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Ying Yang's Outputs (120)

Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues (2015)
Journal Article
Yang. (2015). Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues. RSC advances, 22053 - 22059 (7). https://doi.org/10.1039/C4RA15739G

Tissue engineering strategies for the central nervous system (CNS) have been largely hampered by the complexity of neural cell interactions and limited ability to control functional circuit formation. Although cultures of primary CNS neurons give key... Read More about Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues.

Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM (2014)
Journal Article
Deegan, A. J., Cinque, G., Wehbe, K., Konduru, S., & Yang, Y. (2015). Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM. Analytical and Bioanalytical Chemistry, 407(4), 1097-1105. https://doi.org/10.1007/s00216-014-8316-4

One novel tissue engineering approach to mimic in vivo bone formation is the use of aggregate or micromass cultures. Various qualitative and quantitative techniques, such as histochemical staining, protein assay kits and RT-PCR, have been used previo... Read More about Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM.

4-D Hippocampus Measurements of Neurite Growth in vitro (2014)
Conference Proceeding
Dempsey, K., Lam, K., Smith, W., Collins, D., Jones, D. M., Yang, Y., & Richardson, J. (2014). 4-D Hippocampus Measurements of Neurite Growth in vitro. . https://doi.org/10.1109/cit.2014.160

Current research in neural tissue engineering relies heavily on in vivo animal models of neurological injury. This has a number of major drawbacks. Using innovative imaging technologies and allied data analytics, this paper presents our current work... Read More about 4-D Hippocampus Measurements of Neurite Growth in vitro.

A facile in vitro model to study rapid mineralization in bone tissues (2014)
Journal Article
Yang, Y. (2014). A facile in vitro model to study rapid mineralization in bone tissues. BioMedical Engineering OnLine, 136 - ?. https://doi.org/10.1186/1475-925X-13-136

BACKGROUND: Mineralization in bone tissue involves stepwise cell-cell and cell-ECM interaction. Regulation of osteoblast culture microenvironments can tailor osteoblast proliferation and mineralization rate, and the quality and/or quantity of the fin... Read More about A facile in vitro model to study rapid mineralization in bone tissues.

Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy (2014)
Journal Article
Guilbert, M., Eklouh-Molinier, C., Wehbe, K., Sulé-Suso, J., Yang, Y., Cinque, G., …Sockalingum, G. D. (2014). Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy. Journal of Biomedical Optics, 19(11), 111612. https://doi.org/10.1117/1.jbo.19.11.111612


We report here on a first study using synchrotron radiation-based Fourier transform infrared microspectroscopy and imaging to investigate HT1080 human fibrosarcoma cells grown onto different-aged type I collagen networks. Spectral images were analy... Read More about Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy.

Study of gemcitabine-sensitive/resistant cancer cells by cell cloning and synchrotron FTIR microspectroscopy (2014)
Journal Article
Rutter, A. V., Siddique, M. R., Filik, J., Sandt, C., Dumas, P., Cinque, G., …Sulé-Suso, J. (2014). Study of gemcitabine-sensitive/resistant cancer cells by cell cloning and synchrotron FTIR microspectroscopy. Cytometry Part A, 85(8), 688-697. https://doi.org/10.1002/cyto.a.22488

Over the last few years, significant scientific insight on the effects of chemotherapy drugs at cellular level using synchrotron-based FTIR (S-FTIR) microspectroscopy has been obtained. The work carried out so far has identified spectral differences... Read More about Study of gemcitabine-sensitive/resistant cancer cells by cell cloning and synchrotron FTIR microspectroscopy.

Label free cell tracking in 3-D tissue engineering constructs with high resolution imaging (2014)
Journal Article
Smith, W., Lam, K., Dempsey, K., Mazzocchi-Jones, D., Richardson, J., & Yang, Y. (2014). Label free cell tracking in 3-D tissue engineering constructs with high resolution imaging. Proceedings of SPIE, https://doi.org/10.1117/12.2039354

Within the field of tissue engineering there is an emphasis on studying 3-D live tissue structures. Consequently, to investigate and identify cellular activities and phenotypes in a 3-D environment for all in vitro experiments, including shape, migra... Read More about Label free cell tracking in 3-D tissue engineering constructs with high resolution imaging.

An in vitro spinal cord injury model to screen neuroregenerative materials (2014)
Journal Article
Weightman, A. P., Pickard, M. R., Yang, Y., & Chari, D. M. (2014). An in vitro spinal cord injury model to screen neuroregenerative materials. Biomaterials, 35(12), 3756-3765. https://doi.org/10.1016/j.biomaterials.2014.01.022

Implantable ‘structural bridges’ based on nanofabricated polymer scaffolds have great promise to aid spinal cord regeneration. Their development (optimal formulations, surface functionalizations, safety, topographical influences and degradation profi... Read More about An in vitro spinal cord injury model to screen neuroregenerative materials.

Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain (2014)
Journal Article
Jozwiak, A., Liu, Y., Yang, Y., & Gates, M. (2014). Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain. BioMed Research International, 651236 -?. https://doi.org/10.1155/2014/651236

Implanting pieces of tissue or scaffolding material into the mammalian central nervous system (CNS) is wrought with difficulties surrounding the size of tools needed to conduct such implants and the ability to maintain the orientation and integrity o... Read More about Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain.

Molecular hydrogen emission in the interstellar medium of the Large Magellanic Cloud (2014)
Journal Article
Naslim, N., Kemper, F., Madden, S. C., Hony, S., Chu, Y., Galliano, F., …Reach, W. T. (2014). Molecular hydrogen emission in the interstellar medium of the Large Magellanic Cloud. Monthly Notices of the Royal Astronomical Society, 446(3), 2490 - 2504. https://doi.org/10.1093/mnras/stu2276

We present the detection and analysis of molecular hydrogen emission towards ten interstellar regions in the Large Magellanic Cloud. We examined low-resolution infrared spectral maps of 12 regions obtained with the Spitzer infrared spectrograph (IRS)... Read More about Molecular hydrogen emission in the interstellar medium of the Large Magellanic Cloud.

Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method (2013)
Journal Article
Guan, G., Li, C., Ling, Y., Yang, Y., Vorstius, J. B., Keatch, R. P., …Huang, Z. (2013). Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method. Journal of Biomedical Optics, 18(11), 111417. https://doi.org/10.1117/1.jbo.18.11.111417

Damage of collagen fibers in tendons is often directly related to changes in a tendon’s mechanical properties. Direct quantitative elasticity measurement of tendons will provide important information in tendon dysfunction diagnosis and treatment asse... Read More about Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method.

Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury (2013)
Journal Article
Weightman, A., Jenkins, S., Pickard, M., Chari, D., & Yang, Y. (2014). Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury. Nanomedicine: Nanotechnology, Biology and Medicine, 10(2), 291-295. https://doi.org/10.1016/j.nano.2013.09.001

Non-neuronal cells of the central nervous system (CNS), termed “neuroglia,” play critical roles in neural regeneration; therefore, replacement of glial populations via implantable nanofabricated devices (providing a growth-permissive niche) is a prom... Read More about Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury.

A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response (2013)
Journal Article
Wilson, S. L., Guilbert, M., Sulé‐Suso, J., Torbet, J., Jeannesson, P., Sockalingum, G. D., & Yang, Y. (2014). A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response. FASEB Journal, 28(1), 14-25. https://doi.org/10.1096/fj.13-227579

During aging, collagen structure changes, detrimentally affecting tissues' biophysical and biomechanical properties due to an accumulation of advanced glycation end-products (AGEs). In this investigation, we conducted a parallel study of microscopic... Read More about A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response.

Corneal Stromal Cell Plasticity: In Vitro Regulation of Cell Phenotype Through Cell-Cell Interactions in a Three-Dimensional Model (2013)
Journal Article
Wilson, S. L., Yang, Y., & El Haj, A. J. (2014). Corneal Stromal Cell Plasticity: In Vitro Regulation of Cell Phenotype Through Cell-Cell Interactions in a Three-Dimensional Model. Tissue engineering. Part A, 20(1-2), 225-238. https://doi.org/10.1089/ten.tea.2013.0167

In vivo, epithelial cells are connected both anatomically and functionally with stromal keratocytes. Co-culturing aims at recapturing this cellular anatomy and functionality by bringing together two or more cell types within the same culture environm... Read More about Corneal Stromal Cell Plasticity: In Vitro Regulation of Cell Phenotype Through Cell-Cell Interactions in a Three-Dimensional Model.

Identification of different subsets of lung cells using Raman microspectroscopy and whole cell nucleus isolation (2013)
Journal Article
Pijanka, J. K., Stone, N., Rutter, A. V., Forsyth, N., Sockalingum, G. D., Yang, Y., & Sulé-Suso, J. (2013). Identification of different subsets of lung cells using Raman microspectroscopy and whole cell nucleus isolation. Analyst, 138(17), 5052. https://doi.org/10.1039/c3an00968h

Raman spectroscopy has been widely used to study its possible clinical application in cancer diagnosis. However, in order to make it into clinical practice, it is important that this technique is able not only to identify cancer cells from their norm... Read More about Identification of different subsets of lung cells using Raman microspectroscopy and whole cell nucleus isolation.

Optical Coherence Tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface (2013)
Journal Article
Judd, A. M., Moss, G. P., Heylings, J., Wan, K., & Yang, Y. (2013). Optical Coherence Tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface. Proceedings of SPIE, 8580, Article ARTN 85800G. https://doi.org/10.1117/12.2004754

Polyamidoamine (PAMAM) dendrimers have been topically applied to the skin and utilised as a permeation enhancer for a range of therapeutic compounds. However, very little is known about the mechanism of enhancement. This study used optical coherence... Read More about Optical Coherence Tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface.

Errata: Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography (2013)
Journal Article
Yang, Y., Rupani, A., Bagnaninchi, P., Wimpenny, I., & Weightman, A. (2013). Errata: Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography. Journal of Biomedical Optics, 18(1), 019801. https://doi.org/10.1117/1.JBO.18.1.019801

This article [J. Biomed. Opt.. 17, (8 ), 081417 (2012)] was originally published online on 2 August 2012 with an error in the reference citation of Fig. 1. The correct figure caption and references for Fig. 1 are shown below. A new reference was adde... Read More about Errata: Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography.

Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model (2012)
Journal Article
Rutter, A. V., Chippendale, T. W. E., Yang, Y., Španěl, P., Smith, D., & Sulé-Suso, J. (in press). Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model. Analyst, 138(1), 91-95. https://doi.org/10.1039/c2an36185j

Our previous studies have shown that both lung cancer cells and non-malignant lung cells release acetaldehyde in vitro. However, data from other laboratories have produced conflicting results. Furthermore, all these studies have been carried out in 2... Read More about Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model.