All Outputs (167)

Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis. (2017)
Journal Article
Chapman, V., Markides, H., Sagar, D., Xu, L., Kay, A., Burston, J., …El Haj, A. (2017). Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis. Stem Cells International, 2905104 - ?. https://doi.org/10.1155/2017/2905104

Background: Mesenchymal stem cells (MSCs) have a therapeutic potential for the treatment of osteoarthritic (OA) joint pathology and pain. The aims of this study were to determine the influence of a passage number on the effects of MSCs on pain behavi... Read More about Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis..

Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis (2017)
Journal Article
Kay, A., Long, G., Broadfoot, S., Piccinini, A., Middleton, J., Kehoe, O., …Stefan, A. (2017). Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis. Scientific reports, https://doi.org/10.1038/s41598-017-18144-w

We evaluated the therapeutic potential of mesenchymal stem cell-conditioned medium (CM-MSC) as an alternative to cell therapy in an antigen-induced model of arthritis (AIA). Disease severity and cartilage loss were evaluated by histopathological anal... Read More about Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis.

Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study (2017)
Journal Article
Mamas. (2017). Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study. Journal of epidemiology and community health, 140-147. https://doi.org/10.1136/jech-2017-209999

Background: Socio-economic deprivation is a key determinant for health. In England, the Index of Multiple Deprivation (IMD) is a widely used composite measure of deprivation. However, little is known about its spatial clustering or persistence acros... Read More about Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study.

Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register (2017)
Journal Article
Mamas. (2017). Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register. Journal of the Neurological Sciences, 26-30. https://doi.org/10.1016/j.jns.2017.09.047

AbstractBackground Previous research has demonstrated an association between anaemia and poor outcomes in acute stroke. This study aimed to assess the impact of anaemia on stroke by anaemia subtype. Methods Data from a prospective UK Regional Stroke... Read More about Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register.

A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation (2017)
Journal Article
Mamas. (2017). A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation. Heart, 1109-1116. https://doi.org/10.1136/heartjnl-2017-312489

Objective Existing clinical prediction models (CPM) for short-term mortality after transcatheter aortic valve implantation (TAVI) have limited applicability in the UK due to moderate predictive performance and inconsistent recording practices across... Read More about A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation.

ABT‑737 and pictilisib synergistically enhance pitavastatin‑induced apoptosis in ovarian cancer cells (2017)
Journal Article
De Wolf, E., De Wolf, C., & Richardson, A. (2018). ABT‑737 and pictilisib synergistically enhance pitavastatin‑induced apoptosis in ovarian cancer cells. Oncology Letters, 15(2), 1979-1984. https://doi.org/10.3892/ol.2017.7516

There is considerable interest in redeploying drugs for use in combination with other oncology therapeutics. The single‑agent activity of statins in ovarian cancer has been widely reported, however the drug concentration required to cause cell death... Read More about ABT‑737 and pictilisib synergistically enhance pitavastatin‑induced apoptosis in ovarian cancer cells.

Impact of Infliximab and Etanercept Biosimilars on Biological Disease-Modifying Antirheumatic Drugs Utilisation and NHS Budget in the UK. (2017)
Journal Article
(2017). Impact of Infliximab and Etanercept Biosimilars on Biological Disease-Modifying Antirheumatic Drugs Utilisation and NHS Budget in the UK. BioDrugs, 533 - 544. https://doi.org/10.1007/s40259-017-0252-3

OBJECTIVE: Biological disease-modifying antirheumatic drugs (bDMARDs) are effective but expensive options for treating rheumatoid arthritis. The introduction of infliximab and etanercept biosimilars presents a significant potential cost saving in a f... Read More about Impact of Infliximab and Etanercept Biosimilars on Biological Disease-Modifying Antirheumatic Drugs Utilisation and NHS Budget in the UK..

P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound (2017)
Journal Article
Koenig, C., Atherton, M., Cavazzuti, M., Ramachandran, S., Gomm, C., Strange, R., …Schenkel, T. (2017). P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound. Artery Research, 20(C), 76-76. https://doi.org/10.1016/j.artres.2017.10.099

Introduction: Ischemic heart disease (IHD) has been associated with lower peak systolic velocity (PSV) on penile Doppler measurements [1]. This study establishes whether carotid ultrasound (US) PSV was associated with computational fluid dynamics (CF... Read More about P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound.

Drug-Mediated Shortening of Action Potentials in LQTS2 Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. (2017)
Journal Article
Duncan, G., Firth, K., George, V., Duc Hoang, M., Staniforth, A., Smith, G., & Denning, C. (2017). Drug-Mediated Shortening of Action Potentials in LQTS2 Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells and Development, 26(23), 1695 -1705. https://doi.org/10.1089/scd.2017.0172

Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are now a well-established modality for modeling genetic disorders of the heart. This is especially so for long QT syndrome (LQTS), which is caused by perturbation of ion... Read More about Drug-Mediated Shortening of Action Potentials in LQTS2 Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes..

The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction (2017)
Journal Article
(2017). The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction. Molecular and Cellular Biochemistry, https://doi.org/10.1007/s11010-017-3236-1

Glucose restriction (GR) impairs muscle cell differentiation and evokes myotube atrophy. Resveratrol treatment in skeletal muscle cells improves inflammatory-induced reductions in skeletal muscle cell differentiation. We therefore hypothesised that r... Read More about The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction.

Two cases of spinal muscular atrophy type II with eosinophilic oesophagitis (2017)
Journal Article
Fuller, H. R., Shorrock, H. K., Gillingwater, T. H., Pigott, A., Smith, V., Kulshrestha, R., …Willis, T. A. (2017). Two cases of spinal muscular atrophy type II with eosinophilic oesophagitis. Journal of Neuromuscular Diseases, 357-362

Although primarily characterised by loss of motor neurons from the anterior horn of spinal cord and muscle atrophy, spinal muscular atrophy (SMA) is now recognised as a multi-systemic disorder. Here, we report two SMA Type II patients with eosinophil... Read More about Two cases of spinal muscular atrophy type II with eosinophilic oesophagitis.

Development and Application of an NMR-Based Assay for Polyphenol Oxidases (2017)
Journal Article
Li, Y., Zafar, A., Kilmartin, P. A., Reynisson, J., & Leung, I. K. H. (2017). Development and Application of an NMR-Based Assay for Polyphenol Oxidases. ChemistrySelect, 2(32), 10435-10441. https://doi.org/10.1002/slct.201702144

Polyphenol oxidases (PPOs) are enzymes that catalyse the oxidation of phenolic compounds. We report a NMR-based assay that can be used as a screening and validation tool for PPO activity modulators, which was demonstrated using a series of PPO inhibi... Read More about Development and Application of an NMR-Based Assay for Polyphenol Oxidases.

Murine myoblast migration: influence of replicative ageing and nutrition (2017)
Journal Article
(2017). Murine myoblast migration: influence of replicative ageing and nutrition. Biogerontology, https://doi.org/10.1007/s10522-017-9735-3

Cell migration is central to skeletal muscle repair following damage. Leucine and b-Hydroxy bmethylbutyric acid (HMB) are supplements consumed for recovery from muscle damaging exercise in humans, however, their impact on muscle cell migration with a... Read More about Murine myoblast migration: influence of replicative ageing and nutrition.

Longitudinal deformation bench testing using a coronary artery model: a new standard? (2017)
Journal Article
Mamas. (2017). Longitudinal deformation bench testing using a coronary artery model: a new standard?. Open Heart, https://doi.org/10.1136/openhrt-2016-00053

Objectives To compare susceptibility of five different stent platforms with longitudinal stent deformation (LSD) using a clinically relevant bench testing model simulating both short and long malapposed lengths. Background Recent data suggest that de... Read More about Longitudinal deformation bench testing using a coronary artery model: a new standard?.

Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide (2017)
Journal Article
Mamas. (2017). Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide. FEBS Open Bio, 1672 -1685. https://doi.org/10.1002/2211-5463.12284

Advanced glycation end products (AGE) are central to the development of cardiovascular complications associated with diabetes mellitus. AGE may alter cellular function through cross-linking of cellular proteins or by activating the AGE receptor (RAGE... Read More about Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide.

Project Ponder - using clicker technology to encourage in-class engagement (2017)
Journal Article
Pearson, R. (2017). Project Ponder - using clicker technology to encourage in-class engagement. Pharmacy Education,

Background: ‘Project Ponder’ was created to help pharmacy students think more deeply about their chemistry knowledge through the promotion of peer instruction and debate. This work used the author’s past expe... Read More about Project Ponder - using clicker technology to encourage in-class engagement.

Engagement in an e-Health Tool (ORION) predicts opioid-dependent patient likelihood of behavioural change (2017)
Journal Article
Humphris, G., Carra, G., Frisher, M., Neufeind, J., Cecil, J., Scherbaum, N., …Baldacchino, A. (2017). Engagement in an e-Health Tool (ORION) predicts opioid-dependent patient likelihood of behavioural change. Heroin Addiction And Related Clinical Problems, 19(5), 35-44

Background: An eHealth computer-based tool named ORION was constructed to assist patients in the clinic to appreciate the factors responsible for risks of drug overdose. The aim of this study was to investigate the associations between risk perceptio... Read More about Engagement in an e-Health Tool (ORION) predicts opioid-dependent patient likelihood of behavioural change.

Involvement of the a/ß Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5) (2017)
Journal Article
Hasan, A. M., & Dent, G. (2017). Involvement of the a/ß Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5). American Journal of Immunology, 209-215. https://doi.org/10.3844/ajisp.2017.209.215

Eosinophils are the principal effector cells for allergic inflammation in a variety of diseases, in which they contribute to tissue damage and remodelling processes via the secretion of cytotoxic granular proteins and cytokines. The intracellular mec... Read More about Involvement of the a/ß Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5).

Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry (2017)
Journal Article
Mamas. (2017). Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry. JACC. Cardiovascular interventions, 2040-2047. https://doi.org/10.1016/j.jcin.2017.05.020

Objectives This study sought to determine the risk factors for post-transcatheter aortic valve replacement (TAVR) dialysis and to determine the impact of pre-TAVR or post-TAVR dialysis on mortality. Background TAVR is now established as an alter... Read More about Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry.

Students views of an online ethical decision-support tool (2017)
Journal Article
Allinson, M., & Black, P. (2018). Students views of an online ethical decision-support tool. Currents in Pharmacy Teaching and Learning, 10(2), 226-230. https://doi.org/10.1016/j.cptl.2017.10.008

Background and purpose Ethical reasoning is a key skill that must be developed during the undergraduate pharmacy course to prepare students for ethical decision-making in future practice as pharmacy professionals. In this initial study, we sought an... Read More about Students views of an online ethical decision-support tool.