Assisted Reproduction and Genetics, 31(3), 295-306. https://doi.org/10.1007/s10815-013-0152-5

Purpose We hypothesised that varying native oocyte-secreted factor (OSF) exposure or using different recombinant OSF peptides would have differential effects on post-in vitro maturation (IVM) embryo and fetal development. Methods Mouse cumulus o... Read More about Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development.

Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas (2014)
Journal Article
Jain, H., Richardson, A., Meyer-Hermann, M., & Byrne, H. (2014). Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas. PloS one, e81582 - ?. https://doi.org/10.1371/journal.pone.0081582

Platinum drug-resistance in ovarian cancers mediated by anti-apoptotic proteins such as Bcl-xL is a major factor contributing to the chemotherapeutic resistance of recurrent disease. Consequently, concurrent inhibition of Bcl-xL in combination with c... Read More about Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas.

Multidrug and optimal heart failure therapy prescribing in older general practice populations: a clinical data linkage study (2014)
Journal Article
(2014). Multidrug and optimal heart failure therapy prescribing in older general practice populations: a clinical data linkage study. BMJ Open, e003698 - ?. https://doi.org/10.1136/bmjopen-2013-003698

OBJECTIVE: To investigate multidrug therapy in the cardiovascular disease (CVD) population and whether it was associated with suboptimal drug prescribing in heart failure (HF). DESIGN: A population-based cross-sectional clinical data linkage study. S... Read More about Multidrug and optimal heart failure therapy prescribing in older general practice populations: a clinical data linkage study.

Late diagnosis among our ageing HIV population: a cohort study (2014)
Journal Article
(2014). Late diagnosis among our ageing HIV population: a cohort study. Journal of the International AIDS Society, 19692 -?. https://doi.org/10.7448/IAS.17.4.19692

INTRODUCTION: With the advent of combined antiretroviral therapy (cART), more people infected with HIV are living into older age; 22% of adults receiving care in the UK are aged over 50 years [1]. Age influences HIV infection; the likelihood of seroc... Read More about Late diagnosis among our ageing HIV population: a cohort study.