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Ruoli Chen's Outputs (29)

Inhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: Go broad or go narrow? (2024)
Journal Article
Kawa, H., Ahmed, Z., Majid, A., & Chen, R. (in press). Inhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: Go broad or go narrow?. Neuropharmacology, 262, Article 110192. https://doi.org/10.1016/j.neuropharm.2024.110192

Ischaemic stroke characterises impulsive cerebral-region hypoxia due to deep intracerebral arteriole blockage, often accompanied by permanent cerebral infarction and cognitive impairment. Thrombolysis with recombinant tissue plasminogen activator (rt... Read More about Inhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: Go broad or go narrow?.

Update on the intriguing roles of AQP4 expression and redistribution in the progression and treatment of glioma (2024)
Journal Article
Lan, Y.-L., Zou, S., & Chen, R. (2024). Update on the intriguing roles of AQP4 expression and redistribution in the progression and treatment of glioma. Annals of Medicine, 56(1), https://doi.org/10.1080/07853890.2024.2401111

Aquaporin 4 (AQP4) isabundant in the human brain and has an important role in brain homeostatsis and diseases. AQP4 expression has been found to be associated with glioma malignancies. However, the complete understanding of the biological processes... Read More about Update on the intriguing roles of AQP4 expression and redistribution in the progression and treatment of glioma.

A novel neuronal circuit: Tanycytes mediate defensive metabolic responses following acute high‐temperature exposure (2024)
Journal Article
Chen, Q., Brüning‐Richardson, A., Chen, R., Zou, S., & Lan, Y. (2024). A novel neuronal circuit: Tanycytes mediate defensive metabolic responses following acute high‐temperature exposure. Brain-X, 2(3), 1-3. https://doi.org/10.1002/brx2.70003

The core body temperature, plays a vital role in influencing metabolic rate, enzyme activity, and various other physiological processes.1 Significant progress has been achieved in unraveling the neural mechanisms responsible for lowering body tempera... Read More about A novel neuronal circuit: Tanycytes mediate defensive metabolic responses following acute high‐temperature exposure.

The Duration of Oxygen and Glucose Deprivation (OGD) Determines the Effects of Subsequent Reperfusion on Rat Pheochromocytoma (PC12) Cells and Primary Cortical Neurons (2023)
Journal Article
Chen, R., & Singh, A. (2023). The Duration of Oxygen and Glucose Deprivation (OGD) Determines the Effects of Subsequent Reperfusion on Rat Pheochromocytoma (PC12) Cells and Primary Cortical Neurons. International Journal of Molecular Sciences, 24(8), Article 7106. https://doi.org/10.3390/ijms24087106

Reperfusion is the fundamental treatment for ischaemic stroke; however, many ischaemic stroke patients cannot undergo reperfusion treatment. Furthermore, reperfusion can cause ischaemic reperfusion injuries. This study aimed to determine the effects... Read More about The Duration of Oxygen and Glucose Deprivation (OGD) Determines the Effects of Subsequent Reperfusion on Rat Pheochromocytoma (PC12) Cells and Primary Cortical Neurons.

Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture (2022)
Journal Article
Chen, R., Ahmed, M. A., & Forsyth, N. R. (2022). Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture. Biomolecules, 12(4), 541. https://doi.org/10.3390/biom12040541

Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment. The aim of this study is t... Read More about Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture.

Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain. (2021)
Journal Article
Chen. (2021). Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain. Alzheimer's Research and Therapy, 194 - ?. https://doi.org/10.1186/s13195-021-00935-z

BACKGROUND: Alzheimer's disease (AD) is a progressive, degenerative, and terminal disease without cure. There is an urgent need for a new strategy to treat AD. The aim of this study was to investigate the effects of intermittent hypoxic treatment (IH... Read More about Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain..

Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury (2021)
Journal Article
Chen. (2021). Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury. Spinal Cord, 1216 - 1218. https://doi.org/10.1038/s41393-021-00711-8

<jats:title>Abstract</jats:title><jats:p>Degenerative cervical myelopathy (DCM) is a common non-traumatic spinal cord disorder and characterized by progressive neurological impairment. Generally, it is still underdiagnosed and referral to spine speci... Read More about Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury.

Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke (2021)
Journal Article
Patabendige, A., Singh, A., Jenkins, S., Sen, J., & Chen, R. (2021). Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke. International Journal of Molecular Sciences, 22(8), https://doi.org/10.3390/ijms22084280

Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and cognitive deficits. Despite promising pre-clinical studies, clinically appr... Read More about Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke.

characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons (2020)
Journal Article
Singh, A., Chow, O., Jenkins, S., Zhu, L., Rose, E., Astbury, K., & Chen, R. (2021). characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons. Neuroscience, 453, Article 17-31. https://doi.org/10.1016/j.neuroscience.2020.11.008

Preconditioning tissue with sublethal ischaemia or hypoxia can confer tolerance (protection) against subsequent ischaemic challenge. In vitro ischaemic preconditioning (IPC) is typically achieved through oxygen glucose deprivation (OGD), whereas hypo... Read More about characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons.

Pharmacological properties of rutin and its potential uses for Alzheimer’s disease. (2020)
Journal Article
Chen, R., Hassan, H., Rawlinson, C., & Morgan, D. (2020). Pharmacological properties of rutin and its potential uses for Alzheimer’s disease. Journal of Experimental Stroke and Translational Medicine, 13(2), 1-12

Rutin, a flavonoid with a wide range of biological activities, has a long history of use in nutritional supplements owing to its action against oxidative stress, inflammation, and hyperglycemia. Because of its pharmacological properties such as antio... Read More about Pharmacological properties of rutin and its potential uses for Alzheimer’s disease..

Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. (2020)
Journal Article
Rawlinson, C., Jenkins, S., Thei, L., Dallas, M., & Chen, R. (2020). Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. Brain Sciences, 10(3), https://doi.org/10.3390/brainsci10030159

Microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke. Microglia become "activated", proliferating, and undergoing changes in morphology, gene and prot... Read More about Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy..

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model (2020)
Journal Article
Chen. (2020). Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model. Scientific reports, https://doi.org/10.1038/s41598-020-58482-w

This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary rat neurons following oxygen-glucose deprivation (OGD). At 100 µM, the PHD inhibitors did not cause cytotoxicity and apo... Read More about Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.

Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors. (2018)
Journal Article
Chen. (2018). Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors. Frontiers in Cell and Developmental Biology, -. https://doi.org/10.3389/fcell.2018.00132

Hypoxia inducible factor (HIF) is the master oxygen sensor within cells and is central to the regulation of cell responses to varying oxygen levels. HIF activation during hypoxia ensures optimum ATP production and cell integrity, and is associated bo... Read More about Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors..

Proteomic analysis of age-related changes in ovine cerebrospinal fluid (2018)
Journal Article
Chen, C., Preston, J., Zhou, S., Fuller, H., Morgan, D., & Chen, R. (2018). Proteomic analysis of age-related changes in ovine cerebrospinal fluid. Experimental Gerontology, 108, 181-188. https://doi.org/10.1016/j.exger.2018.04.012

Cerebrospinal fluid (CSF) circulates through the brain and has a unique composition reflecting the biological processes of the brain. Identifying ageing CSF biomarkers can aid in understanding the ageing process and interpreting CSF protein changes i... Read More about Proteomic analysis of age-related changes in ovine cerebrospinal fluid.

Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice (2017)
Journal Article
Chen. (2017). Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice. Brain, Behavior, and Immunity, 226-275. https://doi.org/10.1016/j.bbi.2017.04.013

Abstract High altitude cerebral edema (HACE) is a life-threatening illness that develops during the rapid ascent to high altitudes, but its underlying mechanisms remain unclear. Growing evidence has implicated inflammation in the susceptibility to an... Read More about Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice.