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All Outputs (917)

Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis (2024)
Journal Article
Echrish, J., Pasca, M.-I., Cabrera, D., Yang, Y., & Harper, A. G. S. (2024). Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis. Biomimetics, 9(6), Article 372. https://doi.org/10.3390/biomimetics9060372

Acute cardiovascular events result from clots caused by the rupture and erosion of atherosclerotic plaques. This paper aimed to produce a functional biomimetic hydrogel of the neointimal layer of the atherosclerotic plaque that can support thrombogen... Read More about Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis.

Examining the impact of e-leadership on strategic innovation at work: a moderated-mediation model (2024)
Journal Article
Hassan, Y., Pandey, J., Majumdarr, S., Pereira, V., Behl, A., & Bazal-Shoham, O. (2024). Examining the impact of e-leadership on strategic innovation at work: a moderated-mediation model. Journal of Technology Transfer, https://doi.org/10.1007/s10961-024-10108-3

This research investigates the relationship between e-leadership and strategic innovations in the workplace. It proposes a moderated mediation model that examines inter-team coordi-nation's mediating role and knowledge integration capability's modera... Read More about Examining the impact of e-leadership on strategic innovation at work: a moderated-mediation model.

Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1 (2024)
Journal Article
Campbell, K., Naire, S., & Kuiper, J.-H. (2024). Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1. Journal of Theoretical Biology, 592,

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1.

Long-Term Resistance Trained Human Muscles Have More Fibers, More Myofibrils, and Tighter Myofilament Packing Than Untrained (2024)
Journal Article
MAEO, S., BALSHAW, T. G., MÄRZ, B., ZHOU, Z., HAUG, B., MARTIN, N. R. W., …FOLLAND, J. P. (2024). Long-Term Resistance Trained Human Muscles Have More Fibers, More Myofibrils, and Tighter Myofilament Packing Than Untrained. Medicine & Science in Sports & Exercise, 56(10), 1906-1915. https://doi.org/10.1249/mss.0000000000003495

Introduction
Increases in skeletal muscle size occur in response to prolonged exposure to resistance training that is typically ascribed to increased muscle fiber size. Whether muscle fiber number also changes remains controversial, and a paucity o... Read More about Long-Term Resistance Trained Human Muscles Have More Fibers, More Myofibrils, and Tighter Myofilament Packing Than Untrained.

Powers, persistence, and the problem of temporary intrinsics (2024)
Journal Article
Allen, S. R. (in press). Powers, persistence, and the problem of temporary intrinsics. Philosophical Studies, https://doi.org/10.1007/s11098-024-02157-z

David Lewis uses the problem of temporary intrinsics to motivate a perdurantist account of persistence in which four-dimensional individuals consist of temporal parts. Other philosophers use his argument to conclude that apparently persisting individ... Read More about Powers, persistence, and the problem of temporary intrinsics.

Diabetic myocardial disorder. A clinical consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases (2024)
Journal Article
Seferović, P. M., Paulus, W. J., Rosano, G., Polovina, M., Petrie, M. C., Jhund, P. S., …Coats, A. J. (in press). Diabetic myocardial disorder. A clinical consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases. European Journal of Heart Failure, https://doi.org/10.1002/ejhf.3347

The association between type 2 diabetes mellitus (T2DM) and heart failure (HF) has been firmly established; however, the entity of diabetic myocardial disorder (previously called diabetic cardiomyopathy) remains a matter of debate. Diabetic myocardia... Read More about Diabetic myocardial disorder. A clinical consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases.

Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study (2024)
Journal Article
Bullock, L., Manning, F., Hawarden, A., Fleming, J., Leyland, S., Clark, E. M., …Paskins, Z. (in press). Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study. Archives of Osteoporosis, 19(1), Article 50. https://doi.org/10.1007/s11657-024-01410-6

Summary
Interviews and focus groups with patients, FLS clinicians, and GPs identified challenges relating to clinical and shared decision-making about bone health and osteoporosis medicines. Findings will inform the development of the multicomponent... Read More about Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study.

Powers, persistence, and the problem of temporary intrinsics (2024)
Journal Article
Allen, S. (2024). Powers, persistence, and the problem of temporary intrinsics. Philosophical Studies, Neo-Aristotelian Perspectives on Persistence and (De Re) Modality, https://doi.org/10.1007/s11098-024-02157-z

David Lewis uses the problem of temporary intrinsics to motivate a perdurantist account of persistence in which four-dimensional individuals consist of temporal parts. Other philosophers use his argument to conclude that apparently persisting indivi... Read More about Powers, persistence, and the problem of temporary intrinsics.

