Christopher Adams' Outputs (25)

Development of Multifunctional Magnetic Nanoparticles for Genetic Engineering and Tracking of Neural Stem Cells (2016)
Journal Article
Adams, C., Israel, L. L., Ostrovsky, S., Taylor, A., Poptani, H., Lellouche, J., & Chari, D. (2016). Development of Multifunctional Magnetic Nanoparticles for Genetic Engineering and Tracking of Neural Stem Cells. Advanced healthcare materials, 5(7), 841-849. https://doi.org/10.1002/adhm.201500885

Genetic modification of cell transplant populations and cell tracking ability are key underpinnings for effective cell therapies. Current strategies to achieve these goals utilize methods which are unsuitable for clinical translation because of relat... Read More about Development of Multifunctional Magnetic Nanoparticles for Genetic Engineering and Tracking of Neural Stem Cells.

The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products (2015)
Journal Article
Rafiq, Q. A., Ortega, I., Jenkins, S. I., Wilson, S. L., Patel, A. K., Barnes, A. L., …Smith, D. (2015). The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products. Regenerative Medicine, 989 -1003. https://doi.org/10.2217/rme.15.56

Although the importance of translation for the development of tissue engineering, regenerative medicine and cell-based therapies is widely recognized, the process of translation is less well understood. This is particularly the case among some early... Read More about The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products.

Deploying clinical grade magnetic nanoparticles with magnetic fields to magnetolabel neural stem cells in adherent versus suspension cultures (2015)
Journal Article
Weinberg, D., Adams, C., & Chari, D. (2015). Deploying clinical grade magnetic nanoparticles with magnetic fields to magnetolabel neural stem cells in adherent versus suspension cultures. RSC advances, 5, 43353-43360. https://doi.org/10.1039/c5ra07481a

Neural stem cells (NSCs) have a high therapeutic potential for patients with neurological disease/injury given their neuroregenerative and immunomodulatory capabilities. In recent years, magnetic nanoparticles (MNPs) have been used as contrast agents... Read More about Deploying clinical grade magnetic nanoparticles with magnetic fields to magnetolabel neural stem cells in adherent versus suspension cultures.

Using magnetic nanoparticles for gene transfer to neural stem cells: stem cell propagation method influences outcomes (2015)
Journal Article
Pickard, M., Adams, C., Barraud, P., & Chari, D. (2015). Using magnetic nanoparticles for gene transfer to neural stem cells: stem cell propagation method influences outcomes. Journal of Functional Biomaterials, 6, 259-279. https://doi.org/10.3390/jfb6020259

Genetically engineered neural stem cell (NSC) transplants offer a key strategy to augment neural repair by releasing therapeutic biomolecules into injury sites. Genetic modification of NSCs is heavily reliant on viral vectors but cytotoxic effects ha... Read More about Using magnetic nanoparticles for gene transfer to neural stem cells: stem cell propagation method influences outcomes.

Magnetic nanoparticle mediated transfection of neural stem cell suspension cultures is enhanced by applied oscillating magnetic fields. (2013)
Journal Article
Adams, C., Pickard, M., & Chari, D. (2013). Magnetic nanoparticle mediated transfection of neural stem cell suspension cultures is enhanced by applied oscillating magnetic fields. Nanomedicine, 9, 737--741. https://doi.org/10.1016/j.nano.2013.05.014

UNLABELLED: Safe genetic modification of neural stem cell (NSC) transplant populations is a key goal for regenerative neurology. We describe a technically simple and safe method to increase transfection in NSCs propagated in the neurosphere (suspensi... Read More about Magnetic nanoparticle mediated transfection of neural stem cell suspension cultures is enhanced by applied oscillating magnetic fields..