Outputs (26)

The Duration of Oxygen and Glucose Deprivation (OGD) Determines the Effects of Subsequent Reperfusion on Rat Pheochromocytoma (PC12) Cells and Primary Cortical Neurons (2023)
Journal Article

Reperfusion is the fundamental treatment for ischaemic stroke; however, many ischaemic stroke patients cannot undergo reperfusion treatment. Furthermore, reperfusion can cause ischaemic reperfusion injuries. This study aimed to determine the effects... Read More about The Duration of Oxygen and Glucose Deprivation (OGD) Determines the Effects of Subsequent Reperfusion on Rat Pheochromocytoma (PC12) Cells and Primary Cortical Neurons.

Astrocytic aquaporin 4 subcellular translocation as a therapeutic target for cytotoxic edema in ischemic stroke. (2022)
Journal Article

Editorial: Neuroinflammation in hypoxia and ischaemia (2022)
Journal Article

Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture (2022)
Journal Article

Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment. The aim of this study is t... Read More about Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture.

Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain. (2021)
Journal Article

BACKGROUND: Alzheimer's disease (AD) is a progressive, degenerative, and terminal disease without cure. There is an urgent need for a new strategy to treat AD. The aim of this study was to investigate the effects of intermittent hypoxic treatment (IH... Read More about Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain..

Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury (2021)
Journal Article

AbstractDegenerative cervical myelopathy (DCM) is a common non-traumatic spinal cord disorder and characterized by progressive neurological impairment. Generally, it is still underdiagnosed and referral to spine specialists is often late, when patien... Read More about Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury.

Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke (2021)
Journal Article

Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and cognitive deficits. Despite promising pre-clinical studies, clinically appr... Read More about Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke.

Hypoxia in Alzheimer’s disease: effects of hypoxia inducible factors (2021)
Journal Article

Perspective article.

characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons (2020)
Journal Article

Preconditioning tissue with sublethal ischaemia or hypoxia can confer tolerance (protection) against subsequent ischaemic challenge. In vitro ischaemic preconditioning (IPC) is typically achieved through oxygen glucose deprivation (OGD), whereas hypo... Read More about characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons.

Author Correction: Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model (2020)
Journal Article

Pharmacological properties of rutin and its potential uses for Alzheimer’s disease. (2020)
Journal Article

Rutin, a flavonoid with a wide range of biological activities, has a long history of use in nutritional supplements owing to its action against oxidative stress, inflammation, and hyperglycemia. Because of its pharmacological properties such as antio... Read More about Pharmacological properties of rutin and its potential uses for Alzheimer’s disease..

Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. (2020)
Journal Article

Microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke. Microglia become "activated", proliferating, and undergoing changes in morphology, gene and prot... Read More about Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy..

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model (2020)
Journal Article

This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary rat neurons following oxygen-glucose deprivation (OGD). At 100 µM, the PHD inhibitors did not cause cytotoxicity and apo... Read More about Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.

Editorial: The Development of New Classes of Hypoxia Mimetic Agents for Clinical Use. (2019)
Journal Article

Editorial

Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors. (2018)
Journal Article

Hypoxia inducible factor (HIF) is the master oxygen sensor within cells and is central to the regulation of cell responses to varying oxygen levels. HIF activation during hypoxia ensures optimum ATP production and cell integrity, and is associated bo... Read More about Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors..

Proteomic analysis of age-related changes in ovine cerebrospinal fluid (2018)
Journal Article

Cerebrospinal fluid (CSF) circulates through the brain and has a unique composition reflecting the biological processes of the brain. Identifying ageing CSF biomarkers can aid in understanding the ageing process and interpreting CSF protein changes i... Read More about Proteomic analysis of age-related changes in ovine cerebrospinal fluid.

Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice (2017)
Journal Article

Abstract High altitude cerebral edema (HACE) is a life-threatening illness that develops during the rapid ascent to high altitudes, but its underlying mechanisms remain unclear. Growing evidence has implicated inflammation in the susceptibility to an... Read More about Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice.

Effects of transthyretin on thyroxine and ß-amyloid removal from cerebrospinal fluid in mice. (2016)
Journal Article

Transthyretin (TTR) is a binding protein for the thyroid hormone thyroxine (T4 ), retinol and ß-amyloid peptide. TTR aids the transfer of T4 from the blood to the cerebrospinal fluid (CSF), but also prevents T4 loss from the blood-CSF barrier. It is... Read More about Effects of transthyretin on thyroxine and ß-amyloid removal from cerebrospinal fluid in mice..

Socioeconomic deprivation and survival after stroke in China: a systematic literature review and a new population-based cohort study (2015)
Journal Article

OBJECTIVE: To assess the association of socioeconomic deprivation (SED) with survival after stroke in China. DESIGN: A systematic literature review and a new population-based cohort study. SETTING AND PARTICIPANTS: In urban and rural communities in A... Read More about Socioeconomic deprivation and survival after stroke in China: a systematic literature review and a new population-based cohort study.

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice (2014)
Journal Article

This study investigated the effects of 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetic acid (IOX3), a selective small molecule inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylases, on mouse brains subject to transient focal cerebra... Read More about HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.

Changes of synovial fluid protein concentrations in supra-patellar bursitis patients after the injection of different molecular weights of hyaluronic acid (2014)
Journal Article

Knee pain is commonly seen in orthopedic and rehabilitation outpatient clinical settings, and in the aging population. Bursitis of the knee joint, especially when the volume of the synovial fluid is large enough, can compress and distend the nearby s... Read More about Changes of synovial fluid protein concentrations in supra-patellar bursitis patients after the injection of different molecular weights of hyaluronic acid.

Determinants for undetected dementia and late-life depression (2013)
Journal Article

Background Determinants for undetected dementia and late-life depression have been not well studied. Aims To investigate risk factors for undetected dementia and depression in older communities. Method Using the method of the 10/66 algorithm... Read More about Determinants for undetected dementia and late-life depression.

Editorial (Current and Emerging Pharmacological Therapies of Ischaemic Stroke) (2013)
Journal Article

Stroke is a form of cardiovascular disease affecting blood supply to the brain. About 87% of strokes are ischemic, and the remainder are haemorrhagic. Ischaemic stroke is caused by the obstruction of blood flow in a brain artery leading to the lack o... Read More about Editorial (Current and Emerging Pharmacological Therapies of Ischaemic Stroke).

Stroke syndromes and clinical management (2013)
Journal Article

The knowledge of brain syndromes is essential for stroke physicians and neurologists, particularly those that can be extremely difficult and challenging to diagnose due to the great variability of symptom presentation and yet of clinical significance... Read More about Stroke syndromes and clinical management.

Stem cell therapy for ischaemic stroke: translation from preclinical studies to clinical treatment (2013)
Journal Article

No pharmacological intervention has been shown convincingly to improve neurological outcome in stroke patients after the brain tissue is infarcted. While conventional therapeutic strategies focus on preventing brain damage, stem cell treatment has th... Read More about Stem cell therapy for ischaemic stroke: translation from preclinical studies to clinical treatment.

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy (2013)
Journal Article

Previous attempts to identify neuroprotective targets by studying the ischemic cascade and devising ways to suppress it have failed to translate to efficacious therapies for acute ischemic stroke1. We hypothesized that studying the molecular determin... Read More about Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy.