Sarah Lawton's Outputs (51)

Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol [version 1; peer review: awaiting peer review] (2025)
Journal Article
Ashworth, J., Cornwall, N., Harrisson, S. A., Woodcock, C., Nicholls, E., Hughes, G., Marshall, E., Lawton, S. A., Wathall, S., Helliwell, T., Jowett, S., Avery, A. J., Knaggs, R., Hussain, B., Santer, M., Pincus, T., White, S., Sillitto, C., Jinks, C., & Mallen, C. D. (2025). Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol [version 1; peer review: awaiting peer review]. NIHR Open Research, 5(54), https://doi.org/10.3310/nihropenres.13961.1

Background
Addressing the need for evidence-based interventions to reduce opioid use for persistent pain, we developed the PROMPPT intervention (Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clini... Read More about Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol [version 1; peer review: awaiting peer review].

Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England (2025)
Journal Article
Lawton, S. A., Mallen, C., Chew-Graham, C., Kingstone, T., Muller, S., Lewis, S., Bajpai, R., & Helliwell, T. (2025). Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England. BMJ Open, 15(6), 1-7. https://doi.org/10.1136/bmjopen-2024-095040

To examine the number of patients screening positive for depression, while self-completing an automated check-in screen prior to a general practice consultation. A descriptive cross-sectional study. 10 general practices in the West Midlands, England.... Read More about Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England.

Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial (2025)
Other
Thomas, M. J., Hughes, G., Cooke, K., Butler-Walley, S., Marshall, E., Bowyer, L., Wathall, S., Smith, J., Lawton, S. A., Brammar, J., Burnett, T., Drake, C., Foster, N. E., Hendry, G. J., Holden, M. A., Jaki, T., Joseph, R., Keenan, A.-M., Kigozi, J., Lewis, M., …Roddy, E. (2025). Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial

Plantar heel pain (PHP) is the most common soft tissue foot condition and impairs mobility, physical function, ability to work, and quality of life. Systematic reviews highlight a need for high-quality randomised controlled trials (RCTs) of exercises... Read More about Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial.

Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation (2025)
Journal Article
A Harrisson, S., Myers, H., Wynne Jones, G., Bajpai, R., Bratt, C., Burton, C., Harrison, R., Jowett, S., A Lawton, S., Saunders, B., J Beard, D., Bucknall, M., Chester, R., Heneghan, C., Huckfield, L., Lewis, M., D Mallen, C., Pincus, T., L Rees, J., Roddy, E., & A Van der Windt, D. (2025). Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation. BMJ Open, 15(5), https://doi.org/10.1136/bmjopen-2025-100501

Introduction: Musculoskeletal shoulder pain is a common reason for people to be treated in physiotherapy services, but diagnosis can be difficult and often does not guide treatment or predict outcome. People with shoulder pain cite a need for clear i... Read More about Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation.

Physiotherapists' Experiences and Perceived Acceptability of Delivering a Knee Bracing Intervention for People With Symptomatic Knee Osteoarthritis in a Randomised Trial (PROP OA): A Qualitative Study (2024)
Journal Article
Bullock, L., Holden, M. A., Jinks, C., Atiah Asamane, E., Herron, D., Borrelli, B., Callaghan, M. J., Birrell, F., Halliday, N., Marshall, M., Sowden, G., Ingram, C., McBeth, J., Dziedzic, K., Foster, N. E., Jowett, S., Lawton, S., Mallen, C. D., & Peat, G. (2024). Physiotherapists' Experiences and Perceived Acceptability of Delivering a Knee Bracing Intervention for People With Symptomatic Knee Osteoarthritis in a Randomised Trial (PROP OA): A Qualitative Study. Musculoskeletal Care, 22(4), Article e70021. https://doi.org/10.1002/msc.70021

Objectives: To explore physiotherapists' experiences and perceived acceptability of delivering a bracing intervention for knee osteoarthritis (OA) in the ‘PROvision of braces for Patients with knee OA’ (PROP OA) randomised controlled trial. Method: S... Read More about Physiotherapists' Experiences and Perceived Acceptability of Delivering a Knee Bracing Intervention for People With Symptomatic Knee Osteoarthritis in a Randomised Trial (PROP OA): A Qualitative Study.

Association of air pollution from a landfill site with primary care consultation (2024)
Preprint / Working Paper
Jordan, K. P., Muller, S., Usman, M., Bailey, J., Burton, C., Lawton, S. A., Mallen, C. D., Mason, K. J., Wathall, S., & van der Windt, D. A. Association of air pollution from a landfill site with primary care consultation

Background Waste landfill sites are associated with gaseous emissions and this air pollution can cause unpleasant smells (“malodour”). This causes concerns about its impact on the health of the local population. This study assessed change in general... Read More about Association of air pollution from a landfill site with primary care consultation.

Protocol for the Work And Vocational advicE (WAVE) randomised controlled trial testing the addition of vocational advice to usual primary care (Clinical Trials: NCT04543097) (2024)
Preprint / Working Paper
Wynne-Jones, G., Lewis, M., Sowden, G., Madan, I., Walker-Bone, K., Chew-Graham, C., Bromley, K., Jowett, S., Parsons, V., Mansell, G., Cooke, K., Lawton, S., Saunders, B., Pemberton, J., Cooper, C., & Foster, N. Protocol for the Work And Vocational advicE (WAVE) randomised controlled trial testing the addition of vocational advice to usual primary care (Clinical Trials: NCT04543097)

Objectives To investigate the effectiveness of adding a brief vocational advice intervention to usual care in reducing the number of days absent from work over a period of 6 months in adults given a fit note by their general practice.

Design Multi... Read More about Protocol for the Work And Vocational advicE (WAVE) randomised controlled trial testing the addition of vocational advice to usual primary care (Clinical Trials: NCT04543097).

The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study (2024)
Journal Article
Mughal, F., Chew-Graham, C. A., Saunders, B., Lawton, S. A., Lewis, S., Smith, J., Lancaster, G., Townsend, E., Armitage, C. J., Bower, P., Kapur, N., Kessler, D., Realpe, A. X., Wiles, N., Ougrin, D., & Lewis, M. (2024). The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study. NIHR Open Research, 4(27), https://doi.org/10.3310/nihropenres.13576.1

Background
Self-harm in young people is a growing concern and reducing rates a global priority. General practitioners (GPs) can intervene early after self-harm but there are no effective treatments presently available. We developed the GP-led COPING... Read More about The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study.

775 BRACING ACCEPTABILITY AND ADHERENCE FOR KNEE OSTEOARTHRITIS: FINDINGS FROM A QUALITATIVE STUDY IN THE PROP-OA MULTICENTRE TRIAL (2024)
Presentation / Conference Contribution
Jinks, C., Holden, M., Asaname, E., Bullock, L., Herron, D., Halliday, N., Armitt, G., Bathers, S., Birrell, F., Borrelli, B., Browell, R., Callaghan, M. J., Dobb, K., Dziedzic, K. S., Felson, D., Foster, N., Hartshorne, E., Huckfield, L., Humphries, K., Ingram, C., …Peat, G. (2024, April). 775 BRACING ACCEPTABILITY AND ADHERENCE FOR KNEE OSTEOARTHRITIS: FINDINGS FROM A QUALITATIVE STUDY IN THE PROP-OA MULTICENTRE TRIAL. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England (2024)
Journal Article
Lawton, S., Mallen, C., Hussain, Z., Bajpai, R., Muller, S., Holmstrom, C., Jinks, C., & Helliwell, T. (2024). Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England. BMJ Open, 14(4), Article e083816. https://doi.org/10.1136/bmjopen-2023-083816

Objectives: To determine General Practice (GP) recording of carer status and the number of patients self-identifying as carers, while self-completing an automated check-in screen prior to a GP consultation.

Design: A descriptive cross-sectional st... Read More about Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England.

Undertaking multi-centre randomised controlled trials in primary care: learnings and recommendations from the PULsE-AI trial researchers (2024)
Journal Article
Pollock, K. G., Dickerson, C., Kainth, M., Lawton, S., Hurst, M., Sugrue, D. M., Arden, C., Davies, D. W., Martin, A.-C., Sandler, B., Gordon, J., Farooqui, U., Clifton, D., Mallen, C., Rogers, J., Hill, N. R., Camm, A. J., & Cohen, A. T. (2024). Undertaking multi-centre randomised controlled trials in primary care: learnings and recommendations from the PULsE-AI trial researchers. BMC Primary Care, 25(1), Article 7. https://doi.org/10.1186/s12875-023-02246-8

Background
Conducting effective and translational research can be challenging and few trials undertake formal reflection exercises and disseminate learnings from them. Following completion of our multicentre randomised controlled trial, which was im... Read More about Undertaking multi-centre randomised controlled trials in primary care: learnings and recommendations from the PULsE-AI trial researchers.

The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study. (2024)
Journal Article
Mughal, F., Chew-Graham, C. A., Saunders, B., Lawton, S. A., Lewis, S., Smith, J., Lancaster, G., Townsend, E., Armitage, C. J., Bower, P., Kapur, N., Kessler, D., Realpe, A. X., Wiles, N., Ougrin, D., & Lewis, M. (2024). The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study. NIHR Open Research, 4, https://doi.org/10.3310/nihropenres.13576.2

BackgroundSelf-harm in young people is a growing concern and reducing rates a global priority. Rates of self-harm documented in general practice have been increasing for young people in the UK in the last two decades, especially in 13-16-year-olds. G... Read More about The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study..

Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol. (2023)
Journal Article
Faux-Nightingale, A., Burton, C., Twohig, H., Bucknall, M., Carroll, W., Chew-Graham, C., Dunn, K., Gilchrist, F., Helliwell, T., Lawton, O., Lawton, S., Mallen, C., Saunders, B., Van Der Windt, D., & Welsh, V. (2023). Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol. British Journal of General Practice Open (BJGP Open), 7(2), Article BJGPO20220149. https://doi.org/10.3399/bjgpo.2022.0149

Background: While there is a substantial body of knowledge about acute COVID-19, less is known about long-COVID, where symptoms continue beyond 4 weeks.

Aim: To describe longer-term effects of COVID-19 infection in children and young people (CYP)... Read More about Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol..

Investigating the usefulness of Automated Check-in Data Collection in general practice (AC DC Study): a multicentre, cross-sectional study in England. (2023)
Journal Article
Lawton, S., Mallen, C., Muller, S., Wathall, S., & Helliwell, T. (2023). Investigating the usefulness of Automated Check-in Data Collection in general practice (AC DC Study): a multicentre, cross-sectional study in England. BMJ Open, 13(1), Article e062389. https://doi.org/10.1136/bmjopen-2022-062389

Objectives: To investigate the usefulness of using automated appointment check-in screens to collect brief research data from patients, prior to their general practice consultation.

Design: A descriptive, cross-sectional study.

Setting: Nine ge... Read More about Investigating the usefulness of Automated Check-in Data Collection in general practice (AC DC Study): a multicentre, cross-sectional study in England..

Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care (2022)
Journal Article
Watson, L., Belcher, J., Nicholls, E., Chandratre, P., Blagojevic-Bucknall, M., Hider, S., Lawton, S. A., Mallen, C. D., Muller, S., Rome, K., & Roddy, E. (2022). Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care. Rheumatology, 62(8), 2748-2756. https://doi.org/10.1093/rheumatology/keac706

Objective To describe factors associated with change in health-related quality of life (HRQOL) in people living with gout in primary care. Methods In a UK prospective cohort study, adults with a diagnosis of gout registered with 20 general practices... Read More about Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care.

The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study (2022)
Journal Article
Muller, S., Hider, S. L., Hider, S., Ranasinghe, . P., Helliwell, T., Lawton, S. A., Lawton, S., Protheroe, W., Mallen, C. D., & Mallen, C. (2022). The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study. Rheumatology Advances in Practice, 6(3), https://doi.org/10.1093/rap/rkac070

Objectives To determine the impact of polymyalgia rheumatica (PMR) on intimate and sexual relationships over time. Methods The PMR Cohort study (UKCRN ID16477) is a longitudinal study of patients with incident PMR in English primary care. Participant... Read More about The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study.

Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: cost-effectiveness of a screening strategy evaluated in a randomized controlled trial in England (2022)
Journal Article
Hill, N. R., Groves, L., Dickerson, C., Boyce, R., Lawton, S., Hurst, M., Pollock, K. G., Sugrue, D. M., Lister, S., Arden, C., Davies, D. W., Martin, A.-C., Sandler, B., Gordon, J., Farooqui, U., Clifton, D., Mallen, C., Rogers, J., Camm, A. J., & Cohen, A. T. (2022). Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: cost-effectiveness of a screening strategy evaluated in a randomized controlled trial in England. https://doi.org/10.1080/13696998.2022.2102355

OBJECTIVE: The PULsE-AI trial sought to determine the effectiveness of a screening strategy that included a machine learning risk prediction algorithm in conjunction with diagnostic testing for identification of undiagnosed atrial fibrillation (AF) i... Read More about Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: cost-effectiveness of a screening strategy evaluated in a randomized controlled trial in England.

Long-term use of glucocorticoids for polymyalgia rheumatica: follow-up of the PMR Cohort Study (2022)
Journal Article
Muller, S., Hider, S. L., Sokhal, B. S., Lawton, S. A., Helliwell, T., & Mallen, C. D. (2022). Long-term use of glucocorticoids for polymyalgia rheumatica: follow-up of the PMR Cohort Study. Rheumatology Advances in Practice, 6(2), Article rkac034. https://doi.org/10.1093/rap/rkac034

Objectives PMR is a common inflammatory condition in older adults, characterized by bilateral hip and shoulder pain and stiffness. Reducing oral glucocorticoids, classically used for <= 2 years, are the mainstay of treatment. This study considers the...

Clinical trial management: a profession in crisis? (2022)
Journal Article
Mitchell, E., Goodman, K., Wakefield, N., Cochran, C., Cockayne, S., Connolly, S., Desai, R., Hartley, S., Lawton, S., Oatey, K., Rhodes, S., Savage, J., Taylor, J., & Youssouf, N. (2022). Clinical trial management: a profession in crisis?. Trials, 23(1), Article ARTN 357. https://doi.org/10.1186/s13063-022-06315-8

Clinical trial managers play a vital role in the design and conduct of clinical trials in the UK. There is a current recruitment and retention crisis for this specialist role due to a complex set of factors, most likely to have come to a head due to... Read More about Clinical trial management: a profession in crisis?.

Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: a multi-centre randomised controlled trial in England (2022)
Journal Article
Hill, N. R., Groves, L., Dickerson, C., Ochs, A., Pang, D., Lawton, S., Hurst, M., Pollock, K. G., Sugrue, D. M., Tsang, C., Arden, C., Wyn Davies, D., Celine Martin, A., Sandler, B., Gordon, J., Farooqui, U., Clifton, D., Mallen, C., Rogers, J., John Camm, A., & Cohen, A. T. (2022). Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: a multi-centre randomised controlled trial in England. European Heart Journal, S111 - S111. https://doi.org/10.1093/ehjdh/ztac009