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Mamas Mamas' Outputs (43)

The Global Syndemic of Modifiable Cardiovascular Risk Factors Projected From 2025 to 2050 (2025)
Journal Article
Chong, B., Jayabaskaran, J., Jauhari, S. M., Chia, J., le Roux, C. W., Mehta, A., Dimitriadis, G. K., Chen, Y., Toh, S. A., Manla, Y., Al Mahmeed, W., Chan, S. P., Goh, R., Nagarajan, S., Li, H., Kong, G., Chin, Y. H., Wang, J.-W., Chew, H. S. J., Kontopantelis, E., …Chew, N. W. (2025). The Global Syndemic of Modifiable Cardiovascular Risk Factors Projected From 2025 to 2050. Journal of the American College of Cardiology, 86(3), 165-177. https://doi.org/10.1016/j.jacc.2025.04.061

Background
Cardiovascular diseases (CVDs) are the leading cause of global mortality. Understanding epidemiologic trends in the modifiable risk factors driving CVDs is essential in designing effective countermeasur... Read More about The Global Syndemic of Modifiable Cardiovascular Risk Factors Projected From 2025 to 2050.

OP0005 CARDIOVASCULAR OUTCOMES OF TREAT-TO-TARGET VERSUS FIRE-AND-FORGET URATE-LOWERING TREATMENT IN GOUT: EMULATED TARGET TRIAL STUDIES USING LINKED ENGLISH AND SWEDISH PRIMARY CARE, HOSPITALISATION AND MORTALITY DATA (2025)
Presentation / Conference Contribution
Cipolletta, E., Zverkova Sandstrom, T., Rozza, D., Leyrat, C., Nakafero, G., Drivelegka, P., Avery, A., Mamas, M., Tata, L., Dehlin, M., & Abhishek, A. (2025, June). OP0005 CARDIOVASCULAR OUTCOMES OF TREAT-TO-TARGET VERSUS FIRE-AND-FORGET URATE-LOWERING TREATMENT IN GOUT: EMULATED TARGET TRIAL STUDIES USING LINKED ENGLISH AND SWEDISH PRIMARY CARE, HOSPITALISATION AND MORTALITY DATA. Presented at EULAR 2025: European Congress of Rheumatology, Barcelona, Spain

Background:
Gout flares are temporally associated with cardiovascular events. Treating gout to target (T2T) serum urate (SU) level prevents gout flares. Whether such treatment can prevent cardiovascular events is... Read More about OP0005 CARDIOVASCULAR OUTCOMES OF TREAT-TO-TARGET VERSUS FIRE-AND-FORGET URATE-LOWERING TREATMENT IN GOUT: EMULATED TARGET TRIAL STUDIES USING LINKED ENGLISH AND SWEDISH PRIMARY CARE, HOSPITALISATION AND MORTALITY DATA.

Combination of Suture‐Plug Vascular Closure Devices Versus Suture‐Only Devices Following Transcatheter Aortic Valve Implantation: A Systematic Review and Meta‐Analysis (2025)
Journal Article
Haddad, S., Bashour, G., & Mamas, M. A. (2025). Combination of Suture‐Plug Vascular Closure Devices Versus Suture‐Only Devices Following Transcatheter Aortic Valve Implantation: A Systematic Review and Meta‐Analysis. Catheterization and Cardiovascular Interventions, 1-10. https://doi.org/10.1002/ccd.31655

ABSTRACT
Background
Transcatheter aortic valve implantation (TAVI) is an effective and safe intervention for severe symptomatic aortic stenosis regardless of surgical risk. Vascular complications following TAVI are considered among the most common... Read More about Combination of Suture‐Plug Vascular Closure Devices Versus Suture‐Only Devices Following Transcatheter Aortic Valve Implantation: A Systematic Review and Meta‐Analysis.

Novel risk score for patients undergoing Impella-assisted high-risk percutaneous coronary intervention. (2025)
Journal Article
Lemor, A., Shah, T., Thompson, J. B., Protty, M. B., Mamas, M. A., Kinnaird, T., Bharadwaj, A. S., Truesdell, A. G., Schonning, M. J., Zhang, Y., Hussain, Y., Falah, B., Cohen, D. J., Redfors, B., Baron, S. J., Witzke, C. F., Dixon, S. R., Basir, M. B., Lansky, A. J., & O'Neill, W. W. (2025). Novel risk score for patients undergoing Impella-assisted high-risk percutaneous coronary intervention. Cardiovascular Revascularization Medicine, 75, 1-9. https://doi.org/10.1016/j.carrev.2025.05.031

High-risk percutaneous coronary intervention (HRPCI) procedures supported by percutaneous left ventricular assist devices (pLVAD) are increasingly common, but existing PCI risk scores were developed in patients across the risk spectrum, including few... Read More about Novel risk score for patients undergoing Impella-assisted high-risk percutaneous coronary intervention..

Factors Contributing to Low Utilization of Intracoronary Imaging in Clinical Practice: A White Paper (2025)
Journal Article
Escaned, J., Lombardi, M., Götberg, M., Amabile, N., Banning, A., Barbato, E., Brugaletta, S., Chen, S.-L., Doshi, D., Koo, B.-K., Kozuma, K., Mahadevan, K., Milasinovic, D., Sinning, J.-M., Toth, G., Gonzalo, N., Mamas, M. A., & Kirtane, A. J. (2025). Factors Contributing to Low Utilization of Intracoronary Imaging in Clinical Practice: A White Paper. Journal of the Society for Cardiovascular Angiography & Interventions, 103607. https://doi.org/10.1016/j.jscai.2025.103607

Intracoronary imaging (ICI) was introduced over 3 decades ago to complement conventional coronary angiography, yet its widespread uptake remains limited. This paper seeks to explore the potential causes behind low ICI utilization. The concepts of acc... Read More about Factors Contributing to Low Utilization of Intracoronary Imaging in Clinical Practice: A White Paper.

Percutaneous or surgical revascularization in patients with severe left main coronary artery disease in Latin America: A GRADE clinical practice guideline. (2025)
Journal Article
Lamelas, P., Pompeu Sá, M., Izcovich, A., Bottaro, F., Tisi Baña, M., Sosa Liprandi, M. I., Lanas, F., Vilca Mejia, O. A., Zuñiga Luna, M., Aubanel, P., Munera, A., Contreras Reyes, J., Bagur, R., Whitlock, R., Garcia Garcia, H., Mamas, M., Cohen, M. G., Ricalde, A., Abizaid, A., Mendiz, O., …Ragusa, M. A. (2025). Percutaneous or surgical revascularization in patients with severe left main coronary artery disease in Latin America: A GRADE clinical practice guideline. International Journal of Cardiology, 436(1 October 2025), Article 133401. https://doi.org/10.1016/j.ijcard.2025.133401

Severe left main coronary artery disease (LMD) poses a major treatment challenge in Latin America, where both percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are used. This guideline was developed de novo using the... Read More about Percutaneous or surgical revascularization in patients with severe left main coronary artery disease in Latin America: A GRADE clinical practice guideline..

Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Polyvascular Disease. (2025)
Journal Article
Abomoawad, A., Sedhom, R., Golwala, H., Abdelazeem, M., Mamas, M., Jneid, H., Bavry, A. A., Kumbhani, D. J., Kapadia, S., & Elbadawi, A. (2025). Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Polyvascular Disease. Cardiology and Therapy, https://doi.org/10.1007/s40119-025-00415-7

There is a paucity of data regarding the trends and comparative outcomes of transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement (SAVR) among patients with polyvascular disease (PVD). The Nationwide Readmissions Data... Read More about Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Polyvascular Disease..

Predicting mortality risk using the PREVENT equation across diverse racial groups. (2025)
Journal Article
Kobo, O., Rutter, M. K., Misra, S., Michos, E. D., Myint, P. K., Roguin, A., Sun, L. Y., & Mamas, M. A. (2025). Predicting mortality risk using the PREVENT equation across diverse racial groups. American Journal of Managed Care, 31(5), e113-e119. https://doi.org/10.37765/ajmc.2025.89734

The Predicting Risk of CVD Events (PREVENT) score offers a contemporary tool for assessing cardiovascular risk without incorporating race, which has raised concerns about its performance across diverse racial and ethnic groups. We aimed to validate t... Read More about Predicting mortality risk using the PREVENT equation across diverse racial groups..

Sex-Associated Disparities in Surgical and Percutaneous Management of Aortic Stenosis With Severe Features: Retrospective Analysis From the National Readmission Database. (2025)
Journal Article
Castaldi, G., Matetić, A., Bagur, R., Abbott, J. D., Alasnag, M., Chieffo, A., Wijeysundera, H. C., & Mamas, M. A. (2025). Sex-Associated Disparities in Surgical and Percutaneous Management of Aortic Stenosis With Severe Features: Retrospective Analysis From the National Readmission Database. Journal of the American Heart Association, 14(10), Article e038463. https://doi.org/10.1161/JAHA.124.038463

Referral for valve intervention for severe aortic stenosis (AS) may exhibit sex-associated disparities independent of the growth of transcatheter interventions. This study aimed to determine whether there were sex-associated differences in the use of... Read More about Sex-Associated Disparities in Surgical and Percutaneous Management of Aortic Stenosis With Severe Features: Retrospective Analysis From the National Readmission Database..

Closing gender gap in time delays and mortality in STEMI: insights from the ORPKI Registry (2025)
Journal Article
Doolub, G., Mamas, M. A., Malinowski, K. P., Zabojszcz, M., Dardzińska, N., Jaskulska, P., Hawranek, M., & Siudak, Z. (2025). Closing gender gap in time delays and mortality in STEMI: insights from the ORPKI Registry. Polish Archives of Internal Medicine, 135(6), https://doi.org/10.20452/pamw.17002

Introduction: Despite improvements in cardiovascular care, sex disparities persist in the outcomes of patients presenting with ST-segment elevation myocardial infarction (STEMI).

Objectives: This study aimed to investigate the change in sex-based... Read More about Closing gender gap in time delays and mortality in STEMI: insights from the ORPKI Registry.

P087 Cardioprotective effects of colchicine in people with gout: a systematic review (2025)
Presentation / Conference Contribution
Prior, J. A., Umar, Z., Ibrahim, N., Bajpai, R., Partington, R., Mamas, M., & Roddy, E. (2025, April). P087 Cardioprotective effects of colchicine in people with gout: a systematic review. Poster presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England UK

Background/Aims Colchicine is widely used in clinical practice to prevent and treat gout flares. Randomised controlled trials (RCT) have demonstrated cardiovascular benefits of colchicine in people with chronic coronary artery disease (CAD) or a rece... Read More about P087 Cardioprotective effects of colchicine in people with gout: a systematic review.

OA01 Long-term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in people with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink (2025)
Presentation / Conference Contribution
Partington, R., Muller, S., Mallen, C. D., Mamas, M. A., Forrester, H., & Roddy, E. (2025, April). OA01 Long-term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in people with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink. Presented at British Society for Rheumatology Annual Conference, Manchester Central Convention Complex, Manchester, England

Background/Aims Febuxostat is recommended as first line urate-lowering therapy (ULT) for gout in the UK. However, concerns were raised regarding its cardiovascular (CV) safety. Current guidance advises caution when using it in people with CV disease,... Read More about OA01 Long-term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in people with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink.

Association of Frailty with Readmissions and Outcomes After Impella Mechanical Circulatory Support (2025)
Journal Article
Maffey, M. W., Kuchtaruk, A. A., Damluji, A. A., García, S., Elgendy, I. Y., Villablanca, P., Moroni, F., Denicolai, M., Mamas, M. A., & Bagur, R. (2025). Association of Frailty with Readmissions and Outcomes After Impella Mechanical Circulatory Support. CJC Open, https://doi.org/10.1016/j.cjco.2025.04.011

Background
Frailty is associated with a greater risk of readmission after cardiovascular procedures. However, the impact of frailty on readmission rates and outcomes after Impella mechanical circulatory support (M... Read More about Association of Frailty with Readmissions and Outcomes After Impella Mechanical Circulatory Support.

Impact of obesity on clinical outcomes in patients with high-risk pulmonary embolism: A comparative analysis. (2025)
Journal Article
Shachar, Z., Gatuz, M. V., Folman, A., Barel, M. S., Abu-Fanne, R., Abramov, D., Mamas, M. A., Roguin, A., & Kobo, O. (2025). Impact of obesity on clinical outcomes in patients with high-risk pulmonary embolism: A comparative analysis. International Journal of Cardiology, 58, 101682. https://doi.org/10.1016/j.ijcha.2025.101682

Pulmonary embolism (PE) is a life-threatening cardiovascular condition with increasing global incidence. Obesity is a significant risk factor for PE, although its reported relationship with outcomes is inconsistent. This study aimed to investigate th... Read More about Impact of obesity on clinical outcomes in patients with high-risk pulmonary embolism: A comparative analysis..

Location of Terminal Care in Pulmonary Hypertension (2025)
Journal Article
Ibrahim, R., Habib, A., Olson, A., Shrourou, F., Pham, H. N., Abdelnabi, M., Neyestanak, M. E., Soin, S., Low, S.-W., Natt, B., Mamas, M. A., Barry, T., Ayoub, C., Arsanjani, R., Rischard, F. P., & Lee, K. (2025). Location of Terminal Care in Pulmonary Hypertension. CJC Open, 7(6), 832-839. https://doi.org/10.1016/j.cjco.2025.03.026

Background
Death locations for individuals in the US is influenced by social factors. Pulmonary hypertension (PH) is an uncommon condition, with a substantial impact on morbidity and mortality. We evaluated the patterns in and impact of demographics... Read More about Location of Terminal Care in Pulmonary Hypertension.

Impact of Socioeconomic Disparities on Care and Outcomes of Cancer Patients Presenting With STEMI Between 2005 and 2019; a Nationwide British Study (2025)
Journal Article
Dafaalla, M., Weight, N., Rashid, M., Nolan, J., & Mamas, M. A. (2025). Impact of Socioeconomic Disparities on Care and Outcomes of Cancer Patients Presenting With STEMI Between 2005 and 2019; a Nationwide British Study. Clinical Cardiology, 48(4), Article e70135. https://doi.org/10.1002/clc.70135

Background: While current evidence suggests that the clinical outcomes of STEMI are worse among patients with cancer, it is unknown what role the patient's socioeconomic status plays. Methods: A nationally linked cohort of STEMI patients (January 200... Read More about Impact of Socioeconomic Disparities on Care and Outcomes of Cancer Patients Presenting With STEMI Between 2005 and 2019; a Nationwide British Study.

Impact of Cardiovascular–Kidney–Metabolic Syndrome Staging on Myocardial Infarction Outcomes: A Retrospective Analysis of 2.7 Million Patients (2025)
Journal Article
Shabtai, R., Gatuz, M. V., Folman, A., Barel, M. S., Abu-Fanne, R., Abramov, D., Mamas, M. A., Roguin, A., & Kobo, O. (in press). Impact of Cardiovascular–Kidney–Metabolic Syndrome Staging on Myocardial Infarction Outcomes: A Retrospective Analysis of 2.7 Million Patients. Diseases, 13(4), 97. https://doi.org/10.3390/diseases13040097

Background: Cardiovascular–kidney–metabolic (CKM) syndrome, recently defined by the American Heart Association, encompasses the interplay between obesity, diabetes, chronic kidney disease, and cardiovascular disease. This study aimed to investigate t... Read More about Impact of Cardiovascular–Kidney–Metabolic Syndrome Staging on Myocardial Infarction Outcomes: A Retrospective Analysis of 2.7 Million Patients.

Invasive Versus Conservative Treatment Strategy in Older Patients With Non‐ ST Segment Elevation Acute Coronary Syndromes: A Meta‐Analysis of Randomized Controlled Trials (2025)
Journal Article
Ahmed, M., Ahsan, A., Shafiq, A., Hashmi, T. M., Ahmed, R., Alam, M., Shahid, F., Rana, J. S., Mamas, M. A., & Fonarow, G. C. (in press). Invasive Versus Conservative Treatment Strategy in Older Patients With Non‐ ST Segment Elevation Acute Coronary Syndromes: A Meta‐Analysis of Randomized Controlled Trials. Journal of the American Geriatrics Society, https://doi.org/10.1111/jgs.19447

Background: Non‐ST segment elevation acute coronary syndromes (NSTE‐ACS) are a common cause of hospital admission in older patients. Our study aims to synthesize the available evidence from randomized controlled trials (RCTs) to compare clinical outc... Read More about Invasive Versus Conservative Treatment Strategy in Older Patients With Non‐ ST Segment Elevation Acute Coronary Syndromes: A Meta‐Analysis of Randomized Controlled Trials.

Cardiovascular disease burden and risk factor management in cancer survivors: insights into a multiethnic, socioeconomically deprived urban population (2025)
Journal Article
Szabo, L., Cooper, J., Condurache, D.-G., Dostal, I., Andriamiadana, G., Mathur, R., Walter, F. M., Mamas, M. A., Manisty, C. H., Harvey, N. C., Neubauer, S., Petersen, S. E., Robson, J., & Raisi-Estabragh, Z. (2025). Cardiovascular disease burden and risk factor management in cancer survivors: insights into a multiethnic, socioeconomically deprived urban population. Heart, https://doi.org/10.1136/heartjnl-2024-325309

Background: Cardiovascular disease (CVD) burden and risk factor management among cancer survivors, especially in socioeconomically deprived, multiethnic populations, remain understudied. This study examines CVD burden and risk factor control in survi... Read More about Cardiovascular disease burden and risk factor management in cancer survivors: insights into a multiethnic, socioeconomically deprived urban population.