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Outputs (175)

Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study. (2021)
Journal Article
Mamas. (2021). Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study. https://doi.org/10.1016/j.jaccao.2021.11.001

Background: Myocardial infarction is a cardiac adverse event associated with 5-fluorouracil (5-FU). There are limited data on the incidence, risk, and prognosis of 5-FU-associated myocardial infarction. Objectives: The aim of this study was to examin... Read More about Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study..

Meta-Analysis Comparing Apixaban Versus Rivaroxaban for Management of Patients With Nonvalvular Atrial Fibrillation. (2021)
Journal Article
Mamas. (2021). Meta-Analysis Comparing Apixaban Versus Rivaroxaban for Management of Patients With Nonvalvular Atrial Fibrillation. The American Journal of Cardiology, 58 - 64. https://doi.org/10.1016/j.amjcard.2021.11.021

To compare the efficacy and safety of apixaban and rivaroxaban for the prevention of stroke in patients with nonvalvular atrial fibrillation (NVAF) by way of a meta-analysis informed by real-world evidence. Systematic review and meta-analysis of obse... Read More about Meta-Analysis Comparing Apixaban Versus Rivaroxaban for Management of Patients With Nonvalvular Atrial Fibrillation..

In-Hospital Characteristics and 30-Day Readmissions for Acute Myocardial Infarction and Major Bleeding in Patients With Active Cancer. (2021)
Journal Article
Mamas. (2021). In-Hospital Characteristics and 30-Day Readmissions for Acute Myocardial Infarction and Major Bleeding in Patients With Active Cancer. The American Journal of Cardiology, 25 - 37. https://doi.org/10.1016/j.amjcard.2021.11.015

There are limited data on readmission with ischemic and major bleeding events in patients with acute myocardial infarction (AMI) with active cancer. The purpose of our study was to evaluate in-hospital characteristics and 30-day readmission rates for... Read More about In-Hospital Characteristics and 30-Day Readmissions for Acute Myocardial Infarction and Major Bleeding in Patients With Active Cancer..

Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review. (2021)
Journal Article
Mamas. (2021). Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review. Circulation: Heart Failure, e008685 - ?. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008685

BACKGROUND: Heart failure has a disproportionate burden on patients who are Black, Indigenous, and people of color (BIPOC), but not much is known about representation of these groups in randomized controlled trials (RCTs). We explored temporal trends... Read More about Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review..

Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study (2021)
Journal Article
Rashid, Mamas, & Nolan. (2021). Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study. European Journal of Preventive Cardiology, 1084-1092. https://doi.org/10.1093/eurjpc/zwab200

Background: The importance of standard modifiable cardiovascular risk factors (SMuRFs) in preventing non-ST segment myocardial infarction (NSTEMI) is established. However, NSTEMI may present in the absence of SMuRFs, and little is known about their o... Read More about Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study.

Corrigendum to: Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis. (2021)
Journal Article
Mamas. (2021). Corrigendum to: Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis. European Heart Journal: Acute Cardiovascular Care, 1101 - ?. https://doi.org/10.1093/ehjacc/zuab013

The Impact of Charlson Comorbidity Index on De Novo Cardiac Implantable Electronic Device Procedural Outcomes in the United States (2021)
Journal Article
Mohamed, M. O., Van Spall, H. G., Morillo, C., Wilton, S. B., Kontopantelis, E., Rashid, M., …Mamas, M. (2022). The Impact of Charlson Comorbidity Index on De Novo Cardiac Implantable Electronic Device Procedural Outcomes in the United States. Mayo Clinic Proceedings, 97(1), 88 - 100. https://doi.org/10.1016/j.mayocp.2021.06.029

OBJECTIVE: To investigate the utility of Charlson comorbidity index (CCI) as a measure of comorbidity burden to predict procedural outcomes after de novo cardiac implantable electronic device (CIED) implantation. METHODS: All de novo CIED implantatio... Read More about The Impact of Charlson Comorbidity Index on De Novo Cardiac Implantable Electronic Device Procedural Outcomes in the United States.

Trends of Sex Differences in Clinical Outcomes After Myocardial Infarction in the United States. (2021)
Journal Article
Rashid, & Mamas. (2021). Trends of Sex Differences in Clinical Outcomes After Myocardial Infarction in the United States. https://doi.org/10.1016/j.cjco.2021.06.012

Background: Female patients have been shown to experience worse clinical outcomes after acute myocardial infarction (AMI) compared with male patients. However, it is unclear what trend these differences followed over time. Methods: Data from patients... Read More about Trends of Sex Differences in Clinical Outcomes After Myocardial Infarction in the United States..

Analysis of a Web-Based Dashboard to Support the Use of National Audit Data in Quality Improvement: Realist Evaluation. (2021)
Journal Article
Mamas. (2021). Analysis of a Web-Based Dashboard to Support the Use of National Audit Data in Quality Improvement: Realist Evaluation. Journal of Medical Internet Research, e28854 - ?. https://doi.org/10.2196/28854

BACKGROUND: Dashboards can support data-driven quality improvements in health care. They visualize data in ways intended to ease cognitive load and support data comprehension, but how they are best integrated into working practices needs further inve... Read More about Analysis of a Web-Based Dashboard to Support the Use of National Audit Data in Quality Improvement: Realist Evaluation..

Clinical outcomes of percutaneous coronary intervention for chronic total occlusion by treated segment length (2021)
Journal Article
Shoaib, A., Mamas, M. A., Spratt, J. C., Curzen, N., Wilson, S., Rashid, M., …Kinnaird, T. (2021). Clinical outcomes of percutaneous coronary intervention for chronic total occlusion by treated segment length. Catheterization and Cardiovascular Interventions, 99(2), 234-244. https://doi.org/10.1002/ccd.30015

AbstractBackgroundLong lesions are known to have worse outcomes following percutaneous coronary intervention (PCI), but there are limited data assessing the association between lesion length and clinical outcomes in PCI procedures undertaken in chron... Read More about Clinical outcomes of percutaneous coronary intervention for chronic total occlusion by treated segment length.

Predictors, Treatments, and Outcomes of Do-Not-Resuscitate Status in Acute Myocardial Infarction Patients (from a Nationwide Inpatient Cohort Study). (2021)
Journal Article
Mamas. (2021). Predictors, Treatments, and Outcomes of Do-Not-Resuscitate Status in Acute Myocardial Infarction Patients (from a Nationwide Inpatient Cohort Study). American Journal of Cardiology, 8 - 18. https://doi.org/10.1016/j.amjcard.2021.07.054

Little is known about how frequently do-not-resuscitate (DNR) orders are placed in patients with acute myocardial infarction (AMI), the types of patients in which they are placed, treatment strategies or clinical outcomes of such patients. Using the... Read More about Predictors, Treatments, and Outcomes of Do-Not-Resuscitate Status in Acute Myocardial Infarction Patients (from a Nationwide Inpatient Cohort Study)..

Aortic stenosis post-COVID-19: A mathematical model on waiting lists and mortality (2021)
Journal Article
Mamas. (2021). Aortic stenosis post-COVID-19: A mathematical model on waiting lists and mortality. MedRxiv, https://doi.org/10.1101/2021.11.11.21266212

Objectives To provide estimates for how different treatment pathways for the management of severe aortic stenosis (AS) may affect NHS England waiting list duration and associated mortality. Design We constructed a mathematical model of the excess wai... Read More about Aortic stenosis post-COVID-19: A mathematical model on waiting lists and mortality.

Impact of sex on outcomes of percutaneous coronary intervention for chronic total occlusion: A meta-analysis. (2021)
Journal Article
Mamas, M., Latif, A., Ahsan, M. J., Lateef, N., Aurit, S., Mirza, M. M., …Velagapudi, P. (2022). Impact of sex on outcomes of percutaneous coronary intervention for chronic total occlusion: A meta-analysis. Catheterization and Cardiovascular Interventions, 99(2), 254-262. https://doi.org/10.1002/ccd.30017

AbstractBackgroundWomen are underrepresented in chronic total occlusion (CTO) trials and little is known about sex differences in the outcomes of CTO percutaneous coronary intervention (PCI). This meta‐analysis aims to compare the outcomes of CTO PCI... Read More about Impact of sex on outcomes of percutaneous coronary intervention for chronic total occlusion: A meta-analysis..

Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM) (2021)
Presentation / Conference
Mallen, Mason, Frisher, Mamas, Jordan, Marshall, …White. (2021, November). Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM). Presented at SAPC North 2021, Virtual

Background: There is evidence that painful musculoskeletal conditions are associated with increased risk of cardiovascular disease, but less is known about whether this impacts on prognosis of cardiovascular disease. The aim was to determine whether... Read More about Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM).

Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM) (2021)
Presentation / Conference
Mason, K., Jordan, K. P., Achana, F., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. J. (2021, November). Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM). Paper presented at 2021 SAPC North, Virtual

Background: There is evidence that painful musculoskeletal conditions are associated with increased risk of cardiovascular disease, but less is known about whether this impacts on prognosis of cardiovascular disease. The aim was to determine whether... Read More about Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM).

Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM) (2021)
Presentation / Conference
Mason, K., Jordan, K., Achana, F., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. (2021, November). Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM). Poster presented at 2021 SAPC North, Virtual

Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM) (2021)
Presentation / Conference
Mason, K., Jordan, K., Achana, F., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. (2021, November). Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM). Poster presented at 2021 SAPC North, Virtual

Dual pathway inhibition in atherothrombosis prevention: yes, now we can! (2021)
Journal Article
SUMMARIA, F., BIONDI-ZOCCAI, G., ROMAGNOLI, E., MAMAS, M. A., FRANCHI, F., SEVERINO, P., …BHATT, D. L. (2023). Dual pathway inhibition in atherothrombosis prevention: yes, now we can!. Minerva Cardiology and Angiology, 71(4), 363-373. https://doi.org/10.23736/S2724-5683.21.05867-1

Despite ongoing developments, prevention and treatment of atherothrombotic cardiovascular disease remains a common challenge. Antithrombotic options for cardiocerebrovascular disease prevention involves a choice between dual antiplatelet therapy (DAP... Read More about Dual pathway inhibition in atherothrombosis prevention: yes, now we can!.

Is There a Difference in the Types of Complex High-Risk but Indicated Percutaneous Coronary Interventions (CHIP) Undertaken and Their Outcomes Among Different Racial Groups? Insights From a National Cohort (2021)
Journal Article
Rashid, & Mamas. (2021). Is There a Difference in the Types of Complex High-Risk but Indicated Percutaneous Coronary Interventions (CHIP) Undertaken and Their Outcomes Among Different Racial Groups? Insights From a National Cohort. Journal of the American College of Cardiology, B131 - B132. https://doi.org/10.1016/j.jacc.2021.09.1176

'Meeting Abstract'

Choice and Outcomes of Left Main Coronary Disease Revascularization Strategies in England Before and After the COVID-19 Era (2021)
Journal Article
Mamas, & Rashid. (2021). Choice and Outcomes of Left Main Coronary Disease Revascularization Strategies in England Before and After the COVID-19 Era. Journal of the American College of Cardiology, B27 - B27. https://doi.org/10.1016/j.jacc.2021.09.916

Methods All patients with LM disease (= 50% stenosis) undergoing coronary revascularization in England between January 1, 2017 and August 19, 2020 were included (n = 22,235), stratified by time period (pre-COVID: January 1, 2017 to February 29, 2020;... Read More about Choice and Outcomes of Left Main Coronary Disease Revascularization Strategies in England Before and After the COVID-19 Era.

TCT-66 Choice and Outcomes of Left Main Coronary Disease Revascularization Strategies in England Before and After the COVID-19 Era (2021)
Journal Article
Mohamed, M., Curzen, N., de Belder, M., Spratt, J., Rashid, M., Shoaib, A., …Mamas, M. (2021). TCT-66 Choice and Outcomes of Left Main Coronary Disease Revascularization Strategies in England Before and After the COVID-19 Era. Journal of the American College of Cardiology, B27 - B27. https://doi.org/10.1016/j.jacc.2021.09.916

Background There are limited data on the impact of the COVID-19 pandemic on left main (LM) coronary revascularization activity, choice of strategy, and post-procedural outcomes. Methods All patients with LM disease (= 50% stenosis) undergoing coronar... Read More about TCT-66 Choice and Outcomes of Left Main Coronary Disease Revascularization Strategies in England Before and After the COVID-19 Era.

TCT-359 Treatment Effect of Primary Percutaneous Coronary Intervention on In-Hospital Outcomes of Active Cancer Patients Presenting With ST-Elevation Myocardial Infarction (2021)
Journal Article
Mohamed, M., Van Spall, H., Alkhouli, M., Khan, S., Barac, A., Shoaib, A., …Mamas, M. (2021). TCT-359 Treatment Effect of Primary Percutaneous Coronary Intervention on In-Hospital Outcomes of Active Cancer Patients Presenting With ST-Elevation Myocardial Infarction. Journal of the American College of Cardiology, B148 - B148

TCT-323 Is There a Difference in the Types of Complex High-Risk but Indicated Percutaneous Coronary Interventions (CHIP) Undertaken and Their Outcomes Among Different Racial Groups? Insights From a National Cohort (2021)
Journal Article
Shamkhani, W., Kinnaird, T., Wijeysundera, H., Ludman, P., Rashid, M., & Mamas, M. (2021). TCT-323 Is There a Difference in the Types of Complex High-Risk but Indicated Percutaneous Coronary Interventions (CHIP) Undertaken and Their Outcomes Among Different Racial Groups? Insights From a National Cohort. Journal of the American College of Cardiology, B131 - B132. https://doi.org/10.1016/j.jacc.2021.09.1176

Background In contemporary practice, complex high-risk but indicated percutaneous coronary intervention (CHIP) is increasingly common. Data on race-based differences in the nature of CHIP and their clinical outcomes in patients with stable coronary a... Read More about TCT-323 Is There a Difference in the Types of Complex High-Risk but Indicated Percutaneous Coronary Interventions (CHIP) Undertaken and Their Outcomes Among Different Racial Groups? Insights From a National Cohort.

TCT-110 Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset (2021)
Journal Article
Rashid, & Mamas. (2021). TCT-110 Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset. Journal of the American College of Cardiology, B46 - B47. https://doi.org/10.1016/j.jacc.2021.09.960

Background This study was designed to evaluate temporal trends in elective rates of percutaneous coronary intervention (PCI) for stable angina and, specifically, to study the impact of the COURAGE and ORBITA trials on real-life practice. Methods We a... Read More about TCT-110 Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset.

Treatment Effect of Primary Percutaneous Coronary Intervention on In-Hospital Outcomes of Active Cancer Patients Presenting With ST-Elevation Myocardial Infarction (2021)
Journal Article
Mamas. (2021). Treatment Effect of Primary Percutaneous Coronary Intervention on In-Hospital Outcomes of Active Cancer Patients Presenting With ST-Elevation Myocardial Infarction. Journal of the American College of Cardiology, B148 - B148

Background Primary percutaneous coronary intervention (pPCI) is the optimal strategy for coronary revascularization in patients presenting with ST-segment elevation myocardial infarction (STEMI). However, there are limited data on the utility of pPCI... Read More about Treatment Effect of Primary Percutaneous Coronary Intervention on In-Hospital Outcomes of Active Cancer Patients Presenting With ST-Elevation Myocardial Infarction.

Temporal Trends and Factors Associated With the Inclusion of Patient-Reported Outcomes in Heart Failure Randomized Controlled Trials: A Systematic Review. (2021)
Journal Article
Eliya, Y., Averbuch, T., Le, N., Xie, F., Thabane, L., Mamas, M. A., & Van Spall, H. G. (2021). Temporal Trends and Factors Associated With the Inclusion of Patient-Reported Outcomes in Heart Failure Randomized Controlled Trials: A Systematic Review. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, e022353 - ?. https://doi.org/10.1161/JAHA.121.022353

Background Patient-reported outcomes (PROs) are important measures of treatment response in heart failure. We assessed temporal trends in and factors associated with inclusion of PROs in heart failure randomized controlled trials (RCTs). Methods and... Read More about Temporal Trends and Factors Associated With the Inclusion of Patient-Reported Outcomes in Heart Failure Randomized Controlled Trials: A Systematic Review..

Relation of High-Sensitivity Troponin to 1 Year Mortality in 20,000 Consecutive Hospital Patients Undergoing a Blood Test for Any Reason. (2021)
Journal Article
Hinton, J., Mariathas, M., Gabara, L., Allan, R., Nicholas, Z., Shing Kwok, C., …Curzen, N. (2021). Relation of High-Sensitivity Troponin to 1 Year Mortality in 20,000 Consecutive Hospital Patients Undergoing a Blood Test for Any Reason. American Journal of Cardiology, 124 - 131. https://doi.org/10.1016/j.amjcard.2021.07.050

This was an observational study of the 1-year outcomes of the 20,000 patients included in the original CHARIOT study. The aim of the study was to assess the association between high sensitivity troponin I (hs-cTnI) concentration and 1 year mortality... Read More about Relation of High-Sensitivity Troponin to 1 Year Mortality in 20,000 Consecutive Hospital Patients Undergoing a Blood Test for Any Reason..

Shock index predicts up to 90-day mortality risk after intracerebral haemorrhage. (2021)
Journal Article
Pana, T. A., Quinn, T. J., Perdomo-Lampignano, J. A., Szlachetka, W. A., Knoery, C., Mamas, M. A., …Collaborators, V. (2021). Shock index predicts up to 90-day mortality risk after intracerebral haemorrhage. Clinical Neurology and Neurosurgery, 106994 - ?. https://doi.org/10.1016/j.clineuro.2021.106994

BACKGROUND: Shock index (SI - heart rate/systolic blood pressure) has been studied as a measure of haemodynamic status. We aimed to determine whether SI measures within 72 h of admission were associated with adverse outcomes in intracerebral haemorrh... Read More about Shock index predicts up to 90-day mortality risk after intracerebral haemorrhage..

Trends in cardiovascular mortality of cancer patients in the US over two decades 1999-2019. (2021)
Journal Article
Mamas, M. (2021). Trends in cardiovascular mortality of cancer patients in the US over two decades 1999-2019. International Journal of Clinical Practice, e14841 - ?. https://doi.org/10.1111/ijcp.14841

BACKGROUND: Cancer is the second most common cause of death globally after cardiovascular disease, and cancer patients are at an increased risk of CV death. This recognition has led to publication of cardio-oncological guidelines and to the widesprea... Read More about Trends in cardiovascular mortality of cancer patients in the US over two decades 1999-2019..

Impact of malignancy on In-hospital mortality, stratified by the cause of admission: An analysis of 67 million patients from the National Inpatient Sample. (2021)
Journal Article
Mamas. (2021). Impact of malignancy on In-hospital mortality, stratified by the cause of admission: An analysis of 67 million patients from the National Inpatient Sample. International Journal of Clinical Practice, e14758 - ?. https://doi.org/10.1111/ijcp.14758

OBJECTIVE: To describe the patient characteristics and the reason for admission of patients with malignancy by malignancy, and to study mortality rates for the different causes of admissions among the different types of cancer. PATIENTS AND METHODS:... Read More about Impact of malignancy on In-hospital mortality, stratified by the cause of admission: An analysis of 67 million patients from the National Inpatient Sample..

Outcomes of rotational atherectomy versus orbital atherectomy for the treatment of heavily calcified coronary stenosis: A systematic review and meta-analysis. (2021)
Journal Article
Mamas. (2021). Outcomes of rotational atherectomy versus orbital atherectomy for the treatment of heavily calcified coronary stenosis: A systematic review and meta-analysis. Catheterization and Cardiovascular Interventions, 884 - 892. https://doi.org/10.1002/ccd.29430

INTRODUCTION: The optimal approach to deal with severe coronary artery calcification (CAC) during percutaneous coronary intervention (PCI) remains ill-defined. METHODS: We conducted an electronic database search of all published studies comparing Orb... Read More about Outcomes of rotational atherectomy versus orbital atherectomy for the treatment of heavily calcified coronary stenosis: A systematic review and meta-analysis..

Substantial decline in hospital admissions for heart failure accompanied by increased community mortality during COVID-19 pandemic (2021)
Journal Article
Shoaib, A., Van Spall, H. G. C., Wu, J., Cleland, J. G. F., McDonagh, T. A., Rashid, M., …Mamas, M. A. (2021). Substantial decline in hospital admissions for heart failure accompanied by increased community mortality during COVID-19 pandemic. European Heart Journal - Quality of Care and Clinical Outcomes, 7(4), 378-387. https://doi.org/10.1093/ehjqcco/qcab040

Aims We hypothesized that a decline in admissions with heart failure during COVID-19 pandemic would lead to a reciprocal rise in mortality for patients with heart failure in the community. Methods and results We used National Heart Failure Audit d... Read More about Substantial decline in hospital admissions for heart failure accompanied by increased community mortality during COVID-19 pandemic.

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk. (2021)
Journal Article
Mamas, M. (2021). Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk. https://doi.org/10.1056/NEJMoa2108749

BACKGROUND: The appropriate duration of dual antiplatelet therapy in patients at high risk for bleeding after the implantation of a drug-eluting coronary stent remains unclear. METHODS: One month after they had undergone implantation of a biodegradab... Read More about Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk..

Impact of availability of catheter laboratory facilities on management and outcomes of acute myocardial infarction presenting with out of hospital cardiac arrest. (2021)
Journal Article
Mamas, M., & Rashid, M. (2021). Impact of availability of catheter laboratory facilities on management and outcomes of acute myocardial infarction presenting with out of hospital cardiac arrest. Resuscitation, 327-334. https://doi.org/10.1016/j.resuscitation.2021.10.031

OBJECTIVES: We aimed to identify whether the availability of catheter laboratory affects clinical outcomes of out-of-hospital cardiac arrest (OHCA) complicating myocardial infarction (AMI). METHODS: Patients admitted with a diagnosis of AMI and OHCA... Read More about Impact of availability of catheter laboratory facilities on management and outcomes of acute myocardial infarction presenting with out of hospital cardiac arrest..

Outcomes of intravascular ultrasound versus optical coherence tomography guided percutaneous coronary angiography: A meta regression-based analysis. (2021)
Journal Article
Mamas, M. A., Sattar, Y., Abdul Razzack, A., Kompella, R., Alhajri, N., Arshad, J., …Alraies, M. C. (2022). Outcomes of intravascular ultrasound versus optical coherence tomography guided percutaneous coronary angiography: A meta regression-based analysis. Catheterization and Cardiovascular Interventions, 99(1), E1 - E11. https://doi.org/10.1002/ccd.29976

BACKGROUND: Studies comparing clinical outcomes with intravascular ultrasound (IVUS) versus optical coherence tomography (OCT) guidance for percutaneous coronary intervention (PCI) in patients presenting with coronary artery disease, including stable... Read More about Outcomes of intravascular ultrasound versus optical coherence tomography guided percutaneous coronary angiography: A meta regression-based analysis..

Meta-Analysis of Transradial Versus Transfemoral Access for Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease. (2021)
Journal Article
Mamas. (2021). Meta-Analysis of Transradial Versus Transfemoral Access for Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease. American Journal of Cardiology, 8 - 14. https://doi.org/10.1016/j.amjcard.2021.07.018

Data comparing outcomes of transradial (TR) versus transfemoral (TF) access for percutaneous coronary intervention (PCI) in chronic kidney disease (CKD) including patients with eGFR< 30 ml/min/1.73m2 and patients with end-stage renal disease on dialy... Read More about Meta-Analysis of Transradial Versus Transfemoral Access for Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease..

Impact of cancer diagnosis on causes and outcomes of 5.9 million US patients with cardiovascular admissions. (2021)
Journal Article
Mamas. (2021). Impact of cancer diagnosis on causes and outcomes of 5.9 million US patients with cardiovascular admissions. International Journal of Cardiology, 76 - 83. https://doi.org/10.1016/j.ijcard.2021.07.054

INTRODUCTION: There are limited data on causes of cardiovascular (CV) admissions and associated outcomes among patients with different cancers. METHODS: All CV admissions from the US National Inpatient Sample between October 2015 to December 2017 wer... Read More about Impact of cancer diagnosis on causes and outcomes of 5.9 million US patients with cardiovascular admissions..

Association of quality indicators for acute myocardial infarction and mortality: feasibility and validation study using linked nationwide registry data (2021)
Journal Article
Mamas, & Rashid. (2021). Association of quality indicators for acute myocardial infarction and mortality: feasibility and validation study using linked nationwide registry data. European Heart Journal, https://doi.org/10.1093/eurheartj/ehab724.1328

Abstract Background Quality indicators (QIs) have been increasingly used as tools to assess and improve the quality of care for acute myocardial infarction (AMI). However, it is not known if it is feasible to use the 2020 iteration of international A... Read More about Association of quality indicators for acute myocardial infarction and mortality: feasibility and validation study using linked nationwide registry data.

Comparison of risk factors for coronary event in people with unattributed and non-coronary chest pain: an electronic health record cohort study (2021)
Journal Article
Rathod-Mistry, T., Mamas, M., Bailey, J., Chen, Y., Clarson, L., Denaxas, S., …Jordan, K. (2021). Comparison of risk factors for coronary event in people with unattributed and non-coronary chest pain: an electronic health record cohort study. European Heart Journal, 42(S1), https://doi.org/10.1093/eurheartj/ehab724.1350

Background Patients presenting to primary care with chest pain are often not given a cause. Patients with such unattributed chest pain have an increased risk of future cardiovascular disease (CVD) compared to patients with diagnosed non-coronary che... Read More about Comparison of risk factors for coronary event in people with unattributed and non-coronary chest pain: an electronic health record cohort study.

Temporal trends in the inclusion of patient-reported outcomes in heart failure randomized trials published in high-impact medical journals: a systematic bibliometric review (2021)
Journal Article
Eliya, Y., Averbuch, T., Le, N., Xie, F., Thabane, L., Mamas, M., & Van Spall, H. (2021). Temporal trends in the inclusion of patient-reported outcomes in heart failure randomized trials published in high-impact medical journals: a systematic bibliometric review. European Heart Journal, https://doi.org/10.1093/eurheartj/ehab724.3171

Background Patient reported outcomes (PROs) are important measures of health, particularly in symptomatic conditions such as heart failure (HF), and regulatory agencies have encouraged their collection in randomized controlled trials (RCTs). Purpose... Read More about Temporal trends in the inclusion of patient-reported outcomes in heart failure randomized trials published in high-impact medical journals: a systematic bibliometric review.

Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and SCAI criteria fit for purpose? (2021)
Journal Article
Hinton, J., Augustine, M., Gabara, L., Mariathas, M., Allan, R., Borca, F., …Curzen, N. (2021). Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and SCAI criteria fit for purpose?. European Heart Journal, 42(Supplement_1), https://doi.org/10.1093/eurheartj/ehab724.1442

Introduction The diagnosis and clinical implication of periprocedural myocardial infarction (PPMI) following coronary artery bypass grafting (CABG) is contentious, especially given its importance in the interpretation of trial data. Two accepted def... Read More about Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and SCAI criteria fit for purpose?.

The relationship between high-sensitivity troponin taken on admission to critical care, regardless of whether there was a clinical indication for testing, and one year mortality (2021)
Journal Article
Hinton, J., Augustine, M., Gabara, L., Mariathas, M., Allan, R., Borca, F., …Curzen, N. (2021). The relationship between high-sensitivity troponin taken on admission to critical care, regardless of whether there was a clinical indication for testing, and one year mortality. European Heart Journal, 42(Supplement_1), https://doi.org/10.1093/eurheartj/ehab724.1381

Introduction High-sensitivity troponin (hs-cTn) assays now form a key component of the diagnostic pathways for patients presenting to emergency medical services with chest pain. However, hs-cTn concentrations above the manufacturer-provided upper li... Read More about The relationship between high-sensitivity troponin taken on admission to critical care, regardless of whether there was a clinical indication for testing, and one year mortality.

The association between socioeconomic status, sex, race/ethnicity and in-hospital mortality among patients hospitalized for heart failure (2021)
Journal Article
Mamas. (2021). The association between socioeconomic status, sex, race/ethnicity and in-hospital mortality among patients hospitalized for heart failure. Journal of Cardiac Failure, https://doi.org/10.1016/j.cardfail.2021.09.012

Background The association between socioeconomic status (SES), sex, race/ethnicity and outcomes during hospitalization for heart failure (HF) has not previously been investigated. Methods We analyzed HF hospitalizations in the United States National... Read More about The association between socioeconomic status, sex, race/ethnicity and in-hospital mortality among patients hospitalized for heart failure.

Clinical Characteristics, Management Strategies, and Outcomes of Non-ST-Segment-Elevation Myocardial Infarction Patients With and Without Prior Coronary Artery Bypass Grafting. (2021)
Journal Article
Mamas, M., & Rashid, M. (2021). Clinical Characteristics, Management Strategies, and Outcomes of Non-ST-Segment-Elevation Myocardial Infarction Patients With and Without Prior Coronary Artery Bypass Grafting. https://doi.org/10.1161/JAHA.120.018823

Background There are limited data on the management strategies, temporal trends and clinical outcomes of patients who present with non-ST-segment-elevation myocardial infarction and have a prior history of CABG. Methods and Results We identified 287 ... Read More about Clinical Characteristics, Management Strategies, and Outcomes of Non-ST-Segment-Elevation Myocardial Infarction Patients With and Without Prior Coronary Artery Bypass Grafting..

Racial disparities in management and outcomes of out-of-hospital cardiac arrest complicating myocardial infarction; a national study from England and Wales (2021)
Journal Article
Mamas, & Rashid. (2021). Racial disparities in management and outcomes of out-of-hospital cardiac arrest complicating myocardial infarction; a national study from England and Wales. https://doi.org/10.1016/j.cjco.2021.09.026

Background Studies of racial disparities in patients admitted with an OHCA in the setting of AMI have shown inconsistent results. Whether these differences in care exist in a universal healthcare system in England is unknown. Methods Patients admitte... Read More about Racial disparities in management and outcomes of out-of-hospital cardiac arrest complicating myocardial infarction; a national study from England and Wales.

Comparison of Outcomes of Patients With Versus Without Chronic Liver Disease Undergoing Percutaneous Coronary Intervention. (2021)
Journal Article
Mamas. (2021). Comparison of Outcomes of Patients With Versus Without Chronic Liver Disease Undergoing Percutaneous Coronary Intervention. American Journal of Cardiology, 32 - 38. https://doi.org/10.1016/j.amjcard.2021.06.044

There are limited data on the outcomes of chronic liver disease (CLD) patients admitted for percutaneous coronary intervention (PCI). All PCI hospitalizations from the Nationwide Inpatient Sample (2004 to 2015) were analyzed and stratified by the pre... Read More about Comparison of Outcomes of Patients With Versus Without Chronic Liver Disease Undergoing Percutaneous Coronary Intervention..

Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial. (2021)
Journal Article
Mamas. (2021). Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial. European Heart Journal, 3844 - 3852. https://doi.org/10.1093/eurheartj/ehab444

AIMS: Fractional flow reserve (FFRCT) using computed tomography coronary angiography (CTCA) determines both the presence of coronary artery disease and vessel-specific ischaemia. We tested whether an evaluation strategy based on FFRCT would improve e... Read More about Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial..

Distribution, management and outcomes of AMI according to principal diagnosis priority during inpatient admission. (2021)
Journal Article
Mamas. (2021). Distribution, management and outcomes of AMI according to principal diagnosis priority during inpatient admission. https://doi.org/10.1111/ijcp.14554

BACKGROUND: In recent years, there has been a growing interest in outcomes of patients with acute myocardial infarction (AMI) using large administrative datasets. The present study was designed to compare the characteristics, management strategies an... Read More about Distribution, management and outcomes of AMI according to principal diagnosis priority during inpatient admission..

In-hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease. (2021)
Journal Article
Mamas. (2021). In-hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease. Catheterization and Cardiovascular Interventions, E586 - E593. https://doi.org/10.1161/circinterventions.119.008150

BACKGROUND: The outcome of endovascular intervention (EVI) compared vs. surgical revascularization in patients with peripheral artery disease (PAD) due to chronic total occlusion (CTO) is unknown. METHODS: Using the National Inpatient Sample database... Read More about In-hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease..

Prevalence of Cardiovascular Risk Factors in Osteoarthritis Patients Derived from Primary Care Records: A Systematic Review of Observational Studies. (2021)
Journal Article
Huang, X., Wilkie, R., Mamas, M., & Yu, D. (2021). Prevalence of Cardiovascular Risk Factors in Osteoarthritis Patients Derived from Primary Care Records: A Systematic Review of Observational Studies. Journal of Diabetes and Clinical Research, 3(3), https://doi.org/10.33696/diabetes.3.042

Background: People with osteoarthritis are at a high risk of cardiovascular disease (CVD). Detecting CVD risk factors in this high-risk population will help to improve CVD outcomes. Primary care electronic health records (EHRs) provide opportunities... Read More about Prevalence of Cardiovascular Risk Factors in Osteoarthritis Patients Derived from Primary Care Records: A Systematic Review of Observational Studies..

Outcomes of Elderly Patients Undergoing Left Atrial Appendage Closure. (2021)
Journal Article
Mamas. (2021). Outcomes of Elderly Patients Undergoing Left Atrial Appendage Closure. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, e021973 - ?. https://doi.org/10.1161/JAHA.121.021973

Background Elderly patients have a higher burden of comorbidities that influence clinical outcomes. We aimed to compare in-hospital outcomes in patients =80 years old to younger patients, and to determine the factors associated with increased risk of... Read More about Outcomes of Elderly Patients Undergoing Left Atrial Appendage Closure..

Treatment Effect of Percutaneous Coronary Intervention in Men Versus Women With ST-Segment-Elevation Myocardial Infarction. (2021)
Journal Article
Mamas. (2021). Treatment Effect of Percutaneous Coronary Intervention in Men Versus Women With ST-Segment-Elevation Myocardial Infarction

Background Women are less likely to receive primary percutaneous coronary intervention (pPCI) than men. A potential reason is risk aversion because of the worse outcomes with pPCI among women. However, whether pPCI is associated with a comparable mo... Read More about Treatment Effect of Percutaneous Coronary Intervention in Men Versus Women With ST-Segment-Elevation Myocardial Infarction..

Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta-Analyses in Highest-Impact Journals. (2021)
Journal Article
Mamas. (2021). Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta-Analyses in Highest-Impact Journals

Background Well-conducted meta-analyses are considered to be at the top of the evidence-based hierarchy pyramid, with an expansion of these publications within the cardiovascular research arena. There are limited data evaluating the trends and qual... Read More about Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta-Analyses in Highest-Impact Journals..

Racial, ethnic and socioeconomic disparities in patients undergoing transcatheter mitral edge-to-edge repair. (2021)
Journal Article
Sparrow, R. T., Sanjoy, S. S., Lindman, B. R., Tang, G. H., Kaneko, T., Wasfy, J. H., …Bagur, R. (2021). Racial, ethnic and socioeconomic disparities in patients undergoing transcatheter mitral edge-to-edge repair. International Journal of Cardiology, 73 - 81. https://doi.org/10.1016/j.ijcard.2021.09.037

BACKGROUND: Transcatheter mitral edge-to-edge repair (TEER) is an increasingly common procedure performed on patients with severe mitral regurgitation. This study assessed the impact of race/ethnicity and socioeconomic status on in-hospital complicat... Read More about Racial, ethnic and socioeconomic disparities in patients undergoing transcatheter mitral edge-to-edge repair..

Ultrasound- Versus Fluoroscopy-Guided Strategy for Transfemoral Transcatheter Aortic Valve Replacement Access: A Systematic Review and Meta-Analysis. (2021)
Journal Article
Mamas. (2021). Ultrasound- Versus Fluoroscopy-Guided Strategy for Transfemoral Transcatheter Aortic Valve Replacement Access: A Systematic Review and Meta-Analysis. https://doi.org/10.1161/CIRCINTERVENTIONS.121.010742

BACKGROUND: Access site vascular and bleeding complications remain problematic for patients undergoing transcatheter aortic valve replacement (TAVR). Ultrasound-guided transfemoral access approach has been suggested as a technique to reduce access si... Read More about Ultrasound- Versus Fluoroscopy-Guided Strategy for Transfemoral Transcatheter Aortic Valve Replacement Access: A Systematic Review and Meta-Analysis..

Invasive Hemodynamic Monitoring in Cardiogenic Shock Is Associated With Lower In‐Hospital Mortality (2021)
Journal Article
Osman, M., Syed, M., Patel, B., Munir, M. B., Kheiri, B., Caccamo, M., …Bianco, C. M. (2021). Invasive Hemodynamic Monitoring in Cardiogenic Shock Is Associated With Lower In‐Hospital Mortality. Journal of the American Heart Association, 10(18), https://doi.org/10.1161/jaha.121.021808

BackgroundThere is increasing utilization of cardiogenic shock treatment algorithms. The cornerstone of these algorithms is the use of invasive hemodynamic monitoring (IHM). We sought to compare the in‐hospital outcomes in patients who received IHM v... Read More about Invasive Hemodynamic Monitoring in Cardiogenic Shock Is Associated With Lower In‐Hospital Mortality.

Safety and efficacy of the polymer-free and polymer-coated drug-eluting stents in patients undergoing percutaneous coronary intervention. (2021)
Journal Article
Ullah, W., Zghouzi, M., Ahmad, B., Suleiman, A. M., Zahid, S., Faisaluddin, M., …Alraies, M. C. (2021). Safety and efficacy of the polymer-free and polymer-coated drug-eluting stents in patients undergoing percutaneous coronary intervention. Catheterization and Cardiovascular Interventions, 98(6), E802 - E813. https://doi.org/10.1002/ccd.29953

INTRODUCTION: The relative safety and efficacy of polymer-free (PF) versus polymer-coated (PC) drug-eluting stents (DES) in patients with angina or acute coronary syndrome (ACS) undergoing percutaneous coronary intervention has received limited study... Read More about Safety and efficacy of the polymer-free and polymer-coated drug-eluting stents in patients undergoing percutaneous coronary intervention..

Impact of the admitting ward on care quality and outcomes in non-ST-segment elevation myocardial infarction (NSTEMI): insights from a national registry. (2021)
Journal Article
Mamas. (2021). Impact of the admitting ward on care quality and outcomes in non-ST-segment elevation myocardial infarction (NSTEMI): insights from a national registry. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcab062

BACKGROUND: Little is known about the association between the type of admission ward and quality of care and outcomes for non-ST-segment elevation myocardial infarction (NSTEMI). METHODS & RESULTS: We analysed data from 337,155 NSTEMI admissions betw... Read More about Impact of the admitting ward on care quality and outcomes in non-ST-segment elevation myocardial infarction (NSTEMI): insights from a national registry..

496Higher predicted 10-year risk for cardiovascular disease in primary care consulters for osteoarthritis (2021)
Journal Article
Huang, M., Yu, D., Wilkie, R., & Mamas, M. (2021). 496Higher predicted 10-year risk for cardiovascular disease in primary care consulters for osteoarthritis. International Journal of Epidemiology, i105 - i105. https://doi.org/10.1093/ije/dyab168.295

Abstract Background Osteoarthritis (OA) has a major impact on the global burden of disease and is associated with poorer cardiovascular disease (CVD) outcomes. However it’s unclear whether people with OA have higher long-term (10-year) CVD risk comp... Read More about 496Higher predicted 10-year risk for cardiovascular disease in primary care consulters for osteoarthritis.

A snapshot global survey on side effects of COVID-19 vaccines among healthcare professionals and armed forces with a focus on headache. (2021)
Journal Article
Mamas. (2021). A snapshot global survey on side effects of COVID-19 vaccines among healthcare professionals and armed forces with a focus on headache. https://doi.org/10.23736/S0031-0808.21.04435-9

BACKGROUND: New messenger RNA (mRNA) and adenovirus-based vaccines (AdV) against Coronavirus disease 2019 (COVID-19) have entered large scale clinical trials. Since healthcare professionals (HCPs) and armed forces personnel (AFP) represent a high-ris... Read More about A snapshot global survey on side effects of COVID-19 vaccines among healthcare professionals and armed forces with a focus on headache..

Characteristics and hospital outcomes of coronary atherectomy within the United States: a multivariate and propensity-score matched analysis. (2021)
Journal Article
Mamas. (2021). Characteristics and hospital outcomes of coronary atherectomy within the United States: a multivariate and propensity-score matched analysis. Expert Review of Cardiovascular Therapy, 865 - 870. https://doi.org/10.1080/14779072.2021.1963233

BACKGROUND: Suboptimal stent delivery and deployment in calcified coronary lesions are associated with a poor clinical outcome. METHODS: Using the National Inpatient Sample database, we identified patients undergoing percutaneous coronary interventio... Read More about Characteristics and hospital outcomes of coronary atherectomy within the United States: a multivariate and propensity-score matched analysis..

Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource. (2021)
Journal Article
Mamas. (2021). Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource. https://doi.org/10.1136/bmj.n826

OBJECTIVE: To describe a novel England-wide electronic health record (EHR) resource enabling whole population research on covid-19 and cardiovascular disease while ensuring data security and privacy and maintaining public trust. DESIGN: Data resource... Read More about Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource..

Derivation and validation of a clinical model to predict death or cardiac hospitalizations while on the cardiac surgery waitlist (2021)
Journal Article
Mamas. (2021). Derivation and validation of a clinical model to predict death or cardiac hospitalizations while on the cardiac surgery waitlist. Canadian Medical Association Journal, E1333 - E1340

Background: Waitlist management is a global challenge. For patients with severe cardiovascular diseases awaiting cardiac surgery, prolonged wait times are associated with unplanned hospitalizations. To facilitate evidence-based resource allocation, w... Read More about Derivation and validation of a clinical model to predict death or cardiac hospitalizations while on the cardiac surgery waitlist.

Elixhauser outperformed Charlson comorbidity index in prognostic value after ACS: insights from a national registry. (2021)
Journal Article
Mamas. (2021). Elixhauser outperformed Charlson comorbidity index in prognostic value after ACS: insights from a national registry. Journal of Clinical Epidemiology, 26-35. https://doi.org/10.1016/j.jclinepi.2021.08.025

OBJECTIVE: To compare the performance of risk adjustment models using the Elixhauser and Charlson comorbidity scores in predicting in-hospital outcomes of ACS patients from a nationwide administrative database. STUDY DESIGN AND SETTING: All hospitali... Read More about Elixhauser outperformed Charlson comorbidity index in prognostic value after ACS: insights from a national registry..

Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia (2021)
Journal Article
Mamas. (2021). Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia. Metabolomics, https://doi.org/10.1007/s11306-021-01827-x

Introduction Acute myocardial ischaemia and the transition from reversible to irreversible myocardial injury are associated with abnormal metabolic patterns. Advances in metabolomics have extended our capabilities to define these metabolic perturbati... Read More about Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia.

Predicting 10-year stroke mortality: development and validation of a nomogram (2021)
Journal Article
Mamas. (2021). Predicting 10-year stroke mortality: development and validation of a nomogram. Acta neurologica Belgica, https://doi.org/10.1007/s13760-021-01752-9

Predicting long-term stroke mortality is a clinically important and unmet need. We aimed to develop and internally validate a 10-year ischaemic stroke mortality prediction score. In this UK cohort study, 10,366 patients with first-ever ischaemic stro... Read More about Predicting 10-year stroke mortality: development and validation of a nomogram.

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock. (2021)
Journal Article
Mamas, M. (2021). Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock. https://doi.org/10.3791/62140

The left atrial to femoral artery bypass (LAFAB) system is a mechanical circulatory support (MCS) device used in cardiogenic shock (CS) that bypasses the left ventricle by draining blood from the left atrium (LA) and returning it to the systemic arte... Read More about Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock..

Results of an international crowdsourcing survey on the treatment of non-ST segment elevation ACS patients at high-bleeding risk undergoing percutaneous intervention. (2021)
Journal Article
Bhatt, D. L., Carlos Kaski, J., Delaney, S., Alasnag, M., Andreotti, F., Angiolillo, D. J., …Valgimigli, M. (2021). Results of an international crowdsourcing survey on the treatment of non-ST segment elevation ACS patients at high-bleeding risk undergoing percutaneous intervention. International Journal of Cardiology, 1 - 8. https://doi.org/10.1016/j.ijcard.2021.05.012

AIMS: Choosing an antiplatelet strategy in patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS) at high bleeding risk (HBR), undergoing post-percutaneous coronary intervention (PCI), is complex. We used a unique open-source appro... Read More about Results of an international crowdsourcing survey on the treatment of non-ST segment elevation ACS patients at high-bleeding risk undergoing percutaneous intervention..

Ambulatory intravenous furosemide for decompensated heart failure: safe, feasible, and effective (2021)
Journal Article
Ahmed, F. Z., Taylor, J. K., John, A. V., Khan, M. A., Zaidi, A. M., Mamas, M. A., …Cunnington, C. (2021). Ambulatory intravenous furosemide for decompensated heart failure: safe, feasible, and effective. ESC Heart Failure, 8(5), 3906-3916. https://doi.org/10.1002/ehf2.13368

AIMS: This study aims to establish the feasibility, safety, and efficacy of outpatient intravenous (IV) diuretic treatment for the management of decompensated heart failure (HF) for patients enrolled in the HeartFailure@Home service. METHODS AND RESU... Read More about Ambulatory intravenous furosemide for decompensated heart failure: safe, feasible, and effective.

Intravascular imaging-guided intracoronary lithotripsy: First real-world experience (2021)
Journal Article
Sinclair, H., Fan, L., Fahy, E., Shahid, F., Ratib, K., Nolan, J., …Ahmed, J. (2021). Intravascular imaging-guided intracoronary lithotripsy: First real-world experience. Health Science Reports, 4(3), Article e307. https://doi.org/10.1002/hsr2.307

Background and Aims: Coronary calcification remains a significant challenge for the contemporary interventional cardiologist. We aim to describe the use of intravascular lithotripsy (IVL) in a range of real-world settings. Methods: A retrospective tw... Read More about Intravascular imaging-guided intracoronary lithotripsy: First real-world experience.

Acute Pulmonary Embolism During Pregnancy and Puerperium: National Trends and In-Hospital Outcomes. (2021)
Journal Article
Mamas. (2021). Acute Pulmonary Embolism During Pregnancy and Puerperium: National Trends and In-Hospital Outcomes. Mayo Clinic Proceedings, 2102 - 2113. https://doi.org/10.1016/j.mayocp.2021.01.015

OBJECTIVE: To investigate the trend and outcomes of acute pulmonary embolism (PE) during pregnancy and puerperium using a large national database. PATIENTS AND METHODS: The National Inpatient Sample was queried to identify pregnancy-related hospitali... Read More about Acute Pulmonary Embolism During Pregnancy and Puerperium: National Trends and In-Hospital Outcomes..

Excess deaths from COVID-19 and other causes by region, neighbourhood deprivation level and place of death during the first 30 weeks of the pandemic in England and Wales: A retrospective registry study. (2021)
Journal Article
Mamas. (2021). Excess deaths from COVID-19 and other causes by region, neighbourhood deprivation level and place of death during the first 30 weeks of the pandemic in England and Wales: A retrospective registry study. The Lancet Regional Health Europe, 100144 - ?. https://doi.org/10.1016/j.lanepe.2021.100144

BACKGROUND: Excess deaths during the COVID-19 pandemic compared with those expected from historical trends have been unequally distributed, both geographically and socioeconomically. Not all excess deaths have been directly related to COVID-19 infect... Read More about Excess deaths from COVID-19 and other causes by region, neighbourhood deprivation level and place of death during the first 30 weeks of the pandemic in England and Wales: A retrospective registry study..

Thrombolysis in acute ischaemic stroke patients with chronic kidney disease. (2021)
Journal Article
Mamas, M. (2021). Thrombolysis in acute ischaemic stroke patients with chronic kidney disease. https://doi.org/10.1111/ane.13513

OBJECTIVE: We aimed to determine whether chronic kidney disease (CKD) is associated with adverse in-hospital outcomes after acute ischaemic stroke (AIS) and whether this association is dependent on thrombolysis administration. METHODS: 885,537 record... Read More about Thrombolysis in acute ischaemic stroke patients with chronic kidney disease..

Hidden labour: the skilful work of clinical audit data collection and its implications for secondary use of data via integrated health IT (2021)
Journal Article
Mamas. (2021). Hidden labour: the skilful work of clinical audit data collection and its implications for secondary use of data via integrated health IT. BMC Health Services Research, 1-11. https://doi.org/10.1186/s12913-021-06657-0

Background Secondary use of data via integrated health information technology is fundamental to many healthcare policies and processes worldwide. However, repurposing data can be problematic and little research has been undertaken into the everyday... Read More about Hidden labour: the skilful work of clinical audit data collection and its implications for secondary use of data via integrated health IT.

In-Hospital Complications in Pregnant Women With Current or Historical Cancer Diagnoses (2021)
Journal Article
Wu, P., P. Jordan, K., A. Chew-Graham, C., O. Mohamed, M., Barac, A., P. Lundberg, G., …A. Mamas, M. (2021). In-Hospital Complications in Pregnant Women With Current or Historical Cancer Diagnoses. Mayo Clinic Proceedings, 96(11), 2779-2792. https://doi.org/10.1016/j.mayocp.2021.03.038

Objective To assess the temporal trends, patient characteristics and comorbidities, and in-hospital cardiovascular and obstetric complications and outcomes of pregnant women with current or historical cancer diagnosis at the time of admission for de... Read More about In-Hospital Complications in Pregnant Women With Current or Historical Cancer Diagnoses.

Operator Volumes and In-Hospital Outcomes: An Analysis of 7,740 Rotational Atherectomy Procedures From the BCIS National Database. (2021)
Journal Article
Mamas. (2021). Operator Volumes and In-Hospital Outcomes: An Analysis of 7,740 Rotational Atherectomy Procedures From the BCIS National Database. JACC. Cardiovascular interventions, 1423 - 1430. https://doi.org/10.1016/j.jcin.2021.04.034

OBJECTIVES: The aims of this study were to use a national percutaneous coronary intervention (PCI) registry to study temporal changes in procedure volumes of PCI using rotational atherectomy (ROTA-PCI), the patient and procedural factors associated w... Read More about Operator Volumes and In-Hospital Outcomes: An Analysis of 7,740 Rotational Atherectomy Procedures From the BCIS National Database..

Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020 (2021)
Journal Article
Mamas. (2021). Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020

Background Deaths in the first year of the COVID-19 pandemic in England & Wales have been shown to be unevenly distributed socioeconomically and geographically. However, the full scale of inequalities may have been underestimated as most measures of... Read More about Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020.

Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. (2021)
Journal Article
Mamas, M., & Mallen, C. (2021). Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. Research Square, https://doi.org/10.21203/rs.3.rs-670522/v1

Objectives: To examine the association between ß -blocker prescription and knee or hip total joint replacement (TJR) in a UK primary-care population with incident knee or hip osteoarthritis (OA). Methods: Cohort study using data from the Clinical P... Read More about Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink..

Long Term Prognostic Impact of Sex-specific Longitudinal Changes in Blood Pressure. The EPIC-Norfolk Prospective Population Cohort Study. (2021)
Journal Article
Mamas. (2021). Long Term Prognostic Impact of Sex-specific Longitudinal Changes in Blood Pressure. The EPIC-Norfolk Prospective Population Cohort Study. European Journal of Preventive Cardiology, https://doi.org/10.1093/eurjpc/zwab104

AIMS: We aimed to determine the sex differences in longitudinal systolic and diastolic blood pressure (SBP and DBP) trajectories in mid-life and delineate the associations between these and mortality (all-cause, cardiovascular, and non-cardiovascular... Read More about Long Term Prognostic Impact of Sex-specific Longitudinal Changes in Blood Pressure. The EPIC-Norfolk Prospective Population Cohort Study..

Association between serum secretory phospholipase A2 and risk of ischemic stroke. (2021)
Journal Article
Mamas. (2021). Association between serum secretory phospholipase A2 and risk of ischemic stroke. European Journal of Neurology, https://doi.org/10.1111/ene.15004

BACKGROUND AND PURPOSE: Previous literature has demonstrated an association between high serum levels of type-II secretory phospholipase A2 (sPLA2) concentration and an increased risk of coronary artery disease. However, such association has not been... Read More about Association between serum secretory phospholipase A2 and risk of ischemic stroke..

Sex Differences in Outcomes Following Left Atrial Appendage Closure. (2021)
Journal Article
Sanjoy, S. S., Choi, Y., Sparrow, R. T., Baron, S. J., Abbott, J. D., Azzalini, L., …Bagur, R. (2021). Sex Differences in Outcomes Following Left Atrial Appendage Closure. https://doi.org/10.1016/j.mayocp.2020.11.031

OBJECTIVE: To evaluate the effects of female sex on in-hospital outcomes and to provide estimates for sex-specific prediction models of adverse outcomes following left atrial appendage closure (LAAC). PATIENTS AND METHODS: Cohort-based observational... Read More about Sex Differences in Outcomes Following Left Atrial Appendage Closure..

Safety and Efficacy of Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19 Population. (2021)
Journal Article
Sattar, Y., Mukuntharaj, P., Zghouzi, M., Suleiman, A. M., Attique, H., Ullah, W., …Alraies, M. C. (2021). Safety and Efficacy of Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19 Population. High Blood Pressure and Cardiovascular Prevention, 405 - 416. https://doi.org/10.1007/s40292-021-00462-w

INTRODUCTION: The safety of renin-angiotensin-aldosterone system inhibitors (RAASi) among COVID-19 patients has been controversial since the onset of the pandemic. METHODS: Digital databases were queried to study the safety of RAASi in COVID-19. The... Read More about Safety and Efficacy of Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19 Population..

Impact of Chronic Kidney Disease on Revascularization and Outcomes in Patients with ST-Elevation Myocardial Infarction. (2021)
Journal Article
Mamas. (2021). Impact of Chronic Kidney Disease on Revascularization and Outcomes in Patients with ST-Elevation Myocardial Infarction. https://doi.org/10.1016/j.amjcard.2021.03.057

Chronic kidney disease (CKD) in patients with ST-elevation myocardial infarction (STEMI) is associated with worse outcomes. We assessed the impact of CKD on guideline directed coronary revascularization and outcomes among STEMI patients. The Nationwi... Read More about Impact of Chronic Kidney Disease on Revascularization and Outcomes in Patients with ST-Elevation Myocardial Infarction..

46 The relationship between high-sensitivity troponin taken on admission to critical care, regardless of whether there was a clinical indication for testing, and one year mortality: a novel biomarker for outcome? (2021)
Presentation / Conference
Hinton, J., Augustine, M., Gabara, L., Mariathas, M., Allan, R., Borca, F., …Curzen, N. (2021, June). 46 The relationship between high-sensitivity troponin taken on admission to critical care, regardless of whether there was a clinical indication for testing, and one year mortality: a novel biomarker for outcome?. Paper presented at British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021

In‐hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease (2021)
Journal Article
Zghouzi, M., Moussa Pacha, H., Ullah, W., Sattar, Y., Ahmad, B., Osman, H., …Alraies, M. C. (in press). In‐hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease. Catheterization and Cardiovascular Interventions, 98(4), https://doi.org/10.1002/ccd.29827

Background The outcome of endovascular intervention (EVI) compared vs. surgical revascularization in patients with peripheral artery disease (PAD) due to chronic total occlusion (CTO) is unknown. Methods Using the National Inpatient Sample datab... Read More about In‐hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease.

Coronary revascularisation outcomes in patients with cancer. (2021)
Journal Article
Mamas. (2021). Coronary revascularisation outcomes in patients with cancer. Heart, 507 - 516. https://doi.org/10.1136/heartjnl-2020-318531

Cancer and coronary artery disease (CAD) overlap in traditional risk factors as well as molecular mechanisms underpinning the development of these two disease states. Patients with cancer are at increased risk of developing CAD, representing a high-r... Read More about Coronary revascularisation outcomes in patients with cancer..

Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales. (2021)
Journal Article
Dafaalla, M., Rashid, M., Weston, C., Kinnaird, T., Gurm, H., Appleby, C., …Mamas, M. (2021). Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales. American Journal of Cardiology, 152, 1 - 10. https://doi.org/10.1016/j.amjcard.2021.04.032

We investigated the incidence, management, and outcomes of acute myocardial infarction (AMI) patients according to cardiac arrest location. Patients admitted with a diagnosis of AMI between January 1, 2010 to March 31, 2017 from the Myocardial Ischae... Read More about Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales..

37 Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and scai criteria fit for purpose? (2021)
Presentation / Conference
Hinton, J., Augustine, M., Gabara, L., Mariathas, M., Allan, R., Borca, F., …Curzen, N. (2021, June). 37 Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and scai criteria fit for purpose?. Paper presented at British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021

Introduction The diagnosis and clinical implication of periprocedural myocardial infarction (PPMI) following coronary artery bypass grafting (CABG) is contentious, especially given its importance in the interpretation of trial data. Two accepted defi... Read More about 37 Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and scai criteria fit for purpose?.

184 Association between high-sensitivity troponin and one year mortality in 20,000 consecutive hospital patients undergoing a blood test for any reason (2021)
Presentation / Conference
Hinton, J., Mariathas, M., Gabara, L., Allan, R., Nicholas, Z., Kwok, C. S., …Curzen, N. (2021, June). 184 Association between high-sensitivity troponin and one year mortality in 20,000 consecutive hospital patients undergoing a blood test for any reason. Paper presented at British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021

Introduction High sensitivity troponin (hs-cTn) concentrations above the manufacturer recommended upper limit of normal (ULN) are seen frequently in patients without a clinical presentation consistent with an acute coronary syndrome. There is increas... Read More about 184 Association between high-sensitivity troponin and one year mortality in 20,000 consecutive hospital patients undergoing a blood test for any reason.

Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study (2021)
Journal Article
Mamas. (2021). Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study. https://doi.org/10.22541/au.162273979.95865645/v1

Background: Higher anticholinergic burden from medications is associated with increased risk of cardiovascular disease and cognitive function decline. A mechanistic pathway has never been established. We aimed to determine whether chronic inflammati... Read More about Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study.

Incidence and mortality due to thromboembolic events during the COVID-19 pandemic: Multi-sourced population-based health records cohort study. (2021)
Journal Article
Mamas, & Rashid. (2021). Incidence and mortality due to thromboembolic events during the COVID-19 pandemic: Multi-sourced population-based health records cohort study. Thrombosis Research, 17 - 23. https://doi.org/10.1016/j.thromres.2021.03.006

BACKGROUND: Evidence supports an excess of deaths during the COVID-19 pandemic. We report the incidence and mortality of thrombo-embolic events (TE) during the COVID-19 pandemic. METHODS: Multi-sourced nationwide cohort study of adults (age =18 years... Read More about Incidence and mortality due to thromboembolic events during the COVID-19 pandemic: Multi-sourced population-based health records cohort study..

Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Aortic Stenosis in England. (2021)
Journal Article
Mamas, & Nolan. (2021). Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Aortic Stenosis in England. Circulation: Cardiovascular Interventions, 532-543. https://doi.org/10.1161/CIRCINTERVENTIONS.120.010413

Background: Aortic stenosis requires timely treatment with either surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). This study aimed to investigate the indirect impact of coronavirus disease 2019 (COVID-19) o... Read More about Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Aortic Stenosis in England..

Sex-Based Differences in Prevalence and Outcomes of Common Acute Conditions Associated With Type 2 Myocardial Infarction. (2021)
Journal Article
Mohamed, M. O., Contractor, T., Abramov, D., Parwani, P., Michos, E. D., Fischman, D., …Mamas, M. (2021). Sex-Based Differences in Prevalence and Outcomes of Common Acute Conditions Associated With Type 2 Myocardial Infarction. https://doi.org/10.1016/j.amjcard.2021.02.011

Little is known about the association between acute prevalent conditions in patients with type 2 Myocardial Infarction (T2MI) and clinical outcomes, particularly between genders. Using the Nationwide Inpatient Sample (2017), we examined outcomes of T... Read More about Sex-Based Differences in Prevalence and Outcomes of Common Acute Conditions Associated With Type 2 Myocardial Infarction..

TRENDS OF IN-HOSPITAL AND 30-DAY MORTALITY AFTER PERCUTANEOUS CORONARY INTERVENTION IN ENGLAND BEFORE AND AFTER THE COVID-19 ERA (2021)
Presentation / Conference
Mohamed, M., Curzen, N., Ludman, P., Rashid, M., Shoaib, A., de Belder, M., …Mamas, M. (2021, May). TRENDS OF IN-HOSPITAL AND 30-DAY MORTALITY AFTER PERCUTANEOUS CORONARY INTERVENTION IN ENGLAND BEFORE AND AFTER THE COVID-19 ERA. Poster presented at ACC.21, Virtual

Background Public reporting of percutaneous coronary intervention (PCI) outcomes is a performance metric and a requirement in many healthcare systems. There are inconsistent data on the causes of death after PCI, and what proportion of these are att... Read More about TRENDS OF IN-HOSPITAL AND 30-DAY MORTALITY AFTER PERCUTANEOUS CORONARY INTERVENTION IN ENGLAND BEFORE AND AFTER THE COVID-19 ERA.

Association of admitting physician specialty and care quality and outcomes in non-ST-segment elevation myocardial infarction (NSTEMI): insights from a national registry. (2021)
Journal Article
Moledina, S. M., Shoaib, A., Graham, M. M., Biondi-Zoccai, G., Van Spall, H. G. C., Kontopantelis, E., …Mamas, M. A. (2022). Association of admitting physician specialty and care quality and outcomes in non-ST-segment elevation myocardial infarction (NSTEMI): insights from a national registry. European Heart Journal - Quality of Care and Clinical Outcomes, 8(5), 557–567. https://doi.org/10.1093/ehjqcco/qcab038

BACKGROUND: Little is known about the association between admitting physician specialty and care quality and outcomes for non-ST-segment elevation myocardial infarction (NSTEMI). METHODS & RESULTS: We identified 288,420 patients hospitalised with NST... Read More about Association of admitting physician specialty and care quality and outcomes in non-ST-segment elevation myocardial infarction (NSTEMI): insights from a national registry..

Prognostic impact of comorbidity measures on outcomes following acute coronary syndrome: a systematic review. (2021)
Journal Article
Mamas. (2021). Prognostic impact of comorbidity measures on outcomes following acute coronary syndrome: a systematic review. International Journal of Clinical Practice, e14345 - ?. https://doi.org/10.1111/ijcp.14345

AIM: To identify existing comorbidity measures and summarise their association with acute coronary syndrome (ACS) outcomes. METHODS: We searched published studies from MEDLINE (OVIDSP) and EMBASE from inception to March 2021, studies of the pre-speci... Read More about Prognostic impact of comorbidity measures on outcomes following acute coronary syndrome: a systematic review..

SEX DIFFERENCES IN DISTRIBUTION, MANAGEMENT AND OUTCOMES OF COMBINED ISCHEMIC-BLEEDING RISK FOLLOWING ACUTE CORONARY SYNDROME (2021)
Journal Article
Rashid, & Mamas. (2021). SEX DIFFERENCES IN DISTRIBUTION, MANAGEMENT AND OUTCOMES OF COMBINED ISCHEMIC-BLEEDING RISK FOLLOWING ACUTE CORONARY SYNDROME. Journal of the American College of Cardiology, 39 - 39. https://doi.org/10.1016/S0735-1097%2821%2901398-X

Background: Risk factors of bleeding and recurrent ischemic events after acute coronary syndrome (ACS) often overlap. Whether the distribution and management of these complications vary by sex remains unknown. Methods: ACS hospitalizations in the Uni... Read More about SEX DIFFERENCES IN DISTRIBUTION, MANAGEMENT AND OUTCOMES OF COMBINED ISCHEMIC-BLEEDING RISK FOLLOWING ACUTE CORONARY SYNDROME.

Clinical Outcomes of Proximal Optimization Technique (POT) in Bifurcation Stenting Short title: Impact of proximal optimization technique (2021)
Journal Article
Mamas, Rashid, & Rashid. (2021). Clinical Outcomes of Proximal Optimization Technique (POT) in Bifurcation Stenting Short title: Impact of proximal optimization technique. EuroIntervention, https://doi.org/10.4244/EIJ-D-20-01393

Background: Optimal deployment of coronary stents in a bifurcation lesion remains a matter of debate. Aims: We sought to capture the daily practice of bifurcation stenting by means of a worldwide registry and to investigate how the post-implantati... Read More about Clinical Outcomes of Proximal Optimization Technique (POT) in Bifurcation Stenting Short title: Impact of proximal optimization technique.

Clinical outcomes of percutaneous coronary intervention for chronic total occlusion in prior coronary artery bypass grafting patients (2021)
Journal Article
Rashid, M., Shoaib, A., Mohamed, M., Curzen, N., Ludman, P., Zaman, A., …Mamas, M. A. (2021). Clinical outcomes of percutaneous coronary intervention for chronic total occlusion in prior coronary artery bypass grafting patients. Catheterization and Cardiovascular Interventions, 99(1), 74-84. https://doi.org/10.1002/ccd.29691

OBJECTIVE: To compare the clinical characteristics and outcomes in patients with stable angina who have undergone chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in native arteries with or without prior coronary artery bypass g... Read More about Clinical outcomes of percutaneous coronary intervention for chronic total occlusion in prior coronary artery bypass grafting patients.

Prognosis of Acute Ischaemic Stroke Patients with Cancer: A National Inpatient Sample Study (2021)
Journal Article
Mamas. (2021). Prognosis of Acute Ischaemic Stroke Patients with Cancer: A National Inpatient Sample Study. Cancers, 2193 - 2193. https://doi.org/10.3390/cancers13092193

Whilst cancer is a risk factor for acute ischaemic stroke (AIS), its impact on AIS prognosis between metastatic and non-metastatic (MC and NMC) disease is poorly understood. Furthermore, the receipt of intravenous thrombolysis (IVT) and endovascular... Read More about Prognosis of Acute Ischaemic Stroke Patients with Cancer: A National Inpatient Sample Study.

HYBRID CORONARY REVASCULARIZATION VERSUS CORONARY ARTERY BYPASS GRAFT IN PATIENTS WITH MULTIVESSEL CORONARY ARTERY DISEASE A META-ANALYSIS (2021)
Journal Article
Zghouzi, M., Ullah, W., Sandhyavenu, H., Pacha, H. M., Al-Khadra, Y., Ahmad, B., …Alraies, M. C. (2021). HYBRID CORONARY REVASCULARIZATION VERSUS CORONARY ARTERY BYPASS GRAFT IN PATIENTS WITH MULTIVESSEL CORONARY ARTERY DISEASE A META-ANALYSIS. Journal of the American College of Cardiology, 77(18), 1042. https://doi.org/10.1016/s0735-1097%2821%2902401-3

Background Hybrid coronary artery revascularization (HCR) refers to complete or near complete revascularization using the combination of single vessel CABG and PCI of other significant coronary lesions. The short-term outcomes of HCR compared to CAB... Read More about HYBRID CORONARY REVASCULARIZATION VERSUS CORONARY ARTERY BYPASS GRAFT IN PATIENTS WITH MULTIVESSEL CORONARY ARTERY DISEASE A META-ANALYSIS.

META-ANALYSIS OF SAFETY AND EFFICACY OF RENIN ANGIOTENSIN ALDOSTERONE SYSTEM INHIBITORS IN COVID-19 POPULATION (2021)
Journal Article
Sattar, Y., Mukuntharaj, P., Attique, H., Ullah, W., Sana, M. K., Zaher, N., …Alraies, M. C. (2021). META-ANALYSIS OF SAFETY AND EFFICACY OF RENIN ANGIOTENSIN ALDOSTERONE SYSTEM INHIBITORS IN COVID-19 POPULATION. Journal of the American College of Cardiology, 77(18 S1), 3158. https://doi.org/10.1016/s0735-1097%2821%2904513-7

Background The safety and efficacy of Renin Angiotensin Aldosterone System Inhibitors(RAASi) in COVID 19 patients has been controversial. Methods Digital databases were queried for relevant articles. A random-effect model was used to compute an... Read More about META-ANALYSIS OF SAFETY AND EFFICACY OF RENIN ANGIOTENSIN ALDOSTERONE SYSTEM INHIBITORS IN COVID-19 POPULATION.

THE ASSOCIATION BETWEEN SEX, RACE, SOCIOECONOMIC STATUS, AND IN-HOSPITAL ALL-CAUSE MORTALITY AMONG PATIENTS ADMITTED FOR HEART FAILURE: A RETROSPECTIVE COHORT STUDY (2021)
Journal Article
Averbuch, T., Mohamed, M., Islam, S., Martin, G., Thabane, L., Mamas, M., & Van Spall, H. G. (2021). THE ASSOCIATION BETWEEN SEX, RACE, SOCIOECONOMIC STATUS, AND IN-HOSPITAL ALL-CAUSE MORTALITY AMONG PATIENTS ADMITTED FOR HEART FAILURE: A RETROSPECTIVE COHORT STUDY. Journal of the American College of Cardiology, 77(18), 794. https://doi.org/10.1016/s0735-1097%2821%2902153-7

Background Heart failure (HF) hospitalization is associated with high mortality. We aimed to assess the role of race, sex, and socioeconomic status (SES) in the risk of in-hospital mortality among patients hospitalized for HF. Methods We used th... Read More about THE ASSOCIATION BETWEEN SEX, RACE, SOCIOECONOMIC STATUS, AND IN-HOSPITAL ALL-CAUSE MORTALITY AMONG PATIENTS ADMITTED FOR HEART FAILURE: A RETROSPECTIVE COHORT STUDY.

Clinical phenogroups are more effective than left ventricular ejection fraction categories in stratifying heart failure outcomes (2021)
Journal Article
Gevaert, A. B., Tibebu, S., Mamas, M. A., Ravindra, N. G., Lee, S. F., Ahmad, T., …Van Spall, H. G. (2021). Clinical phenogroups are more effective than left ventricular ejection fraction categories in stratifying heart failure outcomes. ESC Heart Failure, 8(4), 2741-2754. https://doi.org/10.1002/ehf2.13344

Aims Heart failure (HF) guidelines place patients into 3 discrete groups according to left ventricular ejection fraction (LVEF): reduced (

Derivation and validation of a two-variable index to predict 30-day outcomes following heart failure hospitalization (2021)
Journal Article
Mamas, Averbuch, T., Lee, S. F., Mamas, M. A., Oz, U. E., Perez, R., …Van Spall, H. G. C. (2021). Derivation and validation of a two-variable index to predict 30-day outcomes following heart failure hospitalization. ESC Heart Failure, 8(4), 2690-2697. https://doi.org/10.1002/ehf2.13324

Background The LACE index—length of stay (L), acuity (A), Charlson co-morbidities (C), and emergent visits (E)—predicts 30-day outcomes following heart failure (HF) hospitalization but is complex to score. A simpler LE index (length of stay and emer... Read More about Derivation and validation of a two-variable index to predict 30-day outcomes following heart failure hospitalization.

Ethnic disparities in care and outcomes of non-ST-segment elevation myocardial infarction: a nationwide cohort study. (2021)
Journal Article
Mamas, & Rashid. (2021). Ethnic disparities in care and outcomes of non-ST-segment elevation myocardial infarction: a nationwide cohort study. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcab030

BACKGROUND: Little is known about ethnic disparities in care and clinical outcomes of patients admitted with non-ST-segment elevation myocardial infarction (NSTEMI) in national cohorts from universal healthcare systems derived from Europe. METHODS &... Read More about Ethnic disparities in care and outcomes of non-ST-segment elevation myocardial infarction: a nationwide cohort study..

Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study. (2021)
Journal Article
Mamas, Mallen, & Chew-Graham. (2021). Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study. Open Heart, https://doi.org/10.1136/openhrt-2020-001498

OBJECTIVE: Most current cardiovascular disease (CVD) risk stratification tools are for people without CVD, but very few are for prevalent CVD. In this study, we developed and validated a CVD severity score in people with coronary heart disease (CHD)... Read More about Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study..

Cost of inpatient heart failure care and 30-day readmissions in the United States (2021)
Journal Article
Mamas, Kwok, C. S., Abramov, D., Parwani, P., Ghosh, R. K., Kittleson, M., …Van Spall, H. G. C. (2021). Cost of inpatient heart failure care and 30-day readmissions in the United States. International Journal of Cardiology, 329, 115-122. https://doi.org/10.1016/j.ijcard.2020.12.020

BACKGROUND: Heart failure hospitalizations are a major financial cost to healthcare systems. This study aimed to evaluate the costs associated with inpatient hospitalization. METHODS: Patients with a primary diagnosis of heart failure during a hospit... Read More about Cost of inpatient heart failure care and 30-day readmissions in the United States.

In-Hospital Outcomes and Trends of Endovascular Intervention vs Surgical Revascularization in Octogenarians With Peripheral Artery Disease. (2021)
Journal Article
Mamas. (2021). In-Hospital Outcomes and Trends of Endovascular Intervention vs Surgical Revascularization in Octogenarians With Peripheral Artery Disease. American Journal of Cardiology, 143 - 150

It is unknown whether endovascular intervention (EVI) is associated with superior outcomes when compared with surgical revascularization in octogenarian. National Inpatient Sample (NIS) database was used to compare the outcomes of limb revascularizat... Read More about In-Hospital Outcomes and Trends of Endovascular Intervention vs Surgical Revascularization in Octogenarians With Peripheral Artery Disease..

Distribution of High-Sensitivity Troponin Taken Without Conventional Clinical Indications in Critical Care Patients and Its Association With Mortality. (2021)
Journal Article
Mamas, M., Hinton, J., Augustine, M., Gabara, L., Mariathas, M., Allan, R., …Curzen, N. (2021). Distribution of High-Sensitivity Troponin Taken Without Conventional Clinical Indications in Critical Care Patients and Its Association With Mortality. Critical Care Medicine, 49(9), 1451 - 1459. https://doi.org/10.1097/ccm.0000000000005024

OBJECTIVES: To describe the distribution of high-sensitivity troponin in a consecutive cohort of patients in critical care units, regardless of clinical indication, and its association with clinical outcomes. DESIGN: Prospective observational study.... Read More about Distribution of High-Sensitivity Troponin Taken Without Conventional Clinical Indications in Critical Care Patients and Its Association With Mortality..

Evidence-based arterial access site practice in patients with acute coronary syndromes: Has SAFARI-STEMI changed the landscape? (2021)
Journal Article
Nagaraja, V., Rao, S. V., George, S., Mamas, M., & Nolan, J. (2021). Evidence-based arterial access site practice in patients with acute coronary syndromes: Has SAFARI-STEMI changed the landscape?. Catheterization and Cardiovascular Interventions, 97(7), 1417 - 1421. https://doi.org/10.1002/ccd.29684

Key Points Access site practice in acute coronary syndrome (ACS) has been extensively investigated with the data favoring a radial approach. SAFARI‐STEMI does not change the recommendation to use radial access in most patients due to methodological i... Read More about Evidence-based arterial access site practice in patients with acute coronary syndromes: Has SAFARI-STEMI changed the landscape?.

Clinical and Economic Burden of Stroke Among Young, Midlife, and Older Adults in the United States, 2002-2017 (2021)
Journal Article
Mamas, & Rashid. (2021). Clinical and Economic Burden of Stroke Among Young, Midlife, and Older Adults in the United States, 2002-2017. https://doi.org/10.1016/j.mayocpiqo.2021.01.015

Objective To assess trends of stroke hospitalization rates, inpatient mortality, and health care resource use in young (aged =44 years), midlife (aged 45-64 years), and older (aged =65 years) adults. Patients and Methods We studied the National... Read More about Clinical and Economic Burden of Stroke Among Young, Midlife, and Older Adults in the United States, 2002-2017.

Questions and answers on antithrombotic therapy and revascularization strategies in non-ST-elevation acute coronary syndrome (NSTE-ACS): a companion document of the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. (2021)
Journal Article
Barbato, E., Mehilli, J., Sibbing, D., Siontis, G. C. M., Collet, J., Thiele, H., …Mamas, M. (2021). Questions and answers on antithrombotic therapy and revascularization strategies in non-ST-elevation acute coronary syndrome (NSTE-ACS): a companion document of the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. European Heart Journal, 1368 - 1378. https://doi.org/10.1093/eurheartj/ehaa601

Machine Learning-Augmented Propensity Score Analysis of Percutaneous Coronary Intervention in Over 30 Million Cancer and Non-cancer Patients. (2021)
Journal Article
Mamas. (2021). Machine Learning-Augmented Propensity Score Analysis of Percutaneous Coronary Intervention in Over 30 Million Cancer and Non-cancer Patients. Frontiers in Cardiovascular Medicine, -. https://doi.org/10.3389/fcvm.2021.620857

Background: It is unknown to what extent the clinical benefits of PCI outweigh the risks and costs in patients with vs. without cancer and within each cancer type. We performed the first known nationally representative propensity score analysis of PC... Read More about Machine Learning-Augmented Propensity Score Analysis of Percutaneous Coronary Intervention in Over 30 Million Cancer and Non-cancer Patients..

Thin Strut CoCr Biodegradable Polymer Biolimus A9-Eluting Stents versus Thicker Strut Stainless Steel Biodegradable Polymer Biolimus A9-Eluting Stents: Two-Year Clinical Outcomes. (2021)
Journal Article
Mamas. (2021). Thin Strut CoCr Biodegradable Polymer Biolimus A9-Eluting Stents versus Thicker Strut Stainless Steel Biodegradable Polymer Biolimus A9-Eluting Stents: Two-Year Clinical Outcomes. Journal of Interventional Cardiology, https://doi.org/10.1155/2021/6654515

Background: While thinner struts are associated with improved clinical outcomes in bare-metal stents (BMS), reducing strut thickness may affect drug delivery from drug-eluting stents (DES) and there are limited data comparing otherwise similar thin a... Read More about Thin Strut CoCr Biodegradable Polymer Biolimus A9-Eluting Stents versus Thicker Strut Stainless Steel Biodegradable Polymer Biolimus A9-Eluting Stents: Two-Year Clinical Outcomes..

Proteomic and Mechanistic Analysis of Spironolactone in Patients at Risk for HF. (2021)
Journal Article
Pedro Ferreira, J., Verdonschot, J., Wang, P., Pizard, A., Collier, T., Ahmed, F. Z., …Zannad, F. (2021). Proteomic and Mechanistic Analysis of Spironolactone in Patients at Risk for HF. JACC: Heart Failure, 268 - 277. https://doi.org/10.1016/j.jchf.2020.11.010

OBJECTIVES: This study sought to further understand the mechanisms underlying effect of spironolactone and assessed its impact on multiple plasma protein biomarkers and their respective underlying biologic pathways. BACKGROUND: In addition to their b... Read More about Proteomic and Mechanistic Analysis of Spironolactone in Patients at Risk for HF..

Location of death among patients presenting with cardiovascular disease to the emergency department in the United states. (2021)
Journal Article
Mamas. (2021). Location of death among patients presenting with cardiovascular disease to the emergency department in the United states. https://doi.org/10.1111/ijcp.13798

BACKGROUND: In-hospital deaths are an important outcome and little is known about deaths in the emergency department (ED). Among patients who died of cardiovascular diseases (CVD), we assessed causes of death, temporal trends and the relative distrib... Read More about Location of death among patients presenting with cardiovascular disease to the emergency department in the United states..

Trends, Outcomes, and Predictive Score For Emergency Coronary Artery Bypass Graft Surgery After Elective Percutaneous Coronary Intervention (from a Nationwide Dataset). (2021)
Journal Article
Mamas, M. (2021). Trends, Outcomes, and Predictive Score For Emergency Coronary Artery Bypass Graft Surgery After Elective Percutaneous Coronary Intervention (from a Nationwide Dataset). https://doi.org/10.1016/j.amjcard.2020.12.060

The temporal trends and preprocedural predictors of emergency coronary artery bypass graft surgery (ECABG) after elective percutaneous coronary intervention (PCI) in the contemporary era are largely unknown. From January 2003 to December 2014 electiv... Read More about Trends, Outcomes, and Predictive Score For Emergency Coronary Artery Bypass Graft Surgery After Elective Percutaneous Coronary Intervention (from a Nationwide Dataset)..

Racial, ethnic and socioeconomic disparities in patients undergoing left atrial appendage closure (2021)
Journal Article
Sparrow, R., Sanjoy, S., Choi, Y., Elgendy, I. Y., Jneid, H., Villablanca, P. A., …Bagur, R. (2021). Racial, ethnic and socioeconomic disparities in patients undergoing left atrial appendage closure. Heart, 107(24), 1946-1955. https://doi.org/10.1136/heartjnl-2020-318650

OBJECTIVE: This manuscript aims to explore the impact of race/ethnicity and socioeconomic status on in-hospital complication rates after left atrial appendage closure (LAAC). METHODS: The US National Inpatient Sample was used to identify hospitalisat... Read More about Racial, ethnic and socioeconomic disparities in patients undergoing left atrial appendage closure.

Individual participant data meta-analysis for external validation, recalibration, and updating of a flexible parametric prognostic model. (2021)
Journal Article
Ensor, J., Snell, K. I. E., Debray, T. P. A., Lambert, P. C., Look, M. P., Mamas, M. A., …Riley, R. D. (2021). Individual participant data meta-analysis for external validation, recalibration, and updating of a flexible parametric prognostic model. Statistics in Medicine, 40(13), 3066-3084. https://doi.org/10.1002/sim.8959

Individual participant data (IPD) from multiple sources allows external validation of a prognostic model across multiple populations. Often this reveals poor calibration, potentially causing poor predictive performance in some populations. However, r... Read More about Individual participant data meta-analysis for external validation, recalibration, and updating of a flexible parametric prognostic model..

Revascularisation strategies in patients with significant left main coronary disease during the COVID-19 pandemic. (2021)
Journal Article
Rashid, M., Mamas, Mohamed, M. O., Curzen, N., de Belder, M., Goodwin, A. T., …Mamas, M. A. (2021). Revascularisation strategies in patients with significant left main coronary disease during the COVID-19 pandemic. Catheterization & Cardiovascular Interventions, 98(7), 1252-1261. https://doi.org/10.1002/ccd.29663

BACKGROUND: There are limited data on the impact of the COVID-19 pandemic on left main (LM) coronary revascularisation activity, choice of revascularisation strategy, and post-procedural outcomes. METHODS: All patients with LM disease (=50% stenosis)... Read More about Revascularisation strategies in patients with significant left main coronary disease during the COVID-19 pandemic..

Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension. (2021)
Journal Article
Mamas. (2021). Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, e019341 - ?. https://doi.org/10.1161/JAHA.120.019341

Background The association between systemic hypertension and cerebrovascular disease is well documented. However, the impact of pulmonary hypertension (PH) on acute ischemic stroke outcomes is unknown despite PH being recognized as a risk factor for... Read More about Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension..

Impact of pre-existent vascular and poly-vascular disease on acute myocardial infarction management and outcomes: An analysis of 2 million patients from the National Inpatient Sample. (2021)
Journal Article
Mamas. (2021). Impact of pre-existent vascular and poly-vascular disease on acute myocardial infarction management and outcomes: An analysis of 2 million patients from the National Inpatient Sample. https://doi.org/10.1016/j.ijcard.2020.11.051

BACKGROUND: Patients with pre-existing vascular disease are known to have worse outcomes after acute myocardial infarction (AMI). However, there is limited data for outcomes stratified by type and number of vascular territories involved. METHODS: Usi... Read More about Impact of pre-existent vascular and poly-vascular disease on acute myocardial infarction management and outcomes: An analysis of 2 million patients from the National Inpatient Sample..

ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study (2021)
Journal Article
Mamas, & Mallen. (2021). ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study. Rheumatology, https://doi.org/10.1093/rheumatology/keab234

OBJECTIVES: To examine the association between ß-blocker prescription and first primary-care consultation for knee osteoarthritis (OA), hip OA, knee pain and hip pain. METHODS: Data source: Clinical Practice Research Datalink. Participants aged =40?y... Read More about ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study.

Prognosis of Acute Ischaemic Stroke in Cancer Patients: A National Inpatient Sample Study (2021)
Journal Article
Mamas. (2021). Prognosis of Acute Ischaemic Stroke in Cancer Patients: A National Inpatient Sample Study

Background and Purpose Whilst cancer is a risk factor for acute ischaemic stroke (AIS), its impact on AIS prognosis between metastatic and non-metastatic (MC and NMC) disease is poorly understood. Furthermore, the receipt of intravenous thrombolysis... Read More about Prognosis of Acute Ischaemic Stroke in Cancer Patients: A National Inpatient Sample Study.

Racial differences in management and outcomes of acute myocardial infarction during COVID19 pandemic (2021)
Journal Article
Rashid, & Mamas. (2021). Racial differences in management and outcomes of acute myocardial infarction during COVID19 pandemic. Heart, 734-740. https://doi.org/10.1136/heartjnl-2020-318356

Objective: There are concerns that health care and outcomes of BAME communities are disproportionately impacted by the COVID19 pandemic. We investigated admission rates, treatment and mortality of Black, Asian and Minority Ethnic (BAME) with acute my... Read More about Racial differences in management and outcomes of acute myocardial infarction during COVID19 pandemic.

Percutaneous coronary intervention in patients with cancer and readmissions within 90 days for acute myocardial infarction and bleeding in the USA. (2021)
Journal Article
Mamas. (2021). Percutaneous coronary intervention in patients with cancer and readmissions within 90 days for acute myocardial infarction and bleeding in the USA. https://doi.org/10.1093/eurheartj/ehaa1032

AIMS: The post-discharge outcomes of patients with cancer who undergo PCI are not well understood. This study evaluates the rates of readmissions within 90?days for acute myocardial infarction (AMI) and bleeding among patients with cancer who undergo... Read More about Percutaneous coronary intervention in patients with cancer and readmissions within 90 days for acute myocardial infarction and bleeding in the USA..

Efficacy and Safety of Ticagrelor Monotherapy in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis (2021)
Journal Article
Gelbenegger, G., Schoergenhofer, C., Jilma, B., Gager, G. M., Dizdarevic, A. M., Mamas, M. A., …Siller‐Matula, J. M. (2021). Efficacy and Safety of Ticagrelor Monotherapy in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis. Clinical Pharmacology and Therapeutics, 110(2), 424-431. https://doi.org/10.1002/cpt.2226

Dual antiplatelet therapy (DAPT) and subsequent P2Y12 inhibitor monotherapy, particularly ticagrelor, is an emerging treatment strategy in patients undergoing percutaneous coronary intervention (PCI). This meta-analysis was designed to investigate wh... Read More about Efficacy and Safety of Ticagrelor Monotherapy in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis.

Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease. (2021)
Journal Article
Mamas. (2021). Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease. https://doi.org/10.1007/s11886-021-01453-y

PURPOSE OF REVIEW: This article reviews the evidence on optimal medical therapy (OMT) versus coronary revascularization in patients with stable ischemic heart disease (SIHD) and advanced chronic kidney disease (CKD). RECENT FINDINGS: A post hoc analy... Read More about Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease..

Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease (2021)
Journal Article
Paul, T. K., Mamas, M. A., Shanmugasundaram, M., Nagarajarao, H. S., Ojha, C. P., Jneid, H., …White, C. J. (2021). Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease. Current Cardiology Reports, 23(4), https://doi.org/10.1007/s11886-021-01453-y

Purpose of Review This article reviews the evidence on optimal medical therapy (OMT) versus coronary revascularization in patients with stable ischemic heart disease (SIHD) and advanced chronic kidney disease (CKD). Recent Findings A post hoc an... Read More about Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease.

Barriers and facilitators of the uptake of digital health technology in cardiovascular care: a systematic scoping review. (2021)
Journal Article
Mamas. (2021). Barriers and facilitators of the uptake of digital health technology in cardiovascular care: a systematic scoping review. European Heart Journal – Digital Health, 62 - 74. https://doi.org/10.1093/ehjdh/ztab005

Digital health technology (DHT) has the potential to revolutionize healthcare delivery but its uptake has been low in clinical and research settings. The factors that contribute to the limited adoption of DHT, particularly in cardiovascular settings,... Read More about Barriers and facilitators of the uptake of digital health technology in cardiovascular care: a systematic scoping review..

Temporal trends in utilization and outcomes of transcatheter aortic valve replacement in different races: an analysis of the national inpatient sample (2021)
Journal Article
Ullah, W., Al-Khadra, Y., Mir, T., Darmoch, F., Pacha, H. M., Sattar, Y., …Alraies, M. C. (2021). Temporal trends in utilization and outcomes of transcatheter aortic valve replacement in different races: an analysis of the national inpatient sample. Journal of Cardiovascular Medicine, 22(7), 586 - 593. https://doi.org/10.2459/JCM.0000000000001172

AIM: We sought to determine the racial and ethnical disparities in the delivery of TAVR and to evaluate the in-hospital outcomes and utilization of TAVR stratified by patient ethnicity. METHOD: Using a national inpatient sample database between 2011... Read More about Temporal trends in utilization and outcomes of transcatheter aortic valve replacement in different races: an analysis of the national inpatient sample.

Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies (2021)
Journal Article
Huang, X., Wilkie, R., Mamas, M., & Yu, D. (2021). Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies. MedRxiv, https://doi.org/10.1101/2021.02.14.21251130v1

Background People with osteoarthritis are at a high risk of cardiovascular disease (CVD). Detecting CVD risk factors in this high-risk population will help to improve CVD outcomes. Primary care electronic health records (EHRs) provide opportunities f... Read More about Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies.

Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database). (2021)
Journal Article
Mamas, Sykes, R., Mohamed, M. O., Kwok, C. S., Mamas, M. A., & Berry, C. (2021). Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database). Clinical Cardiology, 44(3), 291 - 306. https://doi.org/10.1002/clc.23543

Percutaneous coronary intervention (PCI) improves anginal chest pain in most, but not all, treated patients. PCI is associated with unplanned readmission for angina and non-specific chest pain within 30-days of index PCI. Patients with an index hospi... Read More about Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database)..

Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020 (2021)
Journal Article
Wu, J., Mafham, M., Mamas, M. A., Rashid, M., Kontopantelis, E., Dean, J. E., …Gale, C. P. (2021). Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020. Mayo Clinic Proceedings, 96(4), 952 - 963. https://doi.org/10.1016/j.mayocp.2021.02.007

OBJECTIVE: To describe the place and cause of death during the coronavirus disease 2019 (COVID-19) pandemic to assess its impact on excess mortality. METHODS: This national death registry included all adult (aged =18 years) deaths in England and... Read More about Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020.

Meta-Analysis of Transradial vs Transfemoral Access for Percutaneous Coronary Intervention in Patients With ST Elevation Myocardial Infarction. (2021)
Journal Article
Mamas. (2021). Meta-Analysis of Transradial vs Transfemoral Access for Percutaneous Coronary Intervention in Patients With ST Elevation Myocardial Infarction. https://doi.org/10.1016/j.amjcard.2020.11.016

Transradial access (TRA) has emerged as an alternative to transfemoral access (TFA) for percutaneous coronary intervention (PCI) in ST elevation myocardial infarction (STEMI) patients. However, the rate of TRA adoption has been much slower in the acu... Read More about Meta-Analysis of Transradial vs Transfemoral Access for Percutaneous Coronary Intervention in Patients With ST Elevation Myocardial Infarction..

Excess mortality in England and Wales during the first wave of the COVID-19 pandemic (2021)
Journal Article
Mamas. (2021). Excess mortality in England and Wales during the first wave of the COVID-19 pandemic. Journal of epidemiology and community health, 213-223. https://doi.org/10.1136/jech-2020-214764

Background Deaths during the COVID-19 pandemic result directly from infection and exacerbation of other diseases and indirectly from deferment of care for other conditions, and are socially and geographically patterned. We quantified excess mortality... Read More about Excess mortality in England and Wales during the first wave of the COVID-19 pandemic.

Estimating the population health burden of musculoskeletal conditions using primary care electronic health records (2021)
Journal Article
Yu, D., Peat, G., Jordan, K., Bailey, J., Prieto-Alhambra, D., Robinson, D., …Wilkie, R. (2021). Estimating the population health burden of musculoskeletal conditions using primary care electronic health records. Rheumatology, 60(10), 4832-4843. https://doi.org/10.1093/rheumatology/keab109

Objectives Better indicators from affordable, sustainable data sources are needed to monitor population burden of musculoskeletal conditions. We propose five indicators of musculoskeletal health and assessed if routinely available primary care elect... Read More about Estimating the population health burden of musculoskeletal conditions using primary care electronic health records.

Vascular complications associated with intraaortic balloon pump supported percutaneous coronary intervention (PCI) and clinical outcomes from the British Cardiovascular Intervention Society National PCI Database. (2021)
Journal Article
Kinnaird, T., Anderson, R., Gallagher, S., Sharp, A. S. P., Farooq, V., Ludman, P., …Mamas, M. (2021). Vascular complications associated with intraaortic balloon pump supported percutaneous coronary intervention (PCI) and clinical outcomes from the British Cardiovascular Intervention Society National PCI Database. Catheterization and Cardiovascular Interventions, 98(1), E53-E61. https://doi.org/10.1002/ccd.29549

INTRODUCTION: The impact of a vascular complication (VC) in the setting of intraaortic balloon pump (IABP) supported PCI on clinical outcomes is unclear. METHODS: Using data from the BCIS National PCI Database, multivariate logistic regression was us... Read More about Vascular complications associated with intraaortic balloon pump supported percutaneous coronary intervention (PCI) and clinical outcomes from the British Cardiovascular Intervention Society National PCI Database..

The Effect of Spironolactone on Cardiovascular Function and Markers of Fibrosis in People at Increased Risk of Developing Heart Failure: The Heart “OMics” in AGEing (HOMAGE) Randomised Clinical Trial. (2021)
Journal Article
Mamas. (2021). The Effect of Spironolactone on Cardiovascular Function and Markers of Fibrosis in People at Increased Risk of Developing Heart Failure: The Heart “OMics” in AGEing (HOMAGE) Randomised Clinical Trial. European Heart Journal, 684-696. https://doi.org/10.1093/eurheartj/ehaa758

Importance: Cardiovascular accumulation of collagen (fibrosis) may contribute to the progression from ventricular dysfunction to heart failure. Galectin-3, a potential marker of pro-fibrotic activity, might identify those at greater risk. Objective:... Read More about The Effect of Spironolactone on Cardiovascular Function and Markers of Fibrosis in People at Increased Risk of Developing Heart Failure: The Heart “OMics” in AGEing (HOMAGE) Randomised Clinical Trial..

Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis (2021)
Journal Article
Mamas. (2021). Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis. European Heart Journal: Acute Cardiovascular Care, 829-839. https://doi.org/10.1093/ehjacc/zuaa032

Aims Primary percutaneous coronary intervention (pPCI) is the gold standard, guideline-recommended revascularization strategy in patients presenting with ST-elevation myocardial infarction (STEMI). However, there are limited data on its use and effe... Read More about Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis.

Incidence and Predictors of Postoperative Ischemic Stroke after Coronary Artery Bypass Grafting (2021)
Journal Article
Mamas. (2021). Incidence and Predictors of Postoperative Ischemic Stroke after Coronary Artery Bypass Grafting. International Journal of Clinical Practice, https://doi.org/10.1111/ijcp.14067

Background: Data on the incidence and outcomes of ischemic stroke in patients undergoing coronary artery bypass grafting (CABG) in the current era is limited. The goal of this study was to examine contemporary trends, predictors, and outcomes of isch... Read More about Incidence and Predictors of Postoperative Ischemic Stroke after Coronary Artery Bypass Grafting.

Revascularisation Therapies Improve the Outcomes of Ischemic Stroke Patients with Atrial Fibrillation and Heart Failure (2021)
Journal Article
Mamas. (2021). Revascularisation Therapies Improve the Outcomes of Ischemic Stroke Patients with Atrial Fibrillation and Heart Failure. International Journal of Cardiology, 205-213. https://doi.org/10.1016/j.ijcard.2020.09.076

Background – Atrial fibrillation (AF) and heart failure (HF) carry a poor prognosis in acute ischaemic stroke (AIS). The impact of revascularisation therapies on outcomes in these patients is not fully understood. Methods –National Inpatient Samp... Read More about Revascularisation Therapies Improve the Outcomes of Ischemic Stroke Patients with Atrial Fibrillation and Heart Failure.

Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy (2021)
Journal Article
Mamas, Clarson, Roddy, Mallen, & Helliwell. (2021). Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy. Mayo Clinic Proceedings, 388-399. https://doi.org/10.1016/j.mayocp.2020.04.044

Objectives: The present study sought to examine national-level differences in management strategies and outcomes in patients with autoimmune rheumatic disease (AIRD) with acute myocardial infarction (AMI) between 2004 and 2014. Methods: All AMI hos... Read More about Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy.

Outcomes following Percutaneous Coronary Intervention in Renal Transplant Recipients; A Binational collaborative analysis (2021)
Journal Article
Mamas, & Rashid. (2021). Outcomes following Percutaneous Coronary Intervention in Renal Transplant Recipients; A Binational collaborative analysis. Mayo Clinic Proceedings, 363-376. https://doi.org/10.1016/j.mayocp.2020.04.045

Objective: We sought to investigate the clinical and procedural characteristics in patients with a history of Renal Transplant (RT) and compare the outcomes with non-RT patients in two national cohorts of patients undergoing percutaneous coronary int... Read More about Outcomes following Percutaneous Coronary Intervention in Renal Transplant Recipients; A Binational collaborative analysis.

In-Hospital and 30-Day Mortality After Percutaneous Coronary Intervention in England in the Pre-COVID and COVID Eras (2021)
Journal Article
Mamas, M., & Rashid, M. (2021). In-Hospital and 30-Day Mortality After Percutaneous Coronary Intervention in England in the Pre-COVID and COVID Eras. Journal of Invasive Cardiology,

BACKGROUND: Public reporting of percutaneous coronary intervention (PCI) outcomes is a performance metric and a requirement in many healthcare systems. There are inconsistent data on the causes of death after PCI, and the proportion of these deaths t... Read More about In-Hospital and 30-Day Mortality After Percutaneous Coronary Intervention in England in the Pre-COVID and COVID Eras.

Sex-specific in-hospital outcomes of transcatheter aortic valve replacement with third generation transcatheter heart valves. (2021)
Journal Article
Simard, T., Alqahtani, F., Hibbert, B., Mamas, M. A., El‐Hajj, S., El-Hajj, S., …Alkhouli, M. (2021). Sex-specific in-hospital outcomes of transcatheter aortic valve replacement with third generation transcatheter heart valves. Catheterization and Cardiovascular Interventions, 98(1), 176 - 183. https://doi.org/10.1002/ccd.29499

BACKGROUND: Sex-based differences in transcatheter aortic valve replacement (TAVR) outcomes have been previously documented. However, whether these differences persist with contemporary third generation transcatheter heart valves (THVs) is unknown. M... Read More about Sex-specific in-hospital outcomes of transcatheter aortic valve replacement with third generation transcatheter heart valves..

Best Practices of Social Media for the Clinician. (2021)
Journal Article
Mamas. (2021). Best Practices of Social Media for the Clinician. Current Cardiology Reviews, 118 - 121. https://doi.org/10.2174/1573403X16666200128101509

Over recent years, social media use has substantially expanded not only for millennials, but across all generations. Today, it no longer remains a means for simple social networking. It has evolved into a powerful tool that can be used for career dev... Read More about Best Practices of Social Media for the Clinician..

Mobile health applications for the detection of atrial fibrillation: a systematic review. (2021)
Journal Article
Mamas. (2021). Mobile health applications for the detection of atrial fibrillation: a systematic review. https://doi.org/10.1093/europace/euaa139

AIMS: Atrial fibrillation (AF) is the most common sustained arrhythmia and an important risk factor for stroke and heart failure. We aimed to conduct a systematic review of the literature and summarize the performance of mobile health (mHealth) devic... Read More about Mobile health applications for the detection of atrial fibrillation: a systematic review..

Outcomes of COVID-19 Positive Acute Coronary Syndrome Patients; a multisource Electronic Healthcare Records Study from England. (2021)
Journal Article
Rashid, M., Wu, J., Timmis, A., Curzen, N., Clarke, S., Zaman, A., …Mamas, M. A. (2021). Outcomes of COVID-19 Positive Acute Coronary Syndrome Patients; a multisource Electronic Healthcare Records Study from England. Journal of Internal Medicine, 290(1), 88-100. https://doi.org/10.1111/joim.13246

BACKGROUND: Patients with underlying cardiovascular disease and Coronavirus disease 2019 (COVID-19) infection are at increased risk of morbidity and mortality. OBJECTIVES: This study was designed to characterise the presenting profile and outcomes... Read More about Outcomes of COVID-19 Positive Acute Coronary Syndrome Patients; a multisource Electronic Healthcare Records Study from England..

Clinical Characteristics, Management Strategies and Outcomes of Acute Myocardial Infarction Patients With Prior Coronary Artery Bypass Grafting. (2021)
Journal Article
Shoaib, A., Mohamed, M., Rashid, M., Khan, S. U., Parwani, P., Contractor, T., …Mamas, M. A. (2021). Clinical Characteristics, Management Strategies and Outcomes of Acute Myocardial Infarction Patients With Prior Coronary Artery Bypass Grafting. Mayo Clinic Proceedings, 96(1), 120 - 131. https://doi.org/10.1016/j.mayocp.2020.05.047

OBJECTIVE: To investigate the management strategies, temporal trends, and clinical outcomes of patients with a history of coronary artery bypass graft (CABG) surgery and presenting with acute myocardial infarction (MI). PATIENTS AND METHODS: We under... Read More about Clinical Characteristics, Management Strategies and Outcomes of Acute Myocardial Infarction Patients With Prior Coronary Artery Bypass Grafting..

Breaking the deadlock of calcified coronary artery lesions: A contemporary review. (2021)
Journal Article
Mamas. (2021). Breaking the deadlock of calcified coronary artery lesions: A contemporary review. Catheterization and Cardiovascular Interventions, 108 - 120. https://doi.org/10.1002/ccd.29221

Percutaneous coronary intervention (PCI) of severely calcified lesions is known to result in lower procedural success rates, higher complication rates, and worse long-term clinical outcomes compared to noncalcified lesions. Adequate lesion preparatio... Read More about Breaking the deadlock of calcified coronary artery lesions: A contemporary review..

Trial characteristics associated with under-enrolment of females in randomized controlled trials of heart failure with reduced ejection fraction: a systematic review. (2021)
Journal Article
Mamas, M. (2021). Trial characteristics associated with under-enrolment of females in randomized controlled trials of heart failure with reduced ejection fraction: a systematic review. https://doi.org/10.1002/ejhf.2034

AIMS: To evaluate temporal trends in the enrolment of females in randomized controlled trials (RCTs) of heart failure with reduced ejection fraction (HFrEF) published in high-impact journals, and assess RCT characteristics associated with under-enrol... Read More about Trial characteristics associated with under-enrolment of females in randomized controlled trials of heart failure with reduced ejection fraction: a systematic review..

Comparison of distal radial access versus standard transradial access in patients with smaller diameter radial Arteries(The distal radial versus transradial access in small transradial ArteriesStudy: D.A.T.A - S.T.A.R study). (2021)
Journal Article
Chugh, Y., Sasidhar Kanaparthy, N., Piplani, S., Chugh, S., Shroff, A., Vidovich, M., …Kumar Chugh, S. (2021). Comparison of distal radial access versus standard transradial access in patients with smaller diameter radial Arteries(The distal radial versus transradial access in small transradial ArteriesStudy: D.A.T.A - S.T.A.R study). Indian Heart Journal, 73(1), 26 - 34. https://doi.org/10.1016/j.ihj.2020.11.002

AIMS: To evaluate safety and efficacy of distal right radial access (DRRA) compared to right radial access (RRA), for coronary procedures, in patients with smaller diameter radial arteries (SDRA) (radial artery diameter (RAD) 

Place and causes of acute cardiovascular mortality during the COVID-19 pandemic (2021)
Journal Article
Mamas. (2021). Place and causes of acute cardiovascular mortality during the COVID-19 pandemic. Heart, 113-119. https://doi.org/10.1136/heartjnl-2020-317912

OBJECTIVE: To describe the place and causes of acute cardiovascular death during the COVID-19 pandemic. METHODS: Retrospective cohort of adult (age =18 years) acute cardiovascular deaths (n=5?87?225) in England and Wales, from 1 January 2014 to 30 Ju... Read More about Place and causes of acute cardiovascular mortality during the COVID-19 pandemic.

Cost of coronary syndrome treated with percutaneous coronary intervention and 30-day unplanned readmission in the United States (2021)
Journal Article
Nolan, J., Mamas, M., Kwok, C. S., Amin, A. P., Shah, B., Kinnaird, T., …Bagur, R. (2021). Cost of coronary syndrome treated with percutaneous coronary intervention and 30-day unplanned readmission in the United States. Catheterization and Cardiovascular Interventions, 97(1), 80-93. https://doi.org/10.1002/ccd.28660

Objectives: This study aimed to examine the cost of coronary syndrome treated with percutaneous coronary intervention (PCI) and 30-day unplanned readmissions. Background: There is limited understanding of the hospital cost of index PCI and 30-day... Read More about Cost of coronary syndrome treated with percutaneous coronary intervention and 30-day unplanned readmission in the United States.

Sex disparities in the choice of cardiac resynchronization therapy device utilized: an analysis of trends, predictors and outcomes. (2021)
Journal Article
Rashid, & Mamas. (2021). Sex disparities in the choice of cardiac resynchronization therapy device utilized: an analysis of trends, predictors and outcomes. Canadian Journal of Cardiology, 86-93. https://doi.org/10.1016/j.cjca.2020.02.073

Background There is limited evidence on the influence of sex on the decision to implant a cardiac resynchronization therapy device with pacemaker (CRT-P) or defibrillator (CRT-D) and the existence of sex-dependent differences in complications that m... Read More about Sex disparities in the choice of cardiac resynchronization therapy device utilized: an analysis of trends, predictors and outcomes..