Detailed cool star flare morphology with CHEOPS and TESS (2024)
Journal Article
Bruno, G., Pagano, I., Scandariato, G., Florén, H.-G., Brandeker, A., Olofsson, G., …Wilson, T. G. (2024). Detailed cool star flare morphology with CHEOPS and TESS. Astronomy & Astrophysics, 686, Article A239. https://doi.org/10.1051/0004-6361/202348951

Context. White-light stellar flares are proxies for some of the most energetic types of flares, but their triggering mechanism is still poorly understood. As they are associated with strong X and ultraviolet emission, their study is particularly rele... Read More about Detailed cool star flare morphology with CHEOPS and TESS.

Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule. (2024)
Journal Article
Kelly, G., Kataura, T., Panek, J., Ma, G., Salmonowicz, H., Davis, A., …Korolchuk, V. I. (2024). Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule. Developmental Cell, 59(15), 1924-1939. https://doi.org/10.1016/j.devcel.2024.04.020

Selective degradation of damaged mitochondria by autophagy (mitophagy) is proposed to play an important role in cellular homeostasis. However, the molecular mechanisms and the requirement of mitochondrial quality control by mitophagy for cellular phy... Read More about Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule..

The potential of point-of-care ultrasound in UK general practice (2024)
Journal Article
Poppleton, A., Pursglove, L., Leceaga, E., Dupont, F., Hagiu, D.-P., & Andersen, C. (in press). The potential of point-of-care ultrasound in UK general practice. InnovAiT: Education and inspiration for general practice, https://doi.org/10.1177/17557380241257451

Ultrasound has been described as the stethoscope for the 21st century. It can rapidly answer a specific clinical question or support a procedure. Use of point-of-care ultrasound (PoCUS) by doctors has increased in the UK and internationally over the... Read More about The potential of point-of-care ultrasound in UK general practice.

Impact of Neighborhood Social Deprivation on Delays to Access for Transcatheter Aortic Valve Replacement: Wait‐Times and Clinical Consequences (2024)
Journal Article
Zaheer, A., Qiu, F., Manoragavan, R., Madan, M., Sud, M., Mamas, M. A., & Wijeysundera, H. C. (2024). Impact of Neighborhood Social Deprivation on Delays to Access for Transcatheter Aortic Valve Replacement: Wait‐Times and Clinical Consequences. Journal of the American Heart Association, 13(12), https://doi.org/10.1161/jaha.123.032450

Background Transcatheter aortic valve replacement (TAVR) has become the standard of care for severe aortic stenosis treatment. Exponential growth in demand has led to prolonged wait times and adverse patient outcomes. Social marginalization may contr... Read More about Impact of Neighborhood Social Deprivation on Delays to Access for Transcatheter Aortic Valve Replacement: Wait‐Times and Clinical Consequences.

Meta‐analysis and systematic review for anomaly network intrusion detection systems: Detection methods, dataset, validation methodology, and challenges (2024)
Journal Article
Maseer, Z. K., Kadhim, Q. K., Al‐Bander, B., Yusof, R., & Saif, A. (in press). Meta‐analysis and systematic review for anomaly network intrusion detection systems: Detection methods, dataset, validation methodology, and challenges. IET Networks, https://doi.org/10.1049/ntw2.12128

Intrusion detection systems built on artificial intelligence (AI) are presented as latent mechanisms for actively detecting fresh attacks over a complex network. The authors used a qualitative method for analysing and evaluating the performance of ne... Read More about Meta‐analysis and systematic review for anomaly network intrusion detection systems: Detection methods, dataset, validation methodology, and challenges.

Entomological survey of sibling species in the Anopheles funestus group in Tanzania confirms the role of Anopheles parensis as a secondary malaria vector. (2024)
Journal Article
Mapua, S. A., Samb, B., Nambunga, I. H., Mkandawile, G., Bwanaly, H., Kaindoa, E. W., …Tripet, F. (2024). Entomological survey of sibling species in the Anopheles funestus group in Tanzania confirms the role of Anopheles parensis as a secondary malaria vector. Parasites and Vectors, 17(1), 1-10. https://doi.org/10.1186/s13071-024-06348-9

Malaria transmission in Tanzania is driven by mosquitoes of the Anopheles gambiae complex and Anopheles funestus group. The latter includes An. funestus s.s., an anthropophilic vector, which is now strongly resistant to public health insecticides, an... Read More about Entomological survey of sibling species in the Anopheles funestus group in Tanzania confirms the role of Anopheles parensis as a secondary malaria vector..

Addressing the Global Burden of Cardiovascular Disease in Women JACC State-of-the-Art Review (2024)
Journal Article
Vervoort, D., Wang, R., Li, G., Filbey, L., Maduka, O., Brewer, L. C., …Van Spall, H. G. (2024). Addressing the Global Burden of Cardiovascular Disease in Women JACC State-of-the-Art Review. Journal of the American College of Cardiology, 83(25), 2690-2707. https://doi.org/10.1016/j.jacc.2024.04.028

Cardiovascular diseases (CVDs) are responsible for approximately 35% of all deaths in women. In 2019, the global age-standardized CVD prevalence and mortality of women were 6,403 per 100,000 and 204 per 100,000, respectively. Althou... Read More about Addressing the Global Burden of Cardiovascular Disease in Women JACC State-of-the-Art Review.

The Lived Experience of Informal Caregivers of People Who Have Severe Mental Illness and Coexisting Long-Term Conditions: A Qualitative Study. (2024)
Journal Article
Carswell, C., Brown, J. V. E., Shiers, D., Ajjan, R., Balogun-Katung, A., Bellass, S., …Coventry, P. (2024). The Lived Experience of Informal Caregivers of People Who Have Severe Mental Illness and Coexisting Long-Term Conditions: A Qualitative Study. Health Expectations, 27(3), 1-11. https://doi.org/10.1111/hex.14119

Background
People with severe mental illness (SMI) experience higher rates and poorer outcomes of physical long-term conditions (LTCs). The management of SMI and LTCs is highly complex and many people with SMI rely on informal carers for support, wh... Read More about The Lived Experience of Informal Caregivers of People Who Have Severe Mental Illness and Coexisting Long-Term Conditions: A Qualitative Study..

Coproducing Health Information Materials With Young People: Reflections and Lessons Learned (2024)
Journal Article
Faux-Nightingale, A., Somayajula, G., Bradbury, C., Bray, L., Burton, C., Chew-Graham, C. A., …Welsh, V. (2024). Coproducing Health Information Materials With Young People: Reflections and Lessons Learned. Health Expectations, 27(3), Article e14115. https://doi.org/10.1111/hex.14115

Background
This paper describes and critically reflects on how children and young people (CYP) acted as public advisors to co-produce health information materials about Long Covid for younger audiences. This work was underpinned by the Lundy model,... Read More about Coproducing Health Information Materials With Young People: Reflections and Lessons Learned.

Machine-learning clustering analysis identifies novel phenogroups in patients with ST-elevation acute myocardial infarction. (2024)
Journal Article
Matetic, A., Kyriacou, T., & Mamas, M. A. (2024). Machine-learning clustering analysis identifies novel phenogroups in patients with ST-elevation acute myocardial infarction. International Journal of Cardiology, 411, 1-9. https://doi.org/10.1016/j.ijcard.2024.132272

Machine learning clustering of patients with ST-elevation acute myocardial infarction (STEMI) may provide important insights into their risk profile, management and prognosis. All adult discharges for STEMI in the National Inpatient Sample (October 2... Read More about Machine-learning clustering analysis identifies novel phenogroups in patients with ST-elevation acute myocardial infarction..

Socio‐demographic variation in diagnosis of and prescribing for common mental illnesses among children and young people during the COVID‐19 pandemic: time series analysis of primary care electronic health records (2024)
Journal Article
Hussey, L. J., Kontopantelis, E., Mok, P. L. H., Ashcroft, D. M., Carr, M. J., Garg, S., …Webb, R. T. (in press). Socio‐demographic variation in diagnosis of and prescribing for common mental illnesses among children and young people during the COVID‐19 pandemic: time series analysis of primary care electronic health records. Journal of Child Psychology and Psychiatry, https://doi.org/10.1111/jcpp.14026

Background
The impact of the COVID-19 pandemic on the mental health of children and young people (CYP) has been widely reported. Primary care electronic health records were utilised to examine trends in the diagnosing, recording and treating of thes... Read More about Socio‐demographic variation in diagnosis of and prescribing for common mental illnesses among children and young people during the COVID‐19 pandemic: time series analysis of primary care electronic health records.