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Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis (2024)
Journal Article
Echrish, J., Pasca, M.-I., Cabrera, D., Yang, Y., & Harper, A. G. S. (2024). Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis. Biomimetics, 9(6), Article 372. https://doi.org/10.3390/biomimetics9060372

Acute cardiovascular events result from clots caused by the rupture and erosion of atherosclerotic plaques. This paper aimed to produce a functional biomimetic hydrogel of the neointimal layer of the atherosclerotic plaque that can support thrombogen... Read More about Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis.

Optical Microscopy Using the Faraday Effect Reveals in Situ Magnetization Dynamics of Magnetic Nanoparticles in Biological Samples (2024)
Journal Article
Sharifabad, M. E., Eizadi Sharifabad, M., Soucaille, R., Wang, X., Rotherham, M., Loughran, T., …Telling, N. (2024). Optical Microscopy Using the Faraday Effect Reveals in Situ Magnetization Dynamics of Magnetic Nanoparticles in Biological Samples. ACS Nano, 18(7), 5297-5310. https://doi.org/10.1021/acsnano.3c08955

The study of exogenous and endogenous nanoscale magnetic material in biology is important for developing biomedical nanotechnology as well as for understanding fundamental biological processes such as iron metabolism and biomineralization. Here, we e... Read More about Optical Microscopy Using the Faraday Effect Reveals in Situ Magnetization Dynamics of Magnetic Nanoparticles in Biological Samples.

Fabrication and Characterisation of Hydrogels with Reversible Wrinkled Surfaces for Limbal Study and Reconstruction (2023)
Journal Article
Dimmock, R. L., Rotherham, M., El Haj, A. J., & Yang, Y. (in press). Fabrication and Characterisation of Hydrogels with Reversible Wrinkled Surfaces for Limbal Study and Reconstruction. Gels, 9(11), Article 915. https://doi.org/10.3390/gels9110915

In the biomedical field, there is a demand for the development of novel approaches for the investigation of optical epithelial anatomical features with biomimetic materials. These materials are not only required to replicate structures but also enabl... Read More about Fabrication and Characterisation of Hydrogels with Reversible Wrinkled Surfaces for Limbal Study and Reconstruction.

Antifouling performance of D-enantiomers-based peptide-modified aluminum alloy surfaces with enhanced stability against proteolytic degradation (2023)
Journal Article
Lou, T., Bai, X., He, X., Liu, W., Yang, Z., Yang, Y., & Yuan, C. (2023). Antifouling performance of D-enantiomers-based peptide-modified aluminum alloy surfaces with enhanced stability against proteolytic degradation. Journal of Materials Science, 58, Article 15499–15512

Marine biofouling presents a significant challenge to the sustainable development of the maritime industry. Antimicrobial peptide (AMP) offers a promising strategy to combat biofouling. However, the inherent susceptibility of natural AMPs composed of... Read More about Antifouling performance of D-enantiomers-based peptide-modified aluminum alloy surfaces with enhanced stability against proteolytic degradation.

The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study (2023)
Journal Article
Jakobek, W., Gravino, G., Nayak, S., Yang, Y., Ranjbar, J., & Roffe, C. (in press). The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study. Interventional Neuroradiology, https://doi.org/10.1177/15910199231201518

Endovascular mechanical thrombectomy for ischaemic stroke is one of the most effective treatments. Despite the devices and techniques that have been developed, thrombi are not always successfully retrieved. The incidence of futile reperfusion after s... Read More about The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study.

Probing magnetization dynamics of iron oxide nanoparticles using a point-probe magneto-optical method (2023)
Journal Article
Wang, X., Cabrera, D., Yang, Y., & Telling, N. (in press). Probing magnetization dynamics of iron oxide nanoparticles using a point-probe magneto-optical method. Frontiers in Nanotechnology, 5, Article 1214313. https://doi.org/10.3389/fnano.2023.1214313

Magnetic nanoparticles (MNPs) are promising as local heat generators for magnetic hyperthermia under AC magnetic fields. The heating efficacy of MNPs is determined by the AC hysteresis loop area, which in turn is affected by the dynamic magnetic prop... Read More about Probing magnetization dynamics of iron oxide nanoparticles using a point-probe magneto-optical method.

Developing Biomimetic Hydrogels of the Arterial Wall as a Prothrombotic Substrate for In Vitro Human Thrombosis Models (2023)
Journal Article
Ranjbar, J., Njoroge, W., Gibbins, J. M., Roach, P., Yang, Y., & Harper, A. G. S. (2023). Developing Biomimetic Hydrogels of the Arterial Wall as a Prothrombotic Substrate for In Vitro Human Thrombosis Models. Gels, 9(6), Article 477. https://doi.org/10.3390/gels9060477

Current in vitro thrombosis models utilise simplistic 2D surfaces coated with purified components of the subendothelial matrix. The lack of a realistic humanised model has led to greater study of thrombus formation in in vivo tests in animals. Here w... Read More about Developing Biomimetic Hydrogels of the Arterial Wall as a Prothrombotic Substrate for In Vitro Human Thrombosis Models.

Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties (2023)
Journal Article
Mason, J. H., Luo, L., Reinwald, Y., Taffetani, M., Hallas-Potts, A., Herrington, C. S., …Bagnaninchi, P. O. (2023). Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties. Communications Biology, 6(1), Article 543. https://doi.org/10.1038/s42003-023-04788-0

The role of the mechanical environment in defining tissue function, development and growth has been shown to be fundamental. Assessment of the changes in stiffness of tissue matrices at multiple scales has relied mostly on invasive and often speciali... Read More about Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties.

INVESTIGATION OF CELL AGGREGATE SIZE AND POTENTIAL BONE GROWTH WITH BONE CELL LINE AND HUMAN MESENCHYMAL STEM CELLS (2023)
Conference Proceeding
Deegan, A., Lawlor, L., Yang, X., & Yang, Y. (2023). INVESTIGATION OF CELL AGGREGATE SIZE AND POTENTIAL BONE GROWTH WITH BONE CELL LINE AND HUMAN MESENCHYMAL STEM CELLS. . https://doi.org/10.1302/1358-992x.2023.8.041

Our previous research has demonstrated that minor adjustments to in vitro cellular aggregation parameters, i.e. alterations to aggregate size, can influence temporal and spatial mineral depositions within maturing bone cell nodules. What remains uncl... Read More about INVESTIGATION OF CELL AGGREGATE SIZE AND POTENTIAL BONE GROWTH WITH BONE CELL LINE AND HUMAN MESENCHYMAL STEM CELLS.

Development of Boron-Containing PVA-Based Cryogels with Controllable Boron Releasing Rate and Altered Influence on Osteoblasts (2023)
Journal Article
Ceylan, S., Dimmock, R., & Yang, Y. (in press). Development of Boron-Containing PVA-Based Cryogels with Controllable Boron Releasing Rate and Altered Influence on Osteoblasts. Polymers, 15(7), 1653. https://doi.org/10.3390/polym15071653

Cryogel formation is an effective approach to produce porous scaffolds for tissue engineering. In this study, cryogelation was performed to produce boron-containing scaffolds for bone tissue engineering. A combination of the synthetic polymer, poly(v... Read More about Development of Boron-Containing PVA-Based Cryogels with Controllable Boron Releasing Rate and Altered Influence on Osteoblasts.

Automatic Detection of Skin Cancer Melanoma Using Transfer Learning in Deep Network (2023)
Journal Article
Wang, X., Yang, Y., & Mandal, B. (2023). Automatic Detection of Skin Cancer Melanoma Using Transfer Learning in Deep Network. AIP conference proceedings, 2562, Article ARTN 020009. https://doi.org/10.1063/5.0111909

As the deadliest type of skin cancer, melanoma has a high mortality rate and takes away thousands of lives in the UK every year. However, if detected at earlier stage, the survival rate largely increases. With the development of machine learning, man... Read More about Automatic Detection of Skin Cancer Melanoma Using Transfer Learning in Deep Network.

Enhanced antifouling properties of marine antimicrobial peptides by PEGylation. (2023)
Journal Article
Lou, T., Bai, X., He, X., Liu, W., Yang, Z., Yang, Y., & Yuan, C. (2023). Enhanced antifouling properties of marine antimicrobial peptides by PEGylation. Frontiers in Bioengineering and Biotechnology, 1124389 - ?. https://doi.org/10.3389/fbioe.2023.1124389

Covalent immobilisation of antimicrobial peptides (AMPs) on underwater surfaces to combat marine biofouling is of great interest as it is an efficient, broad-spectrum and environmentally friendly strategy. Similar to post-translational modifications... Read More about Enhanced antifouling properties of marine antimicrobial peptides by PEGylation..

Research Progress of Antimicrobial Peptides in the Field of Marine Antifouling (2022)
Journal Article
Lou, T., Bai, X., He, X., Yang, Y., Yang, Z., & Yuan, C. (2022). Research Progress of Antimicrobial Peptides in the Field of Marine Antifouling. China Surface Engineering, 35(2), 1-11. https://doi.org/10.11933/j.issn.1007-9289.20210611001

Marine biofouling is still a problem that needs to be urgently solved. However, comprehensive studies and reports on the research progress of antimicrobial peptides in the field of marine antifouling remain scant. Three types of antimicrobial peptide... Read More about Research Progress of Antimicrobial Peptides in the Field of Marine Antifouling.

Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation (2022)
Journal Article
Ranjbar, J., Yang, Y., & Harper, A. (2022). Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation. Platelets, 34(1), https://doi.org/10.1080/09537104.2022.2153823

Thrombus formation is highly dependent upon the physico-chemical environment in which it is triggered. Our ability to understand how thrombus formation is initiated, regulated, and resolved in the human body is dependent upon our ability to replicat... Read More about Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation.

Detection of lipid efflux from foam cell models using a label-free infrared method (2022)
Journal Article
Xie, B., Njoroge, W., Dowling, L. M., Sulé-Suso, J., Cinque, G., & Yang, Y. (2022). Detection of lipid efflux from foam cell models using a label-free infrared method. Analyst, 147(23), 5372-5385. https://doi.org/10.1039/D2AN01041K

Cardiovascular diseases are still among the leading causes of mortality and morbidity worldwide. The build-up of fatty plaques in the arteries, leading to atherosclerosis, is the most common cause of cardiovascular diseases. The central player in ath... Read More about Detection of lipid efflux from foam cell models using a label-free infrared method.

Antifouling performance and mechanism analysis of marine peptide modified aluminum alloy surface (2022)
Journal Article
Lou, T., Bai, X., He, X., Liu, W., Yang, Y., & Yuan, C. (2022). Antifouling performance and mechanism analysis of marine peptide modified aluminum alloy surface. Surface and Coatings Technology, 445, 128742. https://doi.org/10.1016/j.surfcoat.2022.128742

Biofouling, the settlement of nuisance fouling organisms on underwater surfaces, seriously affects the performance of the ship and the development of the maritime industry. Using antimicrobial peptides to obtain antifouling performance is one of the... Read More about Antifouling performance and mechanism analysis of marine peptide modified aluminum alloy surface.

Hydrostatic pressure stimulates the osteogenesis and angiogenesis of MSCs/HUVECs co-culture on porous PLGA scaffolds (2022)
Journal Article
Shen, H., Liu, J., Yan, X., Yang, H., Hu, S., Yan, X., …Lü, L. (2022). Hydrostatic pressure stimulates the osteogenesis and angiogenesis of MSCs/HUVECs co-culture on porous PLGA scaffolds. Colloids and Surfaces B: Biointerfaces, 213, 112419. https://doi.org/10.1016/j.colsurfb.2022.112419

In native bone tissue regeneration, blood vessels, providing oxygen and nutrition for tissues, can promote the regeneration of bone and accelerate the repair of a defected area. In this study, Poly(D, L-lactic-co-glycolic acid) (PLGA) inverse opal sc... Read More about Hydrostatic pressure stimulates the osteogenesis and angiogenesis of MSCs/HUVECs co-culture on porous PLGA scaffolds.

In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis. (2022)
Journal Article
Kaur Sandhu, A., Yang, Y., & Li, W. (2022). In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis. ACS Biomaterials Science and Engineering, 1749-1762. https://doi.org/10.1021/acsbiomaterials.1c01307

Biomaterial-associated infection is difficult to detect and brings consequences that can lead to morbidity and mortality. Bacteria can adhere to the implant surface, grow, and form biofilms. Antimicrobial peptides (AMPs) can target and kill bacterial... Read More about In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis..

New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. (2022)
Journal Article
Yang, & Wu. (2022). New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Scientific reports, 12, Article 5109. https://doi.org/10.1038/s41598-022-09005-2

Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indenta... Read More about New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties..

New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties (2022)
Journal Article
Yang, & Wu. (2022). New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Scientific reports, 12, Article 5109. https://doi.org/10.1038/s41598-022-09005-2

Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indenta... Read More about New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties.

Time-dependent mechanical behaviour of the aortic chronic dissection flap (2022)
Journal Article
Panpho, P., Yang, Y., Davies, H. A., Nawaytou, O., Harky, A., Torella, F., …Akhtar, R. (2022). Time-dependent mechanical behaviour of the aortic chronic dissection flap. Interactive Cardiovascular and Thoracic Surgery, 34(5), 892-901. https://doi.org/10.1093/icvts/ivac029

The transition of aortic dissection from acute to chronic is poorly understood. We examined time-dependent mechanical behaviour and biochemical properties of chronic dissection tissues.

Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review (2021)
Journal Article
Ng, C. Y., Chai, J. Y., Foo, J. B., Mohamad Yahaya, N. H., Yang, Y., Ng, M. H., & Law, J. X. (in press). Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review. International Journal of Nanomedicine, Volume 16, 6749-6781. https://doi.org/10.2147/ijn.s327059

Treatment of cartilage defects such as osteoarthritis (OA) and osteochondral defect (OCD) remains a huge clinical challenge in orthopedics. OA is one of the most common chronic health conditions and is mainly characterized by the degeneration of arti... Read More about Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review.

Proceedings of International Conference on Biomedical Engineering (2021)
Presentation / Conference
Yang, & Naire. (2021, September). Proceedings of International Conference on Biomedical Engineering. Presented at International Conference on Biomedical Engineering (ICoBE 2021), UniMAP, Malaysia (Virtual)

Aspiration thrombectomy is a life-saving interventional procedure to remove a blood clot from the brain of stroke patients. The pressure and blood flow dynamics during this procedure are crucial in determining the clinical outcomes. A mathematical mo... Read More about Proceedings of International Conference on Biomedical Engineering.

Molecular dynamics simulation of peptide attachment on Al-based surfaces (2021)
Journal Article
Lou, T., Bai, X., He, X., Yang, Y., & Yuan, C. (2021). Molecular dynamics simulation of peptide attachment on Al-based surfaces. Progress in Organic Coatings, 157, 106310. https://doi.org/10.1016/j.porgcoat.2021.106310

Biofouling is a serious problem for devices or facilities working in marine environment that needs to be solved. Modifying the contact surface with antimicrobial peptides is a promised technique to inhibit biofouling. However, the attachment behavior... Read More about Molecular dynamics simulation of peptide attachment on Al-based surfaces.

The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models (2021)
Journal Article
Njoroge, W., Hernández Hernández, A. C., Idris Musa, F., Butler, R., Harper, A. G. S., & Yang, Y. (2021). The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models. Pharmaceutics, 13(3), Article 340. https://doi.org/10.3390/pharmaceutics13030340

Cardiovascular disease is a major cause of death globally. This has led to significant efforts to develop new anti-thrombotic therapies or re-purpose existing drugs to treat cardiovascular diseases. Due to difficulties of obtaining healthy human bloo... Read More about The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models.

Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE) (2021)
Journal Article
Yang. (2021). Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE). Biomedical Optics Express, 588 - 603. https://doi.org/10.1364/BOE.404096

Corneal wound healing, caused by frequent traumatic injury to the cornea and increasing numbers of refractive surgeries, has become a vital clinical problem. In the cornea, wound healing is an extremely complicated process. However, little is known a... Read More about Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE).

Dose-response association between physical activity and clustering of modifiable cardiovascular risk factors among 26,093 Chinese adults (2020)
Journal Article
Shi, R., Cai, Y., Yang, Y., Yu, D., & Qin, R. (2020). Dose-response association between physical activity and clustering of modifiable cardiovascular risk factors among 26,093 Chinese adults. BMC Cardiovascular Disorders, 20, Article 347. https://doi.org/10.1186/s12872-020-01627-6

Background There is uncertain evidence in the dose-response association between overall physical activity levels and clustering of cardiovascular diseases modifiable risk factors (CVDMRF) in Chinese adults. This study examined the hypothesis whether... Read More about Dose-response association between physical activity and clustering of modifiable cardiovascular risk factors among 26,093 Chinese adults.

Synthesis of magnetic nanoparticles with an IDA or TED modified surface for purification and immobilization of poly-histidine tagged proteins (2020)
Journal Article
Yang. (2020). Synthesis of magnetic nanoparticles with an IDA or TED modified surface for purification and immobilization of poly-histidine tagged proteins. RSC advances, 11524 - 11534. https://doi.org/10.1039/C9RA10473A

Magnetic nanoparticles (MNPs) chelating with metal ions can specifically interact with poly-histidine peptides and facilitate immobilization and purification of proteins with poly-histidine tags. Fabrication of MNPs is generally complicated and time... Read More about Synthesis of magnetic nanoparticles with an IDA or TED modified surface for purification and immobilization of poly-histidine tagged proteins.

Bioactive silver phosphate/polyindole nanocomposites (2020)
Journal Article
Yang. (2020). Bioactive silver phosphate/polyindole nanocomposites. RSC advances, 11060 - 11073. https://doi.org/10.1039/D0RA01129K

Materials capable of releasing reactive oxygen species (ROS) can display antibacterial and anticancer activity, and may also have anti-oxidant capacity if they suppress intracellular ROS (e.g. nitric oxide, NO) resulting in anti-inflammatory activity... Read More about Bioactive silver phosphate/polyindole nanocomposites.

Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin (2019)
Journal Article
Yang. (2019). Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin. Journal of Drug Delivery Science and Technology, https://doi.org/10.1016/j.jddst.2019.101496

Besifloxacin hydrochloride (BSF) is a new ophthalmic antibiotic. However, its low water solubility limits its therapeutic efficacy. This article reported a novel lipid based drug delivery system to enhance ocular bioavailability of BSF. Cationic nano... Read More about Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin.

P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection (2019)
Journal Article
Panpho, P., Davies, H., Field, M., Madine, J., Yang, Y., & Akhtar, R. (2019). P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection. Artery Research, 25(Suppl 1), S43-S43. https://doi.org/10.2991/artres.k.191224.036

Background: Aortic dissection is a devastating condition, beginning with a tear through from intima to the medial layer, leading to splitting of aortic layers and creating the false and true lumen with a septum (or flap). Little is known about the pr... Read More about P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection.

Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials (2019)
Journal Article
Barreto, S., Hamel, L., Schiatti, T., Yang, Y., & George, V. (2019). Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials. Cells, 8(12), https://doi.org/10.3390/cells8121536

Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac function in patients affected by heart disease or heart failure. CPCs are proliferative and committed to cardiac fate, capable of generating cells of all th... Read More about Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials.

Maintenance and Acceleration of Pericellular Matrix Formation within 3D Cartilage Cell Culture Models (2019)
Journal Article
Owida, H. A., Kuiper, N. L., & Yang, Y. (2021). Maintenance and Acceleration of Pericellular Matrix Formation within 3D Cartilage Cell Culture Models. Cartilage, 13(2_suppl), 847S-861S. https://doi.org/10.1177/1947603519870839

In native articular cartilage, chondrocytes are surrounded by a thin pericellular matrix (PCM) forming chondrons. The PCM is exclusively rich in type VI collagen. The retention of the PCM has a significant influence on the metabolic activity of the c... Read More about Maintenance and Acceleration of Pericellular Matrix Formation within 3D Cartilage Cell Culture Models.

Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates (2019)
Journal Article
Yang. (2019). Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates. https://doi.org/10.1016/j.bj.2019.01.003

Background Micro-mass culturing or cellular aggregation is an effective method used to form mineralised bone tissue. Poor core cell viability, however, is often an impeding characteristic of large micro-mass cultures, and equally for large tissue-eng... Read More about Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates.

Dynamic Culture Substrates That Mimic the Topography of the Epidermal-Dermal Junction (2019)
Journal Article
Yang. (2019). Dynamic Culture Substrates That Mimic the Topography of the Epidermal-Dermal Junction. Tissue Engineering Part A, 214 - 223. https://doi.org/10.1089/ten.tea.2018.0125

The junction between the epidermal and dermal layers of human skin undulates, the width and depth of the undulations varying with age and disease. We previously showed that when primary human epidermal keratinocytes are seeded on collagen-coated undu... Read More about Dynamic Culture Substrates That Mimic the Topography of the Epidermal-Dermal Junction.

Model-based iterative reconstruction for spectral-domain optical coherence tomography (2019)
Presentation / Conference
Mason, J. H., Reinwald, Y., Yang, Y., Waters, S., El Haj, A., & Bagnaninchi, P. O. (2019, February). Model-based iterative reconstruction for spectral-domain optical coherence tomography. Paper presented at Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVI, San Francisco, United States

Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon’s Capsule + Conjunctival ModelFibrosis Response Within a 3D Tenon’s + Conjunctival Model (2019)
Journal Article
Gater, R., Ipek, T., Sadiq, S., Nguyen, D., Jones, L., El Haj, A., & Yang, Y. (2019). Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon’s Capsule + Conjunctival ModelFibrosis Response Within a 3D Tenon’s + Conjunctival Model. Investigative ophthalmology & visual science, 60(2), 605 -614. https://doi.org/10.1167/iovs.18-25335

Surgical techniques such as trabeculectomy aim to treat glaucoma by making an incision into the scleral tissue, to create an alternative drainage pathway for aqueous to flow into the sub-Tenon’s/subconjunctival space. However, tissue fibrosis and wou... Read More about Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon’s Capsule + Conjunctival ModelFibrosis Response Within a 3D Tenon’s + Conjunctival Model.

Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model. (2018)
Journal Article
Owida, H., Rutter, A., Cinque, G., Kuiper, N., Sule-Suso, J., & Yang, Y. (2018). Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model. Analyst, 5979-5986. https://doi.org/10.1039/c8an01272e

Isolated and monolayer expanded chondrocytes are not the ideal cell form to produce a cartilage matrix. In articular cartilage, each chondrocyte is surrounded by a 2-4 µm thick collagen VI-rich pericellular matrix (PCM) forming a chondron. Freshly ex... Read More about Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model..

Induction of zonal-specific cellular morphology and matrix synthesis for biomimetic cartilage regeneration using hybrid scaffolds. (2018)
Journal Article
Yang. (2018). Induction of zonal-specific cellular morphology and matrix synthesis for biomimetic cartilage regeneration using hybrid scaffolds. Interface, https://doi.org/10.1098/rsif.2018.0310

Cartilage is anisotropic in nature and organized into distinct zones. Our goal was to develop zonal-specific three-dimensional hybrid scaffolds which could induce the generation of zonal-specific cellular morphology and extracellular matrix (ECM) com... Read More about Induction of zonal-specific cellular morphology and matrix synthesis for biomimetic cartilage regeneration using hybrid scaffolds..

The Effects of Biomimetically Conjugated VEGF on Osteogenesis and Angiogenesis of MSCs (Human and Rat) and HUVECs Co-culture Models (2018)
Journal Article
Yang. (2018). The Effects of Biomimetically Conjugated VEGF on Osteogenesis and Angiogenesis of MSCs (Human and Rat) and HUVECs Co-culture Models. Colloids and Surfaces B: Biointerfaces, https://doi.org/10.1016/j.colsurfb.2018.04.060

The purpose of this work was to investigate if the biomimetically conjugated VEGF and HUVECs co-culture could modulate the osteogenic and angiogenic differentiation of MSCs derived from rat and human bone marrow (rMSCs and hMSCs). After treated by am... Read More about The Effects of Biomimetically Conjugated VEGF on Osteogenesis and Angiogenesis of MSCs (Human and Rat) and HUVECs Co-culture Models.

Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study (2018)
Journal Article
Cao, P., Yang, Y., Ijeoma Uche, F., Ruth Hart, S., Li, W., & Yuan, C. (2018). Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study. International Journal of Molecular Sciences, 793 - 793. https://doi.org/10.3390/ijms19030793

Modification of metal surfaces with antimicrobial peptides is a promising approach to reduce bacterial adhesion. Here, cyclic peptides or cycloids, possessing remarkable stability and antimicrobial activities, were extracted and purified from Viola p... Read More about Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study.

Investigation of the antibiofilm capacity of peptide-modified stainless steel (2018)
Journal Article
Cao, P., Li, W., Morris, A. R., Horrocks, P. D., Yuan, C., & Yang, Y. (2018). Investigation of the antibiofilm capacity of peptide-modified stainless steel. Royal Society Open Science, https://doi.org/10.1098/rsos.172165

Biofilm formation on surfaces is an important research topic in ship tribology and medical implants. In this study, dopamine and two types of synthetic peptides were designed and attached to 304 stainless steel surfaces, aiming to inhibit the formati... Read More about Investigation of the antibiofilm capacity of peptide-modified stainless steel.

Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy (2018)
Journal Article
Yang. (2018). Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy. Methods, 126-133. https://doi.org/10.1016/j.ymeth.2017.10.010

Cell mechanical behaviour is increasingly recognised as a central biophysical parameter in cancer and stem cell research, and methods of investigating their mechanical behaviour are therefore needed. We have developed a novel qualitative method based... Read More about Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy.

Current State-of-the-Art 3D Tissue Models and Their Compatibility with Live Cell Imaging (2017)
Book Chapter
Bardsley, K., Deegan, A. J., El Haj, A., & Yang, Y. (2017). Current State-of-the-Art 3D Tissue Models and Their Compatibility with Live Cell Imaging. In Multi-Parametric Live Cell Microscopy of 3D Tissue Models (3-18). (1). Springer. https://doi.org/10.1007/978-3-319-67358-5_1

Mammalian cells grow within a complex three-dimensional (3D) microenvironment where multiple cells are organized and surrounded by extracellular matrix (ECM). The quantity and types of ECM components, alongside cell-to-cell and cell-to-matrix interac... Read More about Current State-of-the-Art 3D Tissue Models and Their Compatibility with Live Cell Imaging.

Skin advanced glycation content reflects vaginal tissue glycation level in relation to pregnancy (2017)
Journal Article
Yang. (2017). Skin advanced glycation content reflects vaginal tissue glycation level in relation to pregnancy. Medical Hypotheses, https://doi.org/10.1016/j.mehy.2017.09.016

Abstract A few studies have revealed that the advanced glycation content of the vaginal wall in pelvic organ prolapse tissues is elevated. This elevation makes advanced glycation a significant association with the disease. Early detection of vaginal... Read More about Skin advanced glycation content reflects vaginal tissue glycation level in relation to pregnancy.

Co-culture of chondrons and mesenchymal stromal cells reduces the loss of collagen VI and improves extracellular matrix production. (2017)
Journal Article
Yang. (2017). Co-culture of chondrons and mesenchymal stromal cells reduces the loss of collagen VI and improves extracellular matrix production. Histochemistry and Cell Biology, 625-638. https://doi.org/10.1007/s00418-017-1602-4

Adult articular chondrocytes are surrounded by a pericellular matrix (PCM) to form a chondron. The PCM is rich in hyaluronan, proteoglycans, and collagen II, and it is the exclusive location of collagen VI in articular cartilage. Collagen VI anchors... Read More about Co-culture of chondrons and mesenchymal stromal cells reduces the loss of collagen VI and improves extracellular matrix production..

Co-culture of chondrons and mesenchymal stromal cells reduces the loss of collagen VI and improves extracellular matrix production (2017)
Journal Article
Yang. (2017). Co-culture of chondrons and mesenchymal stromal cells reduces the loss of collagen VI and improves extracellular matrix production. Histochemistry and Cell Biology, 625-638. https://doi.org/10.1007/s00418-017-1602-4

Adult articular chondrocytes are surrounded by a pericellular matrix (PCM) to form a chondron. The PCM is rich in hyaluronan, proteoglycans, and collagen II, and it is the exclusive location of collagen VI in articular cartilage. Collagen VI anchors... Read More about Co-culture of chondrons and mesenchymal stromal cells reduces the loss of collagen VI and improves extracellular matrix production.

Electrospun Collagen Nanofibers and Their Applications in Skin Tissue Engineering (2017)
Journal Article
Law, J. X., Liau, L. L., Saim, A., Yang, Y., & Idrus, R. (2017). Electrospun Collagen Nanofibers and Their Applications in Skin Tissue Engineering. Tissue Engineering and Regenerative Medicine, 14(6), 699-718. https://doi.org/10.1007/s13770-017-0075-9

Electrospinning is a simple and versatile technique to fabricate continuous fibers with diameter ranging from micrometers to a few nanometers. To date, the number of polymers that have been electrospun has exceeded 200. In recent years, electrospinni... Read More about Electrospun Collagen Nanofibers and Their Applications in Skin Tissue Engineering.

Advanced glycation products' levels and mechanical properties of vaginal tissue in pregnancy (2017)
Journal Article
Weli, H. K., Akhtar, R., Chang, Z., Li, W., Cooper, J., & Yang, Y. (2017). Advanced glycation products' levels and mechanical properties of vaginal tissue in pregnancy. European Journal of Obstetrics and Gynecology and Reproductive Biology, 78-85. https://doi.org/10.1016/j.ejogrb.2017.04.037

Objectives Non-enzymatic glycation is closely associated with altered mechanical properties of connective tissue. Pregnancy, marked with high levels of female hormones, confers unique alteration to the mechanical properties of pelvic connective tiss... Read More about Advanced glycation products' levels and mechanical properties of vaginal tissue in pregnancy.

Erratum to: Methods for evaluating medical tests and biomarkers (2017)
Journal Article
Gopalakrishna, G., Investigators, S. C., Langendam, M., Scholten, R., Bossuyt, P., Leeflang, M., …Yang, Y. (2017). Erratum to: Methods for evaluating medical tests and biomarkers. Diagnostic and Prognostic Research, 1(1), https://doi.org/10.1186/s41512-017-0011-4

The original MEMTAB Abstracts in Diagnostic and Prognostic Research contains the incorrect year on individual abstracts in the PDF [1]. “Diagnostic and Prognostic Research 2016” under the correspondence line should therefore have been written as “... Read More about Erratum to: Methods for evaluating medical tests and biomarkers.

Fluorescent Labeling of Collagen Production by Cells for Noninvasive Imaging of Extracellular Matrix Deposition. (2017)
Journal Article
Yang, Y. (2017). Fluorescent Labeling of Collagen Production by Cells for Noninvasive Imaging of Extracellular Matrix Deposition. Tissue Engineering Part C: Methods, 228 - 236. https://doi.org/10.1089/ten.TEC.2017.0008

Extracellular matrix (ECM) is an essential component of tissues and provides both integrity and biological cues for cells. Collagen is one of the major proteins found within the ECM and therefore is an essential component of all engineered tissues. T... Read More about Fluorescent Labeling of Collagen Production by Cells for Noninvasive Imaging of Extracellular Matrix Deposition..

Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy (2017)
Journal Article
Gillies, D., Gamal, W., Downes, A., Reinwald, Y., Yang, Y., El Haj, A., & Bagnaninchi, P. O. (2017). Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy. Proceedings of SPIE, https://doi.org/10.1117/12.2251492

There is an unmet need in tissue engineering for non-invasive, label-free monitoring of cell mechanical behaviour in their physiological environment. Here, we describe a novel optical coherence phase microscopy (OCPM) set-up which can map relative... Read More about Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy.

Influence of Additive Manufactured Scaffold Architecture on the Distribution of Surface Strains and Fluid Flow Shear Stresses and Expected Osteochondral Cell Differentiation (2017)
Journal Article
Yang, Y. (2017). Influence of Additive Manufactured Scaffold Architecture on the Distribution of Surface Strains and Fluid Flow Shear Stresses and Expected Osteochondral Cell Differentiation. Frontiers in Bioengineering and Biotechnology, 1-11. https://doi.org/10.3389/fbioe.2017.00006

Scaffolds for regenerative medicine applications should instruct cells with the appropriate signals, including biophysical stimuli such as stress and strain, to form the desired tissue. Apart from that, scaffolds, especially for load-bearing applicat... Read More about Influence of Additive Manufactured Scaffold Architecture on the Distribution of Surface Strains and Fluid Flow Shear Stresses and Expected Osteochondral Cell Differentiation.

Online Monitoring Of Mechanical Properties Of 3D Tissue Engineered Constructs For Quality Assessment (2016)
Conference Proceeding
El Haj, A. J., Reinwald, Y., Baganinchi, P., Gamal, W., & Yang, Y. (2016). Online Monitoring Of Mechanical Properties Of 3D Tissue Engineered Constructs For Quality Assessment.

Introduction: Monitoring the maturation of engineered tissues prior to implantation into the patient is important for defining quality and manufacturing criteria. Key properties include scaffold integrity and mechanical properties. Novel non-invasive... Read More about Online Monitoring Of Mechanical Properties Of 3D Tissue Engineered Constructs For Quality Assessment.

Biocompatibility of biodegradable medical polymers (2016)
Book Chapter
Ozdil, D., Wimpenny, I., Aydin, H., & Yang, Y. (2017). Biocompatibility of biodegradable medical polymers. . Elsevier. https://doi.org/10.1016/b978-0-08-100372-5.00013-1

Biomaterials have various applications in the medical field; whilst biodegradable biomaterials play an important role in regenerative medicine, tissue engineering and drug delivery. In addition to conversional biocompatibility, biodegradable material... Read More about Biocompatibility of biodegradable medical polymers.

Defining a turnover index for the correlation of biomaterial degradation and cell based extracellular matrix synthesis using fluorescent tagging techniques (2016)
Journal Article
Bardsley, K., Wimpenny, I., Wechsler, R., Shachaf, Y., Yang, Y., & El Haj, A. J. (2016). Defining a turnover index for the correlation of biomaterial degradation and cell based extracellular matrix synthesis using fluorescent tagging techniques. Acta biomaterialia, 45, 133-142. https://doi.org/10.1016/j.actbio.2016.09.002

Non-destructive protocols which can define a biomaterial’s degradation and its associated ability to support proliferation and/or promote extracellular matrix deposition will be an essential in vitro tool. In this study we investigate fluorescently t... Read More about Defining a turnover index for the correlation of biomaterial degradation and cell based extracellular matrix synthesis using fluorescent tagging techniques.

Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015. (2016)
Journal Article
Yang, Y. (2016). Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015. Regenerative Medicine, 483 - 492. https://doi.org/10.2217/rme-2016-0053

This paper summarizes the proceedings of a workshop held at Trinity Hall, Cambridge to discuss comparability and includes additional information and references to related information added subsequently to the workshop. Comparability is the need to de... Read More about Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015..

A Real-Time Monitoring System to Assess the Platelet Aggregatory Capacity of Components of a Tissue-Engineered Blood Vessel Wall. (2016)
Journal Article
Yang, Y., Musa, F., & Harper, A. (2016). A Real-Time Monitoring System to Assess the Platelet Aggregatory Capacity of Components of a Tissue-Engineered Blood Vessel Wall. Tissue Engineering Part C: Methods, 691 - 699. https://doi.org/10.1089/ten.tec.2015.0582

Native blood vessels contain both an antiaggregatory intimal layer, which prevents platelet activation in the intact vessel, and a proaggregatory medial layer, which stimulates platelet aggregation upon vascular damage. Yet, current techniques for as... Read More about A Real-Time Monitoring System to Assess the Platelet Aggregatory Capacity of Components of a Tissue-Engineered Blood Vessel Wall..

A comparative study of skin cell activities in collagen and fibrin constructs. (2016)
Journal Article
Yang, Y. (2016). A comparative study of skin cell activities in collagen and fibrin constructs. Medical Engineering and Physics, 854 -861. https://doi.org/10.1016/j.medengphy.2016.05.017

Collagen and fibrin are widely used in tissue engineering due to their excellent biocompatibility and bioactivities that support in vivo tissue formation. These two hydrogels naturally present in different wound healing stages with different regulato... Read More about A comparative study of skin cell activities in collagen and fibrin constructs..

Accelerating and increasing nano-scaled pore formation on electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers. (2016)
Journal Article
Yang, Y. (2016). Accelerating and increasing nano-scaled pore formation on electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers. Journal of Biomaterials Science, Polymer Edition, 1155 - 1169. https://doi.org/10.1080/09205063.2016.1184122

Porous fibers are advantageous for filtration systems, drug delivery systems, and in the field of tissue engineering, in comparison to their non-porous counterparts. In this study, we developed a facile technique including two steps to generate poly(... Read More about Accelerating and increasing nano-scaled pore formation on electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers..

Correction: Optofluidic lens with low spherical and low field curvature aberrations (2016)
Journal Article
Zhao, H. T., Yang, Y., Chin, L. K., Chen, H. F., Zhu, W. M., Zhang, J. B., …Liu, A. Q. (in press). Correction: Optofluidic lens with low spherical and low field curvature aberrations. Lab on a Chip, 16(11), 2135-2135. https://doi.org/10.1039/c6lc90052f

Correction for ‘Optofluidic lens with low spherical and low field curvature aberrations’ by H. T. Zhao et al., Lab Chip, 2016, 16, 1617–1624. Funding information given in the Acknowledgements section is incorrect.

Flourescent, online monitoring of PLGA degradation for regenerative medicine applications (2016)
Journal Article
Yang. (2016). Flourescent, online monitoring of PLGA degradation for regenerative medicine applications. RSC advances, 44364 - 44370. https://doi.org/10.1039/C6RA04690H

Degradable polymers such as poly(lactic-co-glycolic acid) (PLGA) are frequently chosen for tissue engineering, due to their ease of production, controllable degradation rates and Food and Drug Administration (FDA) approval. Within tissue engineering... Read More about Flourescent, online monitoring of PLGA degradation for regenerative medicine applications.

OCT as a convenient tool to assess the quality and application of organotypic retinal samples (2016)
Journal Article
Gater, R., Khoshnaw, N., Nguyen, D., El Haj, A. J., & Yang, Y. (2016). OCT as a convenient tool to assess the quality and application of organotypic retinal samples. Proceedings of SPIE, 9707, https://doi.org/10.1117/12.2213509

Eye diseases such as macular degeneration and glaucoma have profound consequences on the quality of human life. Without treatment, these diseases can lead to loss of sight. To develop better treatments for retinal diseases, including cell therapies a... Read More about OCT as a convenient tool to assess the quality and application of organotypic retinal samples.

Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review (2015)
Journal Article
Yang, Y. (2015). Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review. Journal of Neurorestoratology, 123 - 131. https://doi.org/10.2147/JN.S70337

Restoration of function following damage to the central nervous system (CNS) is severely restricted by several factors. These include the hindrance of axonal regeneration imposed by glial scars resulting from inflammatory response to damage, and limi... Read More about Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review.

Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers (2015)
Journal Article
Kumar, D., Dale, T. P., Yang, Y., & Forsyth, N. R. (2015). Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers. Biomedical Materials, 10(6), Article 065017. https://doi.org/10.1088/1748-6041/10/6/065017

Human embryonic stem cells (hESCs) are conventionally expanded and maintained in vitro on biological substrates. Synthetic electrospun polymer nanofibers have the potential to act as non-biological substrates in the culture of hESCs. Three synthetic,... Read More about Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers.

Image analysis and quantification of tissue scaffolds (2015)
Book Chapter
Yang, Y., & Wimpenny, I. (2015). Image analysis and quantification of tissue scaffolds. In Characterisation and Design of Tissue Scaffolds (201-223). Elsevier. https://doi.org/10.1016/b978-1-78242-087-3.00009-2

If you can measure something, then you can improve it. Measurement of the structural and functional parameters of tissue-engineering scaffolds is important in the context of better scaffold design, regulation of cellular activities, and the predictio... Read More about Image analysis and quantification of tissue scaffolds.

First results of LHCD experiments with 4.6 GHz system toward steady-state plasma in EAST (2015)
Journal Article
Liu, F., Ding, B., Li, J., Wan, B., Shan, J., Wang, M., …the EAST Team. (2015). First results of LHCD experiments with 4.6 GHz system toward steady-state plasma in EAST. Nuclear Fusion, 55(12), 123022. https://doi.org/10.1088/0029-5515/55/12/123022

A 4.6 GHz lower-hybrid current drive (LHCD) system has been firstly commissioned in EAST in the 2014 campaign. The first LHCD results with 4.6 GHz show that LHW can be coupled to plasma with a low reflection coefficient, drive plasma current and plas... Read More about First results of LHCD experiments with 4.6 GHz system toward steady-state plasma in EAST.

Nano-colloid printing of functionalised PLA-b-PEO copolymers: Tailoring the surface pattern of adhesive motif and its effect on cell attachment (2015)
Journal Article
Yang. (2015). Nano-colloid printing of functionalised PLA-b-PEO copolymers: Tailoring the surface pattern of adhesive motif and its effect on cell attachment

n this study, we investigate the preparation of surface pattern of functional groups on poly(lactide) (PLA) surfaces through the controlled deposition of core-shell self-assemblies based on functionalized PLA-b-PEO amphiphilic block copolymers from s... Read More about Nano-colloid printing of functionalised PLA-b-PEO copolymers: Tailoring the surface pattern of adhesive motif and its effect on cell attachment.

Fluorescent Monitoring of Poly(lactic-co-glycolic Acid) Degradation and Extracellular Matrix Turnover of Engineered Tissue Constructs (2015)
Presentation / Conference
Bardsley, K., El Haj, A., & Yang, Y. (2015, September). Fluorescent Monitoring of Poly(lactic-co-glycolic Acid) Degradation and Extracellular Matrix Turnover of Engineered Tissue Constructs. Paper presented at 2015 4th TERMIS World Congress, Boston, Massachusetts, USA

Development of fluorescent tagging techniques for inert polymers is an advantageous tool for monitoring biomaterial degradation online. Here we present a protocol for the fluorescent tagging of poly(lactic-co-glycolic acid) (PLGA) which allows for ac... Read More about Fluorescent Monitoring of Poly(lactic-co-glycolic Acid) Degradation and Extracellular Matrix Turnover of Engineered Tissue Constructs.

Multi-functional PLGA Scaffolds For Vascularization In Bone Tissue Constructs (2015)
Presentation / Conference
Yang, Y., & Lyu, L. (2015, September). Multi-functional PLGA Scaffolds For Vascularization In Bone Tissue Constructs

In our previous work, a new technique in which electrospun nanofibers were rolled into multilayered-rod-like 3D scaffolds has been used in rabbit radius regeneration in vivo. This has been highly successful in bone formation. However these scaffolds... Read More about Multi-functional PLGA Scaffolds For Vascularization In Bone Tissue Constructs.

Preparation and analysis of a new bioorganic metallic material (2015)
Journal Article
Yang. (2015). Preparation and analysis of a new bioorganic metallic material. RSC advances, 78030 -78037. https://doi.org/10.1039/c5ra16340d

Biofouling on metal surfaces is one of the main reasons for increased ship drag. Many methods have already been used to reduce or remove it with moderate success. In this study, a synthetic peptide has been utilized to react with 304 stainless steel... Read More about Preparation and analysis of a new bioorganic metallic material.

In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow (2015)
Journal Article
Roffe, Yang, & Naire. (2015). In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow. Journal of NeuroInterventional Surgery, 969-972. https://doi.org/10.1136/neurintsurg-2015-011909

BACKGROUND: Mechanical thrombectomy with stent retriever devices is associated with significantly better outcomes than thrombolysis alone in the treatment of acute ischemic stroke. Thrombus aspiration achieves high patency rates, but clinical outcome... Read More about In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow.

Engineering In Vitro Differentiation Microenvironments to Study Heart Valve Calcification (2015)
Conference Proceeding
Yang, Y., Bhunia, S., Kontronias, R., Qamar, S., Srinivasan, L., Ipek, T., …Lyu, L. (2015). Engineering In Vitro Differentiation Microenvironments to Study Heart Valve Calcification.

Valvular calcification is one of the most common cardiac conditions affecting the elderly population. The reasons behind the calcification process and the cellular mechanisms involved are not well understood. Valve interstitial cells (VICs) are predo... Read More about Engineering In Vitro Differentiation Microenvironments to Study Heart Valve Calcification.

Freezeout concept and dynamical transport model in intermediate-energy heavy-ion reactions (2015)
Journal Article
Liu, X., Lin, W., Huang, M., Wada, R., Wang, J., Chen, Z., …Hu, Q. Freezeout concept and dynamical transport model in intermediate-energy heavy-ion reactions. Physical Review C - Nuclear Physics, 92(1), https://doi.org/10.1103/physrevc.92.014623

For the central collision events of 40Ca+40Ca, generated by an antisymmetrized molecular dynamics model in the intermediate energy range of 35 to 300 MeV/nucleon, the density and temperature of a fragmenting source have been extracted using a self-co... Read More about Freezeout concept and dynamical transport model in intermediate-energy heavy-ion reactions.

Study on wear behaviours for NBR/stainless steel under sand water-lubricated conditions (2015)
Journal Article
Dong, C., Yuan, C., Bai, X., Yang, Y., & Yan, X. (2015). Study on wear behaviours for NBR/stainless steel under sand water-lubricated conditions. Wear, 332-333, 1012-1020. https://doi.org/10.1016/j.wear.2015.01.009

Nitrile Butadiene Rubber (NBR) is widely used to make ship water-lubricated rubber stern tube bearings for marine applications. The sand in water is an important factor that affects the tribological properties of the rubber stern tube bearings. This... Read More about Study on wear behaviours for NBR/stainless steel under sand water-lubricated conditions.

Application of new optical coherence elastography to monitor the mineralization processing in bone tissue engineering constructs (2015)
Journal Article
Guan, G., Song, S., Huang, Z., & Yang, Y. (2015). Application of new optical coherence elastography to monitor the mineralization processing in bone tissue engineering constructs. Proceedings of SPIE, https://doi.org/10.1117/12.2078013

Generation of functional tissue in vitro through tissue engineering technique is a promising direction to repair and replace malfunctioned organ and tissue in the modern medicine for various diseases which could not been treated well by conventional... Read More about Application of new optical coherence elastography to monitor the mineralization processing in bone tissue engineering constructs.

Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues (2015)
Journal Article
Yang. (2015). Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues. RSC advances, 22053 - 22059 (7). https://doi.org/10.1039/C4RA15739G

Tissue engineering strategies for the central nervous system (CNS) have been largely hampered by the complexity of neural cell interactions and limited ability to control functional circuit formation. Although cultures of primary CNS neurons give key... Read More about Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues.

Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM (2014)
Journal Article
Deegan, A. J., Cinque, G., Wehbe, K., Konduru, S., & Yang, Y. (2015). Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM. Analytical and Bioanalytical Chemistry, 407(4), 1097-1105. https://doi.org/10.1007/s00216-014-8316-4

One novel tissue engineering approach to mimic in vivo bone formation is the use of aggregate or micromass cultures. Various qualitative and quantitative techniques, such as histochemical staining, protein assay kits and RT-PCR, have been used previo... Read More about Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM.

4-D Hippocampus Measurements of Neurite Growth in vitro (2014)
Conference Proceeding
Dempsey, K., Lam, K., Smith, W., Collins, D., Jones, D. M., Yang, Y., & Richardson, J. (2014). 4-D Hippocampus Measurements of Neurite Growth in vitro. . https://doi.org/10.1109/cit.2014.160

Current research in neural tissue engineering relies heavily on in vivo animal models of neurological injury. This has a number of major drawbacks. Using innovative imaging technologies and allied data analytics, this paper presents our current work... Read More about 4-D Hippocampus Measurements of Neurite Growth in vitro.

A facile in vitro model to study rapid mineralization in bone tissues (2014)
Journal Article
Yang, Y. (2014). A facile in vitro model to study rapid mineralization in bone tissues. BioMedical Engineering OnLine, 136 - ?. https://doi.org/10.1186/1475-925X-13-136

BACKGROUND: Mineralization in bone tissue involves stepwise cell-cell and cell-ECM interaction. Regulation of osteoblast culture microenvironments can tailor osteoblast proliferation and mineralization rate, and the quality and/or quantity of the fin... Read More about A facile in vitro model to study rapid mineralization in bone tissues.

Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy (2014)
Journal Article
Guilbert, M., Eklouh-Molinier, C., Wehbe, K., Sulé-Suso, J., Yang, Y., Cinque, G., …Sockalingum, G. D. (2014). Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy. Journal of Biomedical Optics, 19(11), 111612. https://doi.org/10.1117/1.jbo.19.11.111612

We report here on a first study using synchrotron radiation-based Fourier transform infrared microspectroscopy and imaging to investigate HT1080 human fibrosarcoma cells grown onto different-aged type I collagen networks. Spectral images were analy... Read More about Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy.

Study of gemcitabine-sensitive/resistant cancer cells by cell cloning and synchrotron FTIR microspectroscopy (2014)
Journal Article
Rutter, A. V., Siddique, M. R., Filik, J., Sandt, C., Dumas, P., Cinque, G., …Sulé-Suso, J. (2014). Study of gemcitabine-sensitive/resistant cancer cells by cell cloning and synchrotron FTIR microspectroscopy. Cytometry Part A, 85(8), 688-697. https://doi.org/10.1002/cyto.a.22488

Over the last few years, significant scientific insight on the effects of chemotherapy drugs at cellular level using synchrotron-based FTIR (S-FTIR) microspectroscopy has been obtained. The work carried out so far has identified spectral differences... Read More about Study of gemcitabine-sensitive/resistant cancer cells by cell cloning and synchrotron FTIR microspectroscopy.

Label free cell tracking in 3-D tissue engineering constructs with high resolution imaging (2014)
Journal Article
Smith, W., Lam, K., Dempsey, K., Mazzocchi-Jones, D., Richardson, J., & Yang, Y. (2014). Label free cell tracking in 3-D tissue engineering constructs with high resolution imaging. Proceedings of SPIE, https://doi.org/10.1117/12.2039354

Within the field of tissue engineering there is an emphasis on studying 3-D live tissue structures. Consequently, to investigate and identify cellular activities and phenotypes in a 3-D environment for all in vitro experiments, including shape, migra... Read More about Label free cell tracking in 3-D tissue engineering constructs with high resolution imaging.

An in vitro spinal cord injury model to screen neuroregenerative materials (2014)
Journal Article
Weightman, A. P., Pickard, M. R., Yang, Y., & Chari, D. M. (2014). An in vitro spinal cord injury model to screen neuroregenerative materials. Biomaterials, 35(12), 3756-3765. https://doi.org/10.1016/j.biomaterials.2014.01.022

Implantable ‘structural bridges’ based on nanofabricated polymer scaffolds have great promise to aid spinal cord regeneration. Their development (optimal formulations, surface functionalizations, safety, topographical influences and degradation profi... Read More about An in vitro spinal cord injury model to screen neuroregenerative materials.

Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain (2014)
Journal Article
Jozwiak, A., Liu, Y., Yang, Y., & Gates, M. (2014). Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain. BioMed Research International, 651236 -?. https://doi.org/10.1155/2014/651236

Implanting pieces of tissue or scaffolding material into the mammalian central nervous system (CNS) is wrought with difficulties surrounding the size of tools needed to conduct such implants and the ability to maintain the orientation and integrity o... Read More about Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain.

Molecular hydrogen emission in the interstellar medium of the Large Magellanic Cloud (2014)
Journal Article
Naslim, N., Kemper, F., Madden, S. C., Hony, S., Chu, Y., Galliano, F., …Reach, W. T. (2014). Molecular hydrogen emission in the interstellar medium of the Large Magellanic Cloud. Monthly Notices of the Royal Astronomical Society, 446(3), 2490 - 2504. https://doi.org/10.1093/mnras/stu2276

We present the detection and analysis of molecular hydrogen emission towards ten interstellar regions in the Large Magellanic Cloud. We examined low-resolution infrared spectral maps of 12 regions obtained with the Spitzer infrared spectrograph (IRS)... Read More about Molecular hydrogen emission in the interstellar medium of the Large Magellanic Cloud.

Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method (2013)
Journal Article
Guan, G., Li, C., Ling, Y., Yang, Y., Vorstius, J. B., Keatch, R. P., …Huang, Z. (2013). Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method. Journal of Biomedical Optics, 18(11), 111417. https://doi.org/10.1117/1.jbo.18.11.111417

Damage of collagen fibers in tendons is often directly related to changes in a tendon’s mechanical properties. Direct quantitative elasticity measurement of tendons will provide important information in tendon dysfunction diagnosis and treatment asse... Read More about Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method.

Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury (2013)
Journal Article
Weightman, A., Jenkins, S., Pickard, M., Chari, D., & Yang, Y. (2014). Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury. Nanomedicine: Nanotechnology, Biology and Medicine, 10(2), 291-295. https://doi.org/10.1016/j.nano.2013.09.001

Non-neuronal cells of the central nervous system (CNS), termed “neuroglia,” play critical roles in neural regeneration; therefore, replacement of glial populations via implantable nanofabricated devices (providing a growth-permissive niche) is a prom... Read More about Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury.

A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response (2013)
Journal Article
Wilson, S. L., Guilbert, M., Sulé‐Suso, J., Torbet, J., Jeannesson, P., Sockalingum, G. D., & Yang, Y. (2014). A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response. FASEB Journal, 28(1), 14-25. https://doi.org/10.1096/fj.13-227579

During aging, collagen structure changes, detrimentally affecting tissues' biophysical and biomechanical properties due to an accumulation of advanced glycation end-products (AGEs). In this investigation, we conducted a parallel study of microscopic... Read More about A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response.

Corneal Stromal Cell Plasticity: In Vitro Regulation of Cell Phenotype Through Cell-Cell Interactions in a Three-Dimensional Model (2013)
Journal Article
Wilson, S. L., Yang, Y., & El Haj, A. J. (2014). Corneal Stromal Cell Plasticity: In Vitro Regulation of Cell Phenotype Through Cell-Cell Interactions in a Three-Dimensional Model. Tissue engineering. Part A, 20(1-2), 225-238. https://doi.org/10.1089/ten.tea.2013.0167

In vivo, epithelial cells are connected both anatomically and functionally with stromal keratocytes. Co-culturing aims at recapturing this cellular anatomy and functionality by bringing together two or more cell types within the same culture environm... Read More about Corneal Stromal Cell Plasticity: In Vitro Regulation of Cell Phenotype Through Cell-Cell Interactions in a Three-Dimensional Model.

Identification of different subsets of lung cells using Raman microspectroscopy and whole cell nucleus isolation (2013)
Journal Article
Pijanka, J. K., Stone, N., Rutter, A. V., Forsyth, N., Sockalingum, G. D., Yang, Y., & Sulé-Suso, J. (2013). Identification of different subsets of lung cells using Raman microspectroscopy and whole cell nucleus isolation. Analyst, 138(17), 5052. https://doi.org/10.1039/c3an00968h

Raman spectroscopy has been widely used to study its possible clinical application in cancer diagnosis. However, in order to make it into clinical practice, it is important that this technique is able not only to identify cancer cells from their norm... Read More about Identification of different subsets of lung cells using Raman microspectroscopy and whole cell nucleus isolation.

Optical Coherence Tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface (2013)
Journal Article
Judd, A. M., Moss, G. P., Heylings, J., Wan, K., & Yang, Y. (2013). Optical Coherence Tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface. Proceedings of SPIE, 8580, Article ARTN 85800G. https://doi.org/10.1117/12.2004754

Polyamidoamine (PAMAM) dendrimers have been topically applied to the skin and utilised as a permeation enhancer for a range of therapeutic compounds. However, very little is known about the mechanism of enhancement. This study used optical coherence... Read More about Optical Coherence Tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface.

Errata: Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography (2013)
Journal Article
Yang, Y., Rupani, A., Bagnaninchi, P., Wimpenny, I., & Weightman, A. (2013). Errata: Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography. Journal of Biomedical Optics, 18(1), 019801. https://doi.org/10.1117/1.JBO.18.1.019801

This article [J. Biomed. Opt.. 17, (8 ), 081417 (2012)] was originally published online on 2 August 2012 with an error in the reference citation of Fig. 1. The correct figure caption and references for Fig. 1 are shown below. A new reference was adde... Read More about Errata: Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography.

Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model (2012)
Journal Article
Rutter, A. V., Chippendale, T. W. E., Yang, Y., Španěl, P., Smith, D., & Sulé-Suso, J. (in press). Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model. Analyst, 138(1), 91-95. https://doi.org/10.1039/c2an36185j

Our previous studies have shown that both lung cancer cells and non-malignant lung cells release acetaldehyde in vitro. However, data from other laboratories have produced conflicting results. Furthermore, all these studies have been carried out in 2... Read More about Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model.