Outputs (15)

Hypoxic and pro-inflammatory priming of mesenchymal stem cell-derived extracellular vesicles to reduce disease severity and immune responses in inflammatory arthritis (2021)
Presentation / Conference
Kay, A. G., Treadwell, K., Roach, P., Morgan, R., Lodge, R., Hyland, M., …Kehoe, O. (2021, September). Hypoxic and pro-inflammatory priming of mesenchymal stem cell-derived extracellular vesicles to reduce disease severity and immune responses in inflammatory arthritis. Poster presented at 6th European Congress of Immunology, Virtual meeting

Novel biological therapies have revolutionised the management of Rheumatoid Arthritis (RA) but no cure currently exists. Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion... Read More about Hypoxic and pro-inflammatory priming of mesenchymal stem cell-derived extracellular vesicles to reduce disease severity and immune responses in inflammatory arthritis.

Syndecan-3: A Signaling Conductor in the Musculoskeletal System (2021)
Book Chapter
Jones, F. K., Kehoe, O., Daroszewska, A., van’t Hof, R. J., & Pisconti, A. (2021). Syndecan-3: A Signaling Conductor in the Musculoskeletal System. In Proteoglycans in Stem Cells (153-177). Springer. https://doi.org/10.1007/978-3-030-73453-4_7

Syndecan-3 is a transmembrane proteoglycan, the largest of the four syndecan family members and the most mysterious. To date, the number of published studies involving syndecan-3 is only a small fraction of the number of studies involving the other s... Read More about Syndecan-3: A Signaling Conductor in the Musculoskeletal System.

Pro-Inflammatory Priming of Umbilical Cord Mesenchymal Stromal Cells Alters the Protein Cargo of Their Extracellular Vesicles (2020)
Journal Article
Kehoe, O., Hyland, M., Mennan, C., Wilson, E., & Clayton, A. (2020). Pro-Inflammatory Priming of Umbilical Cord Mesenchymal Stromal Cells Alters the Protein Cargo of Their Extracellular Vesicles. Cells, https://doi.org/10.3390/cells9030726

Umbilical cord mesenchymal stromal cells (UCMSCs) have shown an ability to modulate the immune system through the secretion of paracrine mediators, such as extracellular vesicles (EVs). However, the culture conditions that UCMSCs are grown in can alt... Read More about Pro-Inflammatory Priming of Umbilical Cord Mesenchymal Stromal Cells Alters the Protein Cargo of Their Extracellular Vesicles.

The in vitro effect of syndecan-3 gene knockout on bone marrow-derived mesenchymal stem cells' properties (2019)
Journal Article
Stefan, A., Kay, A. . G., Forsyth, N., Jones, F. . K., Pisconti, A., & Kehoe, O. (2019). The in vitro effect of syndecan-3 gene knockout on bone marrow-derived mesenchymal stem cells' properties. International Journal of Experimental Pathology, 99(6),

Introduction: Inflammation is a central feature of rheumatoid arthritis that affects around 1% of the population and can result in disability and morbidity. The immunomodulatory effects of bone marrow-derived mesenchymal stem cells (MSCs) have been w... Read More about The in vitro effect of syndecan-3 gene knockout on bone marrow-derived mesenchymal stem cells' properties.

Anniversary Collection: 35 Years of STEM CELLS Homing of Mesenchymal Stem Cells An Update to: Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing (2017)
Journal Article
Kehoe, O., Fox, J. M., & Middleton, J. (2017). Anniversary Collection: 35 Years of STEM CELLS Homing of Mesenchymal Stem Cells An Update to: Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing. Journal of Stem Cells,