Outputs (5)

In vitro model of traumatic brain injury to screen neuro-regenerative biomaterials (2021)
Journal Article
Basit, R., Tzerakis, N., Jenkins, S., & Chari, D. M. (2021). In vitro model of traumatic brain injury to screen neuro-regenerative biomaterials. Materials Science and Engineering: C, 112253 - 112253. https://doi.org/10.1016/j.msec.2021.112253

Penetrating traumatic brain injury (pTBI) causes serious neurological deficits with no clinical regenerative therapies currently available. Tissue engineering strategies using biomaterial-based ‘structural bridges’ offer high potential to promote neu... Read More about In vitro model of traumatic brain injury to screen neuro-regenerative biomaterials.

Developing a New Strategy for Delivery of Neural Transplant Populations Using Precursor Cell Sprays and Specialized Cell Media (2021)
Journal Article
Woods, W. A., Chowdhury, F., Tzerakis, N., Adams, C. F., & Chari, D. M. (2021). Developing a New Strategy for Delivery of Neural Transplant Populations Using Precursor Cell Sprays and Specialized Cell Media. Advanced NanoBiomed Research, 1(9), 2100051 - 2100051. https://doi.org/10.1002/anbr.202100051

Neural precursor/stem cell transplantation therapies promote regeneration in neurological injuries, but current cell delivery methods have drawbacks. These include risks with surgical microinjection (e.g., hemorrhage, embolism) and high cell loss wit... Read More about Developing a New Strategy for Delivery of Neural Transplant Populations Using Precursor Cell Sprays and Specialized Cell Media.

Stem cell sprays for neurological injuries: a perspective (2021)
Journal Article
Woods, W., Evans, D., Mogas Barcons, A., Tzerakis, N., Adams, C., & Chari, D. (2021). Stem cell sprays for neurological injuries: a perspective. Emerging Topics in Life Sciences, https://doi.org/10.1042/ETLS20210113

Injuries to the brain and spinal cord have major clinical consequences with high costs for healthcare systems. Neural cell transplantation therapies have significant translational potential to promote regeneration post-injury with clinical trials com... Read More about Stem cell sprays for neurological injuries: a perspective.

Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury (2021)
Journal Article
Prager, J., Ito, D., Carwardine, D. R., Jiju, P., Chari, D. M., Granger, N., & Wong, L. (2021). Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury. Experimental Neurology, 1- 14. https://doi.org/10.1016/j.expneurol.2021.113660

Spinal cord injury (SCI) can cause chronic paralysis and incontinence and remains a major worldwide healthcare burden, with no regenerative treatment clinically available. Intraspinal transplantation of olfactory ensheathing cells (OECs) and injectio... Read More about Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury.

Enhancing the regenerative potential of stem cell-laden, clinical-grade implants through laminin engineering (2021)
Journal Article
Mogas Barcons, A., Chari, D., & Adams, C. (2021). Enhancing the regenerative potential of stem cell-laden, clinical-grade implants through laminin engineering. Materials Science and Engineering: C, 123, https://doi.org/10.1016/j.msec.2021.111931

Protected delivery of neural stem cells (NSCs; a major transplant population) within bioscaffolds has the potential to improve regenerative outcomes in sites of spinal cord injury. Emergent research has indicated clinical grade bioscaffolds (e.g. tho... Read More about Enhancing the regenerative potential of stem cell-laden, clinical-grade implants through laminin engineering.