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Outputs (9)

In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation. (2023)
Journal Article
Mogas Barcons, A., Chari, D. M., & Adams, C. (in press). In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation. Alternatives to animal experimentation : a journal for new paths in biomedical science / edited by the Swiss Society ALTEX Edition, 41(2), 202-212. https://doi.org/10.14573/altex.2304171

Effective repair of spinal cord injury sites remains a major clinical challenge. One promising strategy is the implantation of multifunctional bioscaffolds to enhance nerve fibre growth, guide regenerating tissue and modulate scarring/inflammation pr... Read More about In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation..

Enhancing Neural Stem Cell Stimulation with Structured Piezoelectric Composites: An In Vitro Study (2023)
Journal Article
Jarkov, V., Waqar, I., Penev, A., Bowen, C., Adams, C., & Khanbareh, H. (in press). Enhancing Neural Stem Cell Stimulation with Structured Piezoelectric Composites: An In Vitro Study. Advanced engineering materials, 25(23), Article 2300696. https://doi.org/10.1002/adem.202300696

Spinal cord injuries can cause permanent tissue damage with debilitating and lasting effects on patients. Electrical stimulation has been established as an effective approach for promoting neural regeneration. However, the clinical applicability of t... Read More about Enhancing Neural Stem Cell Stimulation with Structured Piezoelectric Composites: An In Vitro Study.

Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds (2022)
Journal Article
Barcons, A. M., Chowdhury, F., Chari, D. M., & Adams, C. (2022). Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds. Materials, 16, 124 - 124. https://doi.org/10.3390/ma16010124

Spinal cord injury is debilitating with functional loss often permanent due to a lack of neuro-regenerative or neuro-therapeutic strategies. A promising approach to enhance biological function is through implantation of tissue engineered constructs,... Read More about Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds.

Electroactive Scaffolds to Improve Neural Stem Cell Therapy for Spinal Cord Injury (2022)
Journal Article
Mutepfa, A. R., Hardy, J. G., & Adams, C. F. (2022). Electroactive Scaffolds to Improve Neural Stem Cell Therapy for Spinal Cord Injury. Frontiers in Medical Technology, 4, 693438. https://doi.org/10.3389/fmedt.2022.693438

Spinal cord injury (SCI) is a serious condition caused by damage to the spinal cord through trauma or disease, often with permanent debilitating effects. Globally, the prevalence of SCI is estimated between 40 to 80 cases per million people per year.... Read More about Electroactive Scaffolds to Improve Neural Stem Cell Therapy for Spinal Cord Injury.

Enhancing the regenerative potential of stem cell-laden, clinical-grade implants through laminin engineering (2021)
Journal Article
Mogas Barcons, A., Chari, D., & Adams, C. (2021). Enhancing the regenerative potential of stem cell-laden, clinical-grade implants through laminin engineering. Materials Science and Engineering: C, 123, https://doi.org/10.1016/j.msec.2021.111931

Protected delivery of neural stem cells (NSCs; a major transplant population) within bioscaffolds has the potential to improve regenerative outcomes in sites of spinal cord injury. Emergent research has indicated clinical grade bioscaffolds (e.g. tho... Read More about Enhancing the regenerative potential of stem cell-laden, clinical-grade implants through laminin engineering.

Quantum Sensing in a Physiological-Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers. (2019)
Journal Article
Adams, C., Mather, M., Radu, V., Simpson, D., Barcons, A., Price, J., & Levett, S. (2019). Quantum Sensing in a Physiological-Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers. Small, 15(22), e1900455. https://doi.org/10.1002/smll.201900455

Fluorescent nanodiamonds (fNDs) containing nitrogen vacancy (NV) centers are promising candidates for quantum sensing in biological environments. This work describes the fabrication and implementation of electrospun poly lactic-co-glycolic acid (PLGA... Read More about Quantum Sensing in a Physiological-Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers..

Development and characterisation of neurocompatible transfection grade magnetic nanoparticles for genetic modification of neural stem cells (2016)
Journal Article
Chari, & Adams. (2016). Development and characterisation of neurocompatible transfection grade magnetic nanoparticles for genetic modification of neural stem cells. Advanced healthcare materials, 841-849. https://doi.org/10.1002/adhm.201500885

Genetic modification of cell transplant populations and cell tracking ability are key underpinnings for effective cell therapies. Current strategies to achieve these goals utilize methods which are unsuitable for clinical translation because of relat... Read More about Development and characterisation of neurocompatible transfection grade magnetic nanoparticles for genetic modification of neural stem cells.

The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products (2015)
Journal Article
Rafiq, Q. A., Ortega, I., Jenkins, S. I., Wilson, S. L., Patel, A. K., Barnes, A. L., …Smith, D. (2015). The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products. Regenerative Medicine, 989 -1003. https://doi.org/10.2217/rme.15.56

Although the importance of translation for the development of tissue engineering, regenerative medicine and cell-based therapies is widely recognized, the process of translation is less well understood. This is particularly the case among some early... Read More about The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products.