All Outputs (39)

Genetic Loss of miR-205 Causes Increased Mammary Gland Development (2023)
Journal Article

MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in differ... Read More about Genetic Loss of miR-205 Causes Increased Mammary Gland Development.

Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature. (2023)
Journal Article

Therapy resistance represents an unmet challenge in the treatment of medulloblastoma. Accordingly, the identification of targets that mark drug-resistant cell populations, or drive the proliferation of resistant cells, may improve treatment strategie... Read More about Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature..

Correction: MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. (2022)
Journal Article

[This corrects the article DOI: 10.1371/journal.pone.0067581.].

UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines. (2021)
Journal Article

In the human genome, there are about 600 ultra-conserved regions (UCRs), long DNA sequences extremely conserved in vertebrates. We performed a large-scale study to quantify transcribed UCR (T-UCR) and miRNA levels in over 6000 cancer and normal tissu... Read More about UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines..

Correction for Jeon et al., A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in Lung cancer (2021)
Journal Article

A KRAS-responsive long non-coding RNA controls microRNA processing (2021)
Journal Article

Wild-type KRAS (KRASWT) amplification has been shown to be a secondary means of KRAS activation in cancer and associated with poor survival. Nevertheless, the precise role of KRASWT overexpression in lung cancer progression is largely unexplored. Her... Read More about A KRAS-responsive long non-coding RNA controls microRNA processing.

Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells (2021)
Journal Article

Medulloblastoma (MB) is the most common aggressive paediatric brain tumour and, despite the recent progress in the treatments of MB patients, there is still an urgent need of complementary or alternative therapeutic options for MB infants. Cyclin Dep... Read More about Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells.

Correction: MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer (2021)
Journal Article

Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition (2020)
Journal Article

A subset of lung adenocarcinomas is driven by the EML4-ALK translocation. Even though ALK inhibitors in the clinic lead to excellent initial responses, acquired resistance to these inhibitors due to on-target mutations or parallel pathway alterations... Read More about Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition.

Telomerase inhibition, telomere attrition and proliferation arrest of cancer cells induced by phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT (2020)
Journal Article

Telomerase activity has been regarded as a critical step in cellular immortalization and carcinogenesis and because of this, regulation of telomerase represents an attractive target for anti-tumor specific therapeutics. Recently, one avenue of cancer... Read More about Telomerase inhibition, telomere attrition and proliferation arrest of cancer cells induced by phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT.

Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface (2019)
Journal Article

Heterogeneity in Circulating Tumor Cells: The Relevance of the Stem-Cell Subset (2019)
Journal Article

The release of circulating tumor cells (CTCs) into vasculature is an early event in the metastatic process. The analysis of CTCs in patients has recently received widespread attention because of its clinical implications, particularly for precision m... Read More about Heterogeneity in Circulating Tumor Cells: The Relevance of the Stem-Cell Subset.

Abstract 1850: CDK inhibitor PHA-848125 preferentially inhibits proliferation of triple negative breast cancer and synergizes with cisplatin (2018)
Journal Article

Circulating Micrornas Predict Survival of Patients with Tumors of Glial Origin (2018)
Journal Article

The World Health Organization has recently introduced molecular prognostic-diagnostic biomarkers in the classification of Central Nervous System (CNS) tumors. In order to characterize subclasses of tumors that cannot find a precise location in the cu... Read More about Circulating Micrornas Predict Survival of Patients with Tumors of Glial Origin.

Loss of miR-204 expression is a key event in melanoma (2018)
Journal Article

Cutaneous melanoma (CM) is a malignancy with increasing occurrence. Its microRNA repertoire has been defined in a number studies, leading to candidates for biological and clinical relevance: miR-200a/b/c, miR-203, miR-205, miR-204, miR-211, miR-23b a... Read More about Loss of miR-204 expression is a key event in melanoma.

miRNAs in bone metastasis (2017)
Journal Article

INTRODUCTION: Bone metastasis is one of the most common forms of metastasis from a number of different primary carcinomas. MicroRNAs (miRNAs) are short, endogenous RNAs that negatively regulate gene expression to control essential pathways, including... Read More about miRNAs in bone metastasis.

Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism (2017)
Journal Article

Malignant pleural mesothelioma (MPM) is an aggressive human cancer and miRNAs can play a key role for this disease. In order to broaden the knowledge in this field, the miRNA expression was investigated in a large series of MPM to discover new pathwa... Read More about Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism.

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface. (2017)
Journal Article

Lysyl oxidase (LOX) remodels the tumour microenvironment by cross-linking the extracellular matrix. LOX overexpression is associated with poor cancer outcomes. Here, we find that LOX regulates the epidermal growth factor receptor (EGFR) to drive tumo... Read More about Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface..

miR-9 and miR-200 Regulate PDGFRß-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer (2016)
Journal Article

Organization of cancer cells into endothelial-like cell-lined structures to support neovascularization and to fuel solid tumors is a hallmark of progression and poor outcome. In triple-negative breast cancer (TNBC), PDGFRß has been identified as a ke... Read More about miR-9 and miR-200 Regulate PDGFRß-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer.

miRNA clusters as therapeutic targets for hormone-resistant breast cancer (2015)
Journal Article

MicroRNAs are small non-coding RNAs that typically inhibit the translation and stability of messenger RNAs, controlling genes involved in cellular processes such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis, and... Read More about miRNA clusters as therapeutic targets for hormone-resistant breast cancer.