Outputs (39)

Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients (2024)
Journal Article
Johal, N., Sharma, R., Belcher, J., Coyle, D., Lindley, E. J., Keane, D., …Davies, S. J. (2024). Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients. BMC Nephrology, 25(1), Article 398. https://doi.org/10.1186/s12882-024-03837-y

Introduction: Fluid assessment and management is a key aspect of good dialysis care and is affected by patient-level characteristics and potentially centre-level practices. In this secondary analysis of the BISTRO trial we wished to establish whether... Read More about Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients.

Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial (2024)
Journal Article
Belcher, J., Coyle, D., Lindley, E. J., Keane, D., Caskey, F. J., Dasgupta, I., …Davies, S. J. (2024). Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial. Kidney360, https://doi.org/10.34067/kid.0000000596

Preservation of residual kidney function (RKF) in dialysis patients has been associated with improved survival. RKF in the BISTRO trial was relatively well preserved and here we describe its association with survival during the trial and extended fol... Read More about Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial.

Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT (2024)
Journal Article
Zanganeh, M., Belcher, J., Fotheringham, J., Coyle, D., Lindley, E. J., Keane, D. F., …Andronis, L. (2024). Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT. Health Technology Assessment, 1-45. https://doi.org/10.3310/jypr4287

Background
The BioImpedance Spectroscopy to maintain Renal Output randomised controlled trial investigated the effect of bioimpedance spectroscopy added to a standardised fluid management protocol on the risk of anuria and preservation of residual k... Read More about Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT.

Improving patient understanding of GEP test results (IMPARTER4): An RCT. (2024)
Presentation / Conference
Fallowfield, L., Solis-Trapala, I., Starkings, R., Matthews, L., May, S., & Jenkins, V. A. (2024, May). Improving patient understanding of GEP test results (IMPARTER4): An RCT. Poster presented at 2024 ASCO Annual Meeting I

527 Background: We developed two 8 min films to aid patients’ understanding about gene expression profiling (GEP) tests (Oncotype DX or Prosigna) in breast cancer. A previous study of 120 women without breast cancer demonstrated significantly better... Read More about Improving patient understanding of GEP test results (IMPARTER4): An RCT..

#2832 Lean tissue mass is associated with mortality across different stages of chronic kidney disease: a systematic review and meta-analysis (2024)
Presentation / Conference
Tabinor, M., Elphick, E., Stephens, C., Wall, N., Ul Hussain, A., Shah, R., …Davies, S. (2024, May). #2832 Lean tissue mass is associated with mortality across different stages of chronic kidney disease: a systematic review and meta-analysis. Presented at 61st ERA Congress, Stockholm, Sweden

Background and Aims Loss of lean tissue mass (LLTM) commonly occurs in multiple long-term conditions (LTC), including chronic kidney disease (CKD), and is thought to be associated with adverse outcomes including mortality, frailty surrogates and poor... Read More about #2832 Lean tissue mass is associated with mortality across different stages of chronic kidney disease: a systematic review and meta-analysis.

#2796 Divergent associations between mortality and different measures of renal function after adjustment for body composition: results from the UK Biobank (2024)
Presentation / Conference
Tabinor, M., Potts, J., Ferro, C. J., Davies, S., & Solis-Trapala, I. (2024, May). #2796 Divergent associations between mortality and different measures of renal function after adjustment for body composition: results from the UK Biobank. Presented at 61st ERA Congress, Stockholm, Sweden

Background and Aims There is data suggesting estimated glomerular filtration rate using Cystatin-C (eGFRCystatin-C) is superior to the creatinine-based (eGFRCreat) method when assessing associations between renal function and mortality (Lees et al. 2... Read More about #2796 Divergent associations between mortality and different measures of renal function after adjustment for body composition: results from the UK Biobank.

#1248 Sex specific associations between fat free mass and weight with mortality: sequences of regressions analyses from the UK Biobank cohort (2024)
Presentation / Conference
Tabinor, M., Potts, J., Ferro, C. J., Davies, S., & Solis-Trapala, I. (2024, May). #1248 Sex specific associations between fat free mass and weight with mortality: sequences of regressions analyses from the UK Biobank cohort. Presented at 61st ERA Congress, Stockholm, Sweden

Background and Aims There is growing evidence that muscle mass (MM) loss, observed in long term conditions (LTCs), including chronic kidney disease (CKD), is associated with mortality. This study aimed to explore the direct association between MM and... Read More about #1248 Sex specific associations between fat free mass and weight with mortality: sequences of regressions analyses from the UK Biobank cohort.

Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England (2024)
Journal Article
Damery, S., Lambie, M., Williams, I., Coyle, D., Fotheringham, J., Solis-Trapala, I., …Davies, S. J. (2024). Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, https://doi.org/10.1177/08968608241232200

Background:
Disparities in home dialysis uptake across England suggest inequity and unexplained variation in access. We surveyed staff at all English kidney centres to identify patterns in service organisation/delivery and explore correlations with... Read More about Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England.

Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage (2024)
Journal Article
Toader, A.-M., Campbell, M. K., Quint, J. K., Robling, M., ydes, M. R., Thorn, J., …Williamson, P. (2024). Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage. Trials, 25(1), https://doi.org/10.1186/s13063-024-07926-z

Background
Healthcare system data (HSD) are increasingly used in clinical trials, augmenting or replacing traditional methods of collecting outcome data. This study, PRIMORANT, set out to identify, in the UK context, issues to be considered before t... Read More about Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage.

How do clinicians prescribe bridging glucocorticoids in people starting or escalating disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a service evaluation survey (2023)
Journal Article
Prior, J. A., Roddy, E., Solis-Trapala, I., Cornwall, N., Jinks, C., Abhishek, A., …Hider, S. (in press). How do clinicians prescribe bridging glucocorticoids in people starting or escalating disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a service evaluation survey. Rheumatology Advances in Practice, 7(3), Article rkad102. https://doi.org/10.1093/rap/rkad102