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Professor Wim Cool's Outputs (64)

Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model (2024)
Journal Article
Perry, J., Mennan, C., Cool, P., McCarthy, H. S., Newell, K., Hopkins, T., …Roberts, S. (2024). Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model. Cartilage, https://doi.org/10.1177/19476035241287832

Objective To determine if mesenchymal stromal cells (MSCs) derived from human umbilical cords (hUC) could reduce degeneration developing when injected into the knee of a large animal model of osteoarthritis (OA). Design Ten million culture-expanded U... Read More about Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.

V2 Ovine UC-MSCs Revised Manuscript (2024)
Journal Article
Perry, J., Mennan, C., Cool, P., McCarthy, H., Newell, K., Hopkins, T., …Roberts, S. (in press). V2 Ovine UC-MSCs Revised Manuscript. Cartilage,

681 USING NANOPORE SEQUENCING TO DIAGNOSE PROSTHETIC JOINT INFECTIONS (2024)
Presentation / Conference
Wilkinson, H., Cool, P., Perry, J., Wright, K. T., McCarthy, H. S., & Hulme, C. H. (2024, April). 681 USING NANOPORE SEQUENCING TO DIAGNOSE PROSTHETIC JOINT INFECTIONS. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study (2024)
Journal Article
Wilkinson, H., McDonald, J., McCarthy, H., Perry, J., Wright, K., Hulme, C., & Cool, P. (in press). Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study. Briefings in Functional Genomics, Article elae008. https://doi.org/10.1093/bfgp/elae008

This project investigates if third-generation genomic sequencing can be used to identify the species of bacteria causing prosthetic joint infections (PJIs) at the time of revision surgery. Samples of prosthetic fluid were taken during revision surger... Read More about Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study.

PRELIMINARY FINDINGS ON THE USE OF GENOMIC SEQUENCING TO DIAGNOSE ORTHOPAEDIC INFECTIONS (2023)
Journal Article
Wilkinson, H., & Cool, P. (2023). PRELIMINARY FINDINGS ON THE USE OF GENOMIC SEQUENCING TO DIAGNOSE ORTHOPAEDIC INFECTIONS. Orthopaedic Proceedings, 105-B(SUPP_16), 43-43. https://doi.org/10.1302/1358-992x.2023.16.043

AbstractObjectivesThe objective of this study is to investigate if genomic sequencing is a useful method to diagnose orthopaedic infections. Current methods used to identify the species of bacteria causing orthopaedic infections take considerable tim... Read More about PRELIMINARY FINDINGS ON THE USE OF GENOMIC SEQUENCING TO DIAGNOSE ORTHOPAEDIC INFECTIONS.

Aneurysmal bone cysts: A UK wide tumor center experience (2023)
Journal Article
Bavan, L., Eastley, N., Stevenson, J., Mifsud, M., Bayliss, L., Mahmoud, S., …Kothari, A. (in press). Aneurysmal bone cysts: A UK wide tumor center experience. Journal of Surgical Oncology, 129(3), 601-608. https://doi.org/10.1002/jso.27499

Background and Objectives
This multicenter retrospective series of consecutive extra-spinal aneurysmal bone cysts aims to identify risk factors for treatment failure.

Methods
Aneurysmal bone cysts treated within seven collaborating centers with... Read More about Aneurysmal bone cysts: A UK wide tumor center experience.

Machine learning models based on routinely sampled blood tests can predict the presence of malignancy amongst patients with suspected musculoskeletal malignancy (2023)
Journal Article
Bentick, K., Runevic, J., Akula, S., Kyriacou, T., Cool, P., & Andras, P. (2023). Machine learning models based on routinely sampled blood tests can predict the presence of malignancy amongst patients with suspected musculoskeletal malignancy. Methods, 220, 55-60. https://doi.org/10.1016/j.ymeth.2023.10.012

This study explores the possibility of using routinely taken blood tests in the diagnosis and triage of patients with suspected musculoskeletal malignancy. A retrospective study was performed on results of patients who had presented for assessment to... Read More about Machine learning models based on routinely sampled blood tests can predict the presence of malignancy amongst patients with suspected musculoskeletal malignancy.

The British Orthopaedic Oncology Management (BOOM) audit (2023)
Journal Article
Archer, J. E., Chauhan, G. S., Dewan, V., Osman, K., Thomson, C., Nandra, R. S., …Stevenson, J. (2023). The British Orthopaedic Oncology Management (BOOM) audit. The Bone & Joint Journal, 105-B(10), 1115-1122. https://doi.org/10.1302/0301-620x.105b10.bjj-2023-0443.r1

AimsMost patients with advanced malignancy suffer bone metastases, which pose a significant challenge to orthopaedic services and burden to the health economy. This study aimed to assess adherence to the British Orthopaedic Oncology Society (BOOS)/Br... Read More about The British Orthopaedic Oncology Management (BOOM) audit.

Clinical outcome of open ankle fractures in patients above 70 years of age (2023)
Journal Article
Zahra, W., Seifo, M., Cool, P., Ford, D., & Okoro, T. (2023). Clinical outcome of open ankle fractures in patients above 70 years of age. World Journal of Orthopedics, 14(7), 554-561. https://doi.org/10.5312/wjo.v14.i7.554

Background: Open fractures of the ankle are complex injuries requiring multidisciplinary input and are associated with significant morbidity and mortality. However, data on the clinical outcomes of open ankle fracture management in patients older tha... Read More about Clinical outcome of open ankle fractures in patients above 70 years of age.

Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report (2023)
Journal Article
Wilkinson, H., McCarthy, H. S., Perry, J., Smith, T., Wright, K., & Cool, P. (2023). Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report. Cureus, 15(5), https://doi.org/10.7759/cureus.38788

There is currently no "gold-standard" method to diagnose prosthetic joint infections (PJI), and the current practice of using microbiological cultures has many limitations. The identification of the bacterial species causing the infection is crucial... Read More about Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report.

Umbilical Cord MSC Treated Osteoarthritic Sheep Display Reduced Radiographic Changes: Proteomic Biomarker Profiling of Synovial Fluids Implicate an Immunomodulatory Mechanism (2023)
Presentation / Conference
Perry, J., Mennan, C., Cool, P., Mccarthy, H., Newell, K., Hulme, C., …Roberts, S. (2023, March). Umbilical Cord MSC Treated Osteoarthritic Sheep Display Reduced Radiographic Changes: Proteomic Biomarker Profiling of Synovial Fluids Implicate an Immunomodulatory Mechanism. Presented at TERMIS 2023 – European Chapter, Manchester Central Conference Centre Manchester, UK

pTERT mutation in the risk-stratification of solitary fibrous tumours (2023)
Presentation / Conference
Butters, T., Andrei, V., Hepburn, E., Connolly, C., Mendes, B., Haefliger, S., …Flanagan, A. (2023, January). pTERT mutation in the risk-stratification of solitary fibrous tumours. Presented at WINTER MEETING, 5th Joint Meeting with the Royal Society of Medicine, 214th Scientific Meeting of the Pathological Society of Great Britain & Ireland, Royal Society of Medicine, London


Pages: S1-S4

A genetic model for central chondrosarcoma evolution correlates with patient outcome (2022)
Journal Article
Cross, W., Lyskjær, I., Lesluyes, T., Hargreaves, S., Strobl, A., Davies, C., …Research Consortium, G. E. (2022). A genetic model for central chondrosarcoma evolution correlates with patient outcome. Genome Medicine, 14(99), https://doi.org/10.1186/s13073-022-01084-0

BACKGROUND: Central conventional chondrosarcoma (CS) is the most common subtype of primary malignant bone tumour in adults. Treatment options are usually limited to surgery, and prognosis is challenging. These tumours are characterised by the presenc... Read More about A genetic model for central chondrosarcoma evolution correlates with patient outcome.

A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome (2022)
Journal Article
Harrington, G. M. B., Cool, P., Hulme, C., Osman, A., Chowdhury, J. R., Kumar, N., …Wright, K. (2022). A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome. arXiv, https://doi.org/10.1101/2022.07.12.499696

<jats:sec><jats:label>1</jats:label><jats:title>Abstract</jats:title><jats:sec><jats:label>1.1</jats:label><jats:title>Introduction</jats:title><jats:p>Spinal Cord Injury (SCI) is a major cause of disability, with complications post-injury often lead... Read More about A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome.

Image Guided Needle Biopsies for Musculoskeletal Soft Tissue Lesions: A 9-Year Analysis of Non-Diagnostic Biopsies (2022)
Journal Article
Morris, R., Winn, N., Singh, J., Tyrrell, P., Kaur, S., Amary, F., & Cool, P. (2022). Image Guided Needle Biopsies for Musculoskeletal Soft Tissue Lesions: A 9-Year Analysis of Non-Diagnostic Biopsies. Journal of Orthopaedic Oncology, 8(3), Article 168. https://doi.org/10.4172/2472-016X.1000168

Background: Non-diagnostic (ND) musculoskeletal biopsies of soft tissue lesions can increase patient anxiety and delay definitive diagnosis and treatment. It is thought the specific histotype of the lesion may influence accuracy of the biopsy. This s... Read More about Image Guided Needle Biopsies for Musculoskeletal Soft Tissue Lesions: A 9-Year Analysis of Non-Diagnostic Biopsies.

Mirels’ score for upper limb metastatic lesions: do we need a different cutoff for recommending prophylactic fixation? (2022)
Journal Article
Hoban, K. A., Downie, S., Adamson, D. J., MacLean, J. G., Cool, P., & Jariwala, A. C. (2022). Mirels’ score for upper limb metastatic lesions: do we need a different cutoff for recommending prophylactic fixation?. https://doi.org/10.1016/j.jseint.2022.03.006

The aim of this study was to investigate the reproducibility, reliability and accuracy of Mirels’s score in upper limb bony metastatic disease and validate its use in predicting pathological fractures. Methods 45 patients with upper limb bony metasta... Read More about Mirels’ score for upper limb metastatic lesions: do we need a different cutoff for recommending prophylactic fixation?.

A Rare Presentation of a Solitary Melanoma Bone Metastasis. (2022)
Journal Article
Cool. (2022). A Rare Presentation of a Solitary Melanoma Bone Metastasis. Cureus, e21479 - ?. https://doi.org/10.7759/cureus.21479

A 74-year-old woman presented with sudden onset pain and swelling in her right wrist. Plain radiographs showed a pathological fracture through a lytic lesion. The patient had a past medical history of melanoma on her right thigh, which had been excis... Read More about A Rare Presentation of a Solitary Melanoma Bone Metastasis..

Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic (2021)
Journal Article
STARSurg Collaborative and COVIDSurg Collaborative, McLean, K. A., Kamarajah, S. K., Chaudhry, D., Gujjuri, R. R., Raubenheimer, K., …Wischhusen, S. (2021). Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic. British Journal of Surgery, 108(12), 1448-1464. https://doi.org/10.1093/bjs/znab336

There is considerable interest in data analytics because of its value in informing decisions in healthcare. Data variables can be derived from routinely collected records or from primary studies. The level of detail for individual variables in quanti... Read More about Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.

Circulating tumour DNA is a promising biomarker for risk stratification of central chondrosarcoma with IDH1/2 and GNAS mutations (2021)
Journal Article
Cool, Lyskjær, I., Davies, C., Strobl, A., Hindley, J., James, S., …Flanagan, A. M. (2021). Circulating tumour DNA is a promising biomarker for risk stratification of central chondrosarcoma with IDH1/2 and GNAS mutations. Molecular Oncology, 15(12), 3679-3690. https://doi.org/10.1002/1878-0261.13102

Chondrosarcoma (CS) is a rare tumour type and the most common primary malignant bone cancer in adults. The prognosis, currently based on tumour grade, imaging and anatomical location, is not reliable and more objective biomarkers are required. We aim... Read More about Circulating tumour DNA is a promising biomarker for risk stratification of central chondrosarcoma with IDH1/2 and GNAS mutations.