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Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome (2024)
Journal Article
Tierney, L., Kuiper, J. H., Roberts, S., Snow, M., Williams, M., Harrington, M. B., Harrison, P., Gallacher, P., Jermin, P., & Wright, K. T. (in press). Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1002/ksa.12433

Purpose
To investigate patient demographic, injury and surgery/treatment-associated factors that can influence the patient-reported outcome (Lysholm score), following autologous chondrocyte implantation (ACI) in a large, ‘real-world’, nonuniform, pr... Read More about Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome.

Shoulder balloon spacer for massive irreparable rotator cuff tears results in significant improvements (2024)
Journal Article
Savarese, E., Aicale, R., Romeo, R., & Maffulli, N. (in press). Shoulder balloon spacer for massive irreparable rotator cuff tears results in significant improvements. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1002/ksa.12445

AbstractPurposeThe aim of the present study was to assess the effectiveness of balloon implantation in patients with irreparable supraspinatus tears alone or in combination with other rotator cuff (RC) tendon tears and the effect of several covariabl... Read More about Shoulder balloon spacer for massive irreparable rotator cuff tears results in significant improvements.

TRANSCULTURAL ADAPTATION AND VALIDATION OF THE 4-DOMAIN SPORTS PROM INTO ITALIAN. (2024)
Journal Article
Piedade, S. R., Canata, G. L., & Maffulli, N. (2024). TRANSCULTURAL ADAPTATION AND VALIDATION OF THE 4-DOMAIN SPORTS PROM INTO ITALIAN. Journal of ISAKOS, https://doi.org/10.1016/j.jisako.2024.100305

This work aims to evaluate and validate the process of cross-cultural adaptation and validation of the 4-Domain Sports PROM (4-DSP) into Italian, assessing its understandability and reproducibility in all questionnaire domains for Italian-speaking pa... Read More about TRANSCULTURAL ADAPTATION AND VALIDATION OF THE 4-DOMAIN SPORTS PROM INTO ITALIAN..

Nanoscale synchrotron x-ray analysis of intranuclear iron in melanised neurons of Parkinson’s substantia nigra (2024)
Journal Article
Brooks, J., Everett, J., Hill, E., Billimoria, K., Morris, C. M., Sadler, P. J., Telling, N., & Collingwood, J. F. (2024). Nanoscale synchrotron x-ray analysis of intranuclear iron in melanised neurons of Parkinson’s substantia nigra. Communications Biology, 7(1), Article 1024. https://doi.org/10.1038/s42003-024-06636-1

Neuromelanin-pigmented neurons of the substantia nigra are selectively lost during the progression of Parkinson’s disease. These neurons accumulate iron in the disease state, and iron-mediated neuron damage is implicated in cell death. Animal models... Read More about Nanoscale synchrotron x-ray analysis of intranuclear iron in melanised neurons of Parkinson’s substantia nigra.

Concurrent validity between self-reported International Physical Activity Questionnaire Short Form and Fibion accelerometer data among young adults in the UAE (2024)
Journal Article
Arumugam, A., Alsaafin, N., Shalash, R. J., Qadah, R. M., Al-Sharman, A., Moustafa, I. M., Shousha, T. M., Kumaran, S. D., Migliorini, F., & Maffulli, N. (in press). Concurrent validity between self-reported International Physical Activity Questionnaire Short Form and Fibion accelerometer data among young adults in the UAE. European Journal of Medical Research, 29(1), Article 426. https://doi.org/10.1186/s40001-024-01975-5

Self-reported physical activity questionnaires (e.g., International Physical Activity Questionnaire, IPAQ) are a cost-effective, time-saving, and accessible method to assess sedentary behaviour and physical activity. There are conflicting findings re... Read More about Concurrent validity between self-reported International Physical Activity Questionnaire Short Form and Fibion accelerometer data among young adults in the UAE.

Metamizole in the Management of Musculoskeletal Disorders: Current Concept Review (2024)
Journal Article
Jeyaraman, N., Migliorini, F., Murugan, S., Ramasubramanian, S., Balaji, S., Maffulli, N., & Jeyaraman, M. (in press). Metamizole in the Management of Musculoskeletal Disorders: Current Concept Review. Journal of Clinical Medicine, 13(16), Article 4794. https://doi.org/10.3390/jcm13164794

Metamizole, or dipyrone, has been used for decades as a non-narcotic analgesic, providing pain relief from musculoskeletal disorders and antipyretic and antispasmolytic properties. Despite being in use since the 1920s, its mechanism of action still n... Read More about Metamizole in the Management of Musculoskeletal Disorders: Current Concept Review.

Testosterone undecanoate is associated with improved ageing male symptoms score in men with type 2 diabetes and adult-onset testosterone deficiency: re-analyzed results from a randomised controlled trial (2024)
Journal Article
Ramachandran, P., Zitzmann, M., König, C. S., Mulhern, J., Ramachandran, S., & Hackett, G. (in press). Testosterone undecanoate is associated with improved ageing male symptoms score in men with type 2 diabetes and adult-onset testosterone deficiency: re-analyzed results from a randomised controlled trial. Exploration of Endocrine and Metabolic Diseases, 2024(1), 177-190. https://doi.org/10.37349/eemd.2024.00015

Aim: To evaluate changes in quality of life via the ageing male symptom scale (AMSS) and somatic, psychological, and sexual sub-scales following testosterone undecanoate (TU) or placebo (P) treatment in men with type 2 diabetes mellitus (T2DM) and ad... Read More about Testosterone undecanoate is associated with improved ageing male symptoms score in men with type 2 diabetes and adult-onset testosterone deficiency: re-analyzed results from a randomised controlled trial.

Antithrombotic prophylaxis following total knee arthroplasty: a level I Bayesian network meta-analysis. (2024)
Journal Article
Migliorini, F., Maffulli, N., Velaj, E., Bell, A., Kämmer, D., Eschweiler, J., & Hofmann, U. K. (in press). Antithrombotic prophylaxis following total knee arthroplasty: a level I Bayesian network meta-analysis. European Journal of Orthopaedic Surgery and Traumatology, https://doi.org/10.1007/s00590-024-04071-w

Venous thromboembolism (VTE) is a major concern following total knee arthroplasty (TKA). The optimal pharmacological prophylaxis remains, however, controversial. The present investigation compared several non-vitamin K antagonist oral anticoagulants... Read More about Antithrombotic prophylaxis following total knee arthroplasty: a level I Bayesian network meta-analysis..

Brain Punch: K-1 Fights Affect Brain Wave Activity in Professional Kickboxers. (2024)
Journal Article
Rydzik, Ł., Kopańska, M., Wąsacz, W., Ouergui, I., Obmiński, Z., Pałka, T., Ambroży, T., Malliaropoulos, N., Maffulli, N., Lota, K. S., Jaszczur-Nowicki, J., Król, P., Czarny, W., & Szczygielski, J. (in press). Brain Punch: K-1 Fights Affect Brain Wave Activity in Professional Kickboxers. Sports Medicine, https://doi.org/10.1007/s40279-024-02082-5

Kickboxing is a popular striking combat sport, and K-1 is a type of kickboxing. Direct head blows can cause significant long-term injury and affect brain wave activity. We aim to compare the changes in brain wave activities of fighters during a K-1 k... Read More about Brain Punch: K-1 Fights Affect Brain Wave Activity in Professional Kickboxers..

Modelling take-off moment arms in an ornithocheiraean pterosaur (2024)
Journal Article
Griffin, B. W., Martin-Silverstone, E., Pêgas, R. V., Meilak, E. A., Costa, F. R., Palmer, C., & Rayfield, E. J. (in press). Modelling take-off moment arms in an ornithocheiraean pterosaur. PeerJ, 12, Article e17678. https://doi.org/10.7717/peerj.17678

Take-off is a vital part of powered flight which likely constrains the size of birds, yet extinct pterosaurs are known to have reached far larger sizes. Three different hypothesised take-off motions (bipedal burst launching, bipedal countermotion lau... Read More about Modelling take-off moment arms in an ornithocheiraean pterosaur.

Exploring non-viral methods for the delivery of CRISPR-Cas ribonucleoprotein to hematopoietic stem cells (2024)
Journal Article
Molaei, Z., Jabbarpour, Z., Omidkhoda, A., & Ahmadbeigi, N. (in press). Exploring non-viral methods for the delivery of CRISPR-Cas ribonucleoprotein to hematopoietic stem cells. Stem Cell Research and Therapy, 15(1), Article 233. https://doi.org/10.1186/s13287-024-03848-4

Gene manipulation of hematopoietic stem cells (HSCs) using the CRISPR/Cas system as a potent genome editing tool holds immense promise for addressing hematologic disorders. An essential hurdle in advancing this treatment lies in effectively deliverin... Read More about Exploring non-viral methods for the delivery of CRISPR-Cas ribonucleoprotein to hematopoietic stem cells.

A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration. (2024)
Journal Article
Younus, Z. M., Ahmed, I., Roach, P., & Forsyth, N. R. (in press). A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration. Biomaterials and Biosystems, 15, Article 100099. https://doi.org/10.1016/j.bbiosy.2024.100099

The bone-cartilage interface is defined by a unique arrangement of cells and tissue matrix. Injury to the interface can contribute to the development of arthritic joint disease. Attempts to repair osteochondral damage through clinical trials have gen... Read More about A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration..

PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review (2024)
Journal Article
Kirkby, M., Sabri, A. H. B., Holmes, A., Moss, G. P. J., & Scurr, D. (in press). PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review. Journal of Pharmacy and Pharmacology, 76(10), 1284–1300. https://doi.org/10.1093/jpp/rgae080

Objectives
Poly(amidoamine) dendrimers have been widely investigated as potential nanomaterials that can enhance the skin permeation of topically applied drugs. This article reviews the studies that have used dendrimers as penetration enhancers and... Read More about PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review.

Heel pain in young athletes - not always Sever's Disease: A Narrative Review. (2024)
Journal Article
Jokela, A., Aho, J., Kosola, J., Stenroos, A., Sinikumpu, J.-J., Maffulli, N., & Lempainen, L. (2024). Heel pain in young athletes - not always Sever's Disease: A Narrative Review. Foot, 60, Article 102114. https://doi.org/10.1016/j.foot.2024.102114

Heel pain is a prevalent issue in young athletes, often arising from overuse and increased sporting demands. While Sever's Disease is the predominant cause, various other entities, including stress-related injuries and pathologies like tumors and bon... Read More about Heel pain in young athletes - not always Sever's Disease: A Narrative Review..

Osteointegration of functionalised high-performance oxide ceramics: imaging from micro-computed tomography (2024)
Journal Article
Migliorini, F., Eschweiler, J., Betsch, M., Maffulli, N., Tingart, M., Hildebrand, F., Lecouturier, S., Rath, B., & Schenker, H. (2024). Osteointegration of functionalised high-performance oxide ceramics: imaging from micro-computed tomography. Journal of Orthopaedic Surgery and Research, 19(1), 1-8. https://doi.org/10.1186/s13018-024-04918-2

Background
This study evaluated the osseointegration potential of functionalised high-performance oxide ceramics (HPOC) in isolation or coated with BMP-2 or RGD peptides in 36 New Zeeland female rabbits using micro-computed tomography (micro CT). Th... Read More about Osteointegration of functionalised high-performance oxide ceramics: imaging from micro-computed tomography.

FIFA 11+ KIDS in the prevention of soccer injuries in children: a systematic review (2024)
Journal Article
Ramos, A. P., de Mesquita, R. S., Migliorini, F., Maffulli, N., & Okubo, R. (2024). FIFA 11+ KIDS in the prevention of soccer injuries in children: a systematic review. Journal of Orthopaedic Surgery and Research, 19(1), 1-10. https://doi.org/10.1186/s13018-024-04876-9

Background: The “FIFA 11+” is an injury prevention program conceived for soccer athletes aged over 14. The use of FIFA 11+ Kids in soccer was associated with a reduction of the overall risk of injuries in children by 48%, and of 74% for serious injur... Read More about FIFA 11+ KIDS in the prevention of soccer injuries in children: a systematic review.

Non‐surgical management of acute proximal hamstring avulsions can produce clinically acceptable results (2024)
Journal Article
Maffulli, N., Hassan, R., Poku, D., Chan, O., & Oliva, F. (in press). Non‐surgical management of acute proximal hamstring avulsions can produce clinically acceptable results. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1002/ksa.12368

AbstractPurposeTo evaluate the mid‐term clinical outcomes for the non‐surgical and surgical management of acute proximal hamstring avulsions.MethodsSixty physically active individuals were offered surgical or non‐surgical management for their proxima... Read More about Non‐surgical management of acute proximal hamstring avulsions can produce clinically acceptable results.

Distribution, tolerance, growth, behaviour and control methods of <i>Limnoperna fortunei</i> (Dunker, 1857) (Bivalvia: Mytilidae): A review (2024)
Journal Article
Liu, Y., He, X., Yang, Y., Bai, X., & Yuan, C. (2024). Distribution, tolerance, growth, behaviour and control methods of Limnoperna fortunei (Dunker, 1857) (Bivalvia: Mytilidae): A review. Aquatic Conservation: Marine and Freshwater Ecosystems, 34(7), https://doi.org/10.1002/aqc.4217

Limnoperna fortunei (L. fortunei) (Dunker, 1857), the golden mussel, is an invasive species possessing exceptional environmental adaptability and a destructive impact on water systems and artificial structures. To better conservation of freshwater ec... Read More about Distribution, tolerance, growth, behaviour and control methods of <i>Limnoperna fortunei</i> (Dunker, 1857) (Bivalvia: Mytilidae): A review.