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Sara Muller's Outputs (145)

Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum (2024)
Journal Article
Scott, I. C., Daud, N., Bailey, J., Twohig, H., Hider, S. L., Mallen, C. D., …Muller, S. (in press). Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum. BMC Medicine, 22(1), 575. https://doi.org/10.1186/s12916-024-03774-5

Background: Gabapentinoids are increasingly prescribed in inflammatory arthritis (IA), despite no trial evidence for efficacy at managing pain in this population. Observational studies in non-IA populations suggest gabapentinoids are associated with... Read More about Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum.

Association of air pollution from a landfill site with primary care consultation (2024)
Working Paper
Jordan, K. P., Muller, S., Usman, M., Bailey, J., Burton, C., Lawton, S. A., …van der Windt, D. A. Association of air pollution from a landfill site with primary care consultation

Background Waste landfill sites are associated with gaseous emissions and this air pollution can cause unpleasant smells (“malodour”). This causes concerns about its impact on the health of the local population. This study assessed change in general... Read More about Association of air pollution from a landfill site with primary care consultation.

Temporal Trends in Parkinson’s Disease Related Mortality from 1999-2020: A National Analysis [version 1; peer review: awaiting peer review] (2024)
Journal Article
Singh Sokhal, B., Prasanna Kumar Menon, S., Shepherd, T., Muller, S., Arora, A., & Mallen, C. (2024). Temporal Trends in Parkinson’s Disease Related Mortality from 1999-2020: A National Analysis [version 1; peer review: awaiting peer review]. NIHR Open Research, https://doi.org/10.3310/nihropenres.13623.1

Introduction
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder and is associated with significant disability. The prevalence is rising, and studies have reported potential sex and race disparities in patient outcomes. D... Read More about Temporal Trends in Parkinson’s Disease Related Mortality from 1999-2020: A National Analysis [version 1; peer review: awaiting peer review].

2235 National Trends in motor neurone disease-associated mortality from 1999–2020 (2024)
Journal Article
Imantalab, D., Sokhal, B., Menon, S., Kara, S., Muller, S., & Mallen, C. (2024). 2235 National Trends in motor neurone disease-associated mortality from 1999–2020. Age and ageing, 53(Supplement_3), https://doi.org/10.1093/ageing/afae139.074

Introduction Motor Neurone Disease (MND) is a neurodegenerative condition affecting the spinal cord and brainstem, commonly associated with a reduced life expectancy. This study describes demographic trends in MND-associated mortality in the United S... Read More about 2235 National Trends in motor neurone disease-associated mortality from 1999–2020.

2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study (2024)
Journal Article
Sokhal, B., Menon, S., Shepherd, T., Muller, S., Arora, A., & Mallen, C. (2024). 2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study. Age and ageing, 53(Supplement_3), iii19. https://doi.org/10.1093/ageing/afae139.073

Introduction Parkinson’s disease (PD) is the most common neurodegenerative movement disorder and is associated with significant disability. The prevalence of PD is increasing and the literature demonstrates potential sex and race disparities in patie... Read More about 2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study.

The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica (2024)
Journal Article
Scott, I. C., Bajpai, R., Hider, S. L., Helliwell, T., Mallen, C. D., & Muller, S. (in press). The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica. Rheumatology Advances in Practice, 8(3), Article rkae081. https://doi.org/10.1093/rap/rkae081

Objective
To examine the association between obesity and patient-reported outcomes measures (PROMs) in a primary care-based cohort of people with polymyalgia rheumatica (PMR).

Methods
The PMR Cohort Study recruited people with incident PMR from... Read More about The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica.

AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM (2024)
Journal Article
Scott, I., Daud, N., Bailey, J., Twohig, H., Hider, S., Mallen, C., …Muller, S. (2024). AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM. Annals of the Rheumatic Diseases, 83(Issue Suppl 1), https://doi.org/10.1136/annrheumdis-2024-eular.4000

associate with an increased risk of fractures. The potential for confounding inherent to non-randomised studies of interventions, however, alongside the conflicting findings of these studies (with some reporting an increased risk [1] and others no re... Read More about AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM.

E041 Feasibility and acceptability of electronic patient reported outcome measures in the routine care of people with inflammatory arthritis: Haywood Arthritis Portal study (2024)
Presentation / Conference
Cox, N., Kettle, C., Wang, H., Dutta, S., Packham, J., Galloway, J., …Scott, I. C. (2024, April). E041 Feasibility and acceptability of electronic patient reported outcome measures in the routine care of people with inflammatory arthritis: Haywood Arthritis Portal study. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Electronic patient-reported outcome measures (ePROMs) assessing disease activity, function, pain, and quality of life can facilitate innovative inflammatory arthritis (IA) care, such as automating patient-initiated follow-up. This mix... Read More about E041 Feasibility and acceptability of electronic patient reported outcome measures in the routine care of people with inflammatory arthritis: Haywood Arthritis Portal study.

P187 Fatigue in people with polymyalgia rheumatica: a key unmet need? (2024)
Presentation / Conference
Muller, S., Belcher, J., Hider, S., Helliwell, T., & Mallen, C. D. (2024, April). P187 Fatigue in people with polymyalgia rheumatica: a key unmet need?. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Polymyalgia rheumatica (PMR) is common in older adults, causing severe pain and stiffness, particularly in the shoulder and hip girdles. Glucocorticoids treatment generally focusses on reducing pain and stiffness, but there are other... Read More about P187 Fatigue in people with polymyalgia rheumatica: a key unmet need?.

P185 Anatomical patterns of pain in primary care patients with polymyalgia rheumatica compared to the general population (2024)
Presentation / Conference
Hammad, N., Partington, R., Hider, S., Butt, H., Helliwell, T., Mallen, C., & Muller, S. (2024, April). P185 Anatomical patterns of pain in primary care patients with polymyalgia rheumatica compared to the general population. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Polymyalgia rheumatica (PMR) is common in older adults, causing severe pain and stiffness, particularly in the shoulder and hip girdles. A tapered course of glucocorticoids is recommended, but not always straightforward, with frequent... Read More about P185 Anatomical patterns of pain in primary care patients with polymyalgia rheumatica compared to the general population.

Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study (2024)
Journal Article
Bajpai, R., Partington, R., Muller, S., Forrester, H., Mallen, C. D., Clarson, L., …Roddy, E. (2024). Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study. Rheumatology, Article keae229. https://doi.org/10.1093/rheumatology/keae229

Objectives
Colchicine is commonly used to prevent flares when starting urate-lowering therapy for gout. Patients with gout are frequently concurrently prescribed other medications (such as statins) that may interact with colchicine, increasing the r... Read More about Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study.

Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England (2024)
Journal Article
Lawton, S., Mallen, C., Hussain, Z., Bajpai, R., Muller, S., Holmstrom, C., …Helliwell, T. (2024). Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England. BMJ Open, 14(4), Article e083816. https://doi.org/10.1136/bmjopen-2023-083816

Objectives: To determine General Practice (GP) recording of carer status and the number of patients self-identifying as carers, while self-completing an automated check-in screen prior to a GP consultation.

Design: A descriptive cross-sectional st... Read More about Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England.

Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study. (2024)
Journal Article
Muller, S., Bailey, J., Bajpai, R., Helliwell, T., Harrisson, S. A., Whittle, R., …Ashworth, J. (in press). Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study. PAIN, https://doi.org/10.1097/j.pain.0000000000003239

Growing evidence from pharmacovigilance data and postmortem toxicology reports highlights the misuse potential of gabapentinoids. This study aimed to investigate the risk of serious adverse outcomes (drug misuse, overdose, major trauma), and their ri... Read More about Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study..

Health Literacy and Gout Characteristics in a Primary Care Cohort (2024)
Journal Article
Watson, L., Protheroe, J., Mallen, C., Muller, S., & Roddy, E. (2024). Health Literacy and Gout Characteristics in a Primary Care Cohort. Rheumatology Advances in Practice, 8(2), Article rkae034. https://doi.org/10.1093/rap/rkae034

Objectives
To examine the cross-sectional association between health literacy and gout characteristics.

Methods
In a primary care cohort of adults living with gout, the prevalence of poor health literacy was defined using the Single-Item Literac... Read More about Health Literacy and Gout Characteristics in a Primary Care Cohort.

Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink (2023)
Journal Article
Scott, I. C., Jordan, K. P., Twohig, H., Whittle, R., Muller, S., Hider, S. L., …Bailey, J. (2023). Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink. Rheumatology, Article kead463. https://doi.org/10.1093/rheumatology/kead463

Despite little evidence that analgesics are effective in inflammatory arthritis (IA), studies report substantial opioid prescribing. The extent this applies to other analgesics is uncertain. We undertook a comprehensive evaluation of analgesic prescr... Read More about Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink.

Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink (2023)
Journal Article
Roddy, E., Bajpai, R., Forrester, H., James Partington, R., D Mallen, C., Clarson, L. E., …Muller, S. (2023). Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, ard-2023-224154. https://doi.org/10.1136/ard-2023-224154

Objectives:
To determine the risk of adverse events associated with colchicine or non-steroidal anti-inflammatory drug (NSAID) prophylaxis when initiating allopurinol for gout.

Methods:
We conducted two matched retrospective cohort studies in... Read More about Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink.

The relationship between pain and depression and anxiety in patients with inflammatory arthritis: a systematic review protocol (2023)
Journal Article
Cox, N., Hawarden, A., Bajpai, R., Farooq, S., Twohig, H., Muller, S., & Scott, I. C. (2024). The relationship between pain and depression and anxiety in patients with inflammatory arthritis: a systematic review protocol. Rheumatology International, 44, 435–440. https://doi.org/10.1007/s00296-023-05450-y

Pain is a major challenge for patients with inflammatory arthritis (IA). Depression and anxiety are common comorbidities in IA, associating with worse outcomes. How they relate to pain is uncertain, with existing systematic reviews (a) mainly conside... Read More about The relationship between pain and depression and anxiety in patients with inflammatory arthritis: a systematic review protocol.

Test-retest reliability of pain VAS/NRS, stiffness VAS/NRS, HAQ-DI and mHAQ in polymyalgia rheumatica: An OMERACT study (2023)
Journal Article
Leung, J. L., Twohig, H., Muller, S., Maxwell, L., Mackie, S. L., Neill, L. M., & Owen, C. E. (2023). Test-retest reliability of pain VAS/NRS, stiffness VAS/NRS, HAQ-DI and mHAQ in polymyalgia rheumatica: An OMERACT study. Seminars in Arthritis and Rheumatism, 62, 152239. https://doi.org/10.1016/j.semarthrit.2023.152239


Objective
To examine the test-retest reliability of four measurement instruments in polymyalgia rheumatica (PMR): pain severity visual analogue scale (VAS) / numerical rating score (NRS), stiffness severity VAS/NR... Read More about Test-retest reliability of pain VAS/NRS, stiffness VAS/NRS, HAQ-DI and mHAQ in polymyalgia rheumatica: An OMERACT study.

P098 Changes in Analgesic Prescribing in Patients with Inflammatory Arthritis in England: An Observational Study in CPRD Aurum (2023)
Presentation / Conference
C Scott, I., Whittle, R., Bailey, J., Twohig, H., L Hider, S., D Mallen, C., …P Jordan, K. (2023, April). P098 Changes in Analgesic Prescribing in Patients with Inflammatory Arthritis in England: An Observational Study in CPRD Aurum. Poster presented at British Society for Rheumatology Annual Conference 2023, Manchester Central Convention Complex, Manchester, UK

Background/Aims
Pain is a common symptom experienced by patients with inflammatory arthritis (IA). Emerging data indicate IA pain treatment focuses on prescribing analgesics despite an absence of evidence for long-term efficacy. Delivering optimal,... Read More about P098 Changes in Analgesic Prescribing in Patients with Inflammatory Arthritis in England: An Observational Study in CPRD Aurum.