Skip to main content

Research Repository

Advanced Search

Jan Kuiper's Outputs (78)

Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome (2024)
Journal Article
Tierney, L., Kuiper, J. H., Roberts, S., Snow, M., Williams, M., Harrington, M. B., …Wright, K. T. (in press). Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1002/ksa.12433

Purpose
To investigate patient demographic, injury and surgery/treatment-associated factors that can influence the patient-reported outcome (Lysholm score), following autologous chondrocyte implantation (ACI) in a large, ‘real-world’, nonuniform, pr... Read More about Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome.

A randomised controlled trial comparing ‘early’ versus ‘late’ periosteal patch attachment to knee chondral defects in autologous chondrocyte implantation (2024)
Journal Article
Kuiper, J. (in press). A randomised controlled trial comparing ‘early’ versus ‘late’ periosteal patch attachment to knee chondral defects in autologous chondrocyte implantation. Cartilage, https://doi.org/10.1177/19476035241279943

Objective
Traditional autologous chondrocyte implantation (ACI) involves arthroscopically harvesting a cartilage biopsy (stage 1), followed by arthrotomy 3-4 weeks later to apply a periosteal patch and implant culture-expanded chondrocytes underneat... Read More about A randomised controlled trial comparing ‘early’ versus ‘late’ periosteal patch attachment to knee chondral defects in autologous chondrocyte implantation.

A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation (2024)
Journal Article
Campbell, K., Naire, S., & Kuiper, J.-H. (2024). A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation. Journal of Theoretical Biology, Article 111874. https://doi.org/10.1016/j.jtbi.2024.111874

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation.

Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1 (2024)
Journal Article
Campbell, K., Naire, S., & Kuiper, J.-H. (2024). Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1. Journal of Theoretical Biology, 592,

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1.

284 Lower Cell Number Implanted is Consistently Associated with Improved Functional Outcome Post-Autologous Chondrocyte Implantation in Longitudinal Multilevel Modelling Analyses. (2024)
Presentation / Conference
Kuiper, J. H., Dewan, V., Tierney, L., Roberts, S., Harrison, P., Gallacher, P., …Wright, K. T. (2024, April). 284 Lower Cell Number Implanted is Consistently Associated with Improved Functional Outcome Post-Autologous Chondrocyte Implantation in Longitudinal Multilevel Modelling Analyses. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

275 PATIENTS LIVING IN AREAS OF HIGHER SOCIOECONOMIC AREA DEPRIVATION HAVE SIGNIFICANTLY POORER PATIENT-REPORTED OUTCOMES FOLLOWING AUTOLOGOUS CHONDROCYTE IMPLANTATION IN THE UNITED KINGDOM (2024)
Presentation / Conference
Ismael, S., McCarthy, H. S., Williams, M., Barnett, A., Gallacher, P., Jermin, P., …Kuiper, J. H. (2024, April). 275 PATIENTS LIVING IN AREAS OF HIGHER SOCIOECONOMIC AREA DEPRIVATION HAVE SIGNIFICANTLY POORER PATIENT-REPORTED OUTCOMES FOLLOWING AUTOLOGOUS CHONDROCYTE IMPLANTATION IN THE UNITED KINGDOM. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Assessment of the effectiveness of weight-adjusted antibiotic administration, for reduced duration, in surgical prophylaxis of primary hip and knee arthroplasty. (2024)
Journal Article
Okoro, T., Wan, M., Mukabeta, T. D., Malev, E., Gross, M., Williams, C., …Murnaghan, J. (in press). Assessment of the effectiveness of weight-adjusted antibiotic administration, for reduced duration, in surgical prophylaxis of primary hip and knee arthroplasty. World Journal of Orthopedics, 15(2), 170-179. https://doi.org/10.5312/wjo.v15.i2.170

Prophylactic antibiotics have significantly led to a reduction in the risk of post-operative surgical site infections (SSI) in orthopaedic surgery. The aim of using antibiotics for this purpose is to achieve serum and tissue drug levels that exceed,... Read More about Assessment of the effectiveness of weight-adjusted antibiotic administration, for reduced duration, in surgical prophylaxis of primary hip and knee arthroplasty..

Circumferential Periosteal Release to Treat Paediatric Leg Length Discrepancy: Medium Term Outcomes. (2023)
Journal Article
Chatterton, B. D., Kuiper, J. H., & Williams, D. P. (2023). Circumferential Periosteal Release to Treat Paediatric Leg Length Discrepancy: Medium Term Outcomes. Strategies in Trauma and Limb Reconstruction, 18(2), 67-72. https://doi.org/10.5005/jp-journals-10080-1591

This study aims to report the medium term outcomes of circumferential periosteal release of the distal femur and distal tibia in treating paediatric leg length discrepancy (LLD). A retrospective case series was performed on all patients undergoing ci... Read More about Circumferential Periosteal Release to Treat Paediatric Leg Length Discrepancy: Medium Term Outcomes..

Comparison of Knee Articular Cartilage Defect Size Between Measurements Obtained on Preoperative MRI Versus During Arthrotomy (2023)
Journal Article
Perry, J., Kuiper, J. H., McCarthy, H. S., Jermin, P., Gallacher, P. D., Tins, B., & Roberts, S. (2023). Comparison of Knee Articular Cartilage Defect Size Between Measurements Obtained on Preoperative MRI Versus During Arthrotomy. Orthopaedic Journal of Sports Medicine, 11(9), Article 23259671231193380. https://doi.org/10.1177/23259671231193380

Background:
Treatment decisions for cartilage defects are often based on lesion size. Magnetic resonance imaging (MRI) is widely used to diagnose cartilage defects noninvasively; however, their size estimated from MRI may differ from defect sizes me... Read More about Comparison of Knee Articular Cartilage Defect Size Between Measurements Obtained on Preoperative MRI Versus During Arthrotomy.

Survival analysis in nonagenarian patients with non-hip lower limb fractures. (2023)
Journal Article
Narayana Murthy, S., Cheruvu, M. S., Siddiqui, R. S., Sharma, N., Dass, D., & Ali, A. (in press). Survival analysis in nonagenarian patients with non-hip lower limb fractures. World Journal of Orthopedics, 14(8), 621-629. https://doi.org/10.5312/wjo.v14.i8.621

The United Kingdom has an aging population with nearly 1 in 5 being over the age of 65, and over 0.5 million over the age of 90. The treatment of acute fractures of the lower limb in the nonagenarian cohort of patients poses a technical challenge to... Read More about Survival analysis in nonagenarian patients with non-hip lower limb fractures..

Mid-term outcome of superior capsular reconstruction using doubled acellular human dermal allograft for irreparable rotator cuff tear (2023)
Journal Article
Snow, M., Kuiper, J. H., Thimmegowda, A., Ramsingh, V., Haikal, M., & Amit, P. (2023). Mid-term outcome of superior capsular reconstruction using doubled acellular human dermal allograft for irreparable rotator cuff tear. Journal of Shoulder and Elbow Surgery, https://doi.org/10.1016/j.jse.2023.06.007

Purpose
Thicker (folded) facia lata autografts have been shown to be superior to thinner grafts and single-layered acellular human dermal (HD) allografts for superior capsular reconstruction (SCR) in biomechanical studies. The aim of this study was... Read More about Mid-term outcome of superior capsular reconstruction using doubled acellular human dermal allograft for irreparable rotator cuff tear.

AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA (2023)
Conference Proceeding
Tierney, L., Kuiper, J., Williams, M., Roberts, S., Harrison, P., Gallacher, P., …Wright, K. (2023). AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA. . https://doi.org/10.1302/1358-992x.2023.9.075

The objectives of the study were to investigate demographic, injury and surgery/treatment-associated factors that could influence clinical outcome, following Autologous Chondrocyte Implantation (ACI) in a large, “real-world”, 20 year longitudinally c... Read More about AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA.

MEASURING OSTEOARTHRITIS KNEE NOCICEPTION USING PHYSIOLOGICAL AND MOVEMENT RESPONSES AND A DEFINED THERMAL STIMULUS: A PROOF OF CONCEPT STUDY (2023)
Conference Proceeding
Hamilton, R., Holt, C., Hamilton, D., Garcia, A., Graham, C., Jones, R., …Mason, D. (2023). MEASURING OSTEOARTHRITIS KNEE NOCICEPTION USING PHYSIOLOGICAL AND MOVEMENT RESPONSES AND A DEFINED THERMAL STIMULUS: A PROOF OF CONCEPT STUDY. . https://doi.org/10.1302/1358-992x.2023.8.020

Mechanical loading of joints with osteoarthritis (OA) results in pain-related functional impairment, altered joint mechanics and physiological nociceptor interactions leading to an experience of pain. However, the current tools to measure this are la... Read More about MEASURING OSTEOARTHRITIS KNEE NOCICEPTION USING PHYSIOLOGICAL AND MOVEMENT RESPONSES AND A DEFINED THERMAL STIMULUS: A PROOF OF CONCEPT STUDY.

Functional outcomes after Medial Patellofemoral Ligament Reconstruction show inverted J-shaped relation with Body Mass Index (2023)
Journal Article
Sharma, N., Al-Mouazzen, L., Kuiper, J. H., Gallacher, P., & Barnett, A. (in press). Functional outcomes after Medial Patellofemoral Ligament Reconstruction show inverted J-shaped relation with Body Mass Index. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1007/s00167-023-07391-2

Purpose
Medial patellofemoral ligament reconstruction (MPFL-R) is a recognised surgical procedure for the treatment of recurrent patellofemoral instability with excellent outcomes reported. The aim of this study is to determine if body mass index ca... Read More about Functional outcomes after Medial Patellofemoral Ligament Reconstruction show inverted J-shaped relation with Body Mass Index.

A pilot randomised controlled trial assessing standard versus dermal patch-augmented rotator cuff repair found no adverse effects and suggest future trials need a minimum of 150 patients (2023)
Journal Article
Snow, M., Kuiper, J. H., James, S., Keeling, E., Rich, S., & Amit, P. (in press). A pilot randomised controlled trial assessing standard versus dermal patch-augmented rotator cuff repair found no adverse effects and suggest future trials need a minimum of 150 patients. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1007/s00167-023-07356-5

The aims of this pilot randomised controlled trial (RCT) were to assess the safety and efficacy of a human dermal allograft patch and assess the feasibility of a future RCT comparing retear rate and functional outcome 12 months following standard and... Read More about A pilot randomised controlled trial assessing standard versus dermal patch-augmented rotator cuff repair found no adverse effects and suggest future trials need a minimum of 150 patients.

Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee. (2023)
Journal Article
Kuiper. (2023). Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee. Orthopaedic Journal of Sports Medicine, 23259671231151925 - ?. https://doi.org/10.1177/23259671231151925

BACKGROUND: Increased activity level is generally reported to be positively related to improved knee function after knee surgery. However, little research has been conducted into this relationship on an individual patient basis, or the influence of d... Read More about Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee..

Histological and Radiological Assessment of Endogenously Generated Repair Tissue In Vivo Following a Chondral Harvest (2023)
Journal Article
McCarthy, H. S., Tins, B., Gallacher, P. D., Jermin, P., Richardson, J. B., Herman Kuiper, J., & Roberts, S. (2023). Histological and Radiological Assessment of Endogenously Generated Repair Tissue In Vivo Following a Chondral Harvest. Cartilage, 48-58. https://doi.org/10.1177/19476035221149523

OBJECTIVE: To examine repair tissue formed approximately 15 months after a chondral harvest in the human knee. DESIGN: Sixteen individuals (12 males, 4 females, mean age 36 ± 9 years) underwent a chondral harvest in the trochlea as a pre-requisite fo... Read More about Histological and Radiological Assessment of Endogenously Generated Repair Tissue In Vivo Following a Chondral Harvest.

A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee (2023)
Journal Article
Snow, M., Middleton, L., Mehta, S., Roberts, A., Gray, R., Richardson, J., …O’Brien, S. (2023). A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee. American Journal of Sports Medicine, 51(2), 367-378. https://doi.org/10.1177/03635465221141907

BACKGROUND: There are limited randomized controlled trials with long-term outcomes comparing autologous chondrocyte implantation (ACI) versus alternative forms of surgical cartilage management within the knee. PURPOSE: To determine at 5 years after s... Read More about A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee.

Psoriatic arthritis: review of potential biomarkers predicting response to TNF inhibitors (2022)
Journal Article
Makos, A., Kuiper, J., Kehoe, O., & Amarasena, R. (2022). Psoriatic arthritis: review of potential biomarkers predicting response to TNF inhibitors. Inflammopharmacology, 77-87. https://doi.org/10.1007/s10787-022-01092-x

Psoriatic arthritis (PsA) is a chronic and painful inflammatory immune-mediated disease. It affects up to 40% of people with psoriasis and it is associated with several comorbidities such as obesity, diabetes, metabolic syndrome and hypertension. PsA... Read More about Psoriatic arthritis: review of potential biomarkers predicting response to TNF inhibitors.

Intrathecal morphine in combination with bupivacaine as pre-emptive analgesia in posterior lumbar fusion surgery: a retrospective cohort study (2022)
Journal Article
Trivedi, R., John, J., Ghodke, A., Trivedi, J., Munigangaiah, S., Dheerendra, S., …Kuiper, J. (2022). Intrathecal morphine in combination with bupivacaine as pre-emptive analgesia in posterior lumbar fusion surgery: a retrospective cohort study. Journal of Orthopaedic Surgery and Research, https://doi.org/10.1186/s13018-022-03124-2

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The purpose of this study was to evaluate the efficacy of intrathecal morphine (ITM) in combination with bupivacaine as pre-emptive analgesia in patients undergoi... Read More about Intrathecal morphine in combination with bupivacaine as pre-emptive analgesia in posterior lumbar fusion surgery: a retrospective cohort study.

Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy (2022)
Journal Article
Kuiper. (2022). Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy. Children, 728 - 728. https://doi.org/10.3390/children9050728

Objective: The North Star Ambulatory Assessment (NSAA) is a validated 17-item functional rating scale and widely used to assess motor function in boys with Duchenne muscular dystrophy (DMD). The SARS-CoV-2 pandemic and subsequent Government 'lockdown... Read More about Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy.

Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study. (2022)
Journal Article
Abas, S., Kuiper, J. H., Roberts, S., McCarthy, H., Williams, M., Bing, A., …Makwana, N. (2022). Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study. Cells, 11(4), 629. https://doi.org/10.3390/cells11040629

Osteochondral defects of the ankle (OCD) are being increasingly identified as a clinically significant consequence of injury to the ankle, with the potential to lead to osteoarthritis if left untreated. The aim of this retrospective cohort study was... Read More about Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study..

Greater trochanteric pain syndrome: focused shockwave therapy versus an ultrasound guided injection: a randomised control trial (2021)
Journal Article
Heaver, C., Pinches, M., Kuiper, J. H., Thomas, G., Lewthwaite, S., Burston, B. J., & Banerjee, R. D. (2023). Greater trochanteric pain syndrome: focused shockwave therapy versus an ultrasound guided injection: a randomised control trial. Hip International, 33(3), 490-499. https://doi.org/10.1177/11207000211060396

Greater trochanteric pain syndrome (GTPS) is a common problem with an incidence of 1.8–5.6 per 1000 population. Physiotherapy, anti-inflammatories, corticosteroid injections and surgery have all been described in the management of GTPS, with limited,... Read More about Greater trochanteric pain syndrome: focused shockwave therapy versus an ultrasound guided injection: a randomised control trial.

Clinical validation of the Oswestry-Bristol Classification as part of a decision algorithm for trochlear dysplasia surgery (2021)
Journal Article
Sharma, N., Rehmatullah, N., Kuiper, J. H., Gallacher, P., & Barnett, A. J. (2021). Clinical validation of the Oswestry-Bristol Classification as part of a decision algorithm for trochlear dysplasia surgery. The Bone & Joint Journal, 103-B(10), 1586-1594. https://doi.org/10.1302/0301-620x.103b10.bjj-2020-1984.r1

The Oswestry-Bristol Classification (OBC) is an MRI-specific assessment tool to grade trochlear dysplasia. The aim of this study is to validate clinically the OBC by demonstrating its use in selecting treatments that are safe and effective.

Contralateral strength training attenuates muscle performance loss following anterior cruciate ligament (ACL) reconstruction: a randomised-controlled trial. (2021)
Journal Article
Kuiper. (2021). Contralateral strength training attenuates muscle performance loss following anterior cruciate ligament (ACL) reconstruction: a randomised-controlled trial. European Journal of Applied Physiology, 3551-3559. https://doi.org/10.1007/s00421-021-04812-3

PURPOSE: To investigate the effects of cross-education (CE) exercise on strength and performance at 10 and 24 weeks post anterior cruciate ligament (ACL) surgery.

METHODS: Design: randomised controlled trial. N?=?44 ACL-reconstruction patients, r... Read More about Contralateral strength training attenuates muscle performance loss following anterior cruciate ligament (ACL) reconstruction: a randomised-controlled trial..

Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study (2021)
Journal Article
Kuiper. (2021). Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study. Surgeries, 286 - 302. https://doi.org/10.3390/surgeries2030029

<jats:p>A range of surgical techniques have been developed for the repair or regeneration of lesioned cartilage in the human knee and a corresponding array of scoring systems have been created to assess their outcomes. The published literature displa... Read More about Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study.

An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. (2021)
Journal Article
Wright, K., Roberts, S., & Kuiper, J. (2021). An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. Cells, https://doi.org/10.3390/cells10081903

Chondrocyte-based cartilage repair strategies, such as articular chondrocyte implantation, are widely used, but few studies addressed the communication between native subchondral bone cells and the transplanted chondrocytes. An indirect co-culture mo... Read More about An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans..

Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair? (2021)
Journal Article
Amit, P., Kuiper, J. H., James, S., & Snow, M. (2021). Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair?. Journal of Shoulder and Elbow Surgery, 2465-2474. https://doi.org/10.1016/j.jse.2021.05.014

PURPOSE: Hyperlipidemia is linked to poor tendon to bone healing and progression of fatty infiltration after rotator cuff repair. Statins effectively treat hyperlipidemia, but it is unknown if they have any potential detrimental effects following rot... Read More about Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair?.

Design and psychometric testing of a new patient-reported outcome measure for ankle treatment (2021)
Journal Article
Sykes, J. G., Bailey, A., Bing, A. J., Kuiper, N. J., Makwana, N., Richardson, J., & Kuiper, J. (2021). Design and psychometric testing of a new patient-reported outcome measure for ankle treatment. Foot, 49, 101793. https://doi.org/10.1016/j.foot.2021.101793

Several outcome scores are used to assess the outcome of ankle surgery, but many are not validated and there is currently no ‘gold-standard’. Consequently, there is demand to develop a new ‘gold-standard’ score to assess ankle surgery. The study aim... Read More about Design and psychometric testing of a new patient-reported outcome measure for ankle treatment.

Mechano-driven regeneration predicts response variations in large animal model based on scaffold implantation site and individual mechano-sensitivity (2021)
Journal Article
Kuiper. (2021). Mechano-driven regeneration predicts response variations in large animal model based on scaffold implantation site and individual mechano-sensitivity. BONE, https://doi.org/10.1016/j.bone.2020.115769

It is well founded that the mechanical environment may regulate bone regeneration in orthopedic applications. The purpose of this study is to investigate the mechanical contributions of the scaffold and the host to bone regeneration, in terms of subj... Read More about Mechano-driven regeneration predicts response variations in large animal model based on scaffold implantation site and individual mechano-sensitivity.

Evaluating patient perspectives on participating in scientific research and clinical trials for the treatment of spinal cord injury (2021)
Journal Article
Bahsoun, S., Kuiper, J., Hulme, C., Twigg, A., El Masri, W., Glass, C., …Wright, K. (2021). Evaluating patient perspectives on participating in scientific research and clinical trials for the treatment of spinal cord injury. Scientific reports, 11, Article 4361. https://doi.org/10.1038/s41598-021-83211-2

A questionnaire was developed to evaluate patients' perspective on research aimed at improving functions and overcoming complications associated with spinal cord injury (SCI). The first three sections were based on published and validated assessment... Read More about Evaluating patient perspectives on participating in scientific research and clinical trials for the treatment of spinal cord injury.

Perlecan in the Natural and Cell Therapy Repair of Human Adult Articular Cartilage: Can Modifications in This Proteoglycan Be a Novel Therapeutic Approach? (2021)
Journal Article
Garcia, J., McCarthy, H. S., Kuiper, J. H., Melrose, J., & Roberts, S. (2021). Perlecan in the Natural and Cell Therapy Repair of Human Adult Articular Cartilage: Can Modifications in This Proteoglycan Be a Novel Therapeutic Approach?. Biomolecules, 11(1), Article ARTN 92. https://doi.org/10.3390/biom11010092

Articular cartilage is considered to have limited regenerative capacity, which has led to the search for therapies to limit or halt the progression of its destruction. Perlecan, a multifunctional heparan sulphate (HS) proteoglycan, promotes embryonic... Read More about Perlecan in the Natural and Cell Therapy Repair of Human Adult Articular Cartilage: Can Modifications in This Proteoglycan Be a Novel Therapeutic Approach?.

Biomechanical Evaluation Comparing Pulvertaft Weave and Side-to-Side Tenorrhaphy Using Porcine Tendons. (2020)
Journal Article
Kuiper. (2020). Biomechanical Evaluation Comparing Pulvertaft Weave and Side-to-Side Tenorrhaphy Using Porcine Tendons. https://doi.org/10.1142/S2424835520500484

Background: Pulvertaft Weave (PTW) is an established method of tenorrhapy in tendon transfers. Previous studies have suggested that a Side-to-Side (STS) tenorrhapy is easier to perform has the same advantages and has greater load to failure, ultimate... Read More about Biomechanical Evaluation Comparing Pulvertaft Weave and Side-to-Side Tenorrhaphy Using Porcine Tendons..

Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues (2020)
Journal Article
Wang, J., Roberts, S., Kuiper, J., Zhang, W., Garcia, J., Cui, Z., & Wright, K. (2020). Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues. Scientific reports, 10, Article 21658. https://doi.org/10.1038/s41598-020-78757-6

Meniscus degeneration is closely related to the progression of knee osteoarthritis (OA). However, there is currently a lack of quantitative and objective metrics to assess OA meniscal cell phenotypes. In this study we investigated the phenotypic mark... Read More about Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues.

Soft Tissue Radiological Knee (SToRK) Index: An observational cohort study to produce an index that quantifies the magnitude of soft tissue around the knee using standard radiographs (2020)
Journal Article
Sajid, S., Kuiper, J. H., Dhawan, R., Banerjee, R., & Lewthwaite, S. (2020). Soft Tissue Radiological Knee (SToRK) Index: An observational cohort study to produce an index that quantifies the magnitude of soft tissue around the knee using standard radiographs. Journal of Clinical Orthopaedics and Trauma, 11, S909-S915. https://doi.org/10.1016/j.jcot.2020.08.001

Scoliosis in paediatric onset spinal cord injuries. (2020)
Journal Article
Kuiper. (2020). Scoliosis in paediatric onset spinal cord injuries. Spinal Cord, https://doi.org/10.1038/s41393-020-0418-6

STUDY DESIGN: This is a retrospective longitudinal review. OBJECTIVE: The purpose of this review was to identify predictors of developing clinical scoliosis and compare between traumatic and neurological aetiologies of SCI. SETTING: This study was co... Read More about Scoliosis in paediatric onset spinal cord injuries..

The Oswestry-Bristol Classification. (2019)
Journal Article
Kuiper. (2019). The Oswestry-Bristol Classification. The Bone & Joint Journal, 102 - 107. https://doi.org/10.1302/0301-620X.102B1.BJJ-2019-0366.R3

AIMS: Trochlear dysplasia is a significant risk factor for patellofemoral instability. The Dejour classification is currently considered the standard for classifying trochlear dysplasia, but numerous studies have reported poor reliability on both pla... Read More about The Oswestry-Bristol Classification..

Isolated medial patellofemoral ligament reconstruction significantly improved quality of life in patients with recurrent patella dislocation: a response to Hiemstra et al.'s letter to the editor. (2019)
Journal Article
Kuiper. (2019). Isolated medial patellofemoral ligament reconstruction significantly improved quality of life in patients with recurrent patella dislocation: a response to Hiemstra et al.'s letter to the editor. Knee Surgery, Sports Traumatology, Arthroscopy, 3735 - 3737. https://doi.org/10.1007/s00167-019-05690-1

Letter to the editor.

Predictors of fracture healing in patients with recalcitrant nonunions treated with autologous culture expanded bone marrow-derived mesenchymal stromal cells. (2019)
Journal Article
Kuiper. (2019). Predictors of fracture healing in patients with recalcitrant nonunions treated with autologous culture expanded bone marrow-derived mesenchymal stromal cells. Journal of Orthopaedic Research, 1303-1309. https://doi.org/10.1002/jor.24184

The study reports the prospective outcome of treating severe recalcitrant fracture nonunion in patients with autologous bone marrow-derived mesenchymal stromal cells (BMSC) from 2003 to 2010 and analyze predictors of union. Autologous BMSC were cultu... Read More about Predictors of fracture healing in patients with recalcitrant nonunions treated with autologous culture expanded bone marrow-derived mesenchymal stromal cells..

A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - II: The effects of co-implantation (2019)
Journal Article
Naire, & Kuiper. (2019). A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - II: The effects of co-implantation. Journal of Tissue Engineering, 1-14. https://doi.org/10.1177/2041731419827792

We present a mathematical model of cartilage regeneration after cell therapy, to show how co-implantation of stem cells (mesenchymal stem cells) and chondrocytes into a cartilage defect can impact chondral healing. The key mechanisms involved in the... Read More about A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - II: The effects of co-implantation.

A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - I: The effects of growth factors (2019)
Journal Article
Campbell, K., Kuiper, J., & Naire, S. (2019). A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - I: The effects of growth factors. Journal of Tissue Engineering, 1-16. https://doi.org/10.1177/2041731419827791

Autologous Chondrocyte Implantation is a cell-based therapy for treating chondral defects. The procedure begins by inserting chondrocytes into the defect region. The chondrocytes initiate healing by proliferating and depositing extracellular matrix,... Read More about A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - I: The effects of growth factors.

Low failure rate at short term for 40?mm heads and second generation triple annealed HCLPE liners in hybrid Hip Replacements (2019)
Journal Article
Kuiper. (2019). Low failure rate at short term for 40?mm heads and second generation triple annealed HCLPE liners in hybrid Hip Replacements. Journal of Clinical Orthopaedics and Trauma, 350-357. https://doi.org/10.1016/j.jcot.2017.12.008

Introduction
40?mm large diameter heads offer the advantages of lesser dislocation rates and better stability while highly cross linked polyethylene have lower wear rates than ultra high molecular weight polyethylene. Studies of the survivorship of... Read More about Low failure rate at short term for 40?mm heads and second generation triple annealed HCLPE liners in hybrid Hip Replacements.

Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. (2018)
Journal Article
Kuiper, J., & Wright, K. (2018). Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. European cells & materials, 255 - 267. https://doi.org/10.22203/eCM.v035a18

High hopes have been pinned on regenerative medicine strategies in order to prevent the progression of cartilage damage to osteoarthritis, particularly by autologous chondrocyte implantation (ACI). The loss of chondrocyte phenotype during in vitro mo... Read More about Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy..

External rotation bracing for first-time anterior dislocation of the shoulder: A discontinued randomised controlled trial comparing external rotation bracing with conventional sling (2018)
Journal Article
Chan, S. K., Bentick, K. R., Kuiper, J. H., & Kelly, C. P. (2019). External rotation bracing for first-time anterior dislocation of the shoulder: A discontinued randomised controlled trial comparing external rotation bracing with conventional sling. Shoulder and Elbow, 11(4), 256-264. https://doi.org/10.1177/1758573218768521

Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy (2018)
Journal Article
Sykes, J., Kuiper, J., Richardson, J., Wright, K., & Kuiper, N. (2018). Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. Osteoarthritis and Cartilage, 26(S1), https://doi.org/10.1016/j.joca.2018.02.221

Purpose
High hopes have been pinned on regenerative medicine strategies to meet the challenge of preventing the progression to osteoarthritis, in particular autologous chondrocyte implantation (ACI). The loss of chondrocyte phenotype during in vitro... Read More about Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy.

The twin peg Oxford knee — Medium term survivorship and surgical principles (2018)
Journal Article
Kuiper. (2018). The twin peg Oxford knee — Medium term survivorship and surgical principles. https://doi.org/10.1016/j.knee.2018.01.001

A multicentre study of single peg Oxford knees reported failure associated with osteoarthritis progression, femoral component loosening, unexplained pain and meniscal bearing dislocation. Suboptimally positioned femoral components and intraoperative... Read More about The twin peg Oxford knee — Medium term survivorship and surgical principles.

Tendon end separation with loading in an Achilles tendon repair model: comparison of non-absorbable vs. absorbable sutures (2017)
Journal Article
Kuiper. (2017). Tendon end separation with loading in an Achilles tendon repair model: comparison of non-absorbable vs. absorbable sutures. Journal of Experimental Orthopaedics, https://doi.org/10.1186/s40634-017-0101-9

Background: Rupture of the Achilles tendon often leads to long-term morbidity, particularly calf weakness associated with tendon elongation. Operative repair of Achilles tendon ruptures leads to reduced tendon elongation. Tendon lengthening is a key... Read More about Tendon end separation with loading in an Achilles tendon repair model: comparison of non-absorbable vs. absorbable sutures.

Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation (2017)
Journal Article
Garcia, J., Hulme, C., Roberts, S., Richardson, J., Kuiper, J., & Wright, K. (2017). Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation. International Journal of Experimental Pathology, 98(3), A23

Introduction

Autologous chondrocyte implantation (ACI) and microfracture are both used in the treatment of cartilage injuries. Previous findings suggest that the efficacy of these two therapies is similar in terms of short-term clinical outcome, h... Read More about Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation.

Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. (2017)
Journal Article
Richardson, J. B., Wright, K. T., Wales, J., Herman Kuiper, J., McCarthy, H. S., Gallacher, P., …Roberts, S. (2017). Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. Regenerative Medicine, 12(5), 493-501. https://doi.org/10.2217/rme-2017-0032

AIM: The main aim of this trial is to test the safety and efficacy of autologous stromal/stem cells, chondrocytes or the two combined in the treatment of knee cartilage defects. PATIENTS & METHODS: Patients with symptomatic chondral/osteochondral def... Read More about Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design..

Cartilage harvest elevates sCD14 and MMP-3 in the synovial fluid of the autologous chondrocyte implantation (ACI) treated joint (2017)
Journal Article
Wright, K. T., Wilson, E., Hulme, C., Kuiper, J. H., Gallacher, P., Richardson, J. B., & Roberts, S. (2017). Cartilage harvest elevates sCD14 and MMP-3 in the synovial fluid of the autologous chondrocyte implantation (ACI) treated joint. International Journal of Experimental Pathology, 97(6), A24

Introduction This study aims to examine the impact of the cartilage harvest procedure on synovial fluid biomarkers at the time of autologous chondrocyte implantation (ACI).

Materials and Methods Hyaluronic acid (HA), cartilage oligomeric matrix pr... Read More about Cartilage harvest elevates sCD14 and MMP-3 in the synovial fluid of the autologous chondrocyte implantation (ACI) treated joint.

The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success (2017)
Journal Article
Kuiper, J., Roberts, S., & Wright, K. (2017). The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success. American Journal of Sports Medicine, 1806-1814

Background:
Autologous chondrocyte implantation (ACI) is used worldwide in the treatment of cartilage defects in the knee. Several demographic and injury-specific risk factors have been identified that can affect the success of ACI treatment. Howeve... Read More about The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success.

Surgical treatment for developmental dysplasia of the hip- a single surgeon series of 47 hips with a 7 year mean follow up). (2016)
Journal Article
Kuiper. (2016). Surgical treatment for developmental dysplasia of the hip- a single surgeon series of 47 hips with a 7 year mean follow up)

The treatment of developmental dysplasia of the hip (DDH) in children remains controversial. We describe the clinical and radiological outcomes of  47 hips in 43 children treated with open surgery by one surgeon between 2004 and 2008 for DDH. The mea... Read More about Surgical treatment for developmental dysplasia of the hip- a single surgeon series of 47 hips with a 7 year mean follow up)..

Nanoengineering neural stem cells on biomimetic substrates using magnetofection technology. (2016)
Journal Article
Adams, C., Dickson, A., Kuiper, J., & Chari, D. (2016). Nanoengineering neural stem cells on biomimetic substrates using magnetofection technology. Nanoscale, 8, 17869-17880. https://doi.org/10.1039/c6nr05244d

Tissue engineering studies are witnessing a major paradigm shift to cell culture on biomimetic materials that replicate native tissue features from which the cells are derived. Few studies have been performed in this regard for neural cells, particul... Read More about Nanoengineering neural stem cells on biomimetic substrates using magnetofection technology..

Biomechanical analysis of tension band wiring (TBW) of transverse fractures of patella (2016)
Journal Article
Kuiper. (2016). Biomechanical analysis of tension band wiring (TBW) of transverse fractures of patella. Chinese Journal of Traumatology (English Edition), 255-258. https://doi.org/10.1016/j.cjtee.2016.06.009

Abstract
Purpose
Tension band wiring is commonly used for fixation of simple transverse fractures. The popular configuration is parallel Kirschner wires (K-wires) and a stainless steel wire loop placed in a vertically oriented figure-of-8.

Metho... Read More about Biomechanical analysis of tension band wiring (TBW) of transverse fractures of patella.

A systematic review – ovarian suppression with GnRH analogues for management of PMS (2016)
Journal Article
Naheed, B., Kuiper, J., & O'Brien, S. (2016). A systematic review – ovarian suppression with GnRH analogues for management of PMS. BJOG: An International Journal of Obstetrics and Gynaecology, 123, 186. https://doi.org/10.1111/1471-0528.14109

Introduction Premenstrual syndrome (PMS) is a psychological and somatic disorder.It occurs in about 5–8% of women .PMS symptoms recur during the luteal phase of the menstrual cycle and remit by the end of menstruation. Premenstrual Disorders have a d... Read More about A systematic review – ovarian suppression with GnRH analogues for management of PMS.

Development of a tool to predict outcome of Autologous Chondrocyte Implantation (2016)
Journal Article
Kuiper. (2016). Development of a tool to predict outcome of Autologous Chondrocyte Implantation. Cartilage, 119-130. https://doi.org/10.1177/1947603516650002

Objective. The study had 2 objectives: first, to evaluate the success of autologous chondrocyte implantation (ACI) in
terms of incidence of surgical re-intervention, including arthroplasty, and investigate predictors of successful treatment
outcome... Read More about Development of a tool to predict outcome of Autologous Chondrocyte Implantation.

Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. (2016)
Journal Article
Garcia, J., Wright, K., Roberts, S., Herman Kuiper, J., Mangham, C., Richardson, J., & Mennan, C. (2016). Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. Scientific reports, 6, 24295 -?. https://doi.org/10.1038/srep24295

The infrapatellar fat pad (FP) and synovial fluid (SF) in the knee serve as reservoirs of mesenchymal stromal cells (MSCs) with potential therapeutic benefit. We determined the influence of the donor on the phenotype of donor matched FP and SF derive... Read More about Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus..

Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. (2016)
Journal Article
Bhattacharjee, A., McCarthy, H. S., Tins, B., Roberts, S., Kuiper, J. H., Harrison, P. E., & Richardson, J. B. (2016). Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. American Journal of Sports Medicine, 44(5), 1249 - 1259. https://doi.org/10.1177/0363546516631739

BACKGROUND: Structural and functional outcome of bone graft with first- or second-generation autologous chondrocyte implantation (ACI) in treating cartilage and subchondral bone defect has not been reported previously. PURPOSE: To evaluate the outcom... Read More about Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee..

Alternative tension band technique for olecranon fractures: A biomechanical study (2016)
Journal Article
Singh, S., Kuiper, J., Behzadian, A., Madhusudhan, T., & Sinha, A. (2016). Alternative tension band technique for olecranon fractures: A biomechanical study. Injury, 47(2), 294-295. https://doi.org/10.1016/j.injury.2015.12.008

Objectives: To investigate whether an alternative tension band wire technique will produce greater compression and less displacement at olecranon (elbow) fracture sites compared to a standard figure of eight tension band technique. Olecranon fracture... Read More about Alternative tension band technique for olecranon fractures: A biomechanical study.

Differences in concentration of metal debris in blood, serum, and plasma samples of patients with metal-on-metal hip resurfacing arthroplasty (2015)
Journal Article
Khan, M., Kuiper, J., Sieniawska, C., & Richardson, J. (2016). Differences in concentration of metal debris in blood, serum, and plasma samples of patients with metal-on-metal hip resurfacing arthroplasty. Journal of Orthopaedics, 13(4), 450-454. https://doi.org/10.1016/j.jor.2015.10.006

Background/aims
Cobalt and chromium are released from MOM hips and their precise nature (ions/particles) is not known. Their distribution in serum, plasma, and whole blood may help to determine their nature.

Methods
We measured cobalt and chromi... Read More about Differences in concentration of metal debris in blood, serum, and plasma samples of patients with metal-on-metal hip resurfacing arthroplasty.

Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability (2015)
Journal Article
Walter, M., Kohli, N., Major, T., Fuller, H., Wright, K., Kuiper, J., & Johnson, W. (2015). Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability. Journal of Stem Cells and Regenerative Medicine, 11(1), 18-24. https://doi.org/10.46582/jsrm.1101004

Mesenchymal stem cells (MSCs) stimulate angiogenesis within a wound environment and this effect is mediated through paracrine interactions with the endothelial cells present. Here we report that human MSC-conditioned medium (n=3 donors) significantly... Read More about Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability.

ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion (2015)
Journal Article
Roberts, S., Evans, H., Wright, K., van Niekerk, L., Caterson, B., Richardson, J., …Kuiper, J. (2015). ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. Osteoarthritis and Cartilage, 23(9), 1622-1626. https://doi.org/10.1016/j.joca.2015.05.006

Objective
To evaluate the potential of ADAMTS-4 (aggrecanase -1) activity in synovial fluid (SF) as a biomarker of knee injury and joint disease.

Design
We have measured ADAMTS-4 activity in the synovial fluid of 170 orthopaedic patients with di... Read More about ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion.

The cemented twin-peg Oxford partial knee replacement survivorship: a cohort study (2015)
Journal Article
Kuiper. (2015). The cemented twin-peg Oxford partial knee replacement survivorship: a cohort study. https://doi.org/10.1016/j.knee.2015.03.011

Background
A new twin-peg version of the Oxford knee was introduced in 2003. However, until now there has been no information about its survivorship. The aim of this study was to determine the survivorship, and the patients' perception of outcome ov... Read More about The cemented twin-peg Oxford partial knee replacement survivorship: a cohort study.

Gonadotropin-releasing hormone (GnRH) analogues for premenstrual syndrome (PMS) (2014)
Journal Article
Naheed, B., Uthman, O. A., O'Mahony, F., Kuiper, J. H., & O'Brien, P. M. S. (2014). Gonadotropin-releasing hormone (GnRH) analogues for premenstrual syndrome (PMS). Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.cd011330

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To evaluate the therapeutic efficacy of GnRH agonists and antagonists in the management of PMS and PMDD.

Hip resurfacing arthroplasty : A new method to assess and quantify learning phase (2014)
Journal Article
AULAKH, T. S., JAYASEKERA, N., SINGH, R., PATEL, A., KUIPER, J. H., & RICHARDSON, J. B. (2014). Hip resurfacing arthroplasty : A new method to assess and quantify learning phase. Acta Orthopaedica Belgica, 80(3), 397-402

Hip resurfacing had initially gained acceptance and popularity as it helps preserve femoral bone stock. In this study we tried to answer the following questions ; 1. Whether there is a learning curve for hip resurfacing ? 2. Is it present in surgeons... Read More about Hip resurfacing arthroplasty : A new method to assess and quantify learning phase.

Orphan receptor GPR15/BOB is up-regulated in rheumatoid arthritis (2014)
Journal Article
Cartwright, A., Schmutz, C., Askari, A., Kuiper, J., & Middleton, J. (2014). Orphan receptor GPR15/BOB is up-regulated in rheumatoid arthritis. Cytokine, 67(2), 53-59. https://doi.org/10.1016/j.cyto.2014.02.015

Chemokine receptors on leukocytes mediate the recruitment and accumulation of these cells within affected joints in chronic inflammatory diseases such as rheumatoid arthritis (RA). Identification of involved receptors offers potential for development... Read More about Orphan receptor GPR15/BOB is up-regulated in rheumatoid arthritis.

Ponseti casting for club foot – above- or below-knee?: A prospective randomised clinical trial (2013)
Journal Article
Maripuri, S. N., Gallacher, P. D., Bridgens, J., Kuiper, J. H., & Kiely, N. T. (2013). Ponseti casting for club foot – above- or below-knee?: A prospective randomised clinical trial. The Bone & Joint Journal, 95-B(11), 1570-1574. https://doi.org/10.1302/0301-620x.95b11.31899

We undertook a randomised clinical trial to compare treatment times and failure rates between above- and below-knee Ponseti casting groups. Eligible children with idiopathic clubfoot, treated using the Ponseti method, were randomised to either below-... Read More about Ponseti casting for club foot – above- or below-knee?: A prospective randomised clinical trial.

The Oswestry Risk Index: An aid in the treatment of metastatic disease of the spine (2013)
Journal Article
Balain, B., Jaiswal, A., Trivedi, J. M., Eisenstein, S. M., Kuiper, J. H., & Jaffray, D. C. (2013). The Oswestry Risk Index: An aid in the treatment of metastatic disease of the spine. The Bone & Joint Journal, 95-B(2), 210-216. https://doi.org/10.1302/0301-620x.95b2.29323

The revised Tokuhashi, Tomita and modified Bauer scores are commonly used to make difficult decisions in the management of patients presenting with spinal metastases. A prospective cohort study of 199 consecutive patients presenting with spinal metas... Read More about The Oswestry Risk Index: An aid in the treatment of metastatic disease of the spine.

No drain, autologous transfusion drain or suction drain? A randomised prospective study in total hip replacement surgery of 168 patients (2010)
Journal Article
Kuiper. (2010). No drain, autologous transfusion drain or suction drain? A randomised prospective study in total hip replacement surgery of 168 patients. Acta Orthopaedica Belgica, 619 - 627

We performed a prospective, randomised controlled trial to assess the differences in the use of a conventional suction drain, an Autologous Blood Transfusion (ABT) drain and no drain, in 168 patients. There was no significant difference between the d... Read More about No drain, autologous transfusion drain or suction drain? A randomised prospective study in total hip replacement surgery of 168 patients.

The effect of newer anti-rheumatic drugs on osteogenic cell proliferation: an in-vitro study. (2009)
Journal Article
Kuiper. (2009). The effect of newer anti-rheumatic drugs on osteogenic cell proliferation: an in-vitro study. Journal of Orthopaedic Surgery and Research, 17 -?. https://doi.org/10.1186/1749-799X-4-17

BACKGROUND: Disease modifying anti-rheumatic drugs (DMARDs) may interfere with bone healing. Previous studies give conflicting advice regarding discontinuation of these drugs in the peri-operative setting. No consensus exists in current practice espe... Read More about The effect of newer anti-rheumatic drugs on osteogenic cell proliferation: an in-vitro study..