Skip to main content

Research Repository

Advanced Search

Jan Kuiper's Outputs (80)

POS0992 PARIS STUDY: POTENTIAL BIOMARKERS PREDICTING RESPONSE TO TNFI IN PSORIATIC ARTHRITIS (2025)
Presentation / Conference Contribution
Makos, A., Grime, H., Amarasena, R., Kuiper, J., & Kehoe, O. POS0992 PARIS STUDY: POTENTIAL BIOMARKERS PREDICTING RESPONSE TO TNFI IN PSORIATIC ARTHRITIS. Presented at EULAR 2024, Vienna, Austria

Background:
Psoriatic Arthritis (PsA) is a complex immune-mediated disease. TNF inhibitors (TNFi) are the first-line biologic drugs to treat PsA, targeting soluble TNF-α (sTNF) and membrane-bound TNF-α (mTNF). TNF... Read More about POS0992 PARIS STUDY: POTENTIAL BIOMARKERS PREDICTING RESPONSE TO TNFI IN PSORIATIC ARTHRITIS.

A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation (2024)
Journal Article
Orfanos, G., McCarthy, H. S., Williams, M., Dugard, N., Gallacher, P. D., Glover, A. W., Roberts, S., Wright, K. T., & Kuiper, J. H. (2024). A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation. Cartilage, https://doi.org/10.1177/19476035241279943

Objective
Traditional autologous chondrocyte implantation (ACI) involves arthroscopically harvesting a cartilage biopsy (stage 1), followed by arthrotomy 3-4 weeks later to apply a periosteal patch and implant culture-expanded chondrocytes underneat... Read More about A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation.

Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome (2024)
Journal Article
Tierney, L., Kuiper, J. H., Roberts, S., Snow, M., Williams, M., Harrington, M. B., Harrison, P., Gallacher, P., Jermin, P., & Wright, K. T. (in press). Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1002/ksa.12433

Purpose
To investigate patient demographic, injury and surgery/treatment-associated factors that can influence the patient-reported outcome (Lysholm score), following autologous chondrocyte implantation (ACI) in a large, ‘real-world’, nonuniform, pr... Read More about Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome.

A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation (2024)
Journal Article
Campbell, K., Naire, S., & Kuiper, J.-H. (2024). A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation. Journal of Theoretical Biology, Article 111874. https://doi.org/10.1016/j.jtbi.2024.111874

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation.

Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1 (2024)
Journal Article
Campbell, K., Naire, S., & Kuiper, J.-H. (2024). Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1. Journal of Theoretical Biology, 592,

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1.

284 Lower Cell Number Implanted is Consistently Associated with Improved Functional Outcome Post-Autologous Chondrocyte Implantation in Longitudinal Multilevel Modelling Analyses. (2024)
Presentation / Conference Contribution
Kuiper, J. H., Dewan, V., Tierney, L., Roberts, S., Harrison, P., Gallacher, P., Jermin, P., Snow, M., & Wright, K. T. (2024, April). 284 Lower Cell Number Implanted is Consistently Associated with Improved Functional Outcome Post-Autologous Chondrocyte Implantation in Longitudinal Multilevel Modelling Analyses. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

275 PATIENTS LIVING IN AREAS OF HIGHER SOCIOECONOMIC AREA DEPRIVATION HAVE SIGNIFICANTLY POORER PATIENT-REPORTED OUTCOMES FOLLOWING AUTOLOGOUS CHONDROCYTE IMPLANTATION IN THE UNITED KINGDOM (2024)
Presentation / Conference Contribution
Ismael, S., McCarthy, H. S., Williams, M., Barnett, A., Gallacher, P., Jermin, P., Richardson, J., Wright, K. T., Roberts, S., & Kuiper, J. H. (2024, April). 275 PATIENTS LIVING IN AREAS OF HIGHER SOCIOECONOMIC AREA DEPRIVATION HAVE SIGNIFICANTLY POORER PATIENT-REPORTED OUTCOMES FOLLOWING AUTOLOGOUS CHONDROCYTE IMPLANTATION IN THE UNITED KINGDOM. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Assessment of the effectiveness of weight-adjusted antibiotic administration, for reduced duration, in surgical prophylaxis of primary hip and knee arthroplasty. (2024)
Journal Article
Okoro, T., Wan, M., Mukabeta, T. D., Malev, E., Gross, M., Williams, C., Manjra, M., Kuiper, J. H., & Murnaghan, J. (in press). Assessment of the effectiveness of weight-adjusted antibiotic administration, for reduced duration, in surgical prophylaxis of primary hip and knee arthroplasty. World Journal of Orthopedics, 15(2), 170-179. https://doi.org/10.5312/wjo.v15.i2.170

Prophylactic antibiotics have significantly led to a reduction in the risk of post-operative surgical site infections (SSI) in orthopaedic surgery. The aim of using antibiotics for this purpose is to achieve serum and tissue drug levels that exceed,... Read More about Assessment of the effectiveness of weight-adjusted antibiotic administration, for reduced duration, in surgical prophylaxis of primary hip and knee arthroplasty..

Circumferential Periosteal Release to Treat Paediatric Leg Length Discrepancy: Medium Term Outcomes. (2023)
Journal Article
Chatterton, B. D., Kuiper, J. H., & Williams, D. P. (2023). Circumferential Periosteal Release to Treat Paediatric Leg Length Discrepancy: Medium Term Outcomes. Strategies in Trauma and Limb Reconstruction, 18(2), 67-72. https://doi.org/10.5005/jp-journals-10080-1591

This study aims to report the medium term outcomes of circumferential periosteal release of the distal femur and distal tibia in treating paediatric leg length discrepancy (LLD). A retrospective case series was performed on all patients undergoing ci... Read More about Circumferential Periosteal Release to Treat Paediatric Leg Length Discrepancy: Medium Term Outcomes..

Comparison of Knee Articular Cartilage Defect Size Between Measurements Obtained on Preoperative MRI Versus During Arthrotomy (2023)
Journal Article
Perry, J., Kuiper, J. H., McCarthy, H. S., Jermin, P., Gallacher, P. D., Tins, B., & Roberts, S. (2023). Comparison of Knee Articular Cartilage Defect Size Between Measurements Obtained on Preoperative MRI Versus During Arthrotomy. Orthopaedic Journal of Sports Medicine, 11(9), Article 23259671231193380. https://doi.org/10.1177/23259671231193380

Background:
Treatment decisions for cartilage defects are often based on lesion size. Magnetic resonance imaging (MRI) is widely used to diagnose cartilage defects noninvasively; however, their size estimated from MRI may differ from defect sizes me... Read More about Comparison of Knee Articular Cartilage Defect Size Between Measurements Obtained on Preoperative MRI Versus During Arthrotomy.

Survival analysis in nonagenarian patients with non-hip lower limb fractures. (2023)
Journal Article
Narayana Murthy, S., Cheruvu, M. S., Siddiqui, R. S., Sharma, N., Dass, D., & Ali, A. (in press). Survival analysis in nonagenarian patients with non-hip lower limb fractures. World Journal of Orthopedics, 14(8), 621-629. https://doi.org/10.5312/wjo.v14.i8.621

The United Kingdom has an aging population with nearly 1 in 5 being over the age of 65, and over 0.5 million over the age of 90. The treatment of acute fractures of the lower limb in the nonagenarian cohort of patients poses a technical challenge to... Read More about Survival analysis in nonagenarian patients with non-hip lower limb fractures..

Mid-term outcome of superior capsular reconstruction using doubled acellular human dermal allograft for irreparable rotator cuff tear (2023)
Journal Article
Snow, M., Kuiper, J. H., Thimmegowda, A., Ramsingh, V., Haikal, M., & Amit, P. (2023). Mid-term outcome of superior capsular reconstruction using doubled acellular human dermal allograft for irreparable rotator cuff tear. Journal of Shoulder and Elbow Surgery, https://doi.org/10.1016/j.jse.2023.06.007

Purpose
Thicker (folded) facia lata autografts have been shown to be superior to thinner grafts and single-layered acellular human dermal (HD) allografts for superior capsular reconstruction (SCR) in biomechanical studies. The aim of this study was... Read More about Mid-term outcome of superior capsular reconstruction using doubled acellular human dermal allograft for irreparable rotator cuff tear.

AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA (2023)
Presentation / Conference Contribution
Tierney, L., Kuiper, J., Williams, M., Roberts, S., Harrison, P., Gallacher, P., Jermin, P., Snow, M., & Wright, K. (2022, September). AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA

The objectives of the study were to investigate demographic, injury and surgery/treatment-associated factors that could influence clinical outcome, following Autologous Chondrocyte Implantation (ACI) in a large, “real-world”, 20 year longitudinally c... Read More about AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA.

MEASURING OSTEOARTHRITIS KNEE NOCICEPTION USING PHYSIOLOGICAL AND MOVEMENT RESPONSES AND A DEFINED THERMAL STIMULUS: A PROOF OF CONCEPT STUDY (2023)
Presentation / Conference Contribution
Hamilton, R., Holt, C., Hamilton, D., Garcia, A., Graham, C., Jones, R., Shilabeer, D., Kuiper, J., Sparkes, V., Khot, S., & Mason, D. (2022, September). MEASURING OSTEOARTHRITIS KNEE NOCICEPTION USING PHYSIOLOGICAL AND MOVEMENT RESPONSES AND A DEFINED THERMAL STIMULUS: A PROOF OF CONCEPT STUDY

Mechanical loading of joints with osteoarthritis (OA) results in pain-related functional impairment, altered joint mechanics and physiological nociceptor interactions leading to an experience of pain. However, the current tools to measure this are la... Read More about MEASURING OSTEOARTHRITIS KNEE NOCICEPTION USING PHYSIOLOGICAL AND MOVEMENT RESPONSES AND A DEFINED THERMAL STIMULUS: A PROOF OF CONCEPT STUDY.

Functional outcomes after Medial Patellofemoral Ligament Reconstruction show inverted J-shaped relation with Body Mass Index (2023)
Journal Article
Sharma, N., Al-Mouazzen, L., Kuiper, J. H., Gallacher, P., & Barnett, A. (in press). Functional outcomes after Medial Patellofemoral Ligament Reconstruction show inverted J-shaped relation with Body Mass Index. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1007/s00167-023-07391-2

Purpose
Medial patellofemoral ligament reconstruction (MPFL-R) is a recognised surgical procedure for the treatment of recurrent patellofemoral instability with excellent outcomes reported. The aim of this study is to determine if body mass index ca... Read More about Functional outcomes after Medial Patellofemoral Ligament Reconstruction show inverted J-shaped relation with Body Mass Index.

A pilot randomised controlled trial assessing standard versus dermal patch-augmented rotator cuff repair found no adverse effects and suggest future trials need a minimum of 150 patients (2023)
Journal Article
Snow, M., Kuiper, J. H., James, S., Keeling, E., Rich, S., & Amit, P. (in press). A pilot randomised controlled trial assessing standard versus dermal patch-augmented rotator cuff repair found no adverse effects and suggest future trials need a minimum of 150 patients. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1007/s00167-023-07356-5

The aims of this pilot randomised controlled trial (RCT) were to assess the safety and efficacy of a human dermal allograft patch and assess the feasibility of a future RCT comparing retear rate and functional outcome 12 months following standard and... Read More about A pilot randomised controlled trial assessing standard versus dermal patch-augmented rotator cuff repair found no adverse effects and suggest future trials need a minimum of 150 patients.

Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee. (2023)
Journal Article
Kuiper. (2023). Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee. Orthopaedic Journal of Sports Medicine, 23259671231151925 - ?. https://doi.org/10.1177/23259671231151925

BACKGROUND: Increased activity level is generally reported to be positively related to improved knee function after knee surgery. However, little research has been conducted into this relationship on an individual patient basis, or the influence of d... Read More about Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee..