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Ying Yang's Outputs (127)

Engineering In Vitro Differentiation Microenvironments to Study Heart Valve Calcification (2015)
Presentation / Conference Contribution
Yang, Y., Bhunia, S., Kontronias, R., Qamar, S., Srinivasan, L., Ipek, T., Deegan, A., & Lyu, L. (2015, September). Engineering In Vitro Differentiation Microenvironments to Study Heart Valve Calcification. Presented at 2015 4th TERMIS World Congress, Boston, Massachusetts, USA

Valvular calcification is one of the most common cardiac conditions affecting the elderly population. The reasons behind the calcification process and the cellular mechanisms involved are not well understood. Valve interstitial cells (VICs) are predo... Read More about Engineering In Vitro Differentiation Microenvironments to Study Heart Valve Calcification.

Fluorescent Monitoring of Poly(lactic-co-glycolic Acid) Degradation and Extracellular Matrix Turnover of Engineered Tissue Constructs (2015)
Presentation / Conference Contribution
Bardsley, K., El Haj, A., & Yang, Y. (2015, September). Fluorescent Monitoring of Poly(lactic-co-glycolic Acid) Degradation and Extracellular Matrix Turnover of Engineered Tissue Constructs. Presented at 2015 4th TERMIS World Congress, Boston, Massachusetts, USA

Development of fluorescent tagging techniques for inert polymers is an advantageous tool for monitoring biomaterial degradation online. Here we present a protocol for the fluorescent tagging of poly(lactic-co-glycolic acid) (PLGA) which allows for ac... Read More about Fluorescent Monitoring of Poly(lactic-co-glycolic Acid) Degradation and Extracellular Matrix Turnover of Engineered Tissue Constructs.

Multi-functional PLGA Scaffolds For Vascularization In Bone Tissue Constructs (2015)
Presentation / Conference Contribution
Yang, Y., & Lyu, L. (2015, September). Multi-functional PLGA Scaffolds For Vascularization In Bone Tissue Constructs. Presented at 2015 4th TERMIS World Congress Boston, Massachusetts, USA

In our previous work, a new technique in which electrospun nanofibers were rolled into multilayered-rod-like 3D scaffolds has been used in rabbit radius regeneration in vivo. This has been highly successful in bone formation. However these scaffolds... Read More about Multi-functional PLGA Scaffolds For Vascularization In Bone Tissue Constructs.

Freezeout concept and dynamical transport model in intermediate-energy heavy-ion reactions (2015)
Journal Article
Liu, X., Lin, W., Huang, M., Wada, R., Wang, J., Chen, Z., Wang, Q., Ren, P., Yang, Y., Jin, S., Ma, P., Ma, J., Bai, Z., & Hu, Q. Freezeout concept and dynamical transport model in intermediate-energy heavy-ion reactions. Physical Review C - Nuclear Physics, 92(1), https://doi.org/10.1103/physrevc.92.014623

For the central collision events of 40Ca+40Ca, generated by an antisymmetrized molecular dynamics model in the intermediate energy range of 35 to 300 MeV/nucleon, the density and temperature of a fragmenting source have been extracted using a self-co... Read More about Freezeout concept and dynamical transport model in intermediate-energy heavy-ion reactions.

Study on wear behaviours for NBR/stainless steel under sand water-lubricated conditions (2015)
Journal Article
Dong, C., Yuan, C., Bai, X., Yang, Y., & Yan, X. (2015). Study on wear behaviours for NBR/stainless steel under sand water-lubricated conditions. Wear, 332-333, 1012-1020. https://doi.org/10.1016/j.wear.2015.01.009

Nitrile Butadiene Rubber (NBR) is widely used to make ship water-lubricated rubber stern tube bearings for marine applications. The sand in water is an important factor that affects the tribological properties of the rubber stern tube bearings. This... Read More about Study on wear behaviours for NBR/stainless steel under sand water-lubricated conditions.

Application of new optical coherence elastography to monitor the mineralization processing in bone tissue engineering constructs (2015)
Presentation / Conference Contribution
Guan, G., Song, S., Huang, Z., & Yang, Y. Application of new optical coherence elastography to monitor the mineralization processing in bone tissue engineering constructs. Presented at SPIE BiOS, San Francisco, California, United States

Generation of functional tissue in vitro through tissue engineering technique is a promising direction to repair and replace malfunctioned organ and tissue in the modern medicine for various diseases which could not been treated well by conventional... Read More about Application of new optical coherence elastography to monitor the mineralization processing in bone tissue engineering constructs.

Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues (2015)
Journal Article
Yang. (2015). Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues. RSC advances, 22053 - 22059 (7). https://doi.org/10.1039/C4RA15739G

Tissue engineering strategies for the central nervous system (CNS) have been largely hampered by the complexity of neural cell interactions and limited ability to control functional circuit formation. Although cultures of primary CNS neurons give key... Read More about Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues.

Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM (2014)
Journal Article
Deegan, A. J., Cinque, G., Wehbe, K., Konduru, S., & Yang, Y. (2015). Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM. Analytical and Bioanalytical Chemistry, 407(4), 1097-1105. https://doi.org/10.1007/s00216-014-8316-4

One novel tissue engineering approach to mimic in vivo bone formation is the use of aggregate or micromass cultures. Various qualitative and quantitative techniques, such as histochemical staining, protein assay kits and RT-PCR, have been used previo... Read More about Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM.

4-D Hippocampus Measurements of Neurite Growth in vitro (2014)
Presentation / Conference Contribution
Dempsey, K., Lam, K., Smith, W., Collins, D., Jones, D. M., Yang, Y., & Richardson, J. (2014, September). 4-D Hippocampus Measurements of Neurite Growth in vitro. Presented at 2014 IEEE International Conference on Computer and Information Technology (CIT), Xi'an, China

Current research in neural tissue engineering relies heavily on in vivo animal models of neurological injury. This has a number of major drawbacks. Using innovative imaging technologies and allied data analytics, this paper presents our current work... Read More about 4-D Hippocampus Measurements of Neurite Growth in vitro.

A facile in vitro model to study rapid mineralization in bone tissues (2014)
Journal Article
Yang, Y. (2014). A facile in vitro model to study rapid mineralization in bone tissues. BioMedical Engineering OnLine, 136 - ?. https://doi.org/10.1186/1475-925X-13-136

BACKGROUND: Mineralization in bone tissue involves stepwise cell-cell and cell-ECM interaction. Regulation of osteoblast culture microenvironments can tailor osteoblast proliferation and mineralization rate, and the quality and/or quantity of the fin... Read More about A facile in vitro model to study rapid mineralization in bone tissues.

Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy (2014)
Journal Article
Guilbert, M., Eklouh-Molinier, C., Wehbe, K., Sulé-Suso, J., Yang, Y., Cinque, G., Jeannesson, P., & Sockalingum, G. D. (2014). Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy. Journal of Biomedical Optics, 19(11), 111612. https://doi.org/10.1117/1.jbo.19.11.111612


We report here on a first study using synchrotron radiation-based Fourier transform infrared microspectroscopy and imaging to investigate HT1080 human fibrosarcoma cells grown onto different-aged type I collagen networks. Spectral images were analy... Read More about Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy.

Study of gemcitabine-sensitive/resistant cancer cells by cell cloning and synchrotron FTIR microspectroscopy (2014)
Journal Article
Rutter, A. V., Siddique, M. R., Filik, J., Sandt, C., Dumas, P., Cinque, G., Sockalingum, G. D., Yang, Y., & Sulé-Suso, J. (2014). Study of gemcitabine-sensitive/resistant cancer cells by cell cloning and synchrotron FTIR microspectroscopy. Cytometry Part A, 85(8), 688-697. https://doi.org/10.1002/cyto.a.22488

Over the last few years, significant scientific insight on the effects of chemotherapy drugs at cellular level using synchrotron-based FTIR (S-FTIR) microspectroscopy has been obtained. The work carried out so far has identified spectral differences... Read More about Study of gemcitabine-sensitive/resistant cancer cells by cell cloning and synchrotron FTIR microspectroscopy.

Label free cell tracking in 3-D tissue engineering constructs with high resolution imaging (2014)
Presentation / Conference Contribution
Smith, W., Lam, K.-P., Dempsey, K., Mazzocchi-Jones, D., Richardson, J., & Yang, Y. Label free cell tracking in 3-D tissue engineering constructs with high resolution imaging. Presented at Dynamics and Fluctuations in Biomedical Photonics XI

Within the field of tissue engineering there is an emphasis on studying 3-D live tissue structures. Consequently, to investigate and identify cellular activities and phenotypes in a 3-D environment for all in vitro experiments, including shape, migra... Read More about Label free cell tracking in 3-D tissue engineering constructs with high resolution imaging.

An in vitro spinal cord injury model to screen neuroregenerative materials (2014)
Journal Article
Weightman, A. P., Pickard, M. R., Yang, Y., & Chari, D. M. (2014). An in vitro spinal cord injury model to screen neuroregenerative materials. Biomaterials, 35(12), 3756-3765. https://doi.org/10.1016/j.biomaterials.2014.01.022

Implantable ‘structural bridges’ based on nanofabricated polymer scaffolds have great promise to aid spinal cord regeneration. Their development (optimal formulations, surface functionalizations, safety, topographical influences and degradation profi... Read More about An in vitro spinal cord injury model to screen neuroregenerative materials.

Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain (2014)
Journal Article
Jozwiak, A., Liu, Y., Yang, Y., & Gates, M. (2014). Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain. BioMed Research International, 651236 -?. https://doi.org/10.1155/2014/651236

Implanting pieces of tissue or scaffolding material into the mammalian central nervous system (CNS) is wrought with difficulties surrounding the size of tools needed to conduct such implants and the ability to maintain the orientation and integrity o... Read More about Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain.

Molecular hydrogen emission in the interstellar medium of the Large Magellanic Cloud (2014)
Journal Article
Naslim, N., Kemper, F., Madden, S. C., Hony, S., Chu, Y.-H., Galliano, F., Bot, C., Yang, Y., Seok, J., Oliveira, J. M., Van Loon, J. T., Meixner, M., Li, A., Hughes, A., Gordon, K. D., Otsuka, M., Hirashita, H., Morata, O., Lebouteiller, V., Indebetouw, R., …Reach, W. T. (2014). Molecular hydrogen emission in the interstellar medium of the Large Magellanic Cloud. Monthly Notices of the Royal Astronomical Society, 446(3), 2490 - 2504. https://doi.org/10.1093/mnras/stu2276

We present the detection and analysis of molecular hydrogen emission towards ten interstellar regions in the Large Magellanic Cloud. We examined low-resolution infrared spectral maps of 12 regions obtained with the Spitzer infrared spectrograph (IRS)... Read More about Molecular hydrogen emission in the interstellar medium of the Large Magellanic Cloud.

Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method (2013)
Journal Article
Guan, G., Li, C., Ling, Y., Yang, Y., Vorstius, J. B., Keatch, R. P., Wang, R. K., & Huang, Z. (2013). Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method. Journal of Biomedical Optics, 18(11), 111417. https://doi.org/10.1117/1.jbo.18.11.111417

Damage of collagen fibers in tendons is often directly related to changes in a tendon’s mechanical properties. Direct quantitative elasticity measurement of tendons will provide important information in tendon dysfunction diagnosis and treatment asse... Read More about Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method.

Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury (2013)
Journal Article
Weightman, A., Jenkins, S., Pickard, M., Chari, D., & Yang, Y. (2014). Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury. Nanomedicine: Nanotechnology, Biology and Medicine, 10(2), 291-295. https://doi.org/10.1016/j.nano.2013.09.001

Non-neuronal cells of the central nervous system (CNS), termed “neuroglia,” play critical roles in neural regeneration; therefore, replacement of glial populations via implantable nanofabricated devices (providing a growth-permissive niche) is a prom... Read More about Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury.