Ivonne Solis-Trapala's Outputs (40)

Improving patient understanding of GEP test results (IMPARTER4): an RCT (2025)
Journal Article
Fallowfield, L., Solis-Trapala, I., Starkings, R., Matthews, L., May, S., & Jenkins, V. (2025). Improving patient understanding of GEP test results (IMPARTER4): an RCT. BMJ Oncology, 4(1), https://doi.org/10.1136/bmjonc-2024-000689

Objective: Explaining gene expression profiling (GEP) test results to patients can be challenging. We examined the utility of two 8 min films about Oncotype DX and Prosigna to aid the knowledge and decision-making of women with early-stage oestrogen... Read More about Improving patient understanding of GEP test results (IMPARTER4): an RCT.

Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients (2024)
Journal Article
Johal, N., Sharma, R., Belcher, J., Coyle, D., Lindley, E. J., Keane, D., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J., Solis-Trapala, I., Sim, J., & Davies, S. J. (2024). Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients. BMC Nephrology, 25(1), Article 398. https://doi.org/10.1186/s12882-024-03837-y

Introduction: Fluid assessment and management is a key aspect of good dialysis care and is affected by patient-level characteristics and potentially centre-level practices. In this secondary analysis of the BISTRO trial we wished to establish whether... Read More about Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients.

Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial (2024)
Journal Article
Belcher, J., Coyle, D., Lindley, E. J., Keane, D., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J., Hugo Macdonald, J., Solis-Trapala, I., Sim, J., & Davies, S. J. (2024). Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial. Kidney360, https://doi.org/10.34067/kid.0000000596

Preservation of residual kidney function (RKF) in dialysis patients has been associated with improved survival. RKF in the BISTRO trial was relatively well preserved and here we describe its association with survival during the trial and extended fol... Read More about Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial.

Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT (2024)
Journal Article
Zanganeh, M., Belcher, J., Fotheringham, J., Coyle, D., Lindley, E. J., Keane, D. F., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J. H., Solis-Trapala, I., Sim, J., Davies, S. J., & Andronis, L. (2024). Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT. Health Technology Assessment, 1-45. https://doi.org/10.3310/jypr4287

Background
The BioImpedance Spectroscopy to maintain Renal Output randomised controlled trial investigated the effect of bioimpedance spectroscopy added to a standardised fluid management protocol on the risk of anuria and preservation of residual k... Read More about Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT.

Improving patient understanding of GEP test results (IMPARTER4): An RCT. (2024)
Presentation / Conference
Fallowfield, L., Solis-Trapala, I., Starkings, R., Matthews, L., May, S., & Jenkins, V. A. (2024, May). Improving patient understanding of GEP test results (IMPARTER4): An RCT. Poster presented at 2024 ASCO Annual Meeting I

527 Background: We developed two 8 min films to aid patients’ understanding about gene expression profiling (GEP) tests (Oncotype DX or Prosigna) in breast cancer. A previous study of 120 women without breast cancer demonstrated significantly better... Read More about Improving patient understanding of GEP test results (IMPARTER4): An RCT..

#2832 Lean tissue mass is associated with mortality across different stages of chronic kidney disease: a systematic review and meta-analysis (2024)
Presentation / Conference Contribution
Tabinor, M., Elphick, E., Stephens, C., Wall, N., Ul Hussain, A., Shah, R., Peracha, J., Anderson, B., Istanbuly, O., Solis-Trapala, I., Ferro, C. J., & Davies, S. (2024, May). #2832 Lean tissue mass is associated with mortality across different stages of chronic kidney disease: a systematic review and meta-analysis. Presented at 61st ERA Congress, Stockholm, Sweden

Background and Aims Loss of lean tissue mass (LLTM) commonly occurs in multiple long-term conditions (LTC), including chronic kidney disease (CKD), and is thought to be associated with adverse outcomes including mortality, frailty surrogates and poor... Read More about #2832 Lean tissue mass is associated with mortality across different stages of chronic kidney disease: a systematic review and meta-analysis.

#2796 Divergent associations between mortality and different measures of renal function after adjustment for body composition: results from the UK Biobank (2024)
Presentation / Conference
Tabinor, M., Potts, J., Ferro, C. J., Davies, S., & Solis-Trapala, I. (2024, May). #2796 Divergent associations between mortality and different measures of renal function after adjustment for body composition: results from the UK Biobank. Presented at 61st ERA Congress, Stockholm, Sweden

Background and Aims There is data suggesting estimated glomerular filtration rate using Cystatin-C (eGFRCystatin-C) is superior to the creatinine-based (eGFRCreat) method when assessing associations between renal function and mortality (Lees et al. 2... Read More about #2796 Divergent associations between mortality and different measures of renal function after adjustment for body composition: results from the UK Biobank.

#1248 Sex specific associations between fat free mass and weight with mortality: sequences of regressions analyses from the UK Biobank cohort (2024)
Presentation / Conference
Tabinor, M., Potts, J., Ferro, C. J., Davies, S., & Solis-Trapala, I. (2024, May). #1248 Sex specific associations between fat free mass and weight with mortality: sequences of regressions analyses from the UK Biobank cohort. Presented at 61st ERA Congress, Stockholm, Sweden

Background and Aims There is growing evidence that muscle mass (MM) loss, observed in long term conditions (LTCs), including chronic kidney disease (CKD), is associated with mortality. This study aimed to explore the direct association between MM and... Read More about #1248 Sex specific associations between fat free mass and weight with mortality: sequences of regressions analyses from the UK Biobank cohort.

Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England (2024)
Journal Article
Damery, S., Lambie, M., Williams, I., Coyle, D., Fotheringham, J., Solis-Trapala, I., Allen, K., Potts, J., Dikomitis, L., & Davies, S. J. (2024). Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, https://doi.org/10.1177/08968608241232200

Background:
Disparities in home dialysis uptake across England suggest inequity and unexplained variation in access. We surveyed staff at all English kidney centres to identify patterns in service organisation/delivery and explore correlations with... Read More about Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England.

Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage (2024)
Journal Article
Toader, A.-M., Campbell, M. K., Quint, J. K., Robling, M., ydes, M. R., Thorn, J., Wright-Hughes, A., Yu, L.-M., Abbott, T. E. F., Bond, S., Caskey, F. J., Clout, M., Collinson, M., Copsey, B., Davies, G., Driscoll, T., Gamble, C., Griffin, X. L., Hamborg, T., Harris, J., …Williamson, P. (2024). Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage. Trials, 25(1), https://doi.org/10.1186/s13063-024-07926-z

Background
Healthcare system data (HSD) are increasingly used in clinical trials, augmenting or replacing traditional methods of collecting outcome data. This study, PRIMORANT, set out to identify, in the UK context, issues to be considered before t... Read More about Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage.

How do clinicians prescribe bridging glucocorticoids in people starting or escalating disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a service evaluation survey (2023)
Journal Article
Prior, J. A., Roddy, E., Solis-Trapala, I., Cornwall, N., Jinks, C., Abhishek, A., Bukhari, M., Galloway, J., Goodson, N., Jowett, S., & Hider, S. (in press). How do clinicians prescribe bridging glucocorticoids in people starting or escalating disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a service evaluation survey. Rheumatology Advances in Practice, 7(3), Article rkad102. https://doi.org/10.1093/rap/rkad102

Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis (2023)
Journal Article
Istanbuly, O., Belcher, J., Tabinor, M., Solis-Trapala, I., Lambie, M., & Davies, S. J. (in press). Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis. BMC Nephrology, 24(1), Article 312. https://doi.org/10.1186/s12882-023-03370-4

Background: Systemic inflammation, measured as circulating Interleukin-6 (IL-6) levels, is associated with cardiovascular and all-cause mortality in chronic kidney disease. However, this has not been convincingly demonstrated in a systematic review o... Read More about Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis.

Catheter Event Rates in Medical Compared to Surgical Peritoneal Dialysis Catheter Insertion (2023)
Journal Article
Fotheringham, J., Solis-Trapala, I., Briggs, V., Lambie, M., McCullough, K., Dunn, L., Rawdin, A., Hill, H., Wailloo, A., Davies, S., & Wilkie, M. (2023). Catheter Event Rates in Medical Compared to Surgical Peritoneal Dialysis Catheter Insertion. Kidney International Reports, 8(12), 2635-2645. https://doi.org/10.1016/j.ekir.2023.09.015

How patient, center, and insertion technique factors interact needs to be understood when designing peritoneal dialysis (PD) catheter insertion pathways. We undertook a prospective cohort study in 44 UK centers enrolling participants planned for firs... Read More about Catheter Event Rates in Medical Compared to Surgical Peritoneal Dialysis Catheter Insertion.

Patients’ experiences of a suppoRted self-manAGeMent pAThway In breast Cancer (PRAGMATIC): quality of life and service use results (2023)
Journal Article
Jenkins, V., Matthews, L., Solis-Trapala, I., Gage, H., May, S., Williams, P., Bloomfield, D., Zammit, C., Elwell-Sutton, D., Betal, D., Finlay, J., Nicholson, K., Kothari, M., Santos, R., Stewart, E., Bell, S., McKinna, F., & Teoh, M. (2023). Patients’ experiences of a suppoRted self-manAGeMent pAThway In breast Cancer (PRAGMATIC): quality of life and service use results. Supportive Care in Cancer, 31(10), Article 570. https://doi.org/10.1007/s00520-023-08002-z

Purpose
To describe trends and explore factors associated with quality of life (QoL) and psychological morbidity and assess breast cancer (BC) health service use over a 12-month period for patients joining the supported self-management (SSM)/patient... Read More about Patients’ experiences of a suppoRted self-manAGeMent pAThway In breast Cancer (PRAGMATIC): quality of life and service use results.

Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients in a randomized controlled trial (2023)
Journal Article
Davies, S. J., Coyle, D., Lindley, E. J., Keane, D., Belcher, J., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J., Zanganeh, M., Andronis, L., Solis-Trapala, I., & Sim, J. (2023). Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients in a randomized controlled trial. Kidney International, 104(3), 587-598. https://doi.org/10.1016/j.kint.2023.05.016

Avoiding excessive dialysis-associated volume depletion may help preserve residual kidney function (RKF). To establish whether knowledge of the estimated normally hydrated weight from bioimpedance measurements (BI-NHW) when setting the post-hemodialy... Read More about Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients in a randomized controlled trial.

Are childhood factors predictive of adult health literacy? A longitudinal birth cohort analysis (2023)
Journal Article
Solis-Trapala, I., Campbell, P., Lacey, R., Rowlands, G., Dunn, K., & Protheroe, J. (2023). Are childhood factors predictive of adult health literacy? A longitudinal birth cohort analysis. SSM - Population Health, 13, Article 101426. https://doi.org/10.1016/j.ssmph.2023.101426

Health literacy (HL), defined as the ability of an individual to understand and appraise health information to make informed decisions on their health, helps maintain and improve one's health and thus reduce the use of healthcare services. There is a... Read More about Are childhood factors predictive of adult health literacy? A longitudinal birth cohort analysis.

Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis (2022)
Journal Article
Gilchrist, F., Aspey, M., Bowler, R., Brodlie, M., Desai, S., Harris, C., Hinton, E., Kulkarni, H., Ogbolosingha, A., Sinha, I., Solis-Trapala, I., Stock, J., & Carroll, W. D. (2022). Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis. BMJ Paediatrics Open, e001722 - e001722. https://doi.org/10.1136/bmjpo-2022-001722

Background Protracted bacterial bronchitis (PBB) is an endobronchial infection and a the most common cause of chronic wet cough in young children. It is treated with antibiotics, which can only be targeted if the causative organism is known. As most... Read More about Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis.

The Bioimpedance Spectroscopy to Preserve Renal Output (BISTRO) Multicentre Randomised Controlled Trial: Quality of Life and Blood Pressure Outcomes (2022)
Presentation / Conference Contribution
Davies, S. J., Zanganeh, M., Solis-Trapala, I., Keane, D. F., Davenport, A., Wilkie, M. E., Ormandy, P., Macdonald, J. H., Dasgupta, I., Farrington, K., & Caskey, F. (2022, November). The Bioimpedance Spectroscopy to Preserve Renal Output (BISTRO) Multicentre Randomised Controlled Trial: Quality of Life and Blood Pressure Outcomes. Poster presented at ASN Kidney Week, Orlando, FL, USA

Talking about Risk, UncertaintieS of Testing IN Genetics (TRUSTING): development and evaluation of an educational programme for healthcare professionals about BRCA1 & BRCA2 testing (2022)
Journal Article
Fallowfield, L., Solis-Trapala, Solis-Trapala, I., Starkings, R., May, S., Matthews, L., Eccles, D., Evans, D. G., Turnbull, C., Crawford, G., & Jenkins, V. (2022). Talking about Risk, UncertaintieS of Testing IN Genetics (TRUSTING): development and evaluation of an educational programme for healthcare professionals about BRCA1 & BRCA2 testing. British Journal of Cancer, 127, 1116-1122. https://doi.org/10.1038/s41416-022-01871-x

Background Mainstreaming of germline testing demands that all healthcare professionals have good communication skills, but few have genetic testing and counselling experience. We developed and evaluated educational workshops-Talking about Risk & Unce... Read More about Talking about Risk, UncertaintieS of Testing IN Genetics (TRUSTING): development and evaluation of an educational programme for healthcare professionals about BRCA1 & BRCA2 testing.

Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle (2022)
Journal Article
Tshimologo, M., Allen, K., Coyle, D., Damery, S., Dikomitis, L., Fotheringham, J., Hill, H., Lambie, M., Phillips-Darby, L., Solis-Trapala, I., Williams, I., & Davies, S. (2022). Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle. BMJ Open, e060922 - ?. https://doi.org/10.1136/bmjopen-2022-060922

INTRODUCTION: Use of home dialysis by centres in the UK varies considerably and is decreasing despite attempts to encourage greater use. Knowing what drives this unwarranted variation requires in-depth understanding of centre cultural and organisatio... Read More about Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle.