Outputs (23)

C-peptide in diabetes: A player in a dual hormone disorder? (2024)
Journal Article

C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) and early T2DM. C-peptide pro... Read More about C-peptide in diabetes: A player in a dual hormone disorder?.

Adrenoceptor Desensitization: Current understanding of mechanisms (2024)
Journal Article

G-protein coupled receptors (GPCRs) transduce a wide range of extracellular signals. They are key players in the majority of biological functions including vision, olfaction, chemotaxis and immunity. However, as essential as most of them are to body... Read More about Adrenoceptor Desensitization: Current understanding of mechanisms.

GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells. (2023)
Journal Article

Raynaud's phenomenon (RP), which results from exaggerated cold-induced vasoconstriction, is more prevalent in females than males. We previously showed that estrogen increases the expression of alpha 2C-adrenoceptors (α2C-AR), the sole mediator of col... Read More about GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells..

Epac as a tractable therapeutic target (2023)
Journal Article

In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing attention given its multi... Read More about Epac as a tractable therapeutic target.

Inflammation and hypertension: Underlying mechanisms and emerging understandings. (2023)
Journal Article

Hypertension remains a major contributor to cardiovascular disease (CVD), a leading cause of global death. One of the major insults that drive increased blood pressure is inflammation. While it is the body's defensive response against some homeostati... Read More about Inflammation and hypertension: Underlying mechanisms and emerging understandings..

Factors associated with infertility among the Lebanese population: a cross-sectional study (2023)
Journal Article

The incidence of female infertility is growing worldwide and its rate varies across countries. . The goal of this study is to assess the rate of female infertility and identify its associated factors among Lebanese women. This cross-sectional study w... Read More about Factors associated with infertility among the Lebanese population: a cross-sectional study.

Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells (2022)
Journal Article

Mechanisms underlying the effects of caloric restriction on hypertension (2022)
Journal Article

Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms (2022)
Journal Article

Cannabinoids and Myocardial Ischemia: Novel insights, UpdatedMechanisms, and Implications for Myocardial Infarction (2021)
Journal Article

Visfatin: An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases (2021)
Journal Article

Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/NAMPT have been implicated in vascular remodeling, vascular inflammation, and atherosclerosis... Read More about Visfatin: An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases.

Inflammatory Basis of Atherosclerosis: Modulation by Sex Hormones (2021)
Journal Article

Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of death globally. Several lines of evidence are supportive of the contributory role of vascular inflammation in atherosclerosis. Diverse immune cell types, including monocy... Read More about Inflammatory Basis of Atherosclerosis: Modulation by Sex Hormones.

Reactive Oxygen Species: Modulators of Phenotypic Switch of Vascular Smooth Muscle Cells (2020)
Journal Article

Reactive oxygen species (ROS) are natural byproducts of oxygen metabolism in the cell. At physiological levels, they play a vital role in cell signaling. However, high ROS levels cause oxidative stress, which is implicated in cardiovascular diseases... Read More about Reactive Oxygen Species: Modulators of Phenotypic Switch of Vascular Smooth Muscle Cells.

Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders (2020)
Journal Article

The Role of Epac in Cancer Progression (2020)
Journal Article

Estrogen increases expression of vascular alpha 2C adrenoceptor through the cAMP/Epac/JNK/AP-1 pathway and potentiates cold-induced vasoconstriction (2020)
Journal Article

EPAC in Vascular Smooth Muscle Cells (2020)
Journal Article

The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy (2020)
Journal Article

Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; however, several processes inv... Read More about The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy.

An Integrated Approach to Teaching Laboratory Data and Pharmacology of Respiratory Diseases to Pharmacy Students (2020)
Journal Article

Estrogen and Bisphenol A in Hypertension (2020)
Journal Article

Sex differences in pain and opioid mediated antinociception: Modulatory role of gonadal hormones (2019)
Journal Article

MicroRNAs in Cardiac Hypertrophy (2019)
Journal Article

Facilitation by the renin-angiotensin system of cyclosporine-evoked hypertension in rats: Role of arterial baroreflexes and vasoreactivity (2016)
Journal Article

Aims Cyclosporine (CSA) elevates blood pressure (BP) and alters arterial baroreflex sensitivity (BRS) and vasoreactivity. In this study we determined whether the renin-angiotensin system (RAS) interplays with other vasopressor pathways in mediating... Read More about Facilitation by the renin-angiotensin system of cyclosporine-evoked hypertension in rats: Role of arterial baroreflexes and vasoreactivity.