Skip to main content

Research Repository

Advanced Search

All Outputs (1770)

Robotic-assisted total knee arthroplasty in clinical practice: protocol for a randomised controlled trial (2023)
Journal Article
Migliorini, F., Maffulli, N., Schäfer, L., Schneider, J., Nobili, A. M., Kämmer, D., …Bell, A. (in press). Robotic-assisted total knee arthroplasty in clinical practice: protocol for a randomised controlled trial. Journal of Orthopaedic Surgery and Research, 18(1), Article 623. https://doi.org/10.1186/s13018-023-04101-z

Between 2 and 20% of patients who undergo total knee arthroplasty (TKA) report restricted motion and anterior knee pain. Non-optimal alignment of the implant components is a common cause of such complaints. Robotic-assisted TKA has been advocated to... Read More about Robotic-assisted total knee arthroplasty in clinical practice: protocol for a randomised controlled trial.

Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy (2023)
Journal Article
Dowling, L. M., Roach, P., Magnussen, E. A., Kohler, A., Pillai, S., van Pittius, D. G., …Sulé-Suso, J. (in press). Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy. PLoS ONE, 18(8), Article e0289824. https://doi.org/10.1371/journal.pone.0289824

The management of cancer patients has markedly improved with the advent of personalised medicine where treatments are given based on tumour antigen expression amongst other. Within this remit, liquid biopsies will no doubt improve this personalised c... Read More about Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy.

Survival analysis in nonagenarian patients with non-hip lower limb fractures. (2023)
Journal Article
Narayana Murthy, S., Cheruvu, M. S., Siddiqui, R. S., Sharma, N., Dass, D., & Ali, A. (in press). Survival analysis in nonagenarian patients with non-hip lower limb fractures. World Journal of Orthopedics, 14(8), 621-629. https://doi.org/10.5312/wjo.v14.i8.621

The United Kingdom has an aging population with nearly 1 in 5 being over the age of 65, and over 0.5 million over the age of 90. The treatment of acute fractures of the lower limb in the nonagenarian cohort of patients poses a technical challenge to... Read More about Survival analysis in nonagenarian patients with non-hip lower limb fractures..

Pharmacists' perspectives on the impact of postgraduate distance learning on their well-being: A qualitative study. (2023)
Journal Article
O'Byrne, R., White, S., & Chew-Graham, C. A. (in press). Pharmacists' perspectives on the impact of postgraduate distance learning on their well-being: A qualitative study. Currents in Pharmacy Teaching and Learning, 15(10), 861-867. https://doi.org/10.1016/j.cptl.2023.07.027

Introduction: Undertaking postgraduate education is becoming increasingly common among United Kingdom (UK) pharmacists to facilitate career progression. However, whilst there is evidence that postgraduate study can negatively affect well-being (defin... Read More about Pharmacists' perspectives on the impact of postgraduate distance learning on their well-being: A qualitative study..

Probing magnetization dynamics of iron oxide nanoparticles using a point-probe magneto-optical method (2023)
Journal Article
Wang, X., Cabrera, D., Yang, Y., & Telling, N. (in press). Probing magnetization dynamics of iron oxide nanoparticles using a point-probe magneto-optical method. Frontiers in Nanotechnology, 5, Article 1214313. https://doi.org/10.3389/fnano.2023.1214313

Magnetic nanoparticles (MNPs) are promising as local heat generators for magnetic hyperthermia under AC magnetic fields. The heating efficacy of MNPs is determined by the AC hysteresis loop area, which in turn is affected by the dynamic magnetic prop... Read More about Probing magnetization dynamics of iron oxide nanoparticles using a point-probe magneto-optical method.

Chain length impact on the retro Diels-Alder mediated release of gemcitabine from hybrid nanoparticles towards pancreatic cancer therapy. (2023)
Journal Article
Oluwasanmi, A., Lindsay, S., Curtis, A., Perrie, Y., & Hoskins, C. (2023). Chain length impact on the retro Diels-Alder mediated release of gemcitabine from hybrid nanoparticles towards pancreatic cancer therapy. International Journal of Pharmaceutics, 644, Article 123304. https://doi.org/10.1016/j.ijpharm.2023.123304

Previously reported gold coated iron oxide nanoparticles (Au-IONP's) have demonstrated their effectiveness as drug delivery vehicles for gemcitabine conjugated to a thermally labile Diels-Alder linker containing a chain of 4 carbon atoms (TTLD4) for... Read More about Chain length impact on the retro Diels-Alder mediated release of gemcitabine from hybrid nanoparticles towards pancreatic cancer therapy..

HaEmaturia After Transurethral resection of bladder Tumour (HEATT): A multicentre, regional collaborative analysis of factors associated with emergency re-admission with haematuria following TURBT (2023)
Journal Article
Sarmah, P. B., Al-Dhahir, W., Chellapuri, A., Damola, A., Eli, N., Foulger, R., …Chakravarti, A. (in press). HaEmaturia After Transurethral resection of bladder Tumour (HEATT): A multicentre, regional collaborative analysis of factors associated with emergency re-admission with haematuria following TURBT. Journal of Clinical Urology, https://doi.org/10.1177/20514158231190035

Objective: To calculate the re-admission rate with haematuria within 30 days of elective transurethral resection of bladder tumour (TURBT), and identify factors associated with this. Materials and Methods: This was a multicentre, retrospective audit,... Read More about HaEmaturia After Transurethral resection of bladder Tumour (HEATT): A multicentre, regional collaborative analysis of factors associated with emergency re-admission with haematuria following TURBT.

Mechanical properties of a bioabsorbable magnesium interference screw for anterior cruciate ligament reconstruction in various testing bone materials (2023)
Journal Article
Siroros, N., Merfort, R., Liu, Y., Praster, M., Migliorini, F., Maffulli, N., …Eschweiler, J. (2023). Mechanical properties of a bioabsorbable magnesium interference screw for anterior cruciate ligament reconstruction in various testing bone materials. Scientific Reports, 13, Article 12342. https://doi.org/10.1038/s41598-023-39513-8

Tears of the anterior cruciate ligament (ACL) negatively impact the stability and kinematics of the knee. Interference screws (ISs) are used for graft fixation in ACL reconstruction and provide sufficient fixation strength to withstand the patients'... Read More about Mechanical properties of a bioabsorbable magnesium interference screw for anterior cruciate ligament reconstruction in various testing bone materials.

AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn2B/- spinal muscular atrophy mice Human Molecular Genetics (2023)
Journal Article
Brown, S., Šoltić, D., Synowsky, S. A., Shirran, S. L., Chilcott, E., Shorrock, H. K., …Fuller, H. (2023). AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn2B/- spinal muscular atrophy mice Human Molecular Genetics. Human Molecular Genetics, Article ddad121. https://doi.org/10.1093/hmg/ddad121

Structural, functional and molecular cardiac defects have been reported in spinal muscular atrophy (SMA) patients and mouse models. Previous quantitative proteomics analyses demonstrated widespread molecular defects in the severe Taiwanese SMA mouse... Read More about AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn2B/- spinal muscular atrophy mice Human Molecular Genetics.

Efficacy of hydrodilatation in frozen shoulder: a systematic review and meta-analysis (2023)
Journal Article
Poku, D., Hassan, R., Migliorini, F., & Maffulli, N. (2023). Efficacy of hydrodilatation in frozen shoulder: a systematic review and meta-analysis. British Medical Bulletin, 147(1), 121-147. https://doi.org/10.1093/bmb/ldad018

Introduction It is unclear whether hydrodilatation is beneficial in the management of frozen shoulder compared with other common conservative management modalities. This systematic review evaluates the efficacy of hydrodilatation for the management... Read More about Efficacy of hydrodilatation in frozen shoulder: a systematic review and meta-analysis.

Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target (2023)
Journal Article
Eurtivong, C., Leung, E., Sharma, N., Leung, I. K. H., & Reynisson, J. (in press). Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target. Molecules, 28(15), 5637. https://doi.org/10.3390/molecules28155637

Phosphatidylcholine-specific phospholipase C (PC-PLC) is an enzyme that catalyzes the formation of the important secondary messengers phosphocholine and diacylglycerol (DAG) from phosphatidylcholine. Although PC-PLC has been linked to the progression... Read More about Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target.

Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming (2023)
Journal Article
Hyland, M., Mennan, C., Davies, R., Wilson, E., Tonge, D. P., Clayton, A., & Kehoe, O. (2023). Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming. Stem Cell Reviews and Reports, 19, 2391–2406. https://doi.org/10.1007/s12015-023-10586-2

Autoimmune conditions, such as rheumatoid arthritis, are characterised by a loss of immune tolerance, whereby the immune cells attack self-antigens causing pain and inflammation. These conditions can be brought into remission using pharmaceutical tre... Read More about Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming.

Duloxetine for fibromyalgia syndrome: a systematic review and meta-analysis (2023)
Journal Article
Migliorini, F., Maffulli, N., Eschweiler, J., Baroncini, A., Bell, A., & Colarossi, G. (in press). Duloxetine for fibromyalgia syndrome: a systematic review and meta-analysis. Journal of Orthopaedic Surgery and Research, 18(1), https://doi.org/10.1186/s13018-023-03995-z

Introduction The optimal dose of duloxetine in the management of fibromyalgia remains still controversial. Therefore, a systematic review and meta-analysis to investigate efficacy and safety of duloxetine was conducted. The outcomes of interests wer... Read More about Duloxetine for fibromyalgia syndrome: a systematic review and meta-analysis.

Factors affecting clinical pharmacist decision-making when reviewing and prescribing z-drugs in primary care: a qualitative interview study. (2023)
Journal Article
Kallis, T. J., & Allinson, M. (in press). Factors affecting clinical pharmacist decision-making when reviewing and prescribing z-drugs in primary care: a qualitative interview study. International Journal of Clinical Pharmacy, https://doi.org/10.1007/s11096-023-01617-6

Background Z-drugs (zopiclone, zolpidem and zaleplon) are drugs with dependence forming characteristics licensed for the short-term management of insomnia. Patients regularly prescribed z-drugs are candidates for ‘structured medication reviews’, rou... Read More about Factors affecting clinical pharmacist decision-making when reviewing and prescribing z-drugs in primary care: a qualitative interview study..

Mid-term outcome of superior capsular reconstruction using doubled acellular human dermal allograft for irreparable rotator cuff tear (2023)
Journal Article
Snow, M., Kuiper, J. H., Thimmegowda, A., Ramsingh, V., Haikal, M., & Amit, P. (2023). Mid-term outcome of superior capsular reconstruction using doubled acellular human dermal allograft for irreparable rotator cuff tear. Journal of Shoulder and Elbow Surgery, https://doi.org/10.1016/j.jse.2023.06.007

Purpose Thicker (folded) facia lata autografts have been shown to be superior to thinner grafts and single-layered acellular human dermal (HD) allografts for superior capsular reconstruction (SCR) in biomechanical studies. The aim of this study was... Read More about Mid-term outcome of superior capsular reconstruction using doubled acellular human dermal allograft for irreparable rotator cuff tear.

Indolo[2,3- e ]benzazocines and indolo[2,3- f ]benzazonines and their copper( ii ) complexes as microtubule destabilizing agents † (2023)
Journal Article
Wittmann, C., Dömötör, O., Kuznetcova, I., Spengler, G., Reynisson, J., Holder, L., …Arion, V. B. (2023). Indolo[2,3- e ]benzazocines and indolo[2,3- f ]benzazonines and their copper( ii ) complexes as microtubule destabilizing agents †. Dalton Transactions, 52(29), 9964-9982. https://doi.org/10.1039/d3dt01632c

A series of four indolo[2,3-e]benzazocines HL1–HL4 and two indolo[2,3-f]benzazonines HL5 and HL6, as well as their respective copper(ii) complexes 1–6, were synthesized and characterized by 1H and 13C NMR spectroscopy, ESI mass spectrometry, single c... Read More about Indolo[2,3- e ]benzazocines and indolo[2,3- f ]benzazonines and their copper( ii ) complexes as microtubule destabilizing agents †.

The Up-Scale Manufacture of Chondrocytes for Allogeneic Cartilage Therapies (2023)
Journal Article
Hulme, C. H., Garcia, J., Mennan, C., Perry, J., Roberts, S., Norris, K., …Wright, K. T. (2023). The Up-Scale Manufacture of Chondrocytes for Allogeneic Cartilage Therapies. Tissue Engineering Part C: Methods, https://doi.org/10.1089/ten.tec.2023.0037

Background: Allogeneic chondrocyte therapies need to be developed to allow more individuals to be treated with a cell therapy for cartilage repair and to reduce the burden and cost of current two-stage autologous procedures. Up-scale manufacture of c... Read More about The Up-Scale Manufacture of Chondrocytes for Allogeneic Cartilage Therapies.