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Adrenoceptor Desensitization: Current Understanding of Mechanisms. (2024)
Journal Article
Maaliki, D., Jaffa, A. A., Nasser, S., Sahbekar, A., & Eid, A. H. (2024). Adrenoceptor Desensitization: Current Understanding of Mechanisms. Pharmacological Reviews, 76(3), 358-387. https://doi.org/10.1124/pharmrev.123.000831

G-protein coupled receptors (GPCRs) transduce a wide range of extracellular signals. They are key players in the majority of biological functions including vision, olfaction, chemotaxis and immunity. However, as essential as most of them are to body... Read More about Adrenoceptor Desensitization: Current Understanding of Mechanisms..

C-peptide in diabetes: A player in a dual hormone disorder? (2024)
Journal Article
Dakroub, A., Dbouk, A., Asfour, A., Nasser, S. A., El‐Yazbi, A. F., Sahebkar, A., …Eid, A. A. (in press). C-peptide in diabetes: A player in a dual hormone disorder?. Journal of Cellular Physiology, 10.1002/jcp.31212. https://doi.org/10.1002/jcp.31212

C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) and early T2DM. C-peptide pro... Read More about C-peptide in diabetes: A player in a dual hormone disorder?.

GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells. (2023)
Journal Article
Fardoun, M., Nasser, S. A., El-Yazbi, A. F., & Eid, A. H. (2023). GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells. Journal of Cardiovascular Pharmacology, 82(6), 470-479. https://doi.org/10.1097/FJC.0000000000001489

Raynaud's phenomenon (RP), which results from exaggerated cold-induced vasoconstriction, is more prevalent in females than males. We previously showed that estrogen increases the expression of alpha 2C-adrenoceptors (α2C-AR), the sole mediator of col... Read More about GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells..

Epac as a tractable therapeutic target (2023)
Journal Article
Slika, H., Mansour, H., Nasser, S., Shaito, A., Kobeissy, F., N. Orekhov, A., …Eid, A. (2023). Epac as a tractable therapeutic target. European Journal of Pharmacology, 945, Article 175645. https://doi.org/10.1016/j.ejphar.2023.175645

In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing attention given its multi... Read More about Epac as a tractable therapeutic target.

Inflammation and hypertension: Underlying mechanisms and emerging understandings. (2023)
Journal Article
Aboukhater, D., Morad, B., Nasrallah, N., Nasser, S. A., Sahebkar, A., Kobeissy, F., …Eid, A. H. (2023). Inflammation and hypertension: Underlying mechanisms and emerging understandings. Journal of Cellular Physiology, 238(6), 1148-1159. https://doi.org/10.1002/jcp.31019

Hypertension remains a major contributor to cardiovascular disease (CVD), a leading cause of global death. One of the major insults that drive increased blood pressure is inflammation. While it is the body's defensive response against some homeostati... Read More about Inflammation and hypertension: Underlying mechanisms and emerging understandings..

Factors associated with infertility among the Lebanese population: a cross-sectional study (2023)
Journal Article
Dia, N., Mansour, S., Kharaba, Z., Malaeb, B., Sarray El Dine, A., Kokash, S., …Malaeb, D. (2023). Factors associated with infertility among the Lebanese population: a cross-sectional study. International Journal of Environmental Health Research, 34(2), 934-942. https://doi.org/10.1080/09603123.2023.2190084

The incidence of female infertility is growing worldwide and its rate varies across countries. . The goal of this study is to assess the rate of female infertility and identify its associated factors among Lebanese women. This cross-sectional study w... Read More about Factors associated with infertility among the Lebanese population: a cross-sectional study.

Visfatin: An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases (2021)
Journal Article
Dakroub, A., Nasser, S. A., Kobeissy, F., Yassine, H. M., Orekhov, A., Sharifi‐Rad, J., …Eid, A. H. (2021). Visfatin: An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases. Journal of Cellular Physiology, 236(9), 6282-6296. https://doi.org/10.1002/jcp.30345

Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/NAMPT have been implicated in vascular remodeling, vascular inflammation, and atherosclerosis... Read More about Visfatin: An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases.

Inflammatory Basis of Atherosclerosis: Modulation by Sex Hormones (2021)
Journal Article
Nasser, S. A., Afify, E. A., Kobeissy, F., Hamam, B., Eid, A. H., & El-Mas, M. M. (2021). Inflammatory Basis of Atherosclerosis: Modulation by Sex Hormones. Current Pharmaceutical Design, 27(18), 2099-2111. https://doi.org/10.2174/1381612827666210122142811

Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of death globally. Several lines of evidence are supportive of the contributory role of vascular inflammation in atherosclerosis. Diverse immune cell types, including monocy... Read More about Inflammatory Basis of Atherosclerosis: Modulation by Sex Hormones.

Reactive Oxygen Species: Modulators of Phenotypic Switch of Vascular Smooth Muscle Cells (2020)
Journal Article
Badran, A., Nasser, S. A., Mesmar, J., El-Yazbi, A. F., Bitto, A., Fardoun, M. M., …Eid, A. H. (2020). Reactive Oxygen Species: Modulators of Phenotypic Switch of Vascular Smooth Muscle Cells. International Journal of Molecular Sciences, 21(22), 8764. https://doi.org/10.3390/ijms21228764

Reactive oxygen species (ROS) are natural byproducts of oxygen metabolism in the cell. At physiological levels, they play a vital role in cell signaling. However, high ROS levels cause oxidative stress, which is implicated in cardiovascular diseases... Read More about Reactive Oxygen Species: Modulators of Phenotypic Switch of Vascular Smooth Muscle Cells.

The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy (2020)
Journal Article
Bhagani, H., Nasser, S. A., Dakroub, A., El-Yazbi, A. F., Eid, A. A., Kobeissy, F., …Eid, A. H. (2020). The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy. International Journal of Molecular Sciences, 21(14), Article ARTN 4962. https://doi.org/10.3390/ijms21144962

Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; however, several processes inv... Read More about The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy.

Facilitation by the renin-angiotensin system of cyclosporine-evoked hypertension in rats: Role of arterial baroreflexes and vasoreactivity (2016)
Journal Article
Nasser, S. A., Sabra, R., Elmallah, A. I., Ei-Din, M. M. M., Khedr, M. M., & El-Mas, M. M. (2016). Facilitation by the renin-angiotensin system of cyclosporine-evoked hypertension in rats: Role of arterial baroreflexes and vasoreactivity. Life Sciences, 163, 1-10. https://doi.org/10.1016/j.lfs.2016.08.024

Aims Cyclosporine (CSA) elevates blood pressure (BP) and alters arterial baroreflex sensitivity (BRS) and vasoreactivity. In this study we determined whether the renin-angiotensin system (RAS) interplays with other vasopressor pathways in mediating... Read More about Facilitation by the renin-angiotensin system of cyclosporine-evoked hypertension in rats: Role of arterial baroreflexes and vasoreactivity